LSBio offers a wide range of products that are useful in studying caspase activity in cellular apoptosis, inflammation, cancer and disease.
Caspases are involved in numerous cell-cycle processes including programmed cell death and inflammation, and comprise one of the primary
mechanisms of apoptosis via the caspase activation cascade. Caspase deficiency and mutation is implicated in disease and cancer progression;
for example, CASP5
are regularly mutated or downregulated in cancers, particularly MSI-positive cancers where these caspases experience
regular pathogenic truncation (Geelen, 2010; Trojan, 2004). In the case of
, this contributes to the loss of functional apoptosis as part of
the tumorigenic process. Additionally, caspases such as inflammatory caspase 1 (CASP1
) are of research interest due to their apparent involvement
in systemic lupus erythematosus (SLE) and other autoimmune diseases (Kahlenberg, 2014).