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Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
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Worldwide Distributors List - To find your local distributor if you're not within the United States.
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Chemokine Research Products
LSBio offers many chemokine antibodies and other products useful for studying chemokines and their receptors in immunology, cell biology, cancer and disease research.

Chemokines are small cytokines involved in the cell signaling of leukocyte migration, immune surveillance and response, angiogenesis, inflammatory processes and wound healing (Graham, 2012; Alejo, 2018). They are chemoattractants that act to lure in a number of different cell-types to sites of inflammation and damage, including monocytes and macrophages, neutrophils, eosinophils, mast cells and T-lymphocytes (Ono, 2003). The roles that chemokines and their receptors play in the immune response and cell migration have made them a research focus in studying autoimmune diseases and cancer. Since the 1990’s, they have also been of interest in controlling HIV infection, as beta chemokines including RANTES (CCL5), MIP-1α (CCL3), and MIP-1β (CCL4) were found to actively suppress HIV-1 through their endogenous inhibition of the HIV receptor CCR5 (Garzino-Demo, 1999; Von Recum, 2014; Hartley, 2018).


LSBio's mouse monoclonal CCR5 Antibody (clone T21/8) LS-B4052 is an optimal antibody for evaluating CCR5 expression by flow cytometry and has also been validated for WB, ELISA and IHC.
More CCR5 Products ->
CCR7 Antibody LS-A847 has been validated for use in IHC and shows highly specific staining to CCR7, a chemokine receptor involved in regulating actin flow during T cell migration (Hons, 2018).
More CCR7 Products ->
CCL27 is of growing interest as a marker in cancer and disease including toxic epidermal necrolysis and multiple sclerosis (Mao, 2018; Wang, 2018; Svetlana, 2015). LSBio offers many elisa kits to this target that can detect low levels of CCL27 in many sample types.
More CCL27 Products ->
LSBio offers antibodies and other reagents to the atypical Chemokine Receptor D6 (also known as ACKR2) useful for studying its regulatory functions in inflammation, lymphatic biology and cancer.
Chemokine Receptor D6 / ACKR2 Products ->


Chemokine Products by Function

Bibliography ▷
  • Alejo, Alí, et al. “Chemokines Cooperate with TNF to Provide Protective Anti-Viral Immunity and to Enhance Inflammation.” Nature Communications. 9:1 (2018): p. 1790
    [Full Text Article]
  • Garzino-Demo, Alfredo et al. Spontaneous and Antigen-Induced Production of HIV-Inhibitory Β-Chemokines Are Associated with AIDS-Free Status. Proceedings of the National Academy of Sciences of the United States of America 96.21 (1999): 11986–11991.
    [Full Text Article] [PMID: 10518563] [PMC: PMC18399]
  • Graham, G. J. and Locati, M. Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6. J. Pathol, 229 (2013): 168-175.
    [Full Text Article]
  • Hartley, Oliver et al. Preventing HIV transmission through blockade of CCR5: rationale, progress and perspectives. Swiss Med Wkly. 2018;148:w14580
    [Full Text Article]
  • Hons, Miroslav et al. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Nature Immunology. 19 (2018): 606–616
    [Full Text Article]
  • Mao, M., Xue, N., Wang, X. et al. Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population. BMC Cancer (2018) 18: 9
    [Full Text Article]
  • Ono, Santa Jeremy et al. Chemokines: Roles in leukocyte development, trafficking, and effector function. Journal of Allergy and Clinical Immunology . 111:6 (2003): 1185 - 1199
    [Full Text Article] [PMID: 12789214]
  • Svetlana F. Khaiboullina, Aigul R. Gumerova, Irina F. Khafizova, et al., “CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis,” BioMed Research International, vol. 2015, Article ID 189638, 10 pages, 2015.
    [Full Text Article]
  • Von Recum, Horst A, and Jonathan K Pokorski. “Peptide and Protein-Based Inhibitors of HIV-1 Co-Receptors.” Experimental biology and medicine (Maywood, N.J.) 238.5 (2013): 442–449. PMC. Web. 30 May 2018.
    [Full Text Article] [PMID: 23856897] [PMC: PMC3908444]
  • Wang, F., Ye, Y., Luo, ZY. et al. Diverse expression of TNF-α and CCL27 in serum and blister of Stevens–Johnson syndrome/toxic epidermal necrolysis. Clin Transl Allergy (2018) 8: 12.
    [Full Text Article]