Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Home > Virology > Papillomaviridae (HPV)

Papillomaviridae (HPV)

Papillomaviruses are non-enveloped, icosahedral double-stranded DNA viruses that range from 45 to 55 nm in diameter, and contain a limited number of genes (6-7).

Papillomaviridae (HPV) Research Products



About Papillomaviridae

Papillomaviruses are highly species-specific and cause tumors (papillomas and carcinomas) in their hosts. The papillomavirus genome contains at least six open reading frames; the early frames code for proteins that are involved in viral replication and cell transformation, whereas the late frames encode capsid proteins. Human papillomaviruses are a diverse group, and more than 200 types exist, associated with different pathologic conditions. They are particularly tropic for squamous epithelial cells, with some types (HPV 6, 11) producing papillomas (warts), and others (HPV 16, 18, 31) producing persistent subclinical infections or transforming the epithelium into oropharyngeal, anogenital, or cervical squamous cell carcinomas. Transmission occurs via direct mucosal contact with an infected person, by sexual transmission, or with viral particles left on a surface.

Papillomaviridae Virus

Papillomaviruses can either infect cells, replicate, and induce cell death upon lysis (permissive cells) or infect cells and transform them rather than undergoing viral replication (non-permissive cells). In permissive cells, the virion attaches to specific surface receptors, enters the cell and is transported to the nucleus, where viral DNA is released. Early phase proteins such as E6 and E7 drive the cell into S phase, then use cellular DNA synthesis proteins such as DNA polymerase and thymidine kinase to replicate. After transcription of late viral RNAs for structural proteins, progeny virions are assembled in the nucleus. Host cell lysis then releases the viral particles.

In non-permissive cells or permissive cells infected with defective viral genomes, the tumor antigens are synthesized, and cellular DNA synthesis is stimulated, but late viral capsid genes are not expressed. Instead, the viral genome integrates randomly into the host chromosome. In human papillomaviruses, the E6 and E7 proteins bind p53 and RB, respectively, leading to immortalization. These transforming proteins produce altered host cell morphology, increased growth rate, loss of contact inhibition, and anchorage independence, all of which promote tumorigenicity.

Back To Top
References
  • Ambalathingal, GR et al. BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies. 2017; Clin Microbiol Reviews. doi: 10.1128/CMR.00074-16
  • Butel, JS. Papovaviruses. Medical Microbiology. 1996; 4th Edition, Chapter 66.

All Papillomaviridae (HPV) Products

☰ Filters
Antibodies (181)
Proteins (10)
Primary (181)
Recombinant (10)
HPV / Human Papilloma Virus (18)
HPV E2 (6)
HPV E6 (7)
HPV E7 (41)
HPV L1 Capsid (41)
HPV11 E6 (1)
HPV11 E7 (6)
HPV16 E2 (6)
HPV16 E6 (8)
HPV16 E7 (13)
HPV16 L1 (11)
HPV16 L2 (5)
HPV16/HPV18 E6 (1)
HPV18 (6)
HPV18 E7 (14)
HPV18 L2 (5)
HPV52 E7 (1)
VACV E6 (1)
Human (24)
Mouse (1)
Coronavirus SARS-CoV (4)
Human Papillomavirus (53)
Human Papillomavirus 1 (5)
Human Papillomavirus 11 (7)
Human Papillomavirus 16 (57)
Human Papillomavirus 18 (38)
Human Papillomavirus 6 (5)
Virus (5)
IHC (40)
IHC-Fr (11)
IHC-P (22)
WB (123)
ELISA (129)
FLISA (1)
IF (6)
IP (21)
RIA (11)
SwELISA (3)
rabbit (20)
mouse (160)
goat (1)
Product Group
Coronavirus Antibodies Proteins cDNAs (8)
Papillomaviridae (191)
IgG (29)
IgG1 (69)
IgG1,k (15)
IgG2a (32)
IgG2a,k (20)
IgG2b (15)
monoclonal mc (158)
polyclonal pc (21)
recombinant monoclonal rmc (2)
13B233 (1)
2C11 (1)
3D6F1 (4)
5E734 (1)
6F3 (1)
716-D1 (1)
716-F10 (1)
B616M (1)
B716M (1)
C1P5 (3)
CamVir-1 (3)
CAMVIR-1 (3)
CIP5 (1)
GF1 (1)
HPV16/1296 (2)
HPV16L1/1058 (2)
MCAPL1 (2)
OTI10D7 (2)
rHPV16L1/1058 (2)
AP Conjugated (1)
APC Conjugated (19)
Azide-free (5)
Biotin Conjugated (24)
BSA-free (4)
Carrier-free (2)
FITC Conjugated (24)
HRP Conjugated (24)
PE Conjugated (19)
Ready-to-Use (2)
Unconjugated (70)
aa1-462 (4)
aa1-473 (4)
N-Terminus (1)
aa1-158 (1)
aa18-41 (1)
No (190)
Yes (1)
6His, N-terminus (5)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His (1)
His-SUMO (2)
Human (9)
Vaccinia Virus (1)
E. coli (7)
Yeast (3)
Purified (4)
Low endotoxin level (1)
HPV E7 Antibody - IHC of paraffin- embedded placenta tissues (left) and ovarian cancer (right) using E7 mouse mAb with DAB staining.
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (2C11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$412
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
100 µg/$409; 1 mg/$909
Select
HPV E7 Mouse anti-Human Papillomavirus 18 Monoclonal (HRP) Antibody
Human Papillomavirus 18
ELISA, WB
HRP Conjugated
100 µl/$1,070
Select
HPV E7 Mouse anti-Human Papillomavirus 18 Monoclonal (APC) Antibody
Human Papillomavirus 18
ELISA, WB
APC Conjugated
100 µl/$1,070
Select
HPV E7 Mouse anti-Human Papillomavirus 18 Monoclonal (PE) Antibody
Human Papillomavirus 18
ELISA, WB
PE Conjugated
100 µl/$1,070
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
100 µg/$400; 500 µg/$560
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) (5E734) Antibody
Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$970
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal Antibody
Human Papillomavirus, Human Papillomavirus 16
ELISA, SwELISA
Unconjugated
1 mg/$694; 5 mg/$1,801
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (GF1) Antibody
Human, Virus, Human Papillomavirus
ELISA
Unconjugated
100 µl/$688
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (HRP) Antibody
Human Papillomavirus 16
ELISA, IHC, IP, RIA, WB
HRP Conjugated
100 µl/$1,046
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (Biotin) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
Biotin Conjugated
100 µl/$1,046
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (FITC) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
FITC Conjugated
100 µl/$1,046
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
APC Conjugated
100 µl/$1,046
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (PE) Antibody
Human Papillomavirus 16
ELISA, IHC-Fr, IP, RIA, WB
PE Conjugated
100 µl/$1,046
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (13B233) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$725
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 mg/$878
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (APC) Antibody
Human Papillomavirus
ELISA, WB
APC Conjugated
100 µl/$1,043
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (PE) Antibody
Human Papillomavirus
ELISA, WB
PE Conjugated
100 µl/$1,043
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal (B716M) Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
1 mg/$909
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human, Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$1,070
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (PE) Antibody
Human, Human Papillomavirus 16
ELISA, WB
PE Conjugated
100 µl/$1,070
Select
HPV E7 Mouse anti-Human Papillomavirus Monoclonal Antibody
Human Papillomavirus
ELISA, WB
Unconjugated
500 µg/$544
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (APC) Antibody
Human Papillomavirus 16
ELISA, WB
APC Conjugated
100 µl/$970
Select
HPV E7 Mouse anti-Human Papillomavirus 16 Monoclonal (PE) Antibody
Human Papillomavirus 16
ELISA, WB
PE Conjugated
100 µl/$970
HPV E7 Antibody - Western blot of E7 mouse mAb against truncated GST-E7 recombinant protein (1).
Select
HPV E7 Mouse Monoclonal (3D6F1) Antibody
ELISA, WB
Unconjugated
0.1 ml/$393
Viewing 1-25 of 191 product results