LSBio offers many chemokine antibodies and other products useful for studying chemokines and their receptors in immunology, cell biology, cancer and disease research.
Chemokines are small cytokines involved in the cell signaling of leukocyte migration, immune surveillance and response, angiogenesis, inflammatory
processes and wound healing (Graham, 2012; Alejo, 2018). They are chemoattractants that act to lure in a number of different cell-types to
sites of inflammation and damage, including monocytes and macrophages, neutrophils, eosinophils, mast cells and T-lymphocytes (Ono, 2003).
The roles that chemokines and their receptors play in the immune response and cell migration have made them a research focus in studying autoimmune diseases and cancer.
Since the 1990’s, they have also been of interest in controlling HIV infection, as beta chemokines including RANTES (CCL5)
, and MIP-1β (CCL4)
were found to actively suppress HIV-1 through their endogenous inhibition of the HIV receptor CCR5
(Garzino-Demo, 1999; Von Recum, 2014; Hartley, 2018).
We have products to a large range of chemokines and their receptors, search below for more: