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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 387,207 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-KISS1R / GPR54 Antibody (Extracellular Domain) IHC-plus™ LS-A1926

LS-A1926 is a rabbit anti-KISS1R / GPR54 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About KISS1R / GPR54: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. (more)

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Anti-OX1R / Orexin Receptor 1 Antibody (C-Terminus) IHC-plus™ LS-A6677

LS-A6677 is a rabbit anti-OX1R / Orexin Receptor 1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About OX1R / Orexin Receptor 1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. (more)

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Anti-IGF1R / IGF1 Receptor Antibody (C-Terminus) LS-C24709

LS-C24709 is a rabbit anti-IGF1R / IGF1 Receptor polyclonal antibody approved for use in Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About IGF1R / IGF1 Receptor: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) IHC-plus™ LS-B1836

LS-B1836 is a rabbit anti-SLC40A1 / Ferroportin-1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2199

LS-B2199 is a sheep anti-EGFR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-HPSE / Heparanase Antibody IHC-plus™ LS-B2441

LS-B2441 is a rabbit anti-HPSE / Heparanase polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About HPSE / Heparanase: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. (more)

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Anti-ERBB2 / HER2 Antibody (clone SP3) LS-C88826

LS-C88826 is a rabbit anti-ERBB2 / HER2 monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ERBB2 / HER2: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. (more)

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Anti-GH / Growth Hormone Antibody (clone G3H5) IHC-plus™ LS-B2974

LS-B2974 is a mouse anti-GH / Growth Hormone monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About GH / Growth Hormone: GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. (more)

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Anti-STEAP1 / STEAP Antibody (aa1-70, clone J2D2) IHC-plus™ LS-B3003

LS-B3003 is a mouse anti-STEAP1 / STEAP monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About STEAP1 / STEAP: Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. (more)

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Anti-XBP1 Antibody (aa2-160, clone 9B7E5) IHC-plus™ LS-B3178

LS-B3178 is a mouse anti-XBP1 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About XBP1: XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (more)

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Mouse Anti-Human IgM Secondary Antibody (clone UCHB1, Azide-free) LS-C134191

LS-C134191 is a mouse anti-Human IgM monoclonal antibody approved for use in Flow Cytometry and Functional Assay.

About Human IgM: Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to an antigen. The spleen where plasmablasts reside is the major site of specific IgM production. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 970 kDa (in its pentamer form). Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically, however, IgM cannot bind 10 antigens at the same time because the large size of most antigens hinders binding to nearby sites. (more)

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Anti-TCR Gamma + TCR Delta Antibody (clone GL-3, FITC) IHC-plus™ LS-B5684

LS-B5684 is a Fluorescein hamster-armenian anti-TCR Gamma + TCR Delta monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About TCR Gamma + TCR Delta: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. (more)

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Anti-KDM6B / JMJD3 Antibody (N-Terminus) LS-C144473

LS-C144473 is a rabbit anti-KDM6B / JMJD3 polyclonal antibody approved for use in Immunocytochemistry and Western blot.

About KDM6B / JMJD3: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. (more)

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Anti-HPGDS Antibody (aa35-84) IHC-plus™ LS-B6886

LS-B6886 is a rabbit anti-HPGDS polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About HPGDS: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. (more)

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Anti-REN / Renin 1 Antibody (clone 7D3-E3) IHC-plus™ LS-B7374

LS-B7374 is a mouse anti-REN / Renin 1 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About REN / Renin 1: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. (more)

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Anti-PDCD1 / CD279 / PD-1 Antibody (clone J116) IHC-plus™ LS-B7883

LS-B7883 is a mouse anti-PDCD1 / CD279 / PD-1 monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About PDCD1 / CD279 / PD-1: PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (more)

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Anti-RPS6KA1 / RSK1 Antibody (phospho-Ser732) LS-C154250

LS-C154250 is a rabbit anti-RPS6KA1 / RSK1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About RPS6KA1 / RSK1: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. (more)

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Anti-B2M / Beta 2 Microglobulin Antibody (clone B2M-01) IHC-plus™ LS-B8113

LS-B8113 is a mouse anti-B2M / Beta 2 Microglobulin monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Paraffin, Immunoprecipitation, Radioimmunoassay and Western blot.

About B2M / Beta 2 Microglobulin: B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. (more)

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Anti-LRAT Antibody (aa111-160) IHC-plus™ LS-B8398

LS-B8398 is a rabbit anti-LRAT polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About LRAT: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. (more)

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Anti-PIK3R1 / p85 Alpha Antibody (clone 6G10) IHC-plus™ LS-B8947

LS-B8947 is a mouse anti-PIK3R1 / p85 Alpha monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About PIK3R1 / p85 Alpha: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. (more)

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Anti-LILRB2 / ILT4 Antibody (C-Terminus) IHC-plus™ LS-B9762

LS-B9762 is a rabbit anti-LILRB2 / ILT4 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About LILRB2 / ILT4: LILRB2 / ILT4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-TJP1 / ZO-1 Antibody (C-Terminus) IHC-plus™ LS-B9774

LS-B9774 is a goat anti-TJP1 / ZO-1 polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About TJP1 / ZO-1: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. (more)

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Anti-Ovalbumin Antibody (HRP) LS-C209236

LS-C209236 is a Horseradish Peroxidase rabbit anti-Ovalbumin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Immunoprecipitation and Western blot.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Anti-VILIP / VSNL1 Antibody IHC-plus™ LS-B10418

LS-B10418 is a rabbit anti-VILIP / VSNL1 polyclonal antibody approved for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About VILIP / VSNL1: VILIP / VSNL1 is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. (more)

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Anti-PVR / CD155 Antibody (aa314-342) IHC-plus™ LS-B10536

LS-B10536 is a rabbit anti-PVR / CD155 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PVR / CD155: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. (more)

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Anti-CD274 / B7-H1 / PD-L1 Antibody (aa261-290) IHC-plus™ LS-B10562

LS-B10562 is a rabbit anti-CD274 / B7-H1 / PD-L1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CD274 / B7-H1 / PD-L1: CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. (more)

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Anti-TNFRSF14 / CD270 / HVEM Antibody IHC-plus™ LS-B11001

LS-B11001 is a rabbit anti-TNFRSF14 / CD270 / HVEM polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About TNFRSF14 / CD270 / HVEM: HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM. (more)

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Anti-DUSP3 / VHR Antibody (aa2-185) LS-C293712

LS-C293712 is a rabbit anti-DUSP3 / VHR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About DUSP3 / VHR: DUSP3 / VHR is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. (more)

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Anti-LPL / Lipoprotein Lipase Antibody (aa313-362) IHC-plus™ LS-B11634

LS-B11634 is a rabbit anti-LPL / Lipoprotein Lipase polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About LPL / Lipoprotein Lipase: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. (more)

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Anti-CD8A / CD8 Alpha Antibody (C-Terminus, clone C8/144B, Azide-free) LS-C389847

LS-C389847 is a mouse anti-CD8A / CD8 Alpha monoclonal antibody approved for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry - Paraffin.

About CD8A / CD8 Alpha: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-TMEM158 / RIS1 Antibody (aa186-218) LS-C393048

LS-C393048 is a rabbit anti-TMEM158 / RIS1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About TMEM158 / RIS1: Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. (more)

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Most Popular ELISA Kits
Mouse TNFSF4 / OX40L ELISA Kit (Sandwich ELISA) - LS-F2725

LS-F2725 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TNFSF4 / OX40L in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNFSF4 / OX40L as low as 10 picograms per milliliter.

About TNFSF4 / OX40L: TNFSF4 / OX40L is a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. (more)

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Mouse CD200 ELISA Kit (Sandwich ELISA) - LS-F2868

LS-F2868 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CD200 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD200 as low as 31.2 picograms per milliliter.

About CD200: CD200, also known as OX-2, is a type I membrane protein belonging to the Ig superfamily. It has a 202 amino acid extracellular domain and a short cytoplasmic domain. CD200 is widely expressed by a variety of cell types. It interacts with CD200R another Ig superfamily inhibitory receptor primarily expresses on leukocytes of the myeloid lineage to inhibit myeloid functions. It has been shown to be up regulated in CLL. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. (more)

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Human IL27 ELISA Kit (Sandwich ELISA) - LS-F4189

LS-F4189 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL27 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL27 as low as 15.63 picograms per milliliter.

About IL27: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. (more)

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Human FCGR1A / CD64 ELISA Kit (Sandwich ELISA) - LS-F4795

LS-F4795 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FCGR1A / CD64 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FCGR1A / CD64 as low as 78.13 picograms per milliliter.

About FCGR1A / CD64: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. (more)

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Human CD32A ELISA Kit (Sandwich ELISA) - LS-F4796

LS-F4796 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CD32A in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD32A as low as 46.88 picograms per milliliter.

About CD32A: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. (more)

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Human CXCL3 / GRO Gamma ELISA Kit (Sandwich ELISA) - LS-F4807

LS-F4807 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CXCL3 / GRO Gamma in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CXCL3 / GRO Gamma as low as 7.81 picograms per milliliter.

About CXCL3 / GRO Gamma: Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. (more)

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Human MUC5AC ELISA Kit (Sandwich ELISA) - LS-F4836

LS-F4836 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MUC5AC in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MUC5AC as low as 78.13 picograms per milliliter.

About MUC5AC: MUC5AC has been isolated from airway secretions. It is found in the protective film of mucus coating the mucosal surfaces of the respiratory tract and the normal gastrointestinal tissues. Mucins are also expressed at low levels in human fetal gut. MUC5AC is involved in epithelial cell proliferation and differentiation in adult airway mucosa and can be used as a marker for hypersecretory disorders. MUC5AC has also been observed in various tumors. For instance it is expressed in primary mucinous ovarian tumors but not in colonic carcinoma metastatic to the ovary, which makes it a useful marker to distinguish the two types of cancer. (more)

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Human Copeptin ELISA Kit (Competitive EIA) - LS-F5248

LS-F5248 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Copeptin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Copeptin as low as 12.35 picograms per milliliter. (more)

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Human MAG ELISA Kit (Sandwich ELISA) - LS-F5260

LS-F5260 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MAG in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MAG as low as 0.119 nanograms per millilter.

About MAG: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid. (more)

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Mouse KLK5 / Kallikrein 5 ELISA Kit (Sandwich ELISA) - LS-F5270

LS-F5270 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse KLK5 / Kallikrein 5 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KLK5 / Kallikrein 5 as low as 78 picograms per milliliter.

About KLK5 / Kallikrein 5: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. (more)

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Human DPYD / DPD ELISA Kit (Sandwich ELISA) - LS-F5283

LS-F5283 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human DPYD / DPD in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DPYD / DPD as low as 62.5 picograms per milliliter.

About DPYD / DPD: Dihydropyrimidine dehydrogenase (DPYD) is a pyrimidine catabolic enzyme and the initial and rate-limiting step in the pathway of uracil and thymidine catabolism and also in the pathway leading to the formation of beta-alanine. The DPYD gene is a large gene of approximately 150 kb consisting of 23 exons encoding a protein of approximately 111-kD. Genetic deficiency of DPYD enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-flourouracil chemotherapy. (more)

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Mouse CCK / Cholecystokinin ELISA Kit (Competitive EIA) - LS-F5654

LS-F5654 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CCK / Cholecystokinin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of CCK / Cholecystokinin as low as 12.35 picograms per milliliter.

About CCK / Cholecystokinin: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (more)

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Rat GUSB / Beta Glucuronidase ELISA Kit (Sandwich ELISA) - LS-F5870

LS-F5870 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat GUSB / Beta Glucuronidase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GUSB / Beta Glucuronidase as low as 0.312 nanograms per millilter.

About GUSB / Beta Glucuronidase: GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. (more)

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Mouse GCK / Glucokinase ELISA Kit (Sandwich ELISA) - LS-F5874

LS-F5874 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse GCK / Glucokinase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GCK / Glucokinase as low as 0.156 nanograms per millilter.

About GCK / Glucokinase: Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. (more)

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Mouse/Human/Rat NOG / Noggin ELISA Kit (Sandwich ELISA) - LS-F5920

LS-F5920 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NOG / Noggin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NOG / Noggin as low as 0.156 nanograms per millilter.

About NOG / Noggin: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. (more)

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Human XDH / Xanthine Oxidase ELISA Kit (Sandwich ELISA) - LS-F6180

LS-F6180 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human XDH / Xanthine Oxidase in samples of Breast Milk, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of XDH / Xanthine Oxidase as low as 0.156 nanograms per millilter.

About XDH / Xanthine Oxidase: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. (more)

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Human DCD / Dermcidin ELISA Kit (Sandwich ELISA) - LS-F6212

LS-F6212 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human DCD / Dermcidin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DCD / Dermcidin as low as 0.781 nanograms per millilter.

About DCD / Dermcidin: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. (more)

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Human CMA1 / Mast Cell Chymase ELISA Kit (Sandwich ELISA) - LS-F6478

LS-F6478 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CMA1 / Mast Cell Chymase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CMA1 / Mast Cell Chymase as low as 31.2 picograms per milliliter.

About CMA1 / Mast Cell Chymase: CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. (more)

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Mouse CALR / Calreticulin ELISA Kit (Sandwich ELISA) - LS-F6663

LS-F6663 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CALR / Calreticulin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CALR / Calreticulin as low as 0.156 nanograms per millilter.

About CALR / Calreticulin: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. (more)

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Human NF-L / NEFL ELISA Kit (Sandwich ELISA) - LS-F6701

LS-F6701 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NF-L / NEFL in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NF-L / NEFL as low as 15.6 picograms per milliliter.

About NF-L / NEFL: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. (more)

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Human RPL6 / Ribosomal Protein L6 ELISA Kit (Sandwich ELISA) - LS-F6793

LS-F6793 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human RPL6 / Ribosomal Protein L6 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RPL6 / Ribosomal Protein L6 as low as 0.156 nanograms per millilter.

About RPL6 / Ribosomal Protein L6: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (more)

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Dog TIMP1 ELISA Kit (Sandwich ELISA) - LS-F6887

LS-F6887 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog TIMP1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP1 as low as 31.2 picograms per milliliter.

About TIMP1: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. (more)

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Human Proteoglycan 4 / Lubricin ELISA Kit (Sandwich ELISA) - LS-F7095

LS-F7095 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Proteoglycan 4 / Lubricin in samples of Plasma, Serum and Synovial Fluid. It is based upon a Sandwich assay principle and can be used to detect levels of Proteoglycan 4 / Lubricin as low as 62.5 picograms per milliliter.

About Proteoglycan 4 / Lubricin: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. (more)

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Human LOXL2 ELISA Kit (Sandwich ELISA) - LS-F7178

LS-F7178 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LOXL2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LOXL2 as low as 0.156 nanograms per millilter.

About LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. (more)

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Rat NPHS1 / Nephrin ELISA Kit (Sandwich ELISA) - LS-F7323

LS-F7323 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat NPHS1 / Nephrin in samples of Cell Lysates, Tissue Homogenates and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of NPHS1 / Nephrin as low as 0.312 nanograms per millilter.

About NPHS1 / Nephrin: NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. (more)

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Human RELB ELISA Kit (Sandwich ELISA) - LS-F7395

LS-F7395 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human RELB in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RELB as low as 0.156 nanograms per millilter.

About RELB: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. (more)

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Human CALB1 / Calbindin ELISA Kit (Sandwich ELISA) - LS-F7744

LS-F7744 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CALB1 / Calbindin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CALB1 / Calbindin as low as 12.5 picograms per milliliter.

About CALB1 / Calbindin: CALB1 / Calbindin is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. (more)

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Human SIRT6 / Sirtuin 6 ELISA Kit (Sandwich ELISA) - LS-F7874

LS-F7874 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SIRT6 / Sirtuin 6 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SIRT6 / Sirtuin 6 as low as 0.313 nanograms per millilter.

About SIRT6 / Sirtuin 6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. (more)

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Human TSG101 ELISA Kit (Sandwich ELISA) - LS-F8581

LS-F8581 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TSG101 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TSG101 as low as 0.313 nanograms per millilter.

About TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. (more)

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Mouse CYR61 ELISA Kit (Sandwich ELISA) - LS-F8609

LS-F8609 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CYR61 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYR61 as low as 6.25 picograms per milliliter.

About CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. (more)

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Human PTHR / PTHR1 ELISA Kit (Sandwich ELISA) - LS-F8828

LS-F8828 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PTHR / PTHR1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PTHR / PTHR1 as low as 0.313 nanograms per millilter.

About PTHR / PTHR1: PTHR / PTHR1 is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. (more)

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Mouse G6PC / Glucose-6-Phosphatase ELISA Kit (Sandwich ELISA) - LS-F9366

LS-F9366 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse G6PC / Glucose-6-Phosphatase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of G6PC / Glucose-6-Phosphatase as low as 0.781 nanograms per millilter.

About G6PC / Glucose-6-Phosphatase: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. (more)

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Mouse LL37 / Cathelicidin ELISA Kit (Sandwich ELISA) - LS-F9642

LS-F9642 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LL37 / Cathelicidin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LL37 / Cathelicidin as low as 0.78 nanograms per millilter.

About LL37 / Cathelicidin: LL37 / Cathelicidin is a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. (more)

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Mouse IL-10 ELISA Kit (Sandwich ELISA) - LS-F9770

LS-F9770 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse IL-10 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL-10 as low as 1.56 picograms per milliliter.

About IL-10: IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. (more)

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Mouse CD33 ELISA Kit (Sandwich ELISA) - LS-F9886

LS-F9886 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD33 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD33 as low as 0.156 nanograms per millilter.

About CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). (more)

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Human AGE ELISA Kit (Sandwich ELISA) - LS-F10641

LS-F10641 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human AGE in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AGE as low as 0.78 nanograms per millilter. (more)

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IP3 / Inositol Trisphosphate ELISA Kit (Competitive EIA) - LS-F10644

LS-F10644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of IP3 / Inositol Trisphosphate in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IP3 / Inositol Trisphosphate as low as 0.625 nanograms per millilter. (more)

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Human CD63 ELISA Kit (Sandwich ELISA) - LS-F11093

LS-F11093 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CD63 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD63 as low as 31.2 picograms per milliliter.

About CD63: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. (more)

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Human CPT1A ELISA Kit (Sandwich ELISA) - LS-F11204

LS-F11204 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CPT1A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CPT1A as low as 15.6 picograms per milliliter.

About CPT1A: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse CRH / CRF ELISA Kit (Competitive EIA) - LS-F11216

LS-F11216 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CRH / CRF in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 15.6 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Human HNE / Neutrophil Elastase ELISA Kit (Sandwich ELISA) - LS-F11365

LS-F11365 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HNE / Neutrophil Elastase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HNE / Neutrophil Elastase as low as 78 picograms per milliliter.

About HNE / Neutrophil Elastase: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. (more)

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Mouse Fgf15 ELISA Kit (Sandwich ELISA) - LS-F11446

LS-F11446 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Fgf15 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Fgf15 as low as 78 picograms per milliliter.

About Fgf15: Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19. (more)

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Human HSPA5 / GRP78 / BiP ELISA Kit (Sandwich ELISA) - LS-F11578

LS-F11578 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HSPA5 / GRP78 / BiP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HSPA5 / GRP78 / BiP as low as 15.6 picograms per milliliter.

About HSPA5 / GRP78 / BiP: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. (more)

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Human HBB / Hemoglobin Beta ELISA Kit (Sandwich ELISA) - LS-F11605

LS-F11605 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HBB / Hemoglobin Beta in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HBB / Hemoglobin Beta as low as 0.78 nanograms per millilter.

About HBB / Hemoglobin Beta: The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin that sickles causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. (more)

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Mouse HAMP / Hepcidin ELISA Kit (Sandwich ELISA) - LS-F11620

LS-F11620 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse HAMP / Hepcidin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HAMP / Hepcidin as low as 6.25 picograms per milliliter.

About HAMP / Hepcidin: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F11641

LS-F11641 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG1 / HMGB1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 0.156 nanograms per millilter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human TREM2 / TREM-2 ELISA Kit (Sandwich ELISA) - LS-F12847

LS-F12847 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TREM2 / TREM-2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TREM2 / TREM-2 as low as 78 picograms per milliliter.

About TREM2 / TREM-2: TREM2 / TREM-2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. (more)

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Human TNFAIP6 / TSG-6 ELISA Kit (Sandwich ELISA) - LS-F12868

LS-F12868 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNFAIP6 / TSG-6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFAIP6 / TSG-6 as low as 0.156 nanograms per millilter.

About TNFAIP6 / TSG-6: TNFAIP6 / TSG-6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. (more)

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Human ACTA2 / Smooth Muscle Actin ELISA Kit (Sandwich ELISA) - LS-F13051

LS-F13051 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ACTA2 / Smooth Muscle Actin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTA2 / Smooth Muscle Actin as low as 3.12 nanograms per millilter.

About ACTA2 / Smooth Muscle Actin: ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Human FAM132B ELISA Kit (Sandwich ELISA) - LS-F13172

LS-F13172 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human FAM132B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FAM132B as low as 0.156 nanograms per millilter. (more)

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Human GNRH ELISA Kit (Sandwich ELISA) - LS-F13203

LS-F13203 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GNRH in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GNRH as low as 15.6 picograms per milliliter.

About GNRH: GNRH is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. (more)

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Bovine F2 / Prothrombin / Thrombin ELISA Kit (Sandwich ELISA) - LS-F13468

LS-F13468 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Bovine F2 / Prothrombin / Thrombin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of F2 / Prothrombin / Thrombin as low as 7.8 nanograms per millilter.

About F2 / Prothrombin / Thrombin: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. (more)

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Human PMAIP1 / NOXA ELISA Kit (Sandwich ELISA) - LS-F16886

LS-F16886 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PMAIP1 / NOXA in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PMAIP1 / NOXA as low as 78 picograms per milliliter.

About PMAIP1 / NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. (more)

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Rat RNASE3 ELISA Kit (Sandwich ELISA) - LS-F18462

LS-F18462 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat RNASE3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RNASE3 as low as 62.5 picograms per milliliter.

About RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. (more)

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Human ACTB / Beta Actin ELISA Kit (Sandwich ELISA) - LS-F21027

LS-F21027 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ACTB / Beta Actin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ACTB / Beta Actin as low as 0.156 nanograms per millilter.

About ACTB / Beta Actin: Actin is a highly conserved protein that participates in a wide variety of cellular functions in eukaryotes including muscle contraction, amoeboid movement, cytokinesis and mitotic division. Beta actin is ubiquitously expressed in all eukaryotic cells. (more)

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Rat FABP3 / H-FABP ELISA Kit (Sandwich ELISA) - LS-F21603

LS-F21603 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat FABP3 / H-FABP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FABP3 / H-FABP as low as 0.156 nanograms per millilter.

About FABP3 / H-FABP: The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. (more)

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Human LPA / Lipoprotein a ELISA Kit (Sandwich ELISA) - LS-F21752

LS-F21752 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human LPA / Lipoprotein a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of LPA / Lipoprotein a as low as 0.23 nanograms per millilter.

About LPA / Lipoprotein a: LPA / Lipoprotein a is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. (more)

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Human APOA4 ELISA Kit (Sandwich ELISA) - LS-F22485

LS-F22485 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human APOA4 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APOA4 as low as 4.688 nanograms per millilter.

About APOA4: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. (more)

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Human PTHLH / PTHRP ELISA Kit (Sandwich ELISA) - LS-F22967

LS-F22967 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human PTHLH / PTHRP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of PTHLH / PTHRP as low as 15.625 picograms per milliliter.

About PTHLH / PTHRP: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. (more)

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Rat Fibrinogen Degradation Product ELISA Kit (Sandwich ELISA) - LS-F23374

LS-F23374 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Fibrinogen Degradation Product in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Fibrinogen Degradation Product as low as 23.44 picograms per milliliter. (more)

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Mouse FGF21 ELISA Kit (Sandwich ELISA) - LS-F23493

LS-F23493 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse FGF21 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FGF21 as low as 31.25 picograms per milliliter.

About FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. (more)

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Rat NT-proBNP ELISA Kit (Sandwich ELISA) - LS-F23593

LS-F23593 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat NT-proBNP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NT-proBNP as low as 31.25 picograms per milliliter. (more)

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Rat Complement C1q ELISA Kit (Sandwich ELISA) - LS-F25231

LS-F25231 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Complement C1q in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C1q as low as 0.781 nanograms per millilter.

About Complement C1q: C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits (C1QA, C1QB, and C1QC). Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. (more)

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Human DOT1L / DOT1 ELISA Kit (Sandwich ELISA) - LS-F25586

LS-F25586 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human DOT1L / DOT1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DOT1L / DOT1 as low as 0.156 nanograms per millilter.

About DOT1L / DOT1: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. (more)

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Mouse KLK7 / Kallikrein 7 ELISA Kit (Competitive EIA) - LS-F28458

LS-F28458 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse KLK7 / Kallikrein 7 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of KLK7 / Kallikrein 7 as low as 0.5 nanograms per millilter.

About KLK7 / Kallikrein 7: KLK7 / Kallikrein 7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. (more)

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Most Popular Proteins
Human PLA2G2D (His) Protein - LS-G17546

LS-G17546 is a Human PLA2G2D. This protein has been engineered to contain a His tag.

About PLA2G2D: PLA2G2D is a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. (more)

Human CLEC4C / CD303 / BDCA-2 Recombinant (His + SUMO) Protein - LS-G21880

LS-G21880 is a Human CLEC4C / CD303 / BDCA-2 recombinant protein generated in E. coli. This protein has been engineered to contain a His + SUMO tag.

About CLEC4C / CD303 / BDCA-2: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. (more)

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