Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CCR9 is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
|Gene Name:||chemokine (C-C motif) receptor 9|
|Family/Subfamily:||GPCR , Chemokine|
|Synonyms:||CCR9, C-C CKR-9, CC-CKR-9, CCR-9, CDw199 antigen, C-C chemokine receptor 9, C-C chemokine receptor type 9, Chemokine c-c motif receptor 9, CDw199, G protein-coupled receptor 28, GPR-9-6, G-protein coupled receptor 28, GPR28|
|Target Sequences:||NM_006641 NP_006632.2 P51686|
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