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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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ACKR3 / CXCR7

atypical chemokine receptor 3

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Gene Name: atypical chemokine receptor 3
Family/Subfamily: GPCR , Chemokine
Synonyms: ACKR3, Chemokine orphan receptor 1, CMKOR1, CXCR7, CXC-R7, GPRN1, RDC1, RDC-1, CXCR-7, G-protein coupled receptor 159, GPR159
Target Sequences: NM_020311 NP_064707.1 P25106

Publications (5)

1
Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status. Gauvin J, Chagnon-Choquet J, Poudrier J, Roger M,; Montreal Primary HIV Infection and Slow Progressor Cohorts. PloS one. 2016 11:e0155868. (Flo; Human) [Full Text Article] [PubMed:27203285] [PMC:PMC4874627] Related Antibodies: LS-C64035.
2
New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle. Evans AE, Tripathi A, LaPorte HM, Brueggemann LI, Singh AK, Albee LJ, Byron KL, Tarasova NI, Volkman BF, Cho TY, Gaponenko V, Majetschak M. International journal of molecular sciences. 2016 17: (Flo, PLA; Mouse, Human) [Full Text Article] [PubMed:27331810] [PMC:PMC4926503] Related Antibodies: LS-B1815.
3
The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Jones SW, Brockbank SM, Mobbs ML, Le Good NJ, Soma-Haddrick S, Heuze AJ, Langham CJ, Timms D, Newham P, Needham MR. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2006 Jun;14:597-608. [Full Text Article] [PubMed:16647866] Related Antibodies: LS-A1893.
4
Heteromerization of chemokine (C-X-C motif) receptor 4 with alpha 1A/B-adrenergic receptors controls alpha 1-adrenergic receptor function. Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M. Proceedings of the National Academy of Sciences of the United States of America. Mar; (PLA; Human, Rat) [Full Text Article] [PubMed:25775528] Related Antibodies: LS-B1815.
5
The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Singh RK, Lokeshwar BL. Cancer research. 2011 May;71:3268-77. [Full Text Article] [PubMed:21398406] [PMC:PMC3085571] Related Antibodies: LS-A1439.
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Viewing 1-25 of 65 items
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
Fast Shipping
(1) Publication(s)
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
FITC Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
APC Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
AP Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
HRP Conjugated, Azide-free
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Horse, Human
IHC, IHC-P, WB
PE Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
(1) Publication(s)
Rabbit Polyclonal to Human ACKR3 / CXCR7
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACKR3 / CXCR7 Antibody - Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
(2) Publication(s)
Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
Select
(1) Publication(s)
Mouse Monoclonal (IgG1) to Human ACKR3 / CXCR7
Human
Flo, IHC, IHC-P
APC Conjugated
100µg   $710.00
Select
Mouse Monoclonal (IgG1) to Human ACKR3 / CXCR7
Human
Flo
APC Conjugated
100tst   $800.00
ACKR3 / CXCR7 Antibody - Anti-CXCR7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR3 / CXCR7
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACKR3 / CXCR7 Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with CXCR7 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human ACKR3 / CXCR7
Mouse, Human
IHC, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG1) to Human ACKR3 / CXCR7
Human
Flo
PE Conjugated
100tst   $755.00
ACKR3 / CXCR7 Antibody - Western blot of CXCR-7 antibody
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Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
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Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Human
ELISA, Flo, WB
Biotin Conjugated
200µl   $740.00
ACKR3 / CXCR7 Antibody - CMKOR1 Antibody western blot of U251 cell line lysates (35 ug/lane). The CMKOR1 antibody detected the CMKOR1 protein (arrow).
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Rabbit Polyclonal to Human ACKR3 / CXCR7
Human
Flo, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100µg   $355.00
Select
Mouse Monoclonal [clone 11n55] (IgG2a) to Human ACKR3 / CXCR7
Human
Flo
PerCP Conjugated
100tst   $815.00
Select
Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal (IgG) to Human ACKR3 / CXCR7
Human
ELISA, Flo, IP, WB
Unconjugated
100µg   $335.00

Viewing 1-25 of 65 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).