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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 553,964 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA and Assay Kits
ELISA and Assay Kits

Our traditional Sandwich, Competitive EIA, and Direct ELISA kits provide a means to quantitatively measure thousands of targets of interest, while our Cell-Based and DNA-Binding ELISA kits are ideal for in-vitro studies and transcription factor analysis. Chemiluminescent CLIA kits provide high-sensitivity detection of low-copy targets and our Development kits enable researchers to cost-effectively run large numbers of assays. Our growing collection of Assay kits provide researchers with the means to monitor a variety of biological processes, such as apoptosis, cell proliferation, metabolism, and more.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-GRM3 / MGLUR3 Antibody (N-Terminus) IHC-plus™ LS-A3208

LS-A3208 is a rabbit anti-GRM3 / MGLUR3 polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About GRM3 / MGLUR3: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. (more)

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Anti-RORC / ROR Gamma Antibody (Ligand-binding Domain) IHC-plus™ LS-A5200

LS-A5200 is a rabbit anti-RORC / ROR Gamma polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About RORC / ROR Gamma: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (more)

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Anti-F2RL1 / PAR2 Antibody (N-Terminus) IHC-plus™ LS-A252

LS-A252 is a rabbit anti-F2RL1 / PAR2 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About F2RL1 / PAR2: Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. (more)

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Anti-CX3CR1 Antibody (aa2-21) LS-C300

LS-C300 is a rabbit anti-CX3CR1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry and Western blot.

About CX3CR1: CX3CR1 a Chemokine Receptor is an HIV coreceptor, as well as a leukocyte chemotactic/adhesion receptor for fractalkine, also known as neurotactin. CX3CR1 mediates chemotactic responses to the soluble form of fractalkine in neutrophils and T cells, and cytoadhesion to cells expressing membrane-anchored fractalkine, such as monocytes, T cells, and neutrophils. Cells transfected with CX3CR1 exhibited chemotaxis and transient increases in intracellular calcium concentration when exposed to fractalkine. (more)

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Anti-MB / Myoglobin Antibody LS-C9183

LS-C9183 is a goat anti-MB / Myoglobin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay.

About MB / Myoglobin: MB / Myoglobin is a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. (more)

Anti-LAG3 Antibody (clone 17B4) LS-C18692

LS-C18692 is a mouse anti-LAG3 monoclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Frozen, Immunoprecipitation and Western blot.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

Anti-ALB / Serum Albumin Antibody (FITC) LS-C18953

LS-C18953 is a Fluorescein rabbit anti-ALB / Serum Albumin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunofluorescence.

About ALB / Serum Albumin: Albumin ALB) is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in the ALB gene on chromosome 4 result in various anomalous proteins. Albumin is a globular unglycosylated serum protein of molecular weight 65000. The human albumin gene is 16961 nucleotides long from the putative 'cap' site to the first poly(A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain. (more)

Anti-EGFR Antibody (clone H11) LS-C26773

LS-C26773 is a mouse anti-EGFR monoclonal antibody approved for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry - Paraffin and Immunoprecipitation.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-B2M / Beta 2 Microglobulin Antibody IHC-plus™ LS-B331

LS-B331 is a rabbit anti-B2M / Beta 2 Microglobulin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About B2M / Beta 2 Microglobulin: B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. (more)

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Anti-CSF1R / CD115 / FMS Antibody (phospho-Tyr723) IHC-plus™ LS-B1070

LS-B1070 is a rabbit anti-CSF1R / CD115 / FMS polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CSF1R / CD115 / FMS: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. (more)

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Anti-CD4 Antibody (clone KEN-4, FITC) LS-C45380

LS-C45380 is a Fluorescein mouse anti-CD4 monoclonal antibody approved for use in Flow Cytometry.

About CD4: CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. (more)

Anti-SCN9A / Nav1.7 Antibody (Internal) IHC-plus™ LS-A9594

LS-A9594 is a rabbit anti-SCN9A / Nav1.7 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About SCN9A / Nav1.7: Scn9a encodes the alpha subunit of the type IX voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone can generate a functional channel in vitro >, but it's kinetic properties are modulated by beta subunits. The type IX channel is tetrodotoxin sensitive and is believed to function in hyperexcitability induced pain. At least two mRNA variants have been reported. Scn9a protein has been observed to accumulate abnormally in human neuromas. (more)

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Anti-HAVCR1 / KIM-1 Antibody (aa200-300) IHC-plus™ LS-B2031

LS-B2031 is a rabbit anti-HAVCR1 / KIM-1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About HAVCR1 / KIM-1: Hepatitis A Virus Cellular Receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. HAVCR1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. (more)

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Anti-HEV / Hepatitis E Virus Antibody (aa 434-457, clone 1E6) LS-C67675

LS-C67675 is a mouse anti-HEV / Hepatitis E Virus monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence and Western blot.

About HEV / Hepatitis E Virus: Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis E virus (HEV). It is one of five known human hepatitis viruses: A, B, C, D, and E. HEV is a positive-sense single-stranded RNA icosahedral virus with a 7.5 kilobase genome. HEV has a fecal-oral transmission route. Infection with this virus was first documented in 1955 during an outbreak in New Delhi, India. A preventative vaccine (HEV 239) is approved for use in China. (more)

Anti-MMP9 / Gelatinase B Antibody IHC-plus™ LS-B2486

LS-B2486 is a rabbit anti-MMP9 / Gelatinase B polyclonal antibody approved for use in Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About MMP9 / Gelatinase B: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (more)

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Anti-CD37 Antibody (clone HH1) LS-C96308

LS-C96308 is a mouse anti-CD37 monoclonal antibody approved for use in Immunohistochemistry - Frozen.

About CD37: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. (more)

Anti-VEGFA / VEGF Antibody LS-C104453

LS-C104453 is a mouse anti-VEGFA / VEGF monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About VEGFA / VEGF: VEGFA / VEGF is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. (more)

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Anti-SELP / P-Selectin / CD62P Antibody IHC-plus™ LS-B3578

LS-B3578 is a rabbit anti-SELP / P-Selectin / CD62P polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About SELP / P-Selectin / CD62P: SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (more)

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Anti-ITGAM / CD11b Antibody (Internal) LS-C141892

LS-C141892 is a rabbit anti-ITGAM / CD11b polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ITGAM / CD11b: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. (more)

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Anti-MMP2 Antibody (clone SB13a) LS-C149696

LS-C149696 is a mouse anti-MMP2 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. (more)

Anti-MYC / c-Myc Antibody (aa386-435) IHC-plus™ LS-B7667

LS-B7667 is a rabbit anti-MYC / c-Myc polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About MYC / c-Myc: MYC / c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (more)

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Anti-KRAS Antibody (clone 2C1) LS-C175665

LS-C175665 is a mouse anti-KRAS monoclonal antibody approved for use in Western blot.

About KRAS: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Mutations in this gene are associated with leukemia, lung, breast, bladder, pancreatic, and stomach cancer. (more)

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Anti-TNFRSF10A / DR4 Antibody (clone DR-4-02) LS-C204830

LS-C204830 is a mouse anti-TNFRSF10A / DR4 monoclonal antibody approved for use in Blocking, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunoprecipitation and Neutralization.

About TNFRSF10A / DR4: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells. (more)

Anti-KIR2DS2 / CD158b Antibody (aa46-75, FITC) LS-C215433

LS-C215433 is a Fluorescein rabbit anti-KIR2DS2 / CD158b polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry and Western blot.

About KIR2DS2 / CD158b: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. (more)

Anti-NEP / DDR1 Antibody (phospho-Tyr792) LS-C291485

LS-C291485 is a rabbit anti-NEP / DDR1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About NEP / DDR1: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). (more)

Anti-CD39 Antibody (aa38-307, clone 2B10) IHC-plus™ LS-B13080

LS-B13080 is a mouse anti-CD39 monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CD39: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. (more)

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Anti-NTRK2 / TRKB Antibody (phospho-Tyr706) LS-C380863

LS-C380863 is a rabbit anti-NTRK2 / TRKB polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry and Western blot.

About NTRK2 / TRKB: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. (more)

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Anti-ANGPTL4 Antibody (Coiled-coil domain, clone Kairos4-397G) IHC-plus™ LS-B13722

LS-B13722 is a mouse anti-ANGPTL4 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. (more)

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Anti-KDR / VEGFR2 / FLK1 Antibody (aa8-290, Biotin) LS-C420388

LS-C420388 is a Biotin rabbit anti-KDR / VEGFR2 / FLK1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About KDR / VEGFR2 / FLK1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. (more)

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa25-234) IHC-plus™ LS-B13944

LS-B13944 is a rabbit anti-FOLR1 / Folate Receptor Alpha polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FOLR1 / Folate Receptor Alpha: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. (more)

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Most Popular ELISA Kits
Mouse/Human/Rat SGK1 / SGK ELISA Kit (Cell-Based ELISA) - LS-F2303

LS-F2303 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SGK1 / SGK in samples of Adherent Cell Cultures. It is based upon a Cell-Based assay principle.

About SGK1 / SGK: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na+ retention, renal K+ elimination, salt appetite, gastric acid secretion, intestinal Na+/H+ exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F4038

LS-F4038 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 62.5 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Rat MBP / Myelin Basic Protein ELISA Kit (Sandwich ELISA) - LS-F4093

LS-F4093 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat MBP / Myelin Basic Protein in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MBP / Myelin Basic Protein as low as 0.156 nanograms per millilter.

About MBP / Myelin Basic Protein: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. (more)

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Mouse Complement C3a ELISA Kit (Sandwich ELISA) - LS-F4210

LS-F4210 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Complement C3a in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 15.63 picograms per milliliter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Rat GFAP ELISA Kit (Sandwich ELISA) - LS-F4259

LS-F4259 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat GFAP in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GFAP as low as 62.5 picograms per milliliter.

About GFAP: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (more)

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Human CBFA1 / RUNX2 ELISA Kit (Sandwich ELISA) - LS-F4390

LS-F4390 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CBFA1 / RUNX2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CBFA1 / RUNX2 as low as 0.156 nanograms per millilter.

About CBFA1 / RUNX2: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. (more)

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Rat CTSK / Cathepsin K ELISA Kit (Sandwich ELISA) - LS-F4597

LS-F4597 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CTSK / Cathepsin K in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTSK / Cathepsin K as low as 15.63 picograms per milliliter.

About CTSK / Cathepsin K: CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. (more)

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Mouse GPT / Alanine Transaminase ELISA Kit (Sandwich ELISA) - LS-F4605

LS-F4605 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse GPT / Alanine Transaminase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GPT / Alanine Transaminase as low as 0.156 nanograms per millilter.

About GPT / Alanine Transaminase: GPT / Alanine Transaminase is cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. (more)

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Human PON1 / ESA ELISA Kit (Sandwich ELISA) - LS-F4609

LS-F4609 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PON1 / ESA in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PON1 / ESA as low as 3.13 nanograms per millilter.

About PON1 / ESA: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. (more)

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Mouse APOE / Apolipoprotein E ELISA Kit (Sandwich ELISA) - LS-F4714

LS-F4714 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse APOE / Apolipoprotein E in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of APOE / Apolipoprotein E as low as 15.63 nanograms per millilter.

About APOE / Apolipoprotein E: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. (more)

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Human MUC5AC ELISA Kit (Sandwich ELISA) - LS-F4836

LS-F4836 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MUC5AC in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MUC5AC as low as 78 picograms per milliliter.

About MUC5AC: MUC5AC has been isolated from airway secretions. It is found in the protective film of mucus coating the mucosal surfaces of the respiratory tract and the normal gastrointestinal tissues. Mucins are also expressed at low levels in human fetal gut. MUC5AC is involved in epithelial cell proliferation and differentiation in adult airway mucosa and can be used as a marker for hypersecretory disorders. MUC5AC has also been observed in various tumors. For instance it is expressed in primary mucinous ovarian tumors but not in colonic carcinoma metastatic to the ovary, which makes it a useful marker to distinguish the two types of cancer. (more)

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Human NPPA / ANP ELISA Kit (Sandwich ELISA) - LS-F4867

LS-F4867 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NPPA / ANP in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NPPA / ANP as low as 15.6 picograms per milliliter.

About NPPA / ANP: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. (more)

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Human MUC7 ELISA Kit (Sandwich ELISA) - LS-F4989

LS-F4989 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MUC7 in samples of Plasma, Saliva, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MUC7 as low as 0.313 nanograms per millilter.

About MUC7: MUC7 is a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. (more)

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Human ERBB2 / HER2 ELISA Kit (Sandwich ELISA) - LS-F5037

LS-F5037 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ERBB2 / HER2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ERBB2 / HER2 as low as 0.625 nanograms per millilter.

About ERBB2 / HER2: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. (more)

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Human TDP-43 / TARDBP ELISA Kit (Sandwich ELISA) - LS-F5278

LS-F5278 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TDP-43 / TARDBP in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TDP-43 / TARDBP as low as 62.5 picograms per milliliter.

About TDP-43 / TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. (more)

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Human GSN / Gelsolin ELISA Kit (Sandwich ELISA) - LS-F5675

LS-F5675 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GSN / Gelsolin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GSN / Gelsolin as low as 62.5 picograms per milliliter.

About GSN / Gelsolin: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. (more)

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Human MAPT / Tau ELISA Kit (Sandwich ELISA) - LS-F5803

LS-F5803 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MAPT / Tau in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MAPT / Tau as low as 31.25 picograms per milliliter.

About MAPT / Tau: Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU. (more)

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Human GDF15 ELISA Kit (Sandwich ELISA) - LS-F5835

LS-F5835 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GDF15 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GDF15 as low as 78 picograms per milliliter.

About GDF15: Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. (more)

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Rat Complement C5 ELISA Kit (Sandwich ELISA) - LS-F5840

LS-F5840 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat Complement C5 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C5 as low as 0.312 nanograms per millilter.

About Complement C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. (more)

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Dog Alpha-Fetoprotein ELISA Kit (Sandwich ELISA) - LS-F6057

LS-F6057 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog Alpha-Fetoprotein in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Alpha-Fetoprotein as low as 0.313 nanograms per millilter.

About Alpha-Fetoprotein: AFP / Alpha Fetoprotein is alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (more)

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Rhesus monkey IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F6091

LS-F6091 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rhesus monkey IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 15.63 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Bovine GH / Growth Hormone ELISA Kit (Sandwich ELISA) - LS-F6308

LS-F6308 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine GH / Growth Hormone in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GH / Growth Hormone as low as 0.31 nanograms per millilter.

About GH / Growth Hormone: GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. (more)

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Human IL23R ELISA Kit (Sandwich ELISA) - LS-F6584

LS-F6584 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL23R in samples of Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL23R as low as 0.156 nanograms per millilter.

About IL23R: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. (more)

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Rat CD71 / Transferrin Receptor ELISA Kit (Sandwich ELISA) - LS-F6637

LS-F6637 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CD71 / Transferrin Receptor in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD71 / Transferrin Receptor as low as 0.625 nanograms per millilter.

About CD71 / Transferrin Receptor: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. (more)

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Human LAMC2 / Laminin Gamma 2 ELISA Kit (Sandwich ELISA) - LS-F6645

LS-F6645 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LAMC2 / Laminin Gamma 2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LAMC2 / Laminin Gamma 2 as low as 15.63 picograms per milliliter.

About LAMC2 / Laminin Gamma 2: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. (more)

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Human AIMP1 / EMAP II ELISA Kit (Sandwich ELISA) - LS-F7291

LS-F7291 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human AIMP1 / EMAP II in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of AIMP1 / EMAP II as low as 125 picograms per milliliter.

About AIMP1 / EMAP II: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. (more)

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Mouse Eosinophil Peroxidase / EPX ELISA Kit (Sandwich ELISA) - LS-F7707

LS-F7707 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Eosinophil Peroxidase / EPX in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Eosinophil Peroxidase / EPX as low as 15.63 picograms per milliliter.

About Eosinophil Peroxidase / EPX: Eosinophil Peroxidase / EPX is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. (more)

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Human CALB1 / Calbindin ELISA Kit (Sandwich ELISA) - LS-F7744

LS-F7744 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CALB1 / Calbindin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CALB1 / Calbindin as low as 12.5 picograms per milliliter.

About CALB1 / Calbindin: CALB1 / Calbindin is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. (more)

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Mouse MAC-2-BP / LGALS3BP ELISA Kit (Sandwich ELISA) - LS-F7991

LS-F7991 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MAC-2-BP / LGALS3BP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MAC-2-BP / LGALS3BP as low as 0.156 nanograms per millilter.

About MAC-2-BP / LGALS3BP: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. (more)

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Mouse ITGB3 / Integrin Beta 3 / CD61 ELISA Kit (Sandwich ELISA) - LS-F8502

LS-F8502 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ITGB3 / Integrin Beta 3 / CD61 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ITGB3 / Integrin Beta 3 / CD61 as low as 31.2 picograms per milliliter.

About ITGB3 / Integrin Beta 3 / CD61: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. (more)

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Human TSG101 ELISA Kit (Sandwich ELISA) - LS-F8581

LS-F8581 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TSG101 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TSG101 as low as 0.313 nanograms per millilter.

About TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. (more)

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Human IL11RA ELISA Kit (Sandwich ELISA) - LS-F8919

LS-F8919 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL11RA in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL11RA as low as 0.156 nanograms per millilter.

About IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. (more)

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Human HGFAC / HGFA ELISA Kit (Sandwich ELISA) - LS-F9127

LS-F9127 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HGFAC / HGFA in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HGFAC / HGFA as low as 15.6 picograms per milliliter.

About HGFAC / HGFA: HGFAC / HGFA is a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. (more)

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Ovalbumin ELISA Kit (Sandwich ELISA) - LS-F9540

LS-F9540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Ovalbumin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Ovalbumin as low as 78 picograms per milliliter.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Human NGF ELISA Kit (Sandwich ELISA) - LS-F9557

LS-F9557 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NGF in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NGF as low as 3.13 picograms per milliliter.

About NGF: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. (more)

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Human SP7 / Osterix ELISA Kit (Sandwich ELISA) - LS-F9569

LS-F9569 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SP7 / Osterix in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SP7 / Osterix as low as 0.156 nanograms per millilter.

About SP7 / Osterix: SP7 / Osterix is a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation. (more)

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Mouse FSH ELISA Kit (Competitive EIA) - LS-F9659

LS-F9659 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse FSH in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of FSH as low as 2.22 nanograms per millilter.

About FSH: Follicle-stimulating hormone (FSH) is a glycoprotein hormone found in humans and other animals. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland, and regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and luteinizing hormone (LH) act synergistically in reproduction. (more)

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Human CA50 / Cancer Antigen 50 ELISA Kit (Sandwich ELISA) - LS-F10207

LS-F10207 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CA50 / Cancer Antigen 50 in samples of Ascitic Fluid, Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CA50 / Cancer Antigen 50 as low as 10 units per milliliter. (more)

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Human Prekallikrein ELISA Kit (Sandwich ELISA) - LS-F10424

LS-F10424 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Prekallikrein in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of Prekallikrein as low as 0.02 micrograms per millilter. (more)

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Mouse Aspartate Aminotransferase ELISA Kit (Sandwich ELISA) - LS-F10709

LS-F10709 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Aspartate Aminotransferase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Aspartate Aminotransferase as low as 1.56 units per liter.

About Aspartate Aminotransferase: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. (more)

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Mouse CCND1 / Cyclin D1 ELISA Kit (Sandwich ELISA) - LS-F11067

LS-F11067 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CCND1 / Cyclin D1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CCND1 / Cyclin D1 as low as 0.312 nanograms per millilter.

About CCND1 / Cyclin D1: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. (more)

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Human DNASE1 / DNase I ELISA Kit (Sandwich ELISA) - LS-F11310

LS-F11310 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human DNASE1 / DNase I in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DNASE1 / DNase I as low as 0.156 nanograms per millilter.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Human FGA / Fibrinogen Alpha ELISA Kit (Sandwich ELISA) - LS-F11466

LS-F11466 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human FGA / Fibrinogen Alpha in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FGA / Fibrinogen Alpha as low as 0.78 nanograms per millilter.

About FGA / Fibrinogen Alpha: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. (more)

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Rat LDLR / LDL Receptor ELISA Kit (Sandwich ELISA) - LS-F11934

LS-F11934 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat LDLR / LDL Receptor in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LDLR / LDL Receptor as low as 1.56 nanograms per millilter.

About LDLR / LDL Receptor: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. (more)

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Human MUC5B ELISA Kit (Sandwich ELISA) - LS-F12105

LS-F12105 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MUC5B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MUC5B as low as 0.312 nanograms per millilter.

About MUC5B: MUC5B is a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. (more)

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Human PDCD1 / CD279 / PD-1 ELISA Kit (Sandwich ELISA) - LS-F12279

LS-F12279 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human PDCD1 / CD279 / PD-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PDCD1 / CD279 / PD-1 as low as 0.156 nanograms per millilter.

About PDCD1 / CD279 / PD-1: PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (more)

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Mouse PTGS2 / COX2 / COX-2 ELISA Kit (Sandwich ELISA) - LS-F12321

LS-F12321 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse PTGS2 / COX2 / COX-2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PTGS2 / COX2 / COX-2 as low as 0.312 nanograms per millilter.

About PTGS2 / COX2 / COX-2: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. (more)

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Mouse TNFSF13 / APRIL ELISA Kit (Sandwich ELISA) - LS-F12794

LS-F12794 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TNFSF13 / APRIL in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFSF13 / APRIL as low as 0.625 nanograms per millilter.

About TNFSF13 / APRIL: TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (more)

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Human TRAF6 ELISA Kit (Sandwich ELISA) - LS-F12845

LS-F12845 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TRAF6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TRAF6 as low as 0.156 nanograms per millilter.

About TRAF6: TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. (more)

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Human VR1 / TRPV1 ELISA Kit (Sandwich ELISA) - LS-F12857

LS-F12857 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human VR1 / TRPV1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of VR1 / TRPV1 as low as 0.156 nanograms per millilter.

About VR1 / TRPV1: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). (more)

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Human TNFAIP6 / TSG-6 ELISA Kit (Sandwich ELISA) - LS-F12868

LS-F12868 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNFAIP6 / TSG-6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFAIP6 / TSG-6 as low as 0.156 nanograms per millilter.

About TNFAIP6 / TSG-6: TNFAIP6 / TSG-6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. (more)

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Human VWF / Von Willebrand Factor ELISA Kit (Sandwich ELISA) - LS-F12963

LS-F12963 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human VWF / Von Willebrand Factor in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of VWF / Von Willebrand Factor as low as 3.12 nanograms per millilter.

About VWF / Von Willebrand Factor: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. (more)

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Rat PLP1 / Myelin PLP ELISA Kit (Sandwich ELISA) - LS-F13344

LS-F13344 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat PLP1 / Myelin PLP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PLP1 / Myelin PLP as low as 78 picograms per milliliter.

About PLP1 / Myelin PLP: PLP1 / Myelin PLP is a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. (more)

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Dog SST / Somatostatin ELISA Kit (Sandwich ELISA) - LS-F14876

LS-F14876 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog SST / Somatostatin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SST / Somatostatin as low as 31.2 picograms per milliliter.

About SST / Somatostatin: The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. (more)

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Mouse NME1 / NM23 ELISA Kit (Sandwich ELISA) - LS-F17248

LS-F17248 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NME1 / NM23 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NME1 / NM23 as low as 0.156 nanograms per millilter.

About NME1 / NM23: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human RGMA ELISA Kit (Sandwich ELISA) - LS-F19853

LS-F19853 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human RGMA in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RGMA as low as 0.312 nanograms per millilter.

About RGMA: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. (more)

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Human ACLP / AEBP1 ELISA Kit (Sandwich ELISA) - LS-F20124

LS-F20124 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ACLP / AEBP1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACLP / AEBP1 as low as 78 picograms per milliliter.

About ACLP / AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. (more)

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Pig Trypsin ELISA Kit (Sandwich ELISA) - LS-F20825

LS-F20825 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig Trypsin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Trypsin as low as 1.56 nanograms per millilter.

About Trypsin: Trypsin is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen, which is encoded by several genes (PRSS1, PRSS2, PRSS3). Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. (more)

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Rat FST / Follistatin ELISA Kit (Sandwich ELISA) - LS-F21531

LS-F21531 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat FST / Follistatin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FST / Follistatin as low as 0.156 nanograms per millilter.

About FST / Follistatin: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. (more)

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Human SDC3 / Syndecan 3 ELISA Kit (Sandwich ELISA) - LS-F22580

LS-F22580 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SDC3 / Syndecan 3 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SDC3 / Syndecan 3 as low as 0.625 nanograms per millilter.

About SDC3 / Syndecan 3: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. (more)

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Human IL35 ELISA Kit (Sandwich ELISA) - LS-F23001

LS-F23001 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL35 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of IL35 as low as 15.63 picograms per milliliter. (more)

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Pig Angiotensin II ELISA Kit (Competitive EIA) - LS-F23294

LS-F23294 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig Angiotensin II in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 15.63 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Human DEFB4A / BD-2 ELISA Kit (Sandwich ELISA) - LS-F23790

LS-F23790 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human DEFB4A / BD-2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of DEFB4A / BD-2 as low as 62.5 picograms per milliliter.

About DEFB4A / BD-2: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. (more)

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Rat MTTP / MTP ELISA Kit (Sandwich ELISA) - LS-F25381

LS-F25381 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat MTTP / MTP in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MTTP / MTP as low as 0.156 nanograms per millilter.

About MTTP / MTP: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. (more)

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Human IL6 / Interleukin 6 ELISA Kit (CLIA) - LS-F25919

LS-F25919 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL6 / Interleukin 6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich CLIA assay principle and can be used to detect levels of IL6 / Interleukin 6 as low as 2.74 picograms per milliliter.

About IL6 / Interleukin 6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. (more)

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Human APOL1 / Apolipoprotein L ELISA Kit (Competitive EIA) - LS-F26631

LS-F26631 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human APOL1 / Apolipoprotein L in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of APOL1 / Apolipoprotein L as low as 2.5 nanograms per millilter.

About APOL1 / Apolipoprotein L: APOL1 / Apolipoprotein L is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. (more)

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Human Citrulline ELISA Kit (Sandwich ELISA) - LS-F26729

LS-F26729 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Citrulline in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Citrulline as low as 1 nanomoles per milliliter. (more)

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Most Popular Proteins
Human GCK / Glucokinase Recombinant (His) Protein - LS-G3456

LS-G3456 is a purified Human GCK / Glucokinase recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About GCK / Glucokinase: Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. (more)

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