Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Home > Coronavirus

Coronavirus Research Products

LSBio offers many products related to coronavirus, including antibodies, proteins, and expression-ready ORF clones.

Coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome and with a helical nucleocapsid. The genomic size of coronavirus ranges from approximately 26 to 32 kilobases, the largest for an RNA virus. Based on genetic and antigenic criteria, CoVs have been organized into three groups: α -CoVs, β-CoVs, γ-CoVs. Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M), and nucleocapsid (N).

The S protein mediates attachment of the virus to the host cell surface receptors and promotes subsequent fusion between the viral and host cell membranes to facilitate viral entry into the host cell. The N protein binds to the CoV genome and makes up the helical nucleocapsid. The M protein is the most abundant structural protein and defines the shape of the viral envelope. It is also regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins. The E protein is the smallest of the major structural proteins, but also the most enigmatic. During the replication cycle, E is abundantly expressed inside the infected cell, but only a small portion is incorporated into the virion envelope. The genome of 2019-nCoV (aka Wuhan Coronavirus) has 89% nucleotide identity with bat SARS-like CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein proteins also clusters closely with those of the bat, civet and human SARS coronaviruses. However, the external subdomain of Spike’s receptor binding domain of 2019-nCoV shares only 40% amino acid identity with other SARS-related coronaviruses. Remarkably, its orf3b encodes a completely novel short protein.

K. Dhama, R.V.S. Pawaiya, S. Chakraborty, R. Tiwari, M. Saminathan and A.K. Verma, 2014. Coronavirus Infection in Equines: A Review. Asian Journal of Animal and Veterinary Advances, 9: 164-176.

Coronavirus Phylogenetic Tree and Heatmap


FELINE CANINE PORCINE SARS COVID-19 (Wuhan) BAT MERS BOVINE CAMEL
FELINE (ASU62488.1) 100.00 49.53 42.42 28.64 28.48 28.66 26.54 29.11 29.2
CANINE (AKA65829.1) 49.53 100.00 41.95 25.5 25.76 25.76 25.72 25.2 25.11
PORCINE (AIA61001.1) 42.42 41.95 100.00 26.37 26.46 26.35 26.85 27.17 27.48
SARS (NP_828851.1) 28.64 25.5 26.37 100.00 77.77 78.23 32.16 32.73 32.56
COVID-19 (YP_009724390.1) 28.48 25.76 26.46 77.77 100.00 97.71 31.79 32.13 32.13
BAT (QHR63300.2) 28.66 25.76 26.35 78.23 97.71 100.00 31.79 32.08 32.25
MERS (YP_009047204.1) 26.54 25.72 26.85 32.16 31.79 31.79 100.00 34.21 34.54
BOVINE (NP_150077.1) 29.11 25.20 27.17 32.73 32.13 32.08 34.21 100.00 94.28
CAMEL (AHN64774.1) 29.20 25.11 27.48 32.56 32.13 32.25 34.54 94.28 100.00
Key
100.00
83.33
66.66
50.00
33.33
16.66
0.00