Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Home > Virology > Herpesviridae (Herpes)

Herpesviridae (Herpes)

Herpesviruses are double stranded DNA viruses that are enclosed by an icosapentahedral capsid, surrounded by a protein coat (tegument), and encased in a glycoprotein-bearing bilayer envelope. They are divided into three groups: alpha-herpesviruses (herpes simplex virus types 1 and 2, and varicella-zoster virus), beta-herpesviruses (cytomegalovirus, HHV-6, and HHV-7) and gamma-herpesviruses (Epstein-Barr and HHV-8). Alpha-herpesviruses have a short reproductive cycle, cause lysis of the host cell, and have a wide host range, as well as the ability to establish latent infections in sensory nerve ganglia. Beta-herpesviruses have a long reproductive life cycle, a limited host range, establish latent infections, and can form accumulations within cells such as within secretory glands, the reticuloendothelial system, and the kidneys. The gamma-herpesviruses have a very limited host range, are replicated in lymphoblastoid cells, and can be both latent and lytic within host cells.

Herpesviridae (Herpes) Research Products



About Herpesviridae

After the virus enters the cell, the DNA is uncoated and transported to the nucleus, whereupon the virus undergoes transcription of immediate-early genes that code for regulatory proteins. This is followed by expression of early and late genes. The viral core and capsid are assembled in the nucleus, then enveloped at the nuclear membrane, transported through the endoplasmic reticulum and the Golgi apparatus, glycosylated, and mature virions are transported to the cell membrane inside vesicles. Release of virus is accompanied by cell death, with the release of non-infectious as well as infectious viral particles.

Figure 1: Herpesviridae Virus Genome
Figure 1: Herpesviridae Virus Genome
Figure 2: Structure of Herpesviridae Virus
Figure 2: Structure of Herpesviridae Virus

The genomes of herpesviruses are linear double-stranded DNA molecules that range in size from 125 to 240 kbp, and contain direct or inverted repeats. The genome replicates by circularization, followed by production of concatemers and cleavage of unit-length genomes during packaging into capsids.

A characteristic of herpesviruses is their ability to establish latent infection in specific host cells, either extra-chromosomally or integrated into the host cell DNA. Latent virus may be reactivated to enter a replicative cycle at any point in time. Also, herpesviruses require intimate contact between the individual shedding the virus and the susceptible host.

Infection with an alpha-herpesvirus follows a characteristic pattern. Four to six days after inoculation onto the skin or the mucous membrane, the virus replicates in epithelial cells, causing cell lysis and inflammation with the formation of vesicles. Viremia follows, and the virus ascends the sensory nerves to reach the dorsal root ganglia. This is where latency is established.

During reactivation, replication in the ganglia is followed by retrograde axonal spread back to other skin surfaces via peripheral sensory nerves.

Diseases caused by herpesvirus include oral and genital herpes (HSV-1, HSV-2), herpetic keratitis and conjunctivitis, neonatal herpes simplex, herpes simplex encephalitis, chickenpox, shingles, cytomegalic inclusion disease, CMV mononucleosis syndrome, Epstein-Barr mononucleosis, HHV-6 and HHV-7 roseola, Kaposi’s sarcoma (HHV-8), and B virus encephalitis.

The only vaccine that is currently available is to the varicella-zoster virus; otherwise, therapy consists of treatment with acyclovir, valaciclovir, famciclovir, or ganciclovir for HSV, zoster, and CMV infections. There are no current antiviral agents for the treatment of EBV, HHV-6, HHV-7, or HHV-8.

Back To Top
References

All Herpesviridae (Herpes) Products

☰ Filters
Antibodies (342)
Proteins (1)
Primary (342)
Recombinant (1)
Feline Herpesvirus 1 (2)
Gallid Herpesvirus 1 Glycoprotein G (1)
Herpes Simplex Virus (HSV-1/HSV-2) ICP5 (1)
Herpes Simplex Virus 1 (HSV-1) ICP0 (1)
HHV-6 (1)
HHV-6 37EA (1)
HHV-6 Capsid, 140kD (1)
HHV-6 Early Antigen (9)
HHV-6 Early Phosphoprotein p41 (1)
HHV-6 gp60,110 (3)
HHV-6 gp90 (2)
HHV-6 p150 (1)
HHV-6b (7)
HHV-8 / HHV8 / KSHV (4)
HHV-8 ORF57 (9)
HSV / Herpes Simplex Virus (45)
HSV gD (35)
HSV Nuclear Regulatory Protein (1)
HSV-1 / Herpes Simplex Virus 1 (43)
HSV-1 + HSV-2 gG1 (4)
HSV-1 + HSV-2 ICP27 (5)
HSV-1 + HSV-2 ICP35 (1)
HSV-1 gB (1)
HSV-1 gC (6)
HSV-1 gD (17)
HSV-1 gE (4)
HSV-1 gG-1 (11)
HSV-1 ICP4 (2)
HSV-1 ICP8 (1)
HSV-1 Nucleocapsid Protein (7)
HSV1 UL42 (1)
HSV-1 US3 (1)
HSV-1/HSV-2 45kD (1)
HSV-1+2 gB (6)
HSV-2 / Herpes Simplex Virus 2 (39)
HSV-2 130 kD (1)
HSV-2 130kD (6)
HSV-2 56-64kD (7)
HSV-2 C2 (7)
HSV-2 gB (3)
HSV-2 gC (2)
HSV-2 gD (10)
HSV-2 gE (5)
HSV-2 gG (17)
HSV-2 gG2 (2)
HSV-2 Nuclear (1)
HSV-2 US3 (1)
HSV-TK (4)
ICP47 Protein (1)
Murine Gammaherpesvirus 68 ORF59 (1)
Human (24)
Mouse (1)
Feline Herpesvirus 1 (2)
Herpes Simplex Virus (141)
Herpes Simplex Virus 1 (78)
Herpes Simplex Virus 2 (70)
Human Herpesvirus 6 (25)
Human Herpesvirus 8 (5)
Infectious Laryngotracheitis Virus (1)
Varicella Zoster Virus (3)
Virus (20)
IHC (45)
IHC-Fr (18)
IHC-P (19)
WB (135)
ELISA (198)
FLISA (1)
GS (1)
ICC (25)
IF (157)
IP (39)
LateralFlow (2)
rabbit (52)
mouse (247)
goat (24)
chicken (2)
rat (1)
sheep (16)
Product Group
Herpesviridae (343)
IgG (94)
IgG1 (96)
IgG1,k (8)
IgG1a,k (2)
IgG1b,k (2)
IgG2 (4)
IgG2a (64)
IgG2a,k (17)
IgG2b (15)
IgG2b,l (1)
IgG2c (1)
IgG3 (7)
monoclonal mc (249)
polyclonal pc (91)
recombinant monoclonal rmc (2)
0195 (1)
10A3 (2)
1116510 (1)
13B10 (3)
1J10 (1)
2002 (1)
2016502 (1)
2116510 (1)
2F11/G13 (1)
3016502 (1)
3D2/B12 (1)
4F5 (1)
6016502 (1)
6116510 (1)
9116510 (1)
A33 (1)
AP1 (B019) (1)
C3108-103 (1)
H1379 (1)
HP1.3 (1)
HP105.4 (1)
HP12.6 (1)
HP5.2 (1)
HP82.5 (1)
HSV1/1934 (2)
LN53 (1)
LP13 (1)
T111 (2)
T303 (4)
T96 (5)
AP Conjugated (25)
APC Conjugated (22)
Azide-free (2)
Biotin Conjugated (31)
Carrier-free (1)
Concentrated (4)
FITC Conjugated (34)
HRP Conjugated (36)
PE Conjugated (25)
Ready-to-Use (8)
Unconjugated (169)
aa33-60 (8)
C-Terminus (1)
Internal (1)
No (342)
Yes (1)
His (1)
Human (1)
Yeast (1)
HHV-8 ORF57 Antibody - Anti-KSHV ORF57 Antibody - Western Blot. Western blot of affinity purified anti-KSHV ORF57 to detect KSHV ORF57 in HEK293 cells transfected with ORF57 expression vector and ORF57 truncations, or in KSHV infected B-cell line (BCBL-1) treated with or without valproic acid to induce viral replication (arrow). The membrane was probed with the primary antibody diluted 1:7500 (left) and 1:1000 (right). Personal Communication, V. Majerciak, M. Zheng, CCR-NCI, Bethesda, MD.
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (C-Terminus) Antibody
Human, Human Herpesvirus 8
ELISA, IHC, WB
Unconjugated
100 µg/$485
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$614
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$767
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$767
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$767
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$767
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$767
HHV-8 ORF57 Antibody - KSHV ORF 57 Antibody western blot analysis Over-expressed GFP-tagged ORF57 in HEK293T cell line.
Select
HHV-8 ORF57 Rabbit anti-Human Herpesvirus 8 Polyclonal (aa33-60) Antibody
Human
WB
Unconjugated
400 µl/$381
Select
HHV-8 / HHV8 / KSHV Mouse anti-Human Herpesvirus 8 Monoclonal (Concentrated) (13B10) Antibody
Human Herpesvirus 8
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$846
HHV-8 / HHV8 / KSHV Antibody - Cultured cells infected with HHV8 stained with HHV8 antibody.
Select
HHV-8 / HHV8 / KSHV Rat anti-Human Herpesvirus 8 Monoclonal (LN53) Antibody
Human Herpesvirus 8
ICC, IHC
Unconjugated
0.1 ml/$257; 0.5 ml/$405; 1 ml/$540
HHV-8 / HHV8 / KSHV Antibody - IHC of HHV-8 on FFPE Infected Pleura tissue.
Select
HHV-8 / HHV8 / KSHV Mouse anti-Human Herpesvirus 8 Monoclonal (13B10) Antibody
Human Herpesvirus 8
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$322; 0.5 ml/$482; 1 ml/$716
HHV-8 / HHV8 / KSHV Antibody - IHC of HHV-8 on FFPE Infected Pleura tissue. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
HHV-8 / HHV8 / KSHV Mouse anti-Human Herpesvirus 8 Monoclonal (Ready-to-Use) (13B10) Antibody
Human Herpesvirus 8
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$340; 7 ml/$454; 15 ml/$702
HSV-TK Antibody - Western blot of extracts from COS7 cells, using KITH_HHV1S antibody.
Select
HSV-TK Rabbit anti-Herpes Simplex Virus 1 Polyclonal Antibody
ELISA, WB
Unconjugated
100 µg/$347
Select
HSV-TK Rabbit anti-Varicella Zoster Virus Polyclonal Antibody
Varicella Zoster Virus
Unconjugated
100 µl/$305
Select
HSV-TK Rabbit anti-Varicella Zoster Virus Polyclonal Antibody
Varicella Zoster Virus
Unconjugated
100 µl/$347
Select
HSV-TK Rabbit anti-Varicella Zoster Virus Polyclonal Antibody
Varicella Zoster Virus
Unconjugated
100 µl/$347
HSV-2 / Herpes Simplex Virus 2 Antibody - IHC of HSV II on FFPE Infected tissue.
Select
HSV-2 / Herpes Simplex Virus 2 Rabbit anti-Herpes Simplex Virus 2 Polyclonal Antibody
Herpes Simplex Virus 2
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$282; 0.5 ml/$346; 1 ml/$417
HSV-2 / Herpes Simplex Virus 2 Antibody - IHC of HSV II on FFPE Infected tissue. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
HSV-2 / Herpes Simplex Virus 2 Rabbit anti-Herpes Simplex Virus 2 Polyclonal (Ready-to-Use) Antibody
Herpes Simplex Virus 2
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$299; 7 ml/$377; 15 ml/$518
HSV-2 / Herpes Simplex Virus 2 Antibody - IHC of HSV II on a FFPE Infected Cell Line
Select
HSV-2 / Herpes Simplex Virus 2 Mouse anti-Herpes Simplex Virus 2 Monoclonal Antibody
Herpes Simplex Virus 2
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$329; 0.5 ml/$396; 1 ml/$513
HSV-2 / Herpes Simplex Virus 2 Antibody - IHC of HSV II on a FFPE Infected Cell Line
Select
HSV-2 / Herpes Simplex Virus 2 Mouse anti-Herpes Simplex Virus 2 Monoclonal (Ready-to-Use) Antibody
Herpes Simplex Virus 2
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$357; 7 ml/$396; 15 ml/$513
Select
HSV-2 / Herpes Simplex Virus 2 Rabbit anti-Herpes Simplex Virus Polyclonal (Ready-to-Use) Antibody
Herpes Simplex Virus
IHC
Unconjugated, Ready-to-Use
5000 µl/$266
Select
HSV-2 / Herpes Simplex Virus 2 Sheep anti-Herpes Simplex Virus Polyclonal (Biotin) Antibody
Herpes Simplex Virus
ELISA, ICC, IF, WB
Biotin Conjugated
1 ml/$513
Select
HSV-2 / Herpes Simplex Virus 2 Sheep anti-Herpes Simplex Virus Polyclonal (HRP) Antibody
Herpes Simplex Virus
ELISA, ICC, IF, WB
HRP Conjugated
1 ml/$528
Select
HSV-2 / Herpes Simplex Virus 2 Sheep anti-Herpes Simplex Virus Polyclonal Antibody
Herpes Simplex Virus
ELISA, IF, WB
Unconjugated
1 ml/$502
Viewing 1-25 of 343 product results