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Home > Virology > Pneumoviridae (RSV)

Pneumoviridae (RSV)

The family of Pneumoviridae are large enveloped, non-segmented, negative-sense, single-stranded RNA viruses. The genus Orthopneumovirus includes human respiratory syncytial virus (HRSV) and bovine respiratory syncytial virus (BRSV), and the Metapneumovirus genus contains avian and human metapneumoviruses.

Pneumoviridae (RSV) Research Products


About Pneumoviridae

Pneumoviruses produce spherical and filamentous virions that range in size from 150-200 nm in diameter and contain a 115-kb genome that encodes 11 proteins. Included are three viral envelope proteins (G and F glycoproteins and the small hydrophobic protein) and eight other proteins, including the large (L) polymerase protein, nucleoprotein (N), phosphoprotein (P), three matrix proteins (M, M2-1, and M2-2), and two nonstructural proteins (NS1 and NS2).

Pneumoviridae Genome

The virus enters the cell by binding to the HN glycoprotein, fusing to the host plasma membrane, and then releasing the nucleocapsid. Viral mRNA is then transcribed by the virally encoded RNA-dependent RNA polymerase, and viral proteins are produced by host ribosomal machinery. After P, N, L, and M2 proteins are produced, a capsid is created around the newly replicated RNA genome to produce a ribonucleocapsid. The virion then buds from the cell membrane.

Respiratory syncytial viruses (RSV) are among the most important pathogenic infectious agents in children, and a leading cause of death globally in infants under 1 year of age. These viruses can cause upper respiratory infections similar to the common cold, but also can cause bronchiolitis, otitis media, pneumonia, and croup, and mortality in children with preexisting cardiac or lung disease. Reinfections, as well as co-infections with rhinovirus and adenoviruses, can also occur. In other cows, bovine respiratory syncytial virus (BRSV) is the major cause of respiratory disease in calves during the first year of life. There is currently no efficacious RSV vaccine and very few therapeutics to treat RSV.

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References
  • Borchers, AT et al. Respiratory Syncytial Virus-A Comprehensive Review. Clin Rev Allergy Immunol. 2013; 45(3):331-379. doi: 10.1007/s12016-013-8368-9
  • Griffiths, C et al. Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment. Clin Microbiol Rev. 2017 Jan; 30(1):277-319. doi: 10.1128/CMR.00010-16
  • Sarmiento-Silva, RE et al. Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus. Viruses. 2012 Dec; 4(12):3452-3467. doi: 10.3390/v4123452

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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal Antibody
Respiratory Syncytial Virus
ELISA, IF
Unconjugated
1 ml/$354
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (Biotin) Antibody
Respiratory Syncytial Virus
ELISA, IF
Biotin Conjugated
1 ml/$366
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (FITC) Antibody
Respiratory Syncytial Virus
ELISA, IF
FITC Conjugated
1 ml/$366
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RSV / Respiratory Syncytial Virus Rabbit anti-Respiratory Syncytial Virus Polyclonal (aa201-211) Antibody
Respiratory Syncytial Virus
ELISA, WB
Unconjugated
100 µg/$316
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal (2F7) Antibody
Respiratory Syncytial Virus
ELISA, IHC, IHC-Fr, WB
Unconjugated
50 µg/$323; 100 µg/$386
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RSV / Respiratory Syncytial Virus Mouse anti-Virus Monoclonal (2017/84) Antibody
Virus
ELISA, WB
Unconjugated
0.2 mg/$444
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RSV / Respiratory Syncytial Virus Mouse anti-Virus Monoclonal (RSV3216 (B016)) Antibody
Virus
ELISA, Flo, IF, IP, WB
Unconjugated
1 mg/$627
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RSV / Respiratory Syncytial Virus Rabbit anti-Respiratory Syncytial Virus Polyclonal (aa201-211) Antibody
Respiratory Syncytial Virus
ELISA, WB
Unconjugated
100 µg/$316
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal (9C5) Antibody
Respiratory Syncytial Virus
ELISA
Unconjugated
0.2 mg/$360; 0.5 mg/$424
RSV / Respiratory Syncytial Virus Antibody - 3 ug of RSV virions (subgroup A-Long strain) were loaded on SDS-PAGE, transferred to a PVDF membrane and detected with rabbit anti-RSV (Long strain) Polyclonal Antibody at a 1:1000 dilution. Goat anti-rabbit secondary antibody was used at 1:10000 dilution. The antibody detects the following RSV proteins: Glycoprotein (G) ~90 kD, Fusion (F) protein) ~55 kD, and nucleocapsid (N) protein) ~46 kD. Overexposure of the blot can result in detection of M2 protein (~22 kDA-not shown).
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RSV / Respiratory Syncytial Virus Rabbit anti-Respiratory Syncytial Virus Polyclonal Antibody
Virus
WB
Unconjugated
0.1 mg/$376
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RSV / Respiratory Syncytial Virus Rabbit anti-Respiratory Syncytial Virus Polyclonal (aa483-488) Antibody
Respiratory Syncytial Virus
ELISA, WB
Unconjugated
100 µg/$316
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
ELISA, IF, LateralFlow
Unconjugated
1 mg/$421
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
ELISA, IF, LateralFlow
Unconjugated
1 mg/$421
Select
RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
ELISA, IF, LateralFlow
Unconjugated
1 mg/$421
Select
RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal Antibody
Respiratory Syncytial Virus
ELISA, IF, WB
Unconjugated
500 µl/$317
Select
RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (HRP) Antibody
Respiratory Syncytial Virus
ELISA, IF, IHC
HRP Conjugated
100 µl/$700
Select
RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (Biotin) Antibody
Respiratory Syncytial Virus
ELISA, IF, IHC
Biotin Conjugated
100 µl/$700
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (FITC) Antibody
Respiratory Syncytial Virus
ELISA, IF, IHC
FITC Conjugated
100 µl/$700
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (APC) Antibody
Respiratory Syncytial Virus
ELISA, IF, IHC
APC Conjugated
100 µl/$700
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (PE) Antibody
Respiratory Syncytial Virus
ELISA, IF, IHC
PE Conjugated
100 µl/$700
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal (8B10) Antibody
Respiratory Syncytial Virus
ELISA, IF
Unconjugated
0.1 mg/$376
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RSV / Respiratory Syncytial Virus Goat anti-Respiratory Syncytial Virus Polyclonal (HRP) Antibody
Respiratory Syncytial Virus
ELISA, IHC, WB
HRP Conjugated
1 ml/$381
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
DB, ELISA
Unconjugated
1 mg/$625
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RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
ELISA, LateralFlow
Unconjugated
1 mg/$728
Select
RSV / Respiratory Syncytial Virus Mouse anti-Respiratory Syncytial Virus Monoclonal Antibody
Respiratory Syncytial Virus
ELISA, LateralFlow
Unconjugated
1 mg/$728
Viewing 1-25 of 278 product results