Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CCR1 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
|Gene Name:||chemokine (C-C motif) receptor 1|
|Family/Subfamily:||GPCR , Chemokine|
|Synonyms:||CCR1, C-C chemokine receptor type 1, CD191, CD191 antigen, CKR-1, CKR1, CMKBR1, CC-CKR-1, CMKR1, HM145, MIP-1 alpha, RANTES-R, RANTES receptor, SCYAR1, MIP-1 alpha receptor, C-C CKR-1, CCR-1, LD78 receptor, MIP-1alpha-R, MIP1aR|
|Target Sequences:||NM_001295 NP_001286.1 P32246|
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