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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chemokine (C-X-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR2, CDw128b, CD182 antigen, CMKAR2, CXCR-2, CD182, CXC-R2, IL-8R B, Il-8 receptor b, IL-8 receptor type 2, Il-8rb, IL8R2, IL8RB, Interleukin-8 receptor type B, GRO/MGSA receptor, Interleukin 8 receptor beta, Interleukin 8 receptor, beta, Chemokine (CXC) receptor 2, IL8RA, Interleukin 8 receptor B, Interleukin 8 receptor type 2
Target Sequences: nm_001557 NP_001548.1 P25025

Publications (4)

1
IL-8-mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation. Kyriakakis E, Cavallari M, Pfaff D, Fabbro D, Mestan J, Philippova M, De Libero G, Erne P, Resink TJ. Journal of leukocyte biology. 2011 90:929-39. [PubMed:21807744]
2
CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y. World journal of surgical oncology. 2015 13:232. (IHC-P; Human) [Full Text Article] [PubMed:26231560] [PMC:PMC4522106]
3
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C171552.
4
Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Miyasho T, Yamada S, Kitagawa Y. Surgery. 2013 Sep;154:512-20. [Full Text Article] [PubMed:23972657] Related Antibodies: LS-A803.
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Viewing 1-25 of 77 items
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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(1) Publication(s)
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal (IgG1) to Human CXCR2
Human
Flo, IHC, IHC-P
Unconjugated
50µg   1mg/ml   $495.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
CXCR2 Antibody - Western blot testing of CXCR2 antibody and Lane 1: rat spleen; 2: rat kidney; 3: rat brain; 4: mouse testis; 5: HEPA; 6: mouse brain at 50ug; Predicted size: 41KD; Observed size: 41KD
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Rat, Human
WB
Unconjugated
100µg   $435.00
CXCR2 Antibody - Breast carcinoma
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Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR2 Antibody
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(1) Publication(s)
Rabbit Polyclonal to Human CXCR2
Rat, Human
WB
Unconjugated
100µg   1mg/ml   $295.00
CXCR2 Antibody - Immunofluorescent analysis of CD182 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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Rabbit Polyclonal to Human CXCR2
Dog, Human
ICC, IF, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
CXCR2 Antibody - Immunohistochemical analysis of CD182 (pS347) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human CXCR2
Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $215.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $325.00
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
CXCR2 Antibody - Immunofluorescence analysis of HepG2 cells, using IL-8R beta/CDw128 beta Antibody. The picture on the right is blocked with the synthesized peptide.
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
CXCR2 Antibody - CXCR2 antibody (0.3 ug/ml) staining of Mouse Colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Goat Polyclonal to Mouse CXCR2
Mouse
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
CXCR2 Antibody
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CXCR2 Antibody
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CXCR2 Antibody - Western blot of IL-8R beta/CDw128 beta phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal to Human CXCR2
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
100µg   $305.00
CXCR2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IL-8R beta/CDw128 beta (Phospho-Ser347) Antibody. The picture on the right is blocked with the phospho peptide.
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
CXCR2 Antibody - Western blot of Phospho-IL8Rbeta (S347) antibody
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
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Mouse Monoclonal (IgG1) to Human CXCR2
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
100µg   $475.00
Select
Rabbit Polyclonal (IgG) to Human CXCR2
Human
ELISA, IF, IP, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
20µl   1mg/ml   $205.00; 60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
CXCR2 Antibody - Immunohistochemistry of human spleen tissue slide (Paraffin embedded) using Rabbit Anti-CXCR2 Polyclonal Antibody.
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Rabbit Polyclonal (IgG) to Human CXCR2
ELISA, IHC, IHC-P, WB
Unconjugated
40µg   80µl   0.5mg/ml   $245.00

Viewing 1-25 of 77 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).