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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Phone: 866-819-4732 (Toll Free North America)
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How to Buy - Details about how to buy our products. - To submit a new order. - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues. - To request technical information requests about an LSBio product or its application. - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

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Caspase Research Products
LSBio offers a wide range of products that are useful in studying caspase activity in cellular apoptosis, inflammation, cancer and disease.

Caspases are involved in numerous cell-cycle processes including programmed cell death and inflammation, and comprise one of the primary mechanisms of apoptosis via the caspase activation cascade. Caspase deficiency and mutation is implicated in disease and cancer progression; for example, CASP5 and CASP8 are regularly mutated or downregulated in cancers, particularly MSI-positive cancers where these caspases experience regular pathogenic truncation (Geelen, 2010; Trojan, 2004). In the case of CASP8, this contributes to the loss of functional apoptosis as part of the tumorigenic process. Additionally, caspases such as inflammatory caspase 1 (CASP1) are of research interest due to their apparent involvement in systemic lupus erythematosus (SLE) and other autoimmune diseases (Kahlenberg, 2014).

Mouse monoclonal CASP1 antibody LS-B112 will recognize with high specificity full-length and cleaved caspase-1 in immunohistochemistry and western blot.
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LSBio's CASP14 Antibody LS-B474 is ideal for use in IHC or western blot in detecting Caspase 14, a protein involved in keratinocyte terminal differentiation in addition to apoptotic processes.
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Biochemical inhibitors such as the pan-specific caspase inhibitor Z-VAD-FMK can be used in apoptosis studies to inhibit caspase activity by irreversibly binding to their catalytic site.
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CASP9 Elisa Kits can be used to accurately detect levels of apoptotic CASP9 protein in adherent cell cultures and other sample types.
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Caspase Products by Type

Caspase Products by Function

Bibliography ▷
  • Kahlenberg, J. Michelle et al. An Essential Role for Caspase-1 in the Induction of Murine Lupus and Its Associated Vascular Damage. Arthritis & rheumatology (Hoboken, N.J.) 66.1 (2014): 152–162.
    [Full Text Article] [PMID: 24449582] [PMC: PMC4135431]
  • van Geelen, Caroline M.M. et al. Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. International Journal of Oncology. 37 (2010). 1031-1041.
    [Full Text Article]
  • Trojan J et al. BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability. Int J Colorectal Dis. 2004 Nov;19(6):538-44.
    [PMID: 15088110]
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