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  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 554,986 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

Our traditional Sandwich, Competitive EIA, and Direct ELISA kits provide a means to quantitatively measure thousands of targets of interest, while our Cell-Based and DNA-Binding ELISA kits are ideal for in-vitro studies and transcription factor analysis. Chemiluminescent CLIA kits provide high-sensitivity detection of low-copy targets and our Development kits enable researchers to cost-effectively run large numbers of assays.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-CDKN2A / p16INK4a Antibody (aa54-75, clone 5-C3-1) LS-C2744

LS-C2744 is a rat anti-CDKN2A / p16INK4a monoclonal antibody approved for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-MBP / Myelin Basic Protein Antibody (aa130-136) IHC-plus™ LS-B2231

LS-B2231 is a mouse anti-MBP / Myelin Basic Protein monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About MBP / Myelin Basic Protein: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. (more)

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Anti-CD163 Antibody (clone 10D6) LS-C87534

LS-C87534 is a mouse anti-CD163 monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. (more)

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Anti-FABP1 / L-FABP Antibody (aa1-127, clone 2G4) IHC-plus™ LS-B3001

LS-B3001 is a mouse anti-FABP1 / L-FABP monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FABP1 / L-FABP: FABP1 / L-FABP is the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. (more)

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Anti-CD144 / CDH5 / VE Cadherin Antibody (clone 16B1) IHC-plus™ LS-B3780

LS-B3780 is a mouse anti-CD144 / CDH5 / VE Cadherin monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About CD144 / CDH5 / VE Cadherin: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. (more)

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Anti-PLIN2 / ADFP / Adipophilin Antibody IHC-plus™ LS-B4850

LS-B4850 is a rabbit anti-PLIN2 / ADFP / Adipophilin polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PLIN2 / ADFP / Adipophilin: PLIN2 / ADFP / Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. (more)

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Anti-TNFRSF10B / Killer / DR5 Antibody (aa380-398) IHC-plus™ LS-B5086

LS-B5086 is a rabbit anti-TNFRSF10B / Killer / DR5 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About TNFRSF10B / Killer / DR5: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. (more)

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Anti-MNK / ATP7A Antibody (clone S60-4) IHC-plus™ LS-B8162

LS-B8162 is a mouse anti-MNK / ATP7A monoclonal antibody approved for use in Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About MNK / ATP7A: MNK / ATP7A is a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. (more)

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Anti-DMD / Dystrophin Antibody IHC-plus™ LS-B8434

LS-B8434 is a rabbit anti-DMD / Dystrophin polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About DMD / Dystrophin: The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. (more)

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Anti-TDO2 Antibody (clone 2A4) LS-C174023

LS-C174023 is a mouse anti-TDO2 monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About TDO2: TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. (more)

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Anti-CD52 Antibody (clone YTH34.5, Low Endotoxin) LS-C188149

LS-C188149 is a rat anti-CD52 monoclonal antibody approved for use in Cytotoxic Assay, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About CD52: May play a role in carrying and orienting carbohydrate, as well as having a more specific role. (more)

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Anti-Delta3 / DLL3 Antibody (aa519-548) IHC-plus™ LS-B10548

LS-B10548 is a rabbit anti-Delta3 / DLL3 polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About Delta3 / DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. (more)

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Anti-MX1 / MX Antibody (aa80-342) LS-C292488

LS-C292488 is a mouse anti-MX1 / MX monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About MX1 / MX: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. (more)

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Anti-Trypsin Antibody (Biotin) LS-C298078

LS-C298078 is a Biotin rabbit anti-Trypsin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Trypsin: Trypsin is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen, which is encoded by several genes (PRSS1, PRSS2, PRSS3). Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. (more)

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Anti-Neuroblastoma Marker Antibody (clone NB84a) LS-C312121

LS-C312121 is a mouse anti-Neuroblastoma Marker monoclonal antibody approved for use in Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin. (more)

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Anti-CD68 Antibody (aa312-326) LS-C312677

LS-C312677 is a rabbit anti-CD68 polyclonal antibody approved for use in Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About CD68: CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. (more)

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Anti-APOL1 / Apolipoprotein L Antibody (aa261-310) IHC-plus™ LS-B11247

LS-B11247 is a rabbit anti-APOL1 / Apolipoprotein L polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About APOL1 / Apolipoprotein L: APOL1 / Apolipoprotein L is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-tdTomato Antibody LS-C340696

LS-C340696 is a goat anti-tdTomato polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot. (more)

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Anti-MC1R Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1040

LS-A1040 is a rabbit anti-MC1R polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About MC1R: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. (more)

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Most Popular ELISA Kits
Human POSTN / Periostin ELISA Kit (Sandwich ELISA) - LS-F3645

LS-F3645 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human POSTN / Periostin in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of POSTN / Periostin as low as 0.082 nanograms per millilter.

About POSTN / Periostin: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX By similarity. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. (more)

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Rat Angiotensin II ELISA Kit (Competitive EIA) - LS-F3953

LS-F3953 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat Angiotensin II in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 24.69 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Mouse AGT / Angiotensinogen ELISA Kit (Sandwich ELISA) - LS-F4241

LS-F4241 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse AGT / Angiotensinogen in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AGT / Angiotensinogen as low as 0.625 nanograms per millilter.

About AGT / Angiotensinogen: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. (more)

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Mouse SFTPA1 / Surfactant Protein A ELISA Kit (Sandwich ELISA) - LS-F4286

LS-F4286 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SFTPA1 / Surfactant Protein A in samples of Lung Lavage Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SFTPA1 / Surfactant Protein A as low as 31.25 picograms per milliliter.

About SFTPA1 / Surfactant Protein A: SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. (more)

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Mouse Osteonectin / SPARC ELISA Kit (Sandwich ELISA) - LS-F4333

LS-F4333 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Osteonectin / SPARC in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Osteonectin / SPARC as low as 0.156 nanograms per millilter.

About Osteonectin / SPARC: SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression. (more)

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Melatonin ELISA Kit (Competitive EIA) - LS-F4837

LS-F4837 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Melatonin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Melatonin as low as 12.35 picograms per milliliter. (more)

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Human Copeptin ELISA Kit (Competitive EIA) - LS-F5248

LS-F5248 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Copeptin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Copeptin as low as 12.35 picograms per milliliter. (more)

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Mouse Osteocalcin ELISA Kit (Sandwich ELISA) - LS-F5375

LS-F5375 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Osteocalcin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Osteocalcin as low as 0.156 nanograms per millilter.

About Osteocalcin: Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone. (more)

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Rabbit IGF1 ELISA Kit (Sandwich ELISA) - LS-F5395

LS-F5395 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit IGF1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of IGF1 as low as 78.13 picograms per milliliter.

About IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. (more)

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Rat IL15 ELISA Kit (Sandwich ELISA) - LS-F5544

LS-F5544 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat IL15 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL15 as low as 15.63 picograms per milliliter.

About IL15: IL15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. (more)

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Human GHRH ELISA Kit (Competitive EIA) - LS-F5546

LS-F5546 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GHRH in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GHRH as low as 12.35 picograms per milliliter.

About GHRH: GHRH belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (more)

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Human IL36RN / IL1F5 ELISA Kit (Sandwich ELISA) - LS-F5630

LS-F5630 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL36RN / IL1F5 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36RN / IL1F5 as low as 15.63 picograms per milliliter.

About IL36RN / IL1F5: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. (more)

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Human GLA / Alpha Galactosidase ELISA Kit (Sandwich ELISA) - LS-F6110

LS-F6110 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GLA / Alpha Galactosidase in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GLA / Alpha Galactosidase as low as 1.56 nanograms per millilter.

About GLA / Alpha Galactosidase: GLA / Alpha Galactosidase encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. (more)

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Mouse AMH / Anti-Mullerian Hormone ELISA Kit (Competitive EIA) - LS-F6145

LS-F6145 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse AMH / Anti-Mullerian Hormone in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of AMH / Anti-Mullerian Hormone as low as 123.5 picograms per milliliter.

About AMH / Anti-Mullerian Hormone: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. (more)

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Human LAIR2 / CD306 ELISA Kit (Sandwich ELISA) - LS-F6502

LS-F6502 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LAIR2 / CD306 in samples of Plasma, Serum, Tissue Homogenates and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of LAIR2 / CD306 as low as 15.63 picograms per milliliter.

About LAIR2 / CD306: The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. (more)

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Rat VGF ELISA Kit (Sandwich ELISA) - LS-F6580

LS-F6580 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat VGF in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of VGF as low as 46.8 picograms per milliliter.

About VGF: VGF is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. (more)

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Mouse CRYAB / Alpha B Crystallin ELISA Kit (Sandwich ELISA) - LS-F6602

LS-F6602 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CRYAB / Alpha B Crystallin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CRYAB / Alpha B Crystallin as low as 0.156 nanograms per millilter.

About CRYAB / Alpha B Crystallin: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Human FGF13 ELISA Kit (Competitive EIA) - LS-F6987

LS-F6987 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FGF13 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of FGF13 as low as 31.2 picograms per milliliter.

About FGF13: FGF13 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. (more)

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Human CD66c / CEACAM6 ELISA Kit (Sandwich ELISA) - LS-F7305

LS-F7305 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CD66c / CEACAM6 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD66c / CEACAM6 as low as 23.44 picograms per milliliter.

About CD66c / CEACAM6: CD66c / CEACAM6 encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. (more)

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Rat SFRP1 ELISA Kit (Sandwich ELISA) - LS-F7706

LS-F7706 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat SFRP1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SFRP1 as low as 0.156 nanograms per millilter.

About SFRP1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. (more)

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Rat SFRP5 ELISA Kit (Sandwich ELISA) - LS-F7769

LS-F7769 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat SFRP5 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SFRP5 as low as 125 picograms per milliliter.

About SFRP5: SARP3 is a frizzled protein that lacks the 7-transmembrane motif used as anchor to the plasma membrane. They modulate Wnt signaling by competing with membrane-bound frizzled receptors for binding secreted Wnt ligands. SARP3 is involved in determining tissue of photoreceptor cells in the retina. It is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. (more)

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Bovine DNASE1 / DNase I ELISA Kit (Sandwich ELISA) - LS-F7823

LS-F7823 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine DNASE1 / DNase I in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DNASE1 / DNase I as low as 1.56 nanograms per millilter.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Human KRT16 / CK16 / Cytokeratin 16 ELISA Kit (Sandwich ELISA) - LS-F7891

LS-F7891 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human KRT16 / CK16 / Cytokeratin 16 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KRT16 / CK16 / Cytokeratin 16 as low as 0.156 nanograms per millilter.

About KRT16 / CK16 / Cytokeratin 16: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. (more)

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Mouse NF-L / NEFL ELISA Kit (Sandwich ELISA) - LS-F8114

LS-F8114 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NF-L / NEFL in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NF-L / NEFL as low as 15.6 picograms per milliliter.

About NF-L / NEFL: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. (more)

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Human TSG101 ELISA Kit (Sandwich ELISA) - LS-F8581

LS-F8581 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TSG101 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TSG101 as low as 0.313 nanograms per millilter.

About TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. (more)

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Mouse PRDX1 / Peroxiredoxin 1 ELISA Kit (Sandwich ELISA) - LS-F8760

LS-F8760 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse PRDX1 / Peroxiredoxin 1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PRDX1 / Peroxiredoxin 1 as low as 0.156 nanograms per millilter.

About PRDX1 / Peroxiredoxin 1: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. (more)

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Rat ADAMTS4 ELISA Kit (Sandwich ELISA) - LS-F9386

LS-F9386 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat ADAMTS4 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ADAMTS4 as low as 0.156 nanograms per millilter.

About ADAMTS4: ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. (more)

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Human CP / Ceruloplasmin ELISA Kit (Sandwich ELISA) - LS-F10412

LS-F10412 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CP / Ceruloplasmin in samples of Cell Culture, Milk, Plasma, Saliva, Serum and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of CP / Ceruloplasmin as low as 0.333 nanograms per millilter.

About CP / Ceruloplasmin: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. (more)

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Diacylglycerol ELISA Kit (Competitive EIA) - LS-F10645

LS-F10645 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Diacylglycerol in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Diacylglycerol as low as 0.625 nanograms per millilter. (more)

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Human AKR1B1 / Aldose Reductase ELISA Kit (Sandwich ELISA) - LS-F10794

LS-F10794 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human AKR1B1 / Aldose Reductase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AKR1B1 / Aldose Reductase as low as 0.156 nanograms per millilter.

About AKR1B1 / Aldose Reductase: AKR1B1 / Aldose Reductase is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. (more)

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Human ANXA2 / Annexin A2 ELISA Kit (Sandwich ELISA) - LS-F10839

LS-F10839 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ANXA2 / Annexin A2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ANXA2 / Annexin A2 as low as 0.625 nanograms per millilter.

About ANXA2 / Annexin A2: ANXA2 / Annexin A2 is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse CRH / CRF ELISA Kit (Competitive EIA) - LS-F11216

LS-F11216 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CRH / CRF in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 15.6 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Mouse CTGF ELISA Kit (Sandwich ELISA) - LS-F11238

LS-F11238 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CTGF in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTGF as low as 15.6 picograms per milliliter.

About CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. (more)

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Human DSG3 / Desmoglein 3 ELISA Kit (Sandwich ELISA) - LS-F11330

LS-F11330 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human DSG3 / Desmoglein 3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DSG3 / Desmoglein 3 as low as 78 picograms per milliliter.

About DSG3 / Desmoglein 3: Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. (more)

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Human CD39 ELISA Kit (Sandwich ELISA) - LS-F11376

LS-F11376 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CD39 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD39 as low as 78 picograms per milliliter.

About CD39: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. (more)

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Rat GFAP ELISA Kit (Sandwich ELISA) - LS-F11532

LS-F11532 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat GFAP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GFAP as low as 31.2 picograms per milliliter.

About GFAP: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (more)

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Human SLC2A1 / GLUT-1 ELISA Kit (Sandwich ELISA) - LS-F11591

LS-F11591 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLC2A1 / GLUT-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SLC2A1 / GLUT-1 as low as 0.156 nanograms per millilter.

About SLC2A1 / GLUT-1: Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. (more)

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Human HMG2 / HMGB2 ELISA Kit (Sandwich ELISA) - LS-F11643

LS-F11643 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG2 / HMGB2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG2 / HMGB2 as low as 0.31 nanograms per millilter.

About HMG2 / HMGB2: HMG2 / HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. (more)

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Human TK1 / TK / Thymidine Kinase ELISA Kit (Sandwich ELISA) - LS-F11880

LS-F11880 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TK1 / TK / Thymidine Kinase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TK1 / TK / Thymidine Kinase as low as 0.0625 picomoles per liter. (more)

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Human LECT2 ELISA Kit (Sandwich ELISA) - LS-F11935

LS-F11935 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human LECT2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LECT2 as low as 0.156 nanograms per millilter.

About LECT2: LECT2 is a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. (more)

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Mouse MMP12 ELISA Kit (Sandwich ELISA) - LS-F12052

LS-F12052 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse MMP12 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP12 as low as 15.6 picograms per milliliter.

About MMP12: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (more)

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Human RAB10 ELISA Kit (Sandwich ELISA) - LS-F12460

LS-F12460 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human RAB10 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RAB10 as low as 0.156 nanograms per millilter.

About RAB10: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. (more)

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Mouse TNFSF13 / APRIL ELISA Kit (Sandwich ELISA) - LS-F12794

LS-F12794 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TNFSF13 / APRIL in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFSF13 / APRIL as low as 0.625 nanograms per millilter.

About TNFSF13 / APRIL: TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (more)

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PGE2 / Prostaglandin E2 ELISA Kit (Competitive EIA) - LS-F13012

LS-F13012 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of PGE2 / Prostaglandin E2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of PGE2 / Prostaglandin E2 as low as 15.6 picograms per milliliter. (more)

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Corticosterone ELISA Kit (Competitive EIA) - LS-F13013

LS-F13013 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Corticosterone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Corticosterone as low as 7.8 nanograms per millilter. (more)

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PGF2 / Prostaglandin F2 Alpha ELISA Kit (Competitive EIA) - LS-F13035

LS-F13035 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of PGF2 / Prostaglandin F2 Alpha in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of PGF2 / Prostaglandin F2 Alpha as low as 0.156 nanograms per millilter. (more)

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Human SERPINB1 ELISA Kit (Sandwich ELISA) - LS-F13273

LS-F13273 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SERPINB1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SERPINB1 as low as 0.312 nanograms per millilter.

About SERPINB1: SERPINB1 is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. (more)

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Mouse HNRNPK / hnRNP K ELISA Kit (Sandwich ELISA) - LS-F14362

LS-F14362 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse HNRNPK / hnRNP K in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HNRNPK / hnRNP K as low as 78 picograms per milliliter.

About HNRNPK / hnRNP K: HNRNPK / hnRNP K belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). (more)

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Human DDX / AKR1C3 ELISA Kit (Sandwich ELISA) - LS-F14889

LS-F14889 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human DDX / AKR1C3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DDX / AKR1C3 as low as 0.156 nanograms per millilter.

About DDX / AKR1C3: DDX / AKR1C3 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (more)

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Mouse OX1R / Orexin Receptor 1 ELISA Kit (Sandwich ELISA) - LS-F15496

LS-F15496 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse OX1R / Orexin Receptor 1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of OX1R / Orexin Receptor 1 as low as 0.312 nanograms per millilter.

About OX1R / Orexin Receptor 1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. (more)

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Mouse TPSAB1 / Mast Cell Tryptase ELISA Kit (Sandwich ELISA) - LS-F15881

LS-F15881 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse TPSAB1 / Mast Cell Tryptase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPSAB1 / Mast Cell Tryptase as low as 0.156 nanograms per millilter.

About TPSAB1 / Mast Cell Tryptase: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. (more)

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Human VTCN1 / B7-H4 ELISA Kit (Sandwich ELISA) - LS-F15920

LS-F15920 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human VTCN1 / B7-H4 in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of VTCN1 / B7-H4 as low as 0.78 nanograms per millilter.

About VTCN1 / B7-H4: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. (more)

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Human 5-Alpha Reductase / SRD5A1 ELISA Kit (Sandwich ELISA) - LS-F17926

LS-F17926 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human 5-Alpha Reductase / SRD5A1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of 5-Alpha Reductase / SRD5A1 as low as 0.156 nanograms per millilter.

About 5-Alpha Reductase / SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (more)

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Rat MCAM / CD146 ELISA Kit (Sandwich ELISA) - LS-F18276

LS-F18276 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat MCAM / CD146 in samples of Cell Culture Supernatants and Tissue Supernatants. It is based upon a Sandwich assay principle and can be used to detect levels of MCAM / CD146 as low as 0.156 nanograms per millilter.

About MCAM / CD146: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. (more)

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Rat Apolipoprotein A-V ELISA Kit (Sandwich ELISA) - LS-F18611

LS-F18611 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat Apolipoprotein A-V in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Apolipoprotein A-V as low as 7.8 nanograms per millilter.

About Apolipoprotein A-V: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. (more)

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Rat ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F19205

LS-F19205 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat ANGPTL4 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ANGPTL4 as low as 0.156 nanograms per millilter.

About ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. (more)

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Rat WIF1 ELISA Kit (Sandwich ELISA) - LS-F19825

LS-F19825 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat WIF1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of WIF1 as low as 15.6 picograms per milliliter.

About WIF1: WIF1 functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. (more)

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Mouse Ferritin ELISA Kit (Sandwich ELISA) - LS-F20757

LS-F20757 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Ferritin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Ferritin as low as 1.56 nanograms per millilter. (more)

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Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F21017

LS-F21017 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLIT2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SLIT2 as low as 0.16 nanograms per millilter.

About SLIT2: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. (more)

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Mouse Complement C3a ELISA Kit (Sandwich ELISA) - LS-F21341

LS-F21341 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Complement C3a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 0.16 nanograms per millilter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Rabbit CKMB / Creatine Kinase MB ELISA Kit (Sandwich ELISA) - LS-F21703

LS-F21703 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rabbit CKMB / Creatine Kinase MB in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CKMB / Creatine Kinase MB as low as 0.16 nanograms per millilter.

About CKMB / Creatine Kinase MB: In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, CK-BB and CK-MB. The genes for these subunits are located on different chromosomes: B on 14q32 and M on 19q13. In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter two mitochondrial CK isoforms is an octamer consisting of four dimers each. Isoenzyme patterns differ in tissues. Skeletal muscle expresses CK-MM (98%) and low levels of CK-MB (1%). The myocardium (heart muscle), in contrast, expresses CK-MM at 70% and CK-MB at 25–30%. (more)

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Rat TNT / Troponin T ELISA Kit (Sandwich ELISA) - LS-F23153

LS-F23153 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TNT / Troponin T in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNT / Troponin T as low as 15.63 picograms per milliliter. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F23444

LS-F23444 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 31.25 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human Fibrinopeptide B ELISA Kit (Sandwich ELISA) - LS-F24008

LS-F24008 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Fibrinopeptide B in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Fibrinopeptide B as low as 78.125 picograms per milliliter. (more)

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Rat GUSB / Beta Glucuronidase ELISA Kit (Sandwich ELISA) - LS-F24073

LS-F24073 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat GUSB / Beta Glucuronidase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GUSB / Beta Glucuronidase as low as 78.13 picograms per milliliter.

About GUSB / Beta Glucuronidase: GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. (more)

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Mouse HAVCR1 / KIM-1 ELISA Kit (Sandwich ELISA) - LS-F24859

LS-F24859 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse HAVCR1 / KIM-1 in samples of Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of HAVCR1 / KIM-1 as low as 31.2 picograms per milliliter.

About HAVCR1 / KIM-1: Hepatitis A Virus Cellular Receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. HAVCR1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. (more)

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Human LAP / Leukocyte Alkaline Phosphatase ELISA Kit (Sandwich ELISA) - LS-F25266

LS-F25266 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LAP / Leukocyte Alkaline Phosphatase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LAP / Leukocyte Alkaline Phosphatase as low as 1.56 nanograms per millilter. (more)

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Mouse CD66a / CEACAM1 ELISA Kit (Sandwich ELISA) - LS-F25400

LS-F25400 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD66a / CEACAM1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD66a / CEACAM1 as low as 78.13 picograms per milliliter.

About CD66a / CEACAM1: CD66a / CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. (more)

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Mouse Crygf / Gamma F Crystallin ELISA Kit (Sandwich ELISA) - LS-F25402

LS-F25402 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Crygf / Gamma F Crystallin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Crygf / Gamma F Crystallin as low as 0.156 nanograms per millilter. (more)

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Mouse CRYBB2 ELISA Kit (Sandwich ELISA) - LS-F25489

LS-F25489 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CRYBB2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CRYBB2 as low as 0.312 nanograms per millilter.

About CRYBB2: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (more)

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Mouse CRYGS ELISA Kit (Sandwich ELISA) - LS-F25490

LS-F25490 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CRYGS in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CRYGS as low as 0.156 nanograms per millilter.

About CRYGS: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (more)

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Human ALPL / Alkaline Phosphatase ELISA Kit (Sandwich ELISA) - LS-F26641

LS-F26641 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ALPL / Alkaline Phosphatase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ALPL / Alkaline Phosphatase as low as 0.5 nanograms per millilter.

About ALPL / Alkaline Phosphatase: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. (more)

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Human Histamine ELISA Kit (Sandwich ELISA) - LS-F26969

LS-F26969 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Histamine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Histamine as low as 5 nanograms per millilter. (more)

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Rat Aldosterone ELISA Kit (Competitive EIA) - LS-F27876

LS-F27876 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Aldosterone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Aldosterone as low as 100 picograms per milliliter. (more)

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Mouse Orexin A ELISA Kit (Competitive EIA) - LS-F28517

LS-F28517 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Orexin A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Orexin A as low as 5 nanograms per millilter. (more)

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Mouse Pentosidine ELISA Kit (Competitive EIA) - LS-F28567

LS-F28567 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Pentosidine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Pentosidine as low as 1 nanograms per millilter. (more)

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Mouse CST3 / Cystatin C ELISA Kit (Sandwich ELISA) - LS-F28681

LS-F28681 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CST3 / Cystatin C in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CST3 / Cystatin C as low as 0.5 nanograms per millilter.

About CST3 / Cystatin C: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. (more)

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Most Popular Proteins
Human DDC / DOPA Decarboxylase Recombinant (His) Protein - LS-G489

LS-G489 is a Human DDC / DOPA Decarboxylase recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About DDC / DOPA Decarboxylase: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. (more)

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Human SPN / CD43 Recombinant (His) Protein - LS-G2541

LS-G2541 is a Human SPN / CD43 recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About SPN / CD43: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. (more)

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Human CLEC4C / CD303 / BDCA-2 Recombinant (His, N-Terminal) Protein (Glu5-Ile183) - LS-G14210

LS-G14210 is a Human CLEC4C / CD303 / BDCA-2 recombinant protein generated in E. coli. This protein has been engineered to contain a His, N-Terminal tag.

About CLEC4C / CD303 / BDCA-2: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. (more)

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