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  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of over 250,000 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-CRFR1 / CRHR1 Antibody (N-Terminus) IHC-plus™ LS-A1778

LS-A1778 is a rabbit anti-CRFR1 / CRHR1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CRFR1 / CRHR1: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. (more)

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Anti-ROBO1 Antibody (aa1632-1644) IHC-plus™ LS-B81

LS-B81 is a rabbit anti-ROBO1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About ROBO1: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-CACNG1 / CACNG Antibody (aa66-115) IHC-plus™ LS-B928

LS-B928 is a rabbit anti-CACNG1 / CACNG polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CACNG1 / CACNG: Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-PKM / Pyruvate Kinase Antibody IHC-plus™ LS-B1450

LS-B1450 is a goat anti-PKM / Pyruvate Kinase polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About PKM / Pyruvate Kinase: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. (more)

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Anti-PDCD1 / CD279 / PD-1 Antibody (clone EH12.2H7) LS-C40800

LS-C40800 is a mouse anti-PDCD1 / CD279 / PD-1 monoclonal antibody approved for use in Flow Cytometry.

About PDCD1 / CD279 / PD-1: PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (more)

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Anti-RORC / ROR Gamma Antibody (aa1-50) IHC-plus™ LS-B1797

LS-B1797 is a rabbit anti-RORC / ROR Gamma polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About RORC / ROR Gamma: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (more)

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Anti-ADORA2A/Adenosine A2A Receptor Antibody (3rd Intracellular Domain) IHC-plus™ LS-B2122

LS-B2122 is a mouse anti-ADORA2A/Adenosine A2A Receptor monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin, Immunohistochemistry - 4% paraformaldehyde and Western blot.

About ADORA2A/Adenosine A2A Receptor: ADORA2A/Adenosine A2A Receptor is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. (more)

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Anti-LAG3 Antibody (N-Terminus, clone 17B4, FITC) IHC-plus™ LS-B2237

LS-B2237 is a Fluorescein mouse anti-LAG3 monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry - Paraffin.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

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Anti-GH / Growth Hormone Antibody (clone G3H5) IHC-plus™ LS-B2974

LS-B2974 is a mouse anti-GH / Growth Hormone monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About GH / Growth Hormone: GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. (more)

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Anti-EGFR Antibody (N-Terminus) LS-C100292

LS-C100292 is a rabbit anti-EGFR polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-TSLP Antibody (Internal) IHC-plus™ LS-B3208

LS-B3208 is a rabbit anti-TSLP polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TSLP: TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. (more)

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Anti-NODAL Antibody (Internal) IHC-plus™ LS-B3955

LS-B3955 is a goat anti-NODAL polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About NODAL: Essential for mesoderm formation and axial patterning during embryonic development. (more)

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Anti-CD27L / CD70 Antibody (clone BU69, RPE) LS-C134547

LS-C134547 is a R. Phycoerythrin mouse anti-CD27L / CD70 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Immunocytochemistry and Immunohistochemistry - Frozen.

About CD27L / CD70: CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. (more)

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Anti-EBI3 / IL-27B Antibody (clone DNT27) IHC-plus™ LS-B5764

LS-B5764 is a rat anti-EBI3 / IL-27B monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About EBI3 / IL-27B: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. (more)

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Anti-TFEB Antibody (N-Terminus) IHC-plus™ LS-B5907

LS-B5907 is a goat anti-TFEB polyclonal antibody approved for use in Chromatin Immunoprecipitation, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TFEB: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. (more)

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Anti-PTGER4 / EP4 Antibody IHC-plus™ LS-B6947

LS-B6947 is a rabbit anti-PTGER4 / EP4 polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About PTGER4 / EP4: PTGER4 / EP4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. (more)

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Anti-IL17A Antibody IHC-plus™ LS-B7397

LS-B7397 is a rabbit anti-IL17A polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Neutralization and Western blot.

About IL17A: IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (more)

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Anti-LINE-1 Antibody LS-C154072

LS-C154072 is a chicken anti-LINE-1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About LINE-1: The L1 (LINE-1), or Long INterspersed Element , retrotransposon ORF2 is the most common open reading frame in the human genome, present in various forms in many thousands of copies. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signaling. Both intact ORF1 and ORF2 are absolutely required for autonomous retro-transposition. ORF2 encodes an endonuclease, reverse transcriptase, and zinc knuckle domains. The expression of ORF2 appears to be tightly regulated except in germ line tissues, embryonic tissues, and certain cancers including teratomas, testicular cancers, and leukemias. (more)

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Anti-Rhizopus arrhizus WSSA Antibody (clone WSSA-RA-1) LS-C188340

LS-C188340 is a mouse anti-Rhizopus arrhizus WSSA monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot. (more)

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Anti-CSF1R / CD115 / FMS Antibody (clone SP211) LS-C210434

LS-C210434 is a rabbit anti-CSF1R / CD115 / FMS monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CSF1R / CD115 / FMS: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. (more)

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Anti-KRT18 / CK18 / Cytokeratin 18 Antibody (clone C-04, Biotin) IHC-plus™ LS-B9908

LS-B9908 is a Biotin mouse anti-KRT18 / CK18 / Cytokeratin 18 monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry - Paraffin.

About KRT18 / CK18 / Cytokeratin 18: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. (more)

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Anti-PSIP1 / LEDGF Antibody (aa225-275) LS-C287695

LS-C287695 is a rabbit anti-PSIP1 / LEDGF polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Immunoprecipitation.

About PSIP1 / LEDGF: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. (more)

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Anti-Fgf15 Antibody (aa25-218) LS-C293897

LS-C293897 is a rabbit anti-Fgf15 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Fgf15: Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19. (more)

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Anti-TIGIT Antibody (aa21-234) LS-C296579

LS-C296579 is a rabbit anti-TIGIT polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About TIGIT: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. (more)

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Anti-KLK1 / Kallikrein 1 Antibody (aa25-261) LS-C313163

LS-C313163 is a rabbit anti-KLK1 / Kallikrein 1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About KLK1 / Kallikrein 1: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. (more)

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Anti-APOBEC3B Antibody (N-Terminus) IHC-plus™ LS-B12051

LS-B12051 is a rabbit anti-APOBEC3B polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About APOBEC3B: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. (more)

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Anti-PVR / CD155 Antibody IHC-plus™ LS-B12331

LS-B12331 is a rabbit anti-PVR / CD155 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PVR / CD155: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. (more)

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Anti-ATF1 Antibody (C-Terminus) LS-C351857

LS-C351857 is a rabbit anti-ATF1 polyclonal antibody approved for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western blot.

About ATF1: ATF1 is an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. (more)

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Most Popular ELISA Kits
Mouse/Human/Rat Phospho-NOS3 / eNOS (Ser1176) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1497

LS-F1497 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NOS3 / eNOS in samples of Adherent Cell Cultures. It is based upon a Cell-Based Phosphorylation assay principle.

About NOS3 / eNOS: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. (more)

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Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, EDTA Plasma, Heparin Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 10 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F4038

LS-F4038 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 62.5 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human LPL / Lipoprotein Lipase ELISA Kit (Sandwich ELISA) - LS-F4064

LS-F4064 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LPL / Lipoprotein Lipase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LPL / Lipoprotein Lipase as low as 0.625 nanograms per millilter.

About LPL / Lipoprotein Lipase: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. (more)

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GABA / Gamma-Aminobutyric Acid ELISA Kit (Competitive EIA) - LS-F4121

LS-F4121 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of GABA / Gamma-Aminobutyric Acid in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GABA / Gamma-Aminobutyric Acid as low as 24.69 picograms per milliliter. (more)

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Rat IAPP / Amylin ELISA Kit (Competitive EIA) - LS-F4222

LS-F4222 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat IAPP / Amylin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IAPP / Amylin as low as 6.17 picograms per milliliter.

About IAPP / Amylin: IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. (more)

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Human Mucin 2 / MUC2 ELISA Kit (Sandwich ELISA) - LS-F4717

LS-F4717 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Mucin 2 / MUC2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Mucin 2 / MUC2 as low as 1.56 nanograms per millilter.

About Mucin 2 / MUC2: Mucin 2 / MUC2 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. (more)

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Human IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F4790

LS-F4790 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IDO1 / IDO in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 0.312 nanograms per millilter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Human IL26 ELISA Kit (Sandwich ELISA) - LS-F4914

LS-F4914 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL26 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL26 as low as 15.6 picograms per milliliter.

About IL26: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. (more)

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Human RNASE3 ELISA Kit (Sandwich ELISA) - LS-F4920

LS-F4920 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human RNASE3 in samples of Cell Lysates, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of RNASE3 as low as 39 picograms per milliliter.

About RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. (more)

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Human TGM2 / Transglutaminase 2 ELISA Kit (Sandwich ELISA) - LS-F5009

LS-F5009 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TGM2 / Transglutaminase 2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TGM2 / Transglutaminase 2 as low as 0.156 nanograms per millilter.

About TGM2 / Transglutaminase 2: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Rabbit SAA1 / SAA / Serum Amyloid A ELISA Kit (Competitive EIA) - LS-F5018

LS-F5018 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit SAA1 / SAA / Serum Amyloid A in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of SAA1 / SAA / Serum Amyloid A as low as 62.5 nanograms per millilter.

About SAA1 / SAA / Serum Amyloid A: SAA1 / SAA / Serum Amyloid A is a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. (more)

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Rabbit TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5127

LS-F5127 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit TNF Alpha in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNF Alpha as low as 3.12 picograms per milliliter.

About TNF Alpha: TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (more)

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Mouse LTA / TNF Beta ELISA Kit (Sandwich ELISA) - LS-F5195

LS-F5195 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LTA / TNF Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LTA / TNF Beta as low as 6.25 picograms per milliliter.

About LTA / TNF Beta: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. (more)

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Human TDP-43 / TARDBP ELISA Kit (Sandwich ELISA) - LS-F5278

LS-F5278 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TDP-43 / TARDBP in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TDP-43 / TARDBP as low as 62.5 picograms per milliliter.

About TDP-43 / TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. (more)

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Rat CRH / CRF ELISA Kit (Competitive EIA) - LS-F5619

LS-F5619 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CRH / CRF in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 12.35 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Rat TRH ELISA Kit (Competitive EIA) - LS-F5620

LS-F5620 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat TRH in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of TRH as low as 6.17 picograms per milliliter.

About TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. (more)

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Human IL36RN / IL1F5 ELISA Kit (Sandwich ELISA) - LS-F5630

LS-F5630 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL36RN / IL1F5 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36RN / IL1F5 as low as 5.9 picograms per milliliter.

About IL36RN / IL1F5: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. (more)

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Mouse MASP1 / MASP ELISA Kit (Sandwich ELISA) - LS-F5806

LS-F5806 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MASP1 / MASP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MASP1 / MASP as low as 15.6 picograms per milliliter.

About MASP1 / MASP: MASP1 / MASP is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. (more)

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Human HPR ELISA Kit (Sandwich ELISA) - LS-F5819

LS-F5819 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HPR in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HPR as low as 78 picograms per milliliter.

About HPR: HPR encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. (more)

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Human ALDH2 ELISA Kit (Sandwich ELISA) - LS-F5833

LS-F5833 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ALDH2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ALDH2 as low as 0.312 nanograms per millilter.

About ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. (more)

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Bovine AHSG / Fetuin ELISA Kit (Sandwich ELISA) - LS-F6106

LS-F6106 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine AHSG / Fetuin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of AHSG / Fetuin as low as 6.25 nanograms per millilter.

About AHSG / Fetuin: Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. (more)

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Mouse SYP / Synaptophysin ELISA Kit (Sandwich ELISA) - LS-F6345

LS-F6345 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SYP / Synaptophysin in samples of Cerebrospinal Fluid, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SYP / Synaptophysin as low as 0.625 nanograms per millilter.

About SYP / Synaptophysin: Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release. (more)

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Human ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F6383

LS-F6383 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ADAM17 / TACE in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ADAM17 / TACE as low as 0.156 nanograms per millilter.

About ADAM17 / TACE: Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. (more)

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Rabbit Complement C5a ELISA Kit (Sandwich ELISA) - LS-F6443

LS-F6443 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit Complement C5a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C5a as low as 6.25 picograms per milliliter.

About Complement C5a: Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b. C5a plays an important role in chemotaxis. C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. (more)

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Human CMA1 / Mast Cell Chymase ELISA Kit (Sandwich ELISA) - LS-F6478

LS-F6478 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CMA1 / Mast Cell Chymase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CMA1 / Mast Cell Chymase as low as 31.2 picograms per milliliter.

About CMA1 / Mast Cell Chymase: CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Human Eosinophil Peroxidase / EPX ELISA Kit (Sandwich ELISA) - LS-F7094

LS-F7094 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Eosinophil Peroxidase / EPX in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Eosinophil Peroxidase / EPX as low as 1.25 nanograms per millilter.

About Eosinophil Peroxidase / EPX: Eosinophil Peroxidase / EPX is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. (more)

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Human Proteoglycan 4 / Lubricin ELISA Kit (Sandwich ELISA) - LS-F7095

LS-F7095 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Proteoglycan 4 / Lubricin in samples of Plasma, Serum and Synovial Fluid. It is based upon a Sandwich assay principle and can be used to detect levels of Proteoglycan 4 / Lubricin as low as 62.5 picograms per milliliter.

About Proteoglycan 4 / Lubricin: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. (more)

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Human APOL1 / Apolipoprotein L ELISA Kit (Sandwich ELISA) - LS-F7103

LS-F7103 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human APOL1 / Apolipoprotein L in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APOL1 / Apolipoprotein L as low as 1.25 nanograms per millilter.

About APOL1 / Apolipoprotein L: APOL1 / Apolipoprotein L is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse DLG4 / PSD95 ELISA Kit (Sandwich ELISA) - LS-F7142

LS-F7142 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse DLG4 / PSD95 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DLG4 / PSD95 as low as 0.156 nanograms per millilter.

About DLG4 / PSD95: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. (more)

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Human FLG / Filaggrin ELISA Kit (Sandwich ELISA) - LS-F7249

LS-F7249 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FLG / Filaggrin in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FLG / Filaggrin as low as 0.122 nanograms per millilter.

About FLG / Filaggrin: FLG / Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. (more)

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Mouse CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F7665

LS-F7665 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD274 / B7-H1 / PD-L1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD274 / B7-H1 / PD-L1 as low as 0.062 nanograms per millilter.

About CD274 / B7-H1 / PD-L1: CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. (more)

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Human SLC40A1 / Ferroportin-1 ELISA Kit (Sandwich ELISA) - LS-F7703

LS-F7703 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SLC40A1 / Ferroportin-1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SLC40A1 / Ferroportin-1 as low as 0.312 nanograms per millilter.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Human SPINK5 / LEKTI ELISA Kit (Sandwich ELISA) - LS-F7754

LS-F7754 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SPINK5 / LEKTI in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SPINK5 / LEKTI as low as 0.312 nanograms per millilter.

About SPINK5 / LEKTI: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. (more)

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Human PH / PAH ELISA Kit (Sandwich ELISA) - LS-F7855

LS-F7855 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PH / PAH in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PH / PAH as low as 1.56 nanograms per millilter.

About PH / PAH: PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. (more)

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Mouse/Human/Rat WNT3A ELISA Kit (Sandwich ELISA) - LS-F8574

LS-F8574 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse WNT3A in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of WNT3A as low as 0.156 nanograms per millilter.

About WNT3A: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. (more)

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Human TNFRSF18 / GITR ELISA Kit (Sandwich ELISA) - LS-F8649

LS-F8649 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TNFRSF18 / GITR in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFRSF18 / GITR as low as 15.6 picograms per milliliter.

About TNFRSF18 / GITR: TNFRSF18 / GITR is a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (more)

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Rabbit Complement C3a ELISA Kit (Sandwich ELISA) - LS-F9563

LS-F9563 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit Complement C3a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 0.78 nanograms per millilter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Dog TMEM27 / Collectrin ELISA Kit (Sandwich ELISA) - LS-F9742

LS-F9742 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog TMEM27 / Collectrin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TMEM27 / Collectrin as low as 0.156 nanograms per millilter.

About TMEM27 / Collectrin: TMEM27 / Collectrin is a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. (more)

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Mouse CD33 ELISA Kit (Sandwich ELISA) - LS-F9886

LS-F9886 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD33 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD33 as low as 0.156 nanograms per millilter.

About CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). (more)

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Biotin ELISA Kit (Competitive EIA) - LS-F10160

LS-F10160 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Biotin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Biotin as low as 4.986 picograms per milliliter.

About Biotin: Biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. Biotin's small size means the biological activity of the protein will most likely be unaffected. This process is called biotinylation. Because both streptavidin and avidin bind biotin with high affinity (Kd of 10-14 mol/l to 10-15 mol/l) and specificity, biotinylated proteins of interest can be isolated from a sample by exploiting this highly stable interaction. The sample is incubated with streptavidin/avidin beads, allowing capture of the biotinylated protein of interest. Any other proteins binding to the biotinylated molecule will also stay with the bead and all other unbound proteins can be washed away. (more)

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Rat ACTH ELISA Kit (Sandwich ELISA) - LS-F10570

LS-F10570 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ACTH in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTH as low as 15.6 picograms per milliliter. (more)

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Human IgG Fc ELISA Kit (Sandwich ELISA) - LS-F10602

LS-F10602 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Human IgG Fc in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Human IgG Fc as low as 1.56 nanograms per millilter.

About Human IgG Fc: The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. (more)

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Human ADA / Adenosine Deaminase ELISA Kit (Sandwich ELISA) - LS-F10747

LS-F10747 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ADA / Adenosine Deaminase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ADA / Adenosine Deaminase as low as 0.312 nanograms per millilter.

About ADA / Adenosine Deaminase: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. (more)

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Human CTSK / Cathepsin K ELISA Kit (Sandwich ELISA) - LS-F11032

LS-F11032 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CTSK / Cathepsin K in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTSK / Cathepsin K as low as 4.69 picomoles per liter.

About CTSK / Cathepsin K: CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. (more)

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Rat CFD / Factor D / Adipsin ELISA Kit (Sandwich ELISA) - LS-F11119

LS-F11119 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CFD / Factor D / Adipsin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CFD / Factor D / Adipsin as low as 12.5 nanograms per millilter.

About CFD / Factor D / Adipsin: Complement factor D is a member of the trypsin family of peptidases. DF is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Adipsin is a serine protease that is secreted by adipocytes into the bloodstream. Adipsin is equivalent to complement factor D and has a high level of expression in fat. This suggests a role for adipose tissue in immune system biology. (more)

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Human HMMR / CD168 / RHAMM ELISA Kit (Sandwich ELISA) - LS-F11646

LS-F11646 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMMR / CD168 / RHAMM in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMMR / CD168 / RHAMM as low as 15.6 picograms per milliliter.

About HMMR / CD168 / RHAMM: The receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts. In human, it is expressed as an intracellular protein in breast cancer cells. No correlation between the level of HMMR mRNA and protein expression with known metastatic/malignant potential of the tumor cell lines was observed. (more)

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Human IL36A ELISA Kit (Sandwich ELISA) - LS-F11791

LS-F11791 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL36A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36A as low as 0.156 nanograms per millilter. (more)

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Human IL36B ELISA Kit (Sandwich ELISA) - LS-F11792

LS-F11792 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL36B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36B as low as 31.2 picograms per milliliter.

About IL36B: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. (more)

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Human KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F11895

LS-F11895 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human KL / Klotho in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KL / Klotho as low as 7.8 picograms per milliliter.

About KL / Klotho: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. (more)

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Mouse Osteocalcin ELISA Kit (Sandwich ELISA) - LS-F12227

LS-F12227 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Osteocalcin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Osteocalcin as low as 15.6 picograms per milliliter.

About Osteocalcin: Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone. (more)

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Human S100A7 / Psoriasin ELISA Kit (Sandwich ELISA) - LS-F12536

LS-F12536 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human S100A7 / Psoriasin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of S100A7 / Psoriasin as low as 0.156 nanograms per millilter.

About S100A7 / Psoriasin: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. (more)

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Human IBSP / Bone Sialoprotein ELISA Kit (Sandwich ELISA) - LS-F12601

LS-F12601 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IBSP / Bone Sialoprotein in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IBSP / Bone Sialoprotein as low as 78 picograms per milliliter.

About IBSP / Bone Sialoprotein: IBSP / Bone Sialoprotein is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. (more)

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Human TNFAIP6 / TSG-6 ELISA Kit (Sandwich ELISA) - LS-F12868

LS-F12868 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNFAIP6 / TSG-6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFAIP6 / TSG-6 as low as 0.156 nanograms per millilter.

About TNFAIP6 / TSG-6: TNFAIP6 / TSG-6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. (more)

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Human WNT7A ELISA Kit (Sandwich ELISA) - LS-F12978

LS-F12978 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human WNT7A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of WNT7A as low as 31.2 picograms per milliliter.

About WNT7A: WNT7A is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. (more)

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Mouse/Human/Rat GNRH ELISA Kit (Competitive EIA) - LS-F13002

LS-F13002 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GNRH in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GNRH as low as 12.35 picograms per milliliter.

About GNRH: GNRH is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. (more)

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Human ACTA2 / Smooth Muscle Actin ELISA Kit (Sandwich ELISA) - LS-F13051

LS-F13051 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ACTA2 / Smooth Muscle Actin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTA2 / Smooth Muscle Actin as low as 3.12 nanograms per millilter.

About ACTA2 / Smooth Muscle Actin: ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Rat AQP2 / Aquaporin 2 ELISA Kit (Sandwich ELISA) - LS-F14835

LS-F14835 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat AQP2 / Aquaporin 2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AQP2 / Aquaporin 2 as low as 0.312 nanograms per millilter.

About AQP2 / Aquaporin 2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (more)

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Mouse ENPP2 / Autotaxin ELISA Kit (Sandwich ELISA) - LS-F16526

LS-F16526 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ENPP2 / Autotaxin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ENPP2 / Autotaxin as low as 0.78 nanograms per millilter.

About ENPP2 / Autotaxin: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Mouse PROS1 / Protein S ELISA Kit (Sandwich ELISA) - LS-F18932

LS-F18932 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse PROS1 / Protein S in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PROS1 / Protein S as low as 0.625 nanograms per millilter.

About PROS1 / Protein S: PROS1 / Protein S is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. (more)

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Human ABCA1 ELISA Kit (Sandwich ELISA) - LS-F20946

LS-F20946 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ABCA1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ABCA1 as low as 0.16 nanograms per millilter.

About ABCA1: ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters. It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway. ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters. (more)

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Human CALR / Calreticulin ELISA Kit (Sandwich ELISA) - LS-F20965

LS-F20965 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CALR / Calreticulin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CALR / Calreticulin as low as 0.16 nanograms per millilter.

About CALR / Calreticulin: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. (more)

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Human CRYAB / Alpha B Crystallin ELISA Kit (Sandwich ELISA) - LS-F21122

LS-F21122 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CRYAB / Alpha B Crystallin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CRYAB / Alpha B Crystallin as low as 0.16 nanograms per millilter.

About CRYAB / Alpha B Crystallin: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (more)

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Human SIRPA / CD172a ELISA Kit (Sandwich ELISA) - LS-F21136

LS-F21136 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SIRPA / CD172a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SIRPA / CD172a as low as 0.157 nanograms per millilter.

About SIRPA / CD172a: CD172A / SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. (more)

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Human MBTPS1 / S1P ELISA Kit (Sandwich ELISA) - LS-F21833

LS-F21833 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MBTPS1 / S1P in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MBTPS1 / S1P as low as 3.13 nanograms per millilter.

About MBTPS1 / S1P: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. (more)

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Human GRIN2B / NMDAR2B / NR2B ELISA Kit (Sandwich ELISA) - LS-F22095

LS-F22095 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GRIN2B / NMDAR2B / NR2B in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GRIN2B / NMDAR2B / NR2B as low as 0.31 nanograms per millilter.

About GRIN2B / NMDAR2B / NR2B: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged; memory impaired animals have deficiencies in NR2B expression. (more)

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Most Popular Proteins
Human CST9 Recombinant (His) Protein - LS-G1476

LS-G1476 is a Human CST9 recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About CST9: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. (more)

Human YWHAG / 14-3-3 Gamma Recombinant Protein - LS-G3601

LS-G3601 is a Human YWHAG / 14-3-3 Gamma recombinant protein generated in E. coli. This protein contains low levels of endotoxin.

About YWHAG / 14-3-3 Gamma: YWHAG / 14-3-3 Gamma belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. (more)

Human YWHAH / 14-3-3 Eta Recombinant (His) Protein - LS-G3603

LS-G3603 is a Human YWHAH / 14-3-3 Eta recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About YWHAH / 14-3-3 Eta: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. (more)


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