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Home > Virology > Polyomaviridae (SV40)

Polyomaviridae (SV40)

Polyomaviruses are non-enveloped, icosahedral double-stranded DNA viruses that range from 45 to 55 nm in diameter, and contain a limited number of genes (6-7).

Polyomaviridae (SV40) Research Products



About Polyomaviridae

Polyomaviruses include members such as SV40, JC, and BK viruses, and encode both early functions (nonstructural proteins) that can induce tumors in animals, and late functions that code for structural proteins such as the viral capsid. Most polyomaviruses produce harmless, persistent infections in their hosts, except for the JC virus, which has been implicated in progressive multifocal leukoencephalopathy, a demyelinating disease that occurs rarely in individuals with impaired immune systems. The BK virus can cause a mild respiratory infection in children, then persists in the kidney. In adults with impaired immunity or who have had renal transplants, the virus can produce nephropathy, ureteric stenosis, or cystitis.

Figure 1: Polyomaviridae viral structure.
Figure 1: Polyomaviridae Virus Genome
Figure 2: Polyomaviridae genome.
Figure 2: Structure of Polyomaviridae Virus

Polyomaviruses can either infect cells, replicate, and induce cell death upon lysis (permissive cells) or infect cells and transform them rather than undergoing viral replication (non-permissive cells). In permissive cells, the virion attaches to specific surface receptors, enters the cell and is transported to the nucleus, where viral DNA is released. Early phase proteins such as large T antigen drive the cell into S phase, then use cellular DNA synthesis proteins such as DNA polymerase and thymidine kinase to replicate. T antigen binding then initiates transcription of late viral RNAs for proteins such as VP1, VP2, and VP3, and progeny virions are assembled in the nucleus. Host cell lysis then releases the viral particles.

In non-permissive cells or permissive cells infected with defective viral genomes, the tumor antigens are synthesized, and cellular DNA synthesis is stimulated, but late viral capsid genes are not expressed. Instead, the viral genome integrates randomly into the host chromosome. In SV40, the large T antigen binds p53 and RB proteins to trigger immortalization. In other polyomaviruses, the middle T antigen binds cellular proteins such as c-src, and promotes cellular replication.

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References
  • Ambalathingal, GR et al. BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies. 2017; Clin Microbiol Reviews. doi: 10.1128/CMR.00074-16
  • Butel, JS. Papovaviruses. Medical Microbiology. 1996; 4th Edition, Chapter 66.

All Polyomaviridae (SV40) Products

☰ Filters
Antibodies (20)
Proteins (3)
Primary (20)
Recombinant (3)
BK Virus VP1 (3)
JC Polyoma Virus VP2 (6)
Polyomavirus Large T Antigen (1)
Polyomavirus Medium T Antigen (1)
SV40 (7)
SV40 Large T Antigen (4)
SV40 T Antigen (1)
Human (1)
Mouse (2)
BK Polyomavirus (2)
JC Polyomavirus (4)
Polyomavirus (5)
Simian Virus 40 (6)
Virus (1)
IHC (1)
IHC-Fr (3)
IHC-P (3)
WB (14)
ELISA (6)
IF (10)
IP (8)
rabbit (4)
mouse (15)
rat (1)
Product Group
Polyomaviridae (23)
IgG (4)
IgG2a (11)
IgG2a,l (1)
IgG2b (2)
monoclonal mc (16)
polyclonal pc (4)
F-tag-01 (1)
KT3 (1)
MRQ-4 (1)
Pab101 (3)
PAb101 (2)
PAb108 (2)
PAb416 (1)
PAb419 (1)
PvMT (1)
PyLT (1)
Azide-free (2)
Biotin Conjugated (1)
Concentrated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Ready-to-Use (1)
Unconjugated (17)
C-Terminus (1)
N-Terminus (1)
No (23)
10His-SUMO, N-terminus + Myc, C-terminus (1)
His (1)
His-SUMO (1)
BK Polyomavirus (1)
JC Polyomavirus (2)
E. coli (2)
Yeast (1)
Purified (1)
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SV40 Mouse anti-Simian Virus 40 Monoclonal (Concentrated) (MRQ-4) Antibody
Simian Virus 40
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$931
SV40 Antibody - IHC of SV40 on FFPE Infected Kidney tissue.
Select
SV40 Mouse anti-Mouse Monoclonal (Pab101) Antibody
Mouse
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$323; 0.5 ml/$474; 1 ml/$785
SV40 Antibody - IHC of SV40 on FFPE Infected Kidney tissue. This image was taken for the unmodified form of this product. Other forms have not been tested.
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SV40 Mouse anti-Mouse Monoclonal (Ready-to-Use) (Pab101) Antibody
Mouse
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$373; 7 ml/$514; 15 ml/$773
SV40 Antibody
Select
SV40 Mouse anti-Simian Virus 40 Monoclonal (C-Terminus) (F-tag-01) Antibody
Simian Virus 40
IF, WB
Unconjugated
100 µg/$366
Select
SV40 Mouse anti-Simian Virus 40 Monoclonal (PAb419) Antibody
Simian Virus 40
IF, IP, WB
Unconjugated
100 µg/$825
Select
SV40 Mouse anti-Simian Virus 40 Monoclonal (PAb416) Antibody
Simian Virus 40
WB
Unconjugated
200 µg/$825
Select
SV40 Mouse anti-Simian Virus 40 Monoclonal (KT3) Antibody
Simian Virus 40
Unconjugated
250 µl/$518
Select
Polyomavirus Large T Antigen Mouse anti-Polyomavirus Monoclonal (PyLT) Antibody
Human, Virus
IF, IP, WB
Unconjugated
0.1 mg/$376
Select
SV40 Large T Antigen Mouse anti-Polyomavirus Monoclonal (PAb108) Antibody
Polyomavirus
IF, IP, WB
Unconjugated
0.1 ml/$305; 0.5 ml/$504; 1 ml/$724
Select
SV40 Large T Antigen Mouse anti-Polyomavirus Monoclonal (Azide-free) (PAb108) Antibody
Polyomavirus
IF, IP, WB
Unconjugated, Azide-free
0.1 ml/$538; 0.2 ml/$787
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SV40 Large T Antigen Mouse anti-Polyomavirus Monoclonal (PAb101) Antibody
Polyomavirus
IF, IP, WB
Unconjugated
100 µl/$466; 500 µl/$830; 1 ml/$931
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SV40 Large T Antigen Mouse anti-Polyomavirus Monoclonal (Azide-free) (PAb101) Antibody
Polyomavirus
IF, IP, WB
Unconjugated, Azide-free
100 µl/$861; 200 µl/$966
Select
SV40 T Antigen Mouse anti-Simian Virus 40 Monoclonal (Pab101) Antibody
Simian Virus 40
IF, IP, WB
Unconjugated
250 µl/$613
Select
BK Virus VP1 Mouse anti-BK Polyomavirus Monoclonal Antibody
BK Polyomavirus
ELISA, IF
Unconjugated
100 µg/$388
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BK Virus VP1 Mouse anti-BK Polyomavirus Monoclonal Antibody
BK Polyomavirus
ELISA, IF
Unconjugated
100 µg/$388
BK Virus VP1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
60.1 kDa
1 mg/$1,646; 100 µg/$490; 20 µg/$354
Select
JC Polyoma Virus VP2 Rabbit anti-JC Polyomavirus Polyclonal Antibody
JC Polyomavirus
ELISA, WB
Unconjugated
50 µg/$284; 100 µg/$351
Select
JC Polyoma Virus VP2 Rabbit anti-JC Polyomavirus Polyclonal (HRP) Antibody
JC Polyomavirus
ELISA, WB
HRP Conjugated
50 µg/$284; 100 µg/$351
Select
JC Polyoma Virus VP2 Rabbit anti-JC Polyomavirus Polyclonal (Biotin) Antibody
JC Polyomavirus
ELISA, WB
Biotin Conjugated
50 µg/$284; 100 µg/$351
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JC Polyoma Virus VP2 Rabbit anti-JC Polyomavirus Polyclonal (FITC) Antibody
JC Polyomavirus
ELISA, WB
FITC Conjugated
50 µg/$284; 100 µg/$351
JC Polyoma Virus VP2 Protein
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Yeast
His
39.2 kD
500 µg/$1,279; 100 µg/$637; 20 µg/$419
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E. coli
His-SUMO
53.2 kD
1 mg/$1,646; 100 µg/$565; 20 µg/$395
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Polyomavirus Medium T Antigen Rat anti-Polyomavirus Monoclonal (N-Terminus) (PvMT) Antibody
Polyomavirus
IP, WB
Unconjugated
0.1 ml/$376
Viewing 1-23 of 23 product results