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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 313,265 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-CXCR4 Antibody (N-Terminus) IHC-plus™ LS-A1376

LS-A1376 is a rabbit anti-CXCR4 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. (more)

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Anti-AGTR2 / AT2 Receptor Antibody (Internal) IHC-plus™ LS-A1322

LS-A1322 is a rabbit anti-AGTR2 / AT2 Receptor polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About AGTR2 / AT2 Receptor: Type 2 Angiotensin Receptor (AT2) has been suggested to affect development, cell differentiation, apoptosis, and regeneration in various tissues. AT2 receptor has been shown to exert counteracting effects on cellular growth and differentiation, vascular tone, and the release of arginine vasopressin (AVP). In each condition, the AT2 receptor appears to down-modulate actions mediated by the AT1 receptor, resulting in decreased cellular proliferation, decreased levels of serum AVP levels, or decreased vasoconstrictor responses. Binding of angiotensin II to the AT2 receptor inhibits guanylate cyclase. Recently, AT2 receptor has been suggested to affect brain development and cognitive function (Vervoort et al. 2002). (more)

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Anti-OXTR / Oxytocin Receptor Antibody (N-Terminus) IHC-plus™ LS-A3878

LS-A3878 is a rabbit anti-OXTR / Oxytocin Receptor polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About OXTR / Oxytocin Receptor: The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect. (more)

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Anti-DKK1 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A2867

LS-A2867 is a rabbit anti-DKK1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. (more)

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Anti-SERPINA1 / Alpha 1 Antitrypsin Antibody (C-Terminus) LS-C31768

LS-C31768 is a rabbit anti-SERPINA1 / Alpha 1 Antitrypsin polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About SERPINA1 / Alpha 1 Antitrypsin: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). (more)

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Anti-Collagen I Antibody IHC-plus™ LS-B342

LS-B342 is a rabbit anti-Collagen I polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About Collagen I: Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is encoded by the COL1A1 gene. Collagen alpha-2(I) chain is encoded by the COL1A2 gene. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. (more)

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Anti-CACNG1 / CACNG Antibody (aa66-115) IHC-plus™ LS-B928

LS-B928 is a rabbit anti-CACNG1 / CACNG polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CACNG1 / CACNG: Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-RAB7A / RAB7 Antibody (aa90-140) IHC-plus™ LS-B1789

LS-B1789 is a rabbit anti-RAB7A / RAB7 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About RAB7A / RAB7: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. (more)

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Anti-HAVCR1 / KIM-1 Antibody (aa200-300) IHC-plus™ LS-B2031

LS-B2031 is a rabbit anti-HAVCR1 / KIM-1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About HAVCR1 / KIM-1: Hepatitis A Virus Cellular Receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. HAVCR1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. (more)

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Anti-LAG3 Antibody (aa70-99, clone 17B4, FITC) IHC-plus™ LS-B2237

LS-B2237 is a Fluorescein mouse anti-LAG3 monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry - Paraffin.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

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Anti-F10 / Factor X Antibody (aa351-400) LS-C80455

LS-C80455 is a rabbit anti-F10 / Factor X polyclonal antibody approved for use in Western blot.

About F10 / Factor X: F10 / Factor X is the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. (more)

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Anti-TSLP Antibody (Internal) IHC-plus™ LS-B3208

LS-B3208 is a rabbit anti-TSLP polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TSLP: TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. (more)

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Anti-NODAL Antibody (aa242-253) IHC-plus™ LS-B3955

LS-B3955 is a goat anti-NODAL polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About NODAL: Essential for mesoderm formation and axial patterning during embryonic development. (more)

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Anti-HAO1 Antibody (clone 5A1) LS-C115788

LS-C115788 is a mouse anti-HAO1 monoclonal antibody approved for use in Immunofluorescence and Western blot.

About HAO1: HAO1 is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. (more)

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Anti-IL17 Antibody (clone TC11-18H10) IHC-plus™ LS-B4912

LS-B4912 is a rat anti-IL17 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About IL17: Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen’s cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. (more)

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Anti-CD27L / CD70 Antibody (clone BU69, RPE) LS-C134547

LS-C134547 is a R. Phycoerythrin mouse anti-CD27L / CD70 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Immunocytochemistry and Immunohistochemistry - Frozen.

About CD27L / CD70: CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. (more)

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Anti-BTLA / CD272 Antibody (clone ANC6E9, Azide-free) LS-C134635

LS-C134635 is a mouse anti-BTLA / CD272 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Flow Cytometry.

About BTLA / CD272: BTLA / CD272 is a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. (more)

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Anti-TNFSF4 / OX40L Antibody (clone ANC10G1, Biotin) LS-C134809

LS-C134809 is a Biotin mouse anti-TNFSF4 / OX40L monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry and Functional Assay.

About TNFSF4 / OX40L: TNFSF4 / OX40L is a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. (more)

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Anti-Mannose Receptor / CD206 Antibody (clone 5C11) IHC-plus™ LS-B5474

LS-B5474 is a mouse anti-Mannose Receptor / CD206 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About Mannose Receptor / CD206: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. (more)

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Anti-TUBB3 / Tubulin Beta 3 Antibody IHC-plus™ LS-B5517

LS-B5517 is a chicken anti-TUBB3 / Tubulin Beta 3 polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About TUBB3 / Tubulin Beta 3: TUBB3 / Tubulin Beta 3 is a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. (more)

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Anti-KRT20 / CK20 / Cytokeratin 20 Antibody (aa375-424) IHC-plus™ LS-B5677

LS-B5677 is a rabbit anti-KRT20 / CK20 / Cytokeratin 20 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About KRT20 / CK20 / Cytokeratin 20: KRT20 / CK20 / Cytokeratin 20 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. (more)

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Anti-FOLH1 / PSMA Antibody (clone 107.1A4) LS-C150527

LS-C150527 is a mouse anti-FOLH1 / PSMA monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunocytochemistry, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About FOLH1 / PSMA: FOLH1 / PSMA is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. (more)

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Anti-IL17A Antibody IHC-plus™ LS-B7397

LS-B7397 is a rabbit anti-IL17A polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Neutralization and Western blot.

About IL17A: IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (more)

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Anti-MSLN / Mesothelin Antibody (Extracellular Domain, clone MB-G10) LS-C154007

LS-C154007 is a mouse anti-MSLN / Mesothelin monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry and Western blot.

About MSLN / Mesothelin: This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. (more)

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Anti-LRAT Antibody (aa111-160) IHC-plus™ LS-B8398

LS-B8398 is a rabbit anti-LRAT polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About LRAT: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. (more)

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Anti-CYBB / NOX2 / gp91phox Antibody (clone 7D5, PE) LS-C179420

LS-C179420 is a Phycoerythrin mouse anti-CYBB / NOX2 / gp91phox monoclonal antibody approved for use in Flow Cytometry.

About CYBB / NOX2 / gp91phox: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. (more)

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Anti-SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5, RPE) LS-C188305

LS-C188305 is a R. Phycoerythrin mouse anti-SELP / P-Selectin / CD62P monoclonal antibody approved for use in Flow Cytometry.

About SELP / P-Selectin / CD62P: SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (more)

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Anti-LDH / Lactate Dehydrogenase Antibody (HRP) LS-C209195

LS-C209195 is a Horseradish Peroxidase goat anti-LDH / Lactate Dehydrogenase polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western blot.

About LDH / Lactate Dehydrogenase: Lactate dehydrogenase is composed of four subunits (tetramer). The two most common subunits are the LDH-M and LDH-H protein, encoded by the LDHA and LDHB genes, respectively. These two subunits can form five possible tetramers (isoenzymes): 4H, 4M, and the three mixed tetramers (3H1M, 2H2M, 1H3M). These five isoforms are enzymatically, similar but show different tissue distribution: The major isoenzymes of skeletal muscle and liver, M4, has four muscle (M) subunits, while H4 is the main isoenzymes for heart muscle in most species, containing four heart (H) subunits. LDH-1 (4H)—in the heart and in RBC (red blood cells), as well as the brain. LDH-2 (3H1M)—in the reticuloendothelial system. LDH-3 (2H2M)—in the lungs. LDH-4 (1H3M)—in the kidneys, placenta, and pancreas. (more)

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Anti-MCAM / CD146 Antibody (aa84-189, clone 6C3F1) LS-C285856

LS-C285856 is a mouse anti-MCAM / CD146 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About MCAM / CD146: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. (more)

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Anti-ZFP91 Antibody (aa520-570) LS-C289940

LS-C289940 is a rabbit anti-ZFP91 polyclonal antibody approved for use in Immunoprecipitation and Western blot.

About ZFP91: ZFP91 is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. (more)

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Anti-HDGFRP2 Antibody (aa425-475) LS-C290952

LS-C290952 is a rabbit anti-HDGFRP2 polyclonal antibody approved for use in Immunoprecipitation.

About HDGFRP2: HDGFRP2 encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. (more)

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Anti-Fgf15 Antibody (aa25-218) LS-C293897

LS-C293897 is a rabbit anti-Fgf15 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Fgf15: Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19. (more)

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Anti-ABCB11 / BSEP Antibody (aa1299-1313) LS-C312556

LS-C312556 is a rabbit anti-ABCB11 / BSEP polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About ABCB11 / BSEP: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. (more)

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Anti-HLA-DQA1 Antibody LS-C331952

LS-C331952 is a rabbit anti-HLA-DQA1 polyclonal antibody approved for use in Western blot.

About HLA-DQA1: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. (more)

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Anti-CDX2 Antibody (clone 2G5) LS-C338581

LS-C338581 is a mouse anti-CDX2 monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. (more)

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Anti-tdTomato Antibody LS-C340696

LS-C340696 is a goat anti-tdTomato polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot. (more)

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Most Popular ELISA Kits
Human SFRP-3 / FRZB ELISA Kit (Sandwich ELISA) (Custom) - LS-F361

LS-F361 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SFRP-3 / FRZB. It is based upon a Sandwich assay principle.

About SFRP-3 / FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (more)

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Mouse/Human Phospho-ZAP70 (Tyr315) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1238

LS-F1238 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ZAP70 in samples of Adherent Cell Cultures. It is based upon a Cell-Based Phosphorylation assay principle.

About ZAP70: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. (more)

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Mouse/Human/Rat Phospho-ADRBK1 / GRK2 (Ser685) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1720

LS-F1720 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ADRBK1 / GRK2 in samples of Adherent Cell Cultures. It is based upon a Cell-Based Phosphorylation assay principle.

About ADRBK1 / GRK2: Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. (more)

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Human NOS2 / iNOS ELISA Kit (Cell-Based ELISA) - LS-F2081

LS-F2081 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NOS2 / iNOS in samples of Adherent Cell Cultures. It is based upon a Cell-Based assay principle.

About NOS2 / iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. (more)

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Human TNFSF13 / APRIL ELISA Kit (Sandwich ELISA) - LS-F2759

LS-F2759 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNFSF13 / APRIL in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNFSF13 / APRIL as low as 10 picograms per milliliter.

About TNFSF13 / APRIL: TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (more)

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Human Angiotensin II ELISA Kit (Competitive EIA) - LS-F3952

LS-F3952 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Angiotensin II in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 24.69 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Mouse LPL / Lipoprotein Lipase ELISA Kit (Sandwich ELISA) - LS-F4201

LS-F4201 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LPL / Lipoprotein Lipase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LPL / Lipoprotein Lipase as low as 15.6 picograms per milliliter.

About LPL / Lipoprotein Lipase: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. (more)

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Mouse Complement C3a ELISA Kit (Sandwich ELISA) - LS-F4210

LS-F4210 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Complement C3a in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 15.6 picograms per milliliter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Human SOD2 / Mn SOD ELISA Kit (Sandwich ELISA) - LS-F4420

LS-F4420 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SOD2 / Mn SOD in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SOD2 / Mn SOD as low as 0.78 nanograms per millilter.

About SOD2 / Mn SOD: MNSOD / SOD2 is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (more)

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Human BPI ELISA Kit (Sandwich ELISA) - LS-F4494

LS-F4494 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human BPI in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BPI as low as 12.5 picograms per milliliter.

About BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. (more)

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Human Complement C4b ELISA Kit (Sandwich ELISA) - LS-F4550

LS-F4550 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Complement C4b in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C4b as low as 4.69 nanograms per millilter.

About Complement C4b: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. (more)

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Human FCGR1A / CD64 ELISA Kit (Sandwich ELISA) - LS-F4795

LS-F4795 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FCGR1A / CD64 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FCGR1A / CD64 as low as 78 picograms per milliliter.

About FCGR1A / CD64: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. (more)

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Rabbit TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5127

LS-F5127 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit TNF Alpha in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNF Alpha as low as 3.12 picograms per milliliter.

About TNF Alpha: TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (more)

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Human ACPP / PAP ELISA Kit (Sandwich ELISA) - LS-F5214

LS-F5214 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ACPP / PAP in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACPP / PAP as low as 0.054 nanograms per millilter.

About ACPP / PAP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. (more)

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Rat IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F5224

LS-F5224 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 7.8 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Rat ACTH ELISA Kit (Competitive EIA) - LS-F5355

LS-F5355 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat ACTH in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of ACTH as low as 4.76 picograms per milliliter. (more)

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Rabbit IGF1 ELISA Kit (Sandwich ELISA) - LS-F5395

LS-F5395 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit IGF1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of IGF1 as low as 78 picograms per milliliter.

About IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. (more)

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Rat MMP3 ELISA Kit (Sandwich ELISA) - LS-F5516

LS-F5516 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat MMP3 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP3 as low as 0.156 nanograms per millilter.

About MMP3: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (more)

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Rat CRH / CRF ELISA Kit (Competitive EIA) - LS-F5619

LS-F5619 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CRH / CRF in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 12.35 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Human SOD1 / Cu-Zn SOD ELISA Kit (Sandwich ELISA) - LS-F5770

LS-F5770 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SOD1 / Cu-Zn SOD in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SOD1 / Cu-Zn SOD as low as 62.5 picograms per milliliter.

About SOD1 / Cu-Zn SOD: SOD1 / Cu-Zn SOD binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. (more)

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Human SOD3 ELISA Kit (Sandwich ELISA) - LS-F5969

LS-F5969 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SOD3 in samples of Cell Lysates, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SOD3 as low as 125 picograms per milliliter.

About SOD3: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. (more)

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Bovine AHSG / Fetuin A ELISA Kit (Sandwich ELISA) - LS-F6106

LS-F6106 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine AHSG / Fetuin A in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of AHSG / Fetuin A as low as 15.6 nanograms per millilter.

About AHSG / Fetuin A: Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. (more)

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Mouse SYP / Synaptophysin ELISA Kit (Sandwich ELISA) - LS-F6345

LS-F6345 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SYP / Synaptophysin in samples of Cerebrospinal Fluid, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SYP / Synaptophysin as low as 0.625 nanograms per millilter.

About SYP / Synaptophysin: Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release. (more)

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Pig FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F6396

LS-F6396 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig FLT1 / VEGFR1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FLT1 / VEGFR1 as low as 0.312 nanograms per millilter.

About FLT1 / VEGFR1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). (more)

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Human Properdin / CFP ELISA Kit (Sandwich ELISA) - LS-F6408

LS-F6408 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Properdin / CFP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Properdin / CFP as low as 15.6 nanograms per millilter.

About Properdin / CFP: Properdin / CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Mouse CALR / Calreticulin ELISA Kit (Sandwich ELISA) - LS-F6663

LS-F6663 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CALR / Calreticulin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CALR / Calreticulin as low as 0.067 nanograms per millilter.

About CALR / Calreticulin: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. (more)

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Mouse DLG4 / PSD95 ELISA Kit (Sandwich ELISA) - LS-F7142

LS-F7142 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse DLG4 / PSD95 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DLG4 / PSD95 as low as 0.156 nanograms per millilter.

About DLG4 / PSD95: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. (more)

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Human LOXL2 ELISA Kit (Sandwich ELISA) - LS-F7178

LS-F7178 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LOXL2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LOXL2 as low as 0.156 nanograms per millilter.

About LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. (more)

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Bovine CSN2 / Beta Casein ELISA Kit (Sandwich ELISA) - LS-F8118

LS-F8118 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine CSN2 / Beta Casein in samples of Milk. It is based upon a Sandwich assay principle and can be used to detect levels of CSN2 / Beta Casein as low as 15.6 nanograms per millilter.

About CSN2 / Beta Casein: CSN2 / Beta Casein is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. (more)

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Human IL37 ELISA Kit (Sandwich ELISA) - LS-F8293

LS-F8293 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL37 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL37 as low as 7.8 picograms per milliliter.

About IL37: IL37 is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. (more)

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Human BPIFA1 / SPLUNC1 ELISA Kit (Sandwich ELISA) - LS-F8634

LS-F8634 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human BPIFA1 / SPLUNC1 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BPIFA1 / SPLUNC1 as low as 0.156 nanograms per millilter.

About BPIFA1 / SPLUNC1: Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. (more)

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Human SRD5A2 ELISA Kit (Sandwich ELISA) - LS-F8796

LS-F8796 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SRD5A2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SRD5A2 as low as 0.312 nanograms per millilter.

About SRD5A2: Steroid 5-alpha reductase 2 is a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. This isoform is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). (more)

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Human PSME3 ELISA Kit (Sandwich ELISA) - LS-F9374

LS-F9374 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PSME3 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PSME3 as low as 0.156 nanograms per millilter.

About PSME3: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. (more)

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Human CTAG1B / NY-ESO-1 ELISA Kit (Sandwich ELISA) - LS-F9808

LS-F9808 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CTAG1B / NY-ESO-1 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTAG1B / NY-ESO-1 as low as 0.156 nanograms per millilter.

About CTAG1B / NY-ESO-1: The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. (more)

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Human Arachidonic Acid ELISA Kit (Competitive EIA) - LS-F10090

LS-F10090 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Arachidonic Acid in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Arachidonic Acid as low as 78.125 nanograms per millilter. (more)

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Human HBV / HBsAg ELISA Kit (Sandwich ELISA) - LS-F10106

LS-F10106 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Qualitative detection of Human HBV / HBsAg in samples of Plasma and Serum. It is based upon a Sandwich assay principle.

About HBV / HBsAg: HBsAg is the surface antigen of hepatitis B virus (HBV). It is present in the sera of patients with viral hepatitis B (with or without clinical symptoms). Patients who developed antibodies against HBsAg (anti-HBsAg seroconversion) are usually considered non-infectious. (more)

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Human CP / Ceruloplasmin ELISA Kit (Sandwich ELISA) - LS-F10412

LS-F10412 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CP / Ceruloplasmin in samples of Cell Culture, Milk, Plasma, Saliva, Serum and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of CP / Ceruloplasmin as low as 0.333 nanograms per millilter.

About CP / Ceruloplasmin: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. (more)

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Angiotensin 1-7 ELISA Kit (Competitive EIA) - LS-F10589

LS-F10589 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Angiotensin 1-7 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin 1-7 as low as 7.8 picograms per milliliter. (more)

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Human HSPA5 / GRP78 / BiP ELISA Kit (Sandwich ELISA) - LS-F11578

LS-F11578 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HSPA5 / GRP78 / BiP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HSPA5 / GRP78 / BiP as low as 0.156 picograms per milliliter.

About HSPA5 / GRP78 / BiP: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F11641

LS-F11641 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG1 / HMGB1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 0.156 nanograms per millilter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Dog LHB / Luteinizing Hormone ELISA Kit (Sandwich ELISA) - LS-F11983

LS-F11983 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Dog LHB / Luteinizing Hormone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LHB / Luteinizing Hormone as low as 0.78 milli international units per milliliter.

About LHB / Luteinizing Hormone: LHB / Luteinizing Hormone is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. (more)

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Mouse AMH / Anti-Mullerian Hormone ELISA Kit (Sandwich ELISA) - LS-F12041

LS-F12041 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse AMH / Anti-Mullerian Hormone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AMH / Anti-Mullerian Hormone as low as 0.156 nanograms per millilter.

About AMH / Anti-Mullerian Hormone: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. (more)

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Human S100A7 / Psoriasin ELISA Kit (Sandwich ELISA) - LS-F12536

LS-F12536 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human S100A7 / Psoriasin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of S100A7 / Psoriasin as low as 0.156 nanograms per millilter.

About S100A7 / Psoriasin: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. (more)

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Rat MMP13 ELISA Kit (Sandwich ELISA) - LS-F13323

LS-F13323 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat MMP13 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP13 as low as 78 picograms per milliliter.

About MMP13: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. (more)

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Mouse SDC1 / Syndecan 1 / CD138 ELISA Kit (Sandwich ELISA) - LS-F13440

LS-F13440 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse SDC1 / Syndecan 1 / CD138 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SDC1 / Syndecan 1 / CD138 as low as 78 picograms per milliliter.

About SDC1 / Syndecan 1 / CD138: SDC1 / Syndecan 1 / CD138 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. (more)

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Mouse CR2 / CD21 ELISA Kit (Sandwich ELISA) - LS-F15152

LS-F15152 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CR2 / CD21 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CR2 / CD21 as low as 0.78 nanograms per millilter.

About CR2 / CD21: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. (more)

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Human VTCN1 / B7-H4 ELISA Kit (Sandwich ELISA) - LS-F15920

LS-F15920 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human VTCN1 / B7-H4 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of VTCN1 / B7-H4 as low as 0.78 nanograms per millilter.

About VTCN1 / B7-H4: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. (more)

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Pig S100A12 ELISA Kit (Sandwich ELISA) - LS-F17699

LS-F17699 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig S100A12 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of S100A12 as low as 0.156 nanograms per millilter.

About S100A12: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. (more)

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Human ASPA ELISA Kit (Sandwich ELISA) - LS-F19625

LS-F19625 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ASPA in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ASPA as low as 78 picograms per milliliter.

About ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. (more)

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Rat APP / Beta Amyloid Precursor ELISA Kit (Sandwich ELISA) - LS-F20815

LS-F20815 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat APP / Beta Amyloid Precursor in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APP / Beta Amyloid Precursor as low as 1.56 nanograms per millilter.

About APP / Beta Amyloid Precursor: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. (more)

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Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F21017

LS-F21017 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLIT2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SLIT2 as low as 0.16 nanograms per millilter.

About SLIT2: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. (more)

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Human OGG1 ELISA Kit (Sandwich ELISA) - LS-F21195

LS-F21195 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human OGG1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of OGG1 as low as 0.156 nanograms per millilter.

About OGG1: OGG1 is the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. (more)

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Rat C5b-9 Terminal Complement Complex / TCC ELISA Kit (Sandwich ELISA) - LS-F21613

LS-F21613 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat C5b-9 Terminal Complement Complex / TCC in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of C5b-9 Terminal Complement Complex / TCC as low as 0.16 nanograms per millilter.

About C5b-9 Terminal Complement Complex / TCC: The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. (more)

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Rat CBFA1 / RUNX2 ELISA Kit (Sandwich ELISA) - LS-F22350

LS-F22350 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CBFA1 / RUNX2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CBFA1 / RUNX2 as low as 0.31 nanograms per millilter.

About CBFA1 / RUNX2: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. (more)

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Mouse TNNT2 / CTNT ELISA Kit (Sandwich ELISA) - LS-F23127

LS-F23127 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TNNT2 / CTNT in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNNT2 / CTNT as low as 15.625 picograms per milliliter.

About TNNT2 / CTNT: TNNT2 / CTNT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. (more)

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Pig CLDN3 / Claudin 3 ELISA Kit (Sandwich ELISA) - LS-F23922

LS-F23922 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig CLDN3 / Claudin 3 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CLDN3 / Claudin 3 as low as 62.5 picograms per milliliter.

About CLDN3 / Claudin 3: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. (more)

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Rat Complement C1q ELISA Kit (Sandwich ELISA) - LS-F25231

LS-F25231 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Complement C1q in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C1q as low as 0.781 nanograms per millilter.

About Complement C1q: C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits (C1QA, C1QB, and C1QC). Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. (more)

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Human Copeptin ELISA Kit (Competitive EIA) - LS-F25728

LS-F25728 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Copeptin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Copeptin as low as 31.25 picograms per milliliter. (more)

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Rat Acetylcholine ELISA Kit (Competitive EIA) - LS-F27870

LS-F27870 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Acetylcholine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Acetylcholine as low as 50 picograms per milliliter. (more)

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Rat PAF / Platelet Activating Factor ELISA Kit (Competitive EIA) - LS-F28056

LS-F28056 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat PAF / Platelet Activating Factor in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of PAF / Platelet Activating Factor as low as 1 picograms per milliliter. (more)

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Most Popular Proteins
Human Eosinophil Peroxidase / EPX Native Protein - LS-G4246

LS-G4246 is a Human Eosinophil Peroxidase / EPX native protein from Human. This protein is biologically active.

About Eosinophil Peroxidase / EPX: Eosinophil Peroxidase / EPX is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. (more)

Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Mouse PLA2G2D Recombinant (His) Protein - LS-G13312

LS-G13312 is a Mouse PLA2G2D recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About PLA2G2D: PLA2G2D is a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. (more)


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