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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACKR2 / CCR10 / D6

atypical chemokine receptor 2

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene Name: atypical chemokine receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: ACKR2, C-C chemokine receptor D6, CCBP2, Chemokine (C-C) receptor 9, Chemokine binding protein 2, C-C chemokine receptor 10, Chemokine-binding protein 2, CMKBR9, Chemokine receptor CCR-9, G protein coupled receptor d6, HD6, Cc-chemokine receptor type 10, Chemokine receptor CCR-10, Chemokine receptor D6, Chemokine-binding protein D6, D6
Target Sequences: NM_001296 NP_001287.2 O00590

Viewing 1-25 of 46 items
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
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Neuroscience
Fast Shipping
Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Human
ELISA, IHC, IHC-P
AP Conjugated
100µl   $650.00
ACKR2 / CCR10 / D6 Antibody - Anti-ACKR2 / CCR10 / D6 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Human
ELISA, IHC
Unconjugated
100µg   2mg/ml   $335.00
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Mouse Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Human
WB
Unconjugated
50µg   0.5mg/ml   $560.00
ACKR2 / CCR10 / D6 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
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Goat Polyclonal (IgG) to Mouse ACKR2 / CCR10 / D6
Flo, ICC, IHC, IHC-P, WB
Unconjugated
200µg   $560.00
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
Select
Neuroscience
Fast Shipping
Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
Select
Fast Shipping
Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Human
IHC, IHC-P
PE Conjugated
100µl   1.08mg/ml   $650.00
ACKR2 / CCR10 / D6 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
ACKR2 / CCR10 / D6 Antibody - Western blot of Chemokine Receptor D6 antibody
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Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
ICC, IHC, IP, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, IP, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Mouse, Human
ELISA, ICC, IHC, WB
PE Conjugated
200µl   $740.00
ACKR2 / CCR10 / D6 Antibody - Western blot of Chemokine Receptor D6 (S383) pAb in extracts from HepG2.
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Rabbit Polyclonal to Human ACKR2 / CCR10 / D6
Human
IF, IHC, WB
Unconjugated
100µl   $345.00

Viewing 1-25 of 46 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).