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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CCL2 / MCP1

chemokine (C-C motif) ligand 2

CCL2 / MCP1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Gene Name: chemokine (C-C motif) ligand 2
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL2, C-C motif chemokine 2, Chemokine (C-C motif) ligand 2, GDCF-2, HC11, HSMCR30, MCP1, SCYA2, Small-inducible cytokine A2, Monocyte secretory protein JE, MCAF, MCP-1, Monocyte chemotactic protein 1, SMC-CF
Target Sequences: NM_002982 NP_002973.1 P13500

Publications (5)

1
Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis. Zenebech Wondimu, Tania Santodomingo-Garzon, Tai Le, and Mark G. Swain. The American journal of pathology. 2010 177:2334-46. (IHC-P; Mouse) [Full Text Article] [PubMed:20847291] [PMC:PMC2966792]
2
Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, Fiebeler A, Klinge U, Park JK, Barth S, Thepen T, Tolba RH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:3149-55. (IHC; Rat) [PubMed:22402584]
3
Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 release and macrophage transepithelial migration. Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection and immunity. 2012 80:3225-35. (Human) [PubMed:22778093] [PMC:PMC3418758]
4
Small heat shock proteins induce a cerebral inflammatory reaction. Bruinsma IB, de Jager M, Carrano A, Versleijen AA, Veerhuis R, Boelens W, Rozemuller AJ, de Waal RM, Verbeek MM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11992-2000. (ICC; Human) [Full Text Article] [PubMed:21849559] Related Antibodies: LS-C8642.
5
Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. El-Gazzar AM, Abdelgied M, Alexander DB, Alexander WT, Numano T, Iigo M, Naiki A, Takahashi S, Takase H, Hirose A, Kannno J, Elokle OS, Nazem AM, Tsuda H. Archives of toxicology. 2019 January;93:49-59. [Full Text Article] [PubMed:30341734] [PMC:PMC6343020]
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Viewing 1-25 of 302 items
CCL2 / MCP1 Antibody - Anti-CCL2 / MCP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Select
Rabbit Polyclonal to Human CCL2 / MCP1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200µl   $425.00
Select
(1) Publication(s)
Mouse Monoclonal [clone 5D3-F7 (aka MNA.1)] (IgG1) to Human CCL2 / MCP1
Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg   $755.00
CCL2 / MCP1 Antibody - Anti-MCP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal to Human CCL2 / MCP1
Dog, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
CCL2 / MCP1 Antibody - IHC of paraffin-embedded liver cancer tissues using CCL2 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 2D8] (IgG1) to Human CCL2 / MCP1
Mouse, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $365.00
CCL2 / MCP1 Antibody - Immunohistochemistry of CCL2 in spleen tissue with CCL2 antibody at 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1mg   1mg/ml   $365.00
Select
Rat Monoclonal [clone ECE.2] (IgG1) to Mouse CCL2 / MCP1
Mouse
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $435.00
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
Select
Mouse Monoclonal (IgG1) to Human CCL2 / MCP1
Human
ELISA, WB
Unconjugated
500µg   $255.00
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
Select
Rabbit Polyclonal to Mouse CCL2 / MCP1
Mouse
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
CCL2 / MCP1 Antibody - Anti-Human MCP-1 Antibody - Western Blot. Anti-human MCP-1 by western blot shows detection of recombinant human MCP-1 raised in E. coli. Recombinant (0.1 ug, 8.6 kD) protein was loaded onto and resolved by SDS-PAGE, then transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with Anti-Human MCP-1. After washing, membrane was probed with secondary antibody Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Goat) Antibody ( diluted 1:20000 in blocking buffer (p/n MB-070) for 30 min. at RT. Data was collected using Bio-Rad VersaDoc 4000 MP imaging system.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Human
ELISA, WB
Unconjugated
100µg   1mg/ml   $425.00
CCL2 / MCP1 Antibody - Western Blot (reducing) of CCL2 / MCP-1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat CCL2 / MCP1
Rat
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
Select
Mouse Monoclonal [clone MNA1] (IgG1) to Human CCL2 / MCP1
Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $435.00
CCL2 / MCP1 Antibody - Immunohistochemistry of paraffin-embedded human colon tissue.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Mouse, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
CCL2 / MCP1 Antibody
Select
Hamster Monoclonal [clone 2H5] (IgG) to Mouse CCL2 / MCP1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µg   0.5mg/ml   $215.00
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
Select
Rabbit Polyclonal to Human CCL2 / MCP1
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
CCL2 / MCP1 Antibody - Anti-Bovine CCL2 Antibody - Western Blot. Western blot of protein-A purified anti-bovine CCL2 antibody shows detection of recombinant bovine CCL2 at 8.8kD (arrow) raised in yeast. Protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Inc. Anti-bovine CCL2. After washing, membrane was probed with Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody (.
Select
Rabbit Polyclonal (IgG) to Bovine CCL2 / MCP1
Mouse, Dog, Bovine, Pig, Cat, Human
ELISA, WB
Unconjugated
100µg   1mg/ml   $425.00
Select
Mouse Monoclonal (IgG1) to Human CCL2 / MCP1
Human
IHC, IHC-Fr
Unconjugated
100µg   $455.00
Select
Rabbit Polyclonal to Mouse CCL2 / MCP1
Mouse
ELISA, WB
Unconjugated
50µg   $355.00; 100µg   $435.00
CCL2 / MCP1 Antibody - Anti-CCL2 / MCP1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Human
ELISA, IHC, IHC-P
Unconjugated
100µg   1mg/ml   $565.00
CCL2 / MCP1 Antibody - Anti-CCL2 / MCP1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Human
ELISA, IHC, IHC-P
FITC Conjugated
50µg   0.25mg/ml   $285.00; 100µg   0.25mg/ml   $385.00
CCL2 / MCP1 Antibody - Mouse thioglycollate induced PEC were stimulated with LPS in the presence of Brefeldin A for 24 hours. The cells were surface stained with FITC anti-mouse F4/80 antigen and intracellularly stained with PE anti-mouse CCL2 (2H5). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Hamster Monoclonal [clone 2H5] (IgG) to Mouse CCL2 / MCP1
Mouse
ELISA, Flo
Biotin Conjugated
50µg   0.5mg/ml   $245.00; 500µg   $365.00
CCL2 / MCP1 Antibody - Staining of 1-day LPS activated normal human peripheral blood mononuclear cells with 0.5 ug of FITC Armenian Hamster IgG isotype control (open histogram) or 0.5 ug of FITC anti-mo/hu/rat CCL2/MCP-1 (2H5) (colored histogram). Cells in the monocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Hamster-Armenian Monoclonal [clone 2H5] (IgG) to Mouse CCL2 / MCP1
Mouse
Flo
FITC Conjugated
25tst   $225.00; 50µg   0.5mg/ml   $245.00
Select
Rat Monoclonal [clone ECE.2] (IgG1) to Mouse CCL2 / MCP1
Mouse
IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
50µg   $355.00
CCL2 / MCP1 Antibody - Anti-CCL2 / MCP1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human CCL2 / MCP1
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50µg   $285.00; 100µg   0.25mg/ml   $305.00
CCL2 / MCP1 Antibody - Immunohistochemistry-Paraffin: MCP1 Antibody (2D8) - Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MCP1 mouse mAb with DAB staining.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2D8] (IgG1) to Human CCL2 / MCP1
Mouse, Human, Primate
ELISA, Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $335.00
CCL2 / MCP1 Antibody - MCP-1 Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 2D8] (IgG1) to Human CCL2 / MCP1
Mouse, Human, Non-Human Primate
Flo, ICC, IF, IHC, WB
Unconjugated
100µg   $405.00

Viewing 1-25 of 302 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).