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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
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CCL5 / RANTES

chemokine (C-C motif) ligand 5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gene Name: chemokine (C-C motif) ligand 5
Family/Subfamily: Intercrine , not assigned-Intercrine
Synonyms: CCL5, Chemokine (C-C motif) ligand 5, D17S136E, EoCP, T-cell specific protein p288, SCYA5, SISd, T cell-specific protein P228, Beta-chemokine RANTES, C-C motif chemokine 5, RANTES, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES, TCP228
Target Sequences: NM_002985 NP_002976.2 P13501

Publications (2)

1
RANKL-Expressing Ectopic Extramammary Paget's Disease on the Lower Abdomen. Hagiwara-Takita A, Fujimura T, Kakizaki A, Aiba S. Case reports in dermatology. 2016 8:130-5. (IF; Human) [Full Text Article] [PubMed:27462221] [PMC:PMC4943311] Related Antibodies: LS-B6426.
2
Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain. Lanfranco MF, Mocchetti I, Burns MP, Villapol S. Frontiers in neuroanatomy. 2018 January;11:137. (Mouse) [Full Text Article] [PubMed:29375328] [PMC:PMC5770405] Related Antibodies: LS-C104689.

Viewing 1-25 of 162 items
CCL5 / RANTES Antibody - Anti-CCL5 / RANTES antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Select
(1) Publication(s)
Mouse Monoclonal [clone 50013-5] (IgG1) to Human CCL5 / RANTES
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
CCL5 / RANTES Antibody - Anti-CCL5 / RANTES antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 8.PP.11] (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, IHC-P, Neut
Unconjugated
50µg   1mg/ml   $425.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
HRP Conjugated
100µl   $495.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
Biotin Conjugated
100µl   $495.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
FITC Conjugated
100µl   $495.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
AP Conjugated
100µl   $495.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
APC Conjugated
100µl   $495.00
Select
Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, IHC, Neut, WB
PE Conjugated
100µl   $495.00
CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
(1) Publication(s)
Rabbit Polyclonal to Mouse CCL5 / RANTES
Mouse
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CCL5 / RANTES
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
CCL5 / RANTES Antibody - Western Blot (non-reducing) of CCL5 / RANTES antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat CCL5 / RANTES
Rat
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $325.00
CCL5 / RANTES Antibody - Anti-Human RANTES (CCL5) Western Blot Unreduced
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Mouse Monoclonal (IgG2b) to Human CCL5 / RANTES
Human
ELISA, WB
Unconjugated
500µg   $255.00
Select
Mouse Monoclonal [clone 5J49] (IgG1,k) to Human CCL5 / RANTES
Human
ELISA
Biotin Conjugated
100µg   $635.00
CCL5 / RANTES Antibody
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Rat CCL5 / RANTES
Mouse, Rat
WB
Unconjugated
250µg   $455.00
Select
Rabbit Polyclonal (IgG) to Mouse CCL5 / RANTES
Mouse
ELISA, Func, Neut, WB
Unconjugated
100µg   $755.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Mouse, Rat, Human
ELISA, ICC, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
CCL5 / RANTES Antibody
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CCL5 / RANTES Antibody - Western blot of C-C motif chemokine 5 antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate . Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution . Predicted band size: 10 kDa . Observed band size: 70 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IP, Neut, WB
HRP Conjugated
100µl   $905.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IP, Neut, WB
Biotin Conjugated
100µl   $905.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IP, Neut, WB
FITC Conjugated
100µl   $905.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IP, Neut, WB
AP Conjugated
100µl   $905.00
Select
Rabbit Polyclonal (IgG) to Human CCL5 / RANTES
Human
ELISA, IP, Neut, WB
PE Conjugated
100µl   $905.00
Select
Sheep Polyclonal (IgG) to Cat CCL5 / RANTES
Cat
ELISA, Func, Neut, WB
Unconjugated
100µg   $770.00

Viewing 1-25 of 162 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).