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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Gene Name: chemokine (C-X-C motif) ligand 12
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL12, C-X-C motif chemokine 12, HIRH, IRH, SDF-1, SDF-1b, SDF1A, SDF1B, TPAR1, TLSF-a, TLSF-b, SDF-1a, SDF1, Sdf1alpha, Stromal cell-derived factor 1, TLSF, HSDF-1, PBSF, SCYB12
Target Sequences: NM_000609 NP_000600.1 P48061

Viewing 1-25 of 110 items
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Rat SDF1 / CXCL12
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $485.00
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SDF1 / CXCL12
Xenopus, Chicken, Mouse, Dog, Guinea pig, Bat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human SDF1 / CXCL12
Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SDF1 / CXCL12
Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SDF1 / CXCL12
Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $425.00
Select
Rabbit Polyclonal to Mouse SDF1 / CXCL12
Mouse, Rat
IHC, IP, WB
Unconjugated
30µg   $245.00; 100µg   200µl   0.5mg/ml   $435.00
SDF1 / CXCL12 Antibody - Western blot of SDF-1 antibody
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
SDF1 / CXCL12 Antibody - Detection limit for recombinant GST tagged CXCL12 is approximately 1 ng/ml as a capture antibody.
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Mouse Monoclonal [clone 1E5] (IgG2b,k) to Human SDF1 / CXCL12
Human
ELISA
Unconjugated
100µg   $365.00
SDF1 / CXCL12 Antibody - Anti-Murine SDF-1a (CXCL12) Western Blot Reduced
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Goat Polyclonal to Mouse SDF1 / CXCL12
Mouse
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
SDF1 / CXCL12 Antibody - CXCL12 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human SDF1 / CXCL12
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
SDF1 / CXCL12 Antibody - Western Blot (non-reducing) of SDF-1 / CXCL12 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Goat Polyclonal to Human SDF1 / CXCL12
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
SDF1 / CXCL12 Antibody - Western Blot (non-reducing) of SDF-1 / CXCL12 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Goat Polyclonal to Human SDF1 / CXCL12
Human
ELISA, WB
Biotin Conjugated
25µg   $285.00; 50µg   $325.00
Select
Rabbit Polyclonal to Human SDF1 / CXCL12
Human
ELISA, Neut, WB
AP Conjugated
50µg   $355.00
Select
Goat Polyclonal (IgG) to Human SDF1 / CXCL12
Human
ELISA, WB
HRP Conjugated
100µl   $935.00
SDF1 / CXCL12 Antibody - Western blot of recombinant SDF-1 / CXCL12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse SDF1 / CXCL12
Mouse
WB
Biotin Conjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $530.00
SDF1 / CXCL12 Antibody - Western blot of recombinant SDF-1 / CXCL12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse SDF1 / CXCL12
Mouse
WB
FITC Conjugated
100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $315.00; 1ml   0.5mg/ml   $575.00
SDF1 / CXCL12 Antibody - IHC analysis of CXCL12 using anti-CXCL12 antibody. CXCL12 was detected in paraffin-embedded section of rat spleen tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-CXCL12 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
SDF1 / CXCL12 Antibody - Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200.
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
SDF1 / CXCL12 Antibody - IHC staining of FFPE human tonsil with CXCL12 antibody at 0.5ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Select
Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Human
ELISA, IHC-P, WB
Unconjugated
100µg   $435.00
SDF1 / CXCL12 Antibody
Select
Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
SDF1 / CXCL12 Antibody - Immunocytochemistry of CXCL12 in HeLa cells with CXCL12 antibody at 5 µg/mL.
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Rabbit Polyclonal (IgG) to Human SDF1 / CXCL12
Mouse, Human
ELISA, ICC, WB
Unconjugated
0.1mg   1mg/ml   $365.00

Viewing 1-25 of 110 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).