Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
206-374-1102
Fax:
206-577-4565
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Home > Virology > Papillomaviridae (HPV)

Papillomaviridae (HPV)

Papillomaviruses are non-enveloped, icosahedral double-stranded DNA viruses that range from 45 to 55 nm in diameter, and contain a limited number of genes (6-7).

Papillomaviridae (HPV) Research Products



About Papillomaviridae

Papillomaviruses are highly species-specific and cause tumors (papillomas and carcinomas) in their hosts. The papillomavirus genome contains at least six open reading frames; the early frames code for proteins that are involved in viral replication and cell transformation, whereas the late frames encode capsid proteins. Human papillomaviruses are a diverse group, and more than 200 types exist, associated with different pathologic conditions. They are particularly tropic for squamous epithelial cells, with some types (HPV 6, 11) producing papillomas (warts), and others (HPV 16, 18, 31) producing persistent subclinical infections or transforming the epithelium into oropharyngeal, anogenital, or cervical squamous cell carcinomas. Transmission occurs via direct mucosal contact with an infected person, by sexual transmission, or with viral particles left on a surface.

Papillomaviridae Virus

Papillomaviruses can either infect cells, replicate, and induce cell death upon lysis (permissive cells) or infect cells and transform them rather than undergoing viral replication (non-permissive cells). In permissive cells, the virion attaches to specific surface receptors, enters the cell and is transported to the nucleus, where viral DNA is released. Early phase proteins such as E6 and E7 drive the cell into S phase, then use cellular DNA synthesis proteins such as DNA polymerase and thymidine kinase to replicate. After transcription of late viral RNAs for structural proteins, progeny virions are assembled in the nucleus. Host cell lysis then releases the viral particles.

In non-permissive cells or permissive cells infected with defective viral genomes, the tumor antigens are synthesized, and cellular DNA synthesis is stimulated, but late viral capsid genes are not expressed. Instead, the viral genome integrates randomly into the host chromosome. In human papillomaviruses, the E6 and E7 proteins bind p53 and RB, respectively, leading to immortalization. These transforming proteins produce altered host cell morphology, increased growth rate, loss of contact inhibition, and anchorage independence, all of which promote tumorigenicity.

Back To Top
References
  • Ambalathingal, GR et al. BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies. 2017; Clin Microbiol Reviews. doi: 10.1128/CMR.00074-16
  • Butel, JS. Papovaviruses. Medical Microbiology. 1996; 4th Edition, Chapter 66.

All Papillomaviridae (HPV) Products

☰ Filters
Antibodies (225)
Proteins (11)
Primary (225)
Recombinant (11)
HPV / Human Papilloma Virus (20)
HPV E2 (7)
HPV E6 (8)
HPV E7 (55)
HPV L1 Capsid (47)
HPV11 E6 (1)
HPV11 E7 (9)
HPV16 E2 (7)
HPV16 E6 (8)
HPV16 E7 (21)
HPV16 L1 (13)
HPV16 L2 (5)
HPV16/HPV18 E6 (1)
HPV18 (7)
HPV18 E7 (19)
HPV18 L2 (6)
HPV52 E7 (1)
VACV E6 (1)
Human (29)
Mouse (1)
Coronavirus SARS-CoV (5)
Human Papillomavirus (79)
Human Papillomavirus 1 (6)
Human Papillomavirus 11 (8)
Human Papillomavirus 16 (63)
Human Papillomavirus 18 (44)
Human Papillomavirus 6 (6)
Virus (5)
IHC (47)
IHC-Fr (11)
IHC-P (22)
WB (161)
Flo (2)
ELISA (163)
FLISA (1)
IF (11)
IP (24)
Peptide-ELISA (1)
RIA (13)
SwELISA (3)
rabbit (20)
mouse (204)
goat (1)
Product Group
Coronavirus Antibodies Proteins cDNAs (9)
Papillomaviridae (236)
IgG (30)
IgG1 (88)
IgG1,k (19)
IgG2a (39)
IgG2a,k (24)
IgG2b (23)
monoclonal mc (202)
polyclonal pc (21)
recombinant monoclonal rmc (2)
13B233 (1)
2C11 (1)
3D6F1 (3)
5E734 (1)
6F3 (1)
711-45 (1)
711-66 (1)
716-281 (1)
716-325 (1)
716-332 (1)
716-D1 (2)
716-F10 (2)
718-15 (1)
718-238 (1)
718-67 (1)
B616M (1)
B716M (1)
C1P5 (3)
CamVir-1 (3)
CAMVIR-1 (3)
CIP5 (1)
GF1 (1)
HPV16/1296 (2)
HPV16L1/1058 (2)
MCAPL1 (2)
OTI10D7 (2)
rHPV16L1/1058 (2)
SPM275 (2)
TVG701Y (2)
AP Conjugated (20)
APC Conjugated (20)
Azide-free (7)
Biotin Conjugated (25)
BSA-free (4)
Carrier-free (2)
FITC Conjugated (25)
HRP Conjugated (25)
PE Conjugated (20)
Ready-to-Use (2)
Unconjugated (90)
aa1-462 (4)
aa1-473 (4)
N-Terminus (1)
aa1-158 (1)
aa18-41 (1)
No (235)
Yes (1)
6His, N-terminus (4)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His (2)
His-SUMO (3)
Human (10)
Vaccinia Virus (1)
E. coli (8)
Yeast (3)
Purified (4)
Low endotoxin level (1)
HPV E7 Antibody - IHC of paraffin- embedded placenta tissues (left) and ovarian cancer (right) using E7 mouse mAb with DAB staining.
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (2C11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$412
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
100 µg/$400; 500 µg/$560
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) (5E734) Antibody
Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$924
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
100 µg/$403; 1 mg/$878
Select
HPV E7 Mouse anti-Human Papillomavirus 18 Monoclonal (HRP) Antibody
Human Papillomavirus 18
ELISA, WB
HRP Conjugated
100 µl/$962
Select
HPV E7 Mouse anti-Human Papillomavirus 18 Monoclonal (APC) Antibody
Human Papillomavirus 18
ELISA, WB
APC Conjugated
100 µl/$962
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (GF1) Antibody
Human, Virus, Human Papillomavirus
ELISA
Unconjugated
100 µl/$586
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (HRP) Antibody
Human Papillomavirus 16
ELISA, IHC, IP, RIA, WB
HRP Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (Biotin) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
Biotin Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (FITC) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
FITC Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (AP) Antibody
Human Papillomavirus 16
ELISA, IHC, IP, RIA, WB
AP Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
APC Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (PE) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
PE Conjugated
100 µl/$928
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (13B233) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$612
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
500 µg/$544
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$947
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 ml/$545
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 ml/$545
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (B716M) Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 mg/$878
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human, Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$962
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 mg/$806
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (APC) Antibody
Human Papillomavirus
ELISA, WB
APC Conjugated
100 µl/$894
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 mg/$878
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (APC) Antibody
Human Papillomavirus
ELISA, WB
APC Conjugated
100 µl/$973
HPV E7 Antibody - Western blot of E7 mouse mAb against truncated GST-E7 recombinant protein (1).
Select
HPV E7 Mouse Monoclonal (3D6F1) Antibody
ELISA, WB
Unconjugated
100 µl/$393
Viewing 1-25 of 236 product results