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  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of over 250,000 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-CRFR1 / CRHR1 Antibody (N-Terminus) IHC-plus™ LS-A1778

LS-A1778 is a rabbit anti-CRFR1 / CRHR1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CRFR1 / CRHR1: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. (more)

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Anti-OXTR / Oxytocin Receptor Antibody (N-Terminus) IHC-plus™ LS-A3878

LS-A3878 is a rabbit anti-OXTR / Oxytocin Receptor polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About OXTR / Oxytocin Receptor: The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect. (more)

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Anti-STEAP1 / STEAP Antibody (N-Terminus) IHC-plus™ LS-B1260

LS-B1260 is a rabbit anti-STEAP1 / STEAP polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About STEAP1 / STEAP: Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-PKM / Pyruvate Kinase Antibody IHC-plus™ LS-B1450

LS-B1450 is a goat anti-PKM / Pyruvate Kinase polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About PKM / Pyruvate Kinase: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. (more)

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Anti-PDCD1 / CD279 / PD-1 Antibody (clone EH12.2H7) LS-C40800

LS-C40800 is a mouse anti-PDCD1 / CD279 / PD-1 monoclonal antibody approved for use in Flow Cytometry.

About PDCD1 / CD279 / PD-1: PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (more)

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Anti-RORC / ROR Gamma Antibody (aa1-50) IHC-plus™ LS-B1797

LS-B1797 is a rabbit anti-RORC / ROR Gamma polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About RORC / ROR Gamma: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (more)

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Anti-LAG3 Antibody (N-Terminus, clone 17B4, FITC) IHC-plus™ LS-B2237

LS-B2237 is a Fluorescein mouse anti-LAG3 monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry - Paraffin.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

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Anti-IL1R1 Antibody (Extracellular Domain, clone 40101) IHC-plus™ LS-B2859

LS-B2859 is a mouse anti-IL1R1 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Radioimmunoassay.

About IL1R1: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. (more)

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Anti-EGFR Antibody (N-Terminus) LS-C100292

LS-C100292 is a rabbit anti-EGFR polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-TSLP Antibody (Internal) IHC-plus™ LS-B3208

LS-B3208 is a rabbit anti-TSLP polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TSLP: TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. (more)

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Anti-IL12 Antibody (Biotin) LS-C104425

LS-C104425 is a Biotin goat anti-IL12 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot. (more)

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Anti-NODAL Antibody (Internal) IHC-plus™ LS-B3955

LS-B3955 is a goat anti-NODAL polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About NODAL: Essential for mesoderm formation and axial patterning during embryonic development. (more)

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Anti-CD27L / CD70 Antibody (clone BU69, RPE) LS-C134547

LS-C134547 is a R. Phycoerythrin mouse anti-CD27L / CD70 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Immunocytochemistry and Immunohistochemistry - Frozen.

About CD27L / CD70: CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. (more)

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Anti-EBI3 / IL-27B Antibody (clone DNT27) IHC-plus™ LS-B5764

LS-B5764 is a rat anti-EBI3 / IL-27B monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About EBI3 / IL-27B: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. (more)

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Anti-CLU / Clusterin Antibody (aa400-449) IHC-plus™ LS-B6759

LS-B6759 is a rabbit anti-CLU / Clusterin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About CLU / Clusterin: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. (more)

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Anti-PTGER4 / EP4 Antibody IHC-plus™ LS-B6947

LS-B6947 is a rabbit anti-PTGER4 / EP4 polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About PTGER4 / EP4: PTGER4 / EP4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. (more)

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Anti-IL17A Antibody IHC-plus™ LS-B7397

LS-B7397 is a rabbit anti-IL17A polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Neutralization and Western blot.

About IL17A: IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (more)

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Anti-BTK Antibody (Lys216) LS-C176566

LS-C176566 is a rabbit anti-BTK polyclonal antibody approved for use in Immunohistochemistry and Western blot.

About BTK: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. (more)

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Anti-Rhizopus arrhizus WSSA Antibody (clone WSSA-RA-1) LS-C188340

LS-C188340 is a mouse anti-Rhizopus arrhizus WSSA monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot. (more)

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Anti-NEUROD1 Antibody LS-C192400

LS-C192400 is a rabbit anti-NEUROD1 polyclonal antibody approved for use in Immunohistochemistry and Western blot.

About NEUROD1: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. (more)

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Anti-TMEM173 / STING Antibody (aa318-348) IHC-plus™ LS-B9374

LS-B9374 is a rabbit anti-TMEM173 / STING polyclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About TMEM173 / STING: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. (more)

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Anti-TNFRSF4 / CD134 / OX40 Antibody IHC-plus™ LS-B9399

LS-B9399 is a rabbit anti-TNFRSF4 / CD134 / OX40 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About TNFRSF4 / CD134 / OX40: TNFRSF4 / CD134 / OX40 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. (more)

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Anti-TJP1 / ZO-1 Antibody (C-Terminus) IHC-plus™ LS-B9774

LS-B9774 is a goat anti-TJP1 / ZO-1 polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About TJP1 / ZO-1: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. (more)

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Anti-CSF1R / CD115 / FMS Antibody (clone SP211) LS-C210434

LS-C210434 is a rabbit anti-CSF1R / CD115 / FMS monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CSF1R / CD115 / FMS: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. (more)

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Anti-PSIP1 / LEDGF Antibody (aa225-275) LS-C287695

LS-C287695 is a rabbit anti-PSIP1 / LEDGF polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Immunoprecipitation.

About PSIP1 / LEDGF: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. (more)

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Anti-KLK1 / Kallikrein 1 Antibody (aa25-261) LS-C313163

LS-C313163 is a rabbit anti-KLK1 / Kallikrein 1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About KLK1 / Kallikrein 1: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. (more)

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Anti-Complement C1s Antibody (clone 4D9) IHC-plus™ LS-B12071

LS-B12071 is a mouse anti-Complement C1s monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About Complement C1s: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. (more)

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Anti-PVR / CD155 Antibody IHC-plus™ LS-B12331

LS-B12331 is a rabbit anti-PVR / CD155 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PVR / CD155: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. (more)

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Anti-ATF1 Antibody (C-Terminus) LS-C351857

LS-C351857 is a rabbit anti-ATF1 polyclonal antibody approved for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western blot.

About ATF1: ATF1 is an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. (more)

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Anti-FCGR1A / CD64 Antibody (clone 1A8) IHC-plus™ LS-B12662

LS-B12662 is a mouse anti-FCGR1A / CD64 monoclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About FCGR1A / CD64: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. (more)

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Most Popular ELISA Kits
Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, EDTA Plasma, Heparin Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 10 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F4038

LS-F4038 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 62.5 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human LPL / Lipoprotein Lipase ELISA Kit (Sandwich ELISA) - LS-F4064

LS-F4064 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LPL / Lipoprotein Lipase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LPL / Lipoprotein Lipase as low as 0.625 nanograms per millilter.

About LPL / Lipoprotein Lipase: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. (more)

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GABA / Gamma-Aminobutyric Acid ELISA Kit (Competitive EIA) - LS-F4121

LS-F4121 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of GABA / Gamma-Aminobutyric Acid in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GABA / Gamma-Aminobutyric Acid as low as 24.69 picograms per milliliter. (more)

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Human IBSP / Bone Sialoprotein ELISA Kit (Sandwich ELISA) - LS-F4424

LS-F4424 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IBSP / Bone Sialoprotein in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IBSP / Bone Sialoprotein as low as 125 picograms per milliliter.

About IBSP / Bone Sialoprotein: IBSP / Bone Sialoprotein is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. (more)

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Human CXCL3 / GRO Gamma ELISA Kit (Sandwich ELISA) - LS-F4807

LS-F4807 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CXCL3 / GRO Gamma in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CXCL3 / GRO Gamma as low as 3.3 picograms per milliliter.

About CXCL3 / GRO Gamma: Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. (more)

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Human TGM2 / Transglutaminase 2 ELISA Kit (Sandwich ELISA) - LS-F5009

LS-F5009 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TGM2 / Transglutaminase 2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TGM2 / Transglutaminase 2 as low as 0.156 nanograms per millilter.

About TGM2 / Transglutaminase 2: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Rabbit SAA1 / SAA / Serum Amyloid A ELISA Kit (Competitive EIA) - LS-F5018

LS-F5018 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit SAA1 / SAA / Serum Amyloid A in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of SAA1 / SAA / Serum Amyloid A as low as 62.5 nanograms per millilter.

About SAA1 / SAA / Serum Amyloid A: SAA1 / SAA / Serum Amyloid A is a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. (more)

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Rabbit TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5127

LS-F5127 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit TNF Alpha in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNF Alpha as low as 3.12 picograms per milliliter.

About TNF Alpha: TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (more)

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Mouse LTA / TNF Beta ELISA Kit (Sandwich ELISA) - LS-F5195

LS-F5195 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LTA / TNF Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LTA / TNF Beta as low as 6.25 picograms per milliliter.

About LTA / TNF Beta: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. (more)

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Human TDP-43 / TARDBP ELISA Kit (Sandwich ELISA) - LS-F5278

LS-F5278 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TDP-43 / TARDBP in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TDP-43 / TARDBP as low as 62.5 picograms per milliliter.

About TDP-43 / TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. (more)

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Rat CRH / CRF ELISA Kit (Competitive EIA) - LS-F5619

LS-F5619 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CRH / CRF in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 12.35 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Rat TRH ELISA Kit (Competitive EIA) - LS-F5620

LS-F5620 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat TRH in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of TRH as low as 6.17 picograms per milliliter.

About TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. (more)

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Human IL36RN / IL1F5 ELISA Kit (Sandwich ELISA) - LS-F5630

LS-F5630 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL36RN / IL1F5 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36RN / IL1F5 as low as 5.9 picograms per milliliter.

About IL36RN / IL1F5: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. (more)

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Mouse NRG1 / Heregulin / Neuregulin ELISA Kit (Sandwich ELISA) - LS-F5751

LS-F5751 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NRG1 / Heregulin / Neuregulin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NRG1 / Heregulin / Neuregulin as low as 15.6 picograms per milliliter.

About NRG1 / Heregulin / Neuregulin: Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. (more)

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Mouse MASP1 / MASP ELISA Kit (Sandwich ELISA) - LS-F5806

LS-F5806 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MASP1 / MASP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MASP1 / MASP as low as 15.6 picograms per milliliter.

About MASP1 / MASP: MASP1 / MASP is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. (more)

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Human HPR ELISA Kit (Sandwich ELISA) - LS-F5819

LS-F5819 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HPR in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HPR as low as 78 picograms per milliliter.

About HPR: HPR encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. (more)

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Human ALDH2 ELISA Kit (Sandwich ELISA) - LS-F5833

LS-F5833 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ALDH2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ALDH2 as low as 0.312 nanograms per millilter.

About ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. (more)

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Pig Trypsin ELISA Kit (Sandwich ELISA) - LS-F6198

LS-F6198 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig Trypsin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Trypsin as low as 1.56 nanograms per millilter.

About Trypsin: Trypsin is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen, which is encoded by several genes (PRSS1, PRSS2, PRSS3). Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. (more)

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Dog CALCA ELISA Kit (Competitive EIA) - LS-F6315

LS-F6315 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog CALCA in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of CALCA as low as 5.14 picograms per milliliter.

About CALCA: CALCA encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse SYP / Synaptophysin ELISA Kit (Sandwich ELISA) - LS-F6345

LS-F6345 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SYP / Synaptophysin in samples of Cerebrospinal Fluid, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SYP / Synaptophysin as low as 0.625 nanograms per millilter.

About SYP / Synaptophysin: Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release. (more)

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Human Properdin / CFP ELISA Kit (Sandwich ELISA) - LS-F6408

LS-F6408 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Properdin / CFP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Properdin / CFP as low as 15.6 nanograms per millilter.

About Properdin / CFP: Properdin / CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Rabbit Complement C5a ELISA Kit (Sandwich ELISA) - LS-F6443

LS-F6443 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit Complement C5a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C5a as low as 6.25 picograms per milliliter.

About Complement C5a: Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b. C5a plays an important role in chemotaxis. C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. (more)

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Human CMA1 / Mast Cell Chymase ELISA Kit (Sandwich ELISA) - LS-F6478

LS-F6478 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CMA1 / Mast Cell Chymase in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CMA1 / Mast Cell Chymase as low as 31.2 picograms per milliliter.

About CMA1 / Mast Cell Chymase: CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Human APOL1 / Apolipoprotein L ELISA Kit (Sandwich ELISA) - LS-F7103

LS-F7103 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human APOL1 / Apolipoprotein L in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APOL1 / Apolipoprotein L as low as 1.25 nanograms per millilter.

About APOL1 / Apolipoprotein L: APOL1 / Apolipoprotein L is a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. (more)

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Human FLG / Filaggrin ELISA Kit (Sandwich ELISA) - LS-F7249

LS-F7249 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FLG / Filaggrin in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FLG / Filaggrin as low as 0.122 nanograms per millilter.

About FLG / Filaggrin: FLG / Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. (more)

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Mouse IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F7495

LS-F7495 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse IDO1 / IDO in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 15.63 picograms per milliliter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Human GAA / Alpha-Glucosidase, Acid ELISA Kit (Sandwich ELISA) - LS-F7547

LS-F7547 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GAA / Alpha-Glucosidase, Acid in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GAA / Alpha-Glucosidase, Acid as low as 0.054 nanograms per millilter.

About GAA / Alpha-Glucosidase, Acid: GAA / Alpha-Glucosidase, Acid is acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene. (more)

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Mouse CD274 / B7-H1 / PD-L1 ELISA Kit (Sandwich ELISA) - LS-F7665

LS-F7665 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD274 / B7-H1 / PD-L1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD274 / B7-H1 / PD-L1 as low as 0.062 nanograms per millilter.

About CD274 / B7-H1 / PD-L1: CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. (more)

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Human SLC40A1 / Ferroportin-1 ELISA Kit (Sandwich ELISA) - LS-F7703

LS-F7703 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SLC40A1 / Ferroportin-1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SLC40A1 / Ferroportin-1 as low as 0.312 nanograms per millilter.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Human SPINK5 / LEKTI ELISA Kit (Sandwich ELISA) - LS-F7754

LS-F7754 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SPINK5 / LEKTI in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SPINK5 / LEKTI as low as 0.312 nanograms per millilter.

About SPINK5 / LEKTI: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. (more)

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Mouse/Human/Rat WNT3A ELISA Kit (Sandwich ELISA) - LS-F8574

LS-F8574 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse WNT3A in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of WNT3A as low as 0.156 nanograms per millilter.

About WNT3A: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. (more)

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Bovine HSP90AB1 / HSP90 Alpha B1 ELISA Kit (Sandwich ELISA) - LS-F8840

LS-F8840 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine HSP90AB1 / HSP90 Alpha B1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HSP90AB1 / HSP90 Alpha B1 as low as 1.35 nanograms per millilter.

About HSP90AB1 / HSP90 Alpha B1: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. (more)

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Human G6PC / Glucose-6-Phosphatase ELISA Kit (Sandwich ELISA) - LS-F9019

LS-F9019 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human G6PC / Glucose-6-Phosphatase in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of G6PC / Glucose-6-Phosphatase as low as 0.156 nanograms per millilter.

About G6PC / Glucose-6-Phosphatase: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. (more)

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Rabbit Complement C3a ELISA Kit (Sandwich ELISA) - LS-F9563

LS-F9563 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit Complement C3a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 0.78 nanograms per millilter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Dog TMEM27 / Collectrin ELISA Kit (Sandwich ELISA) - LS-F9742

LS-F9742 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog TMEM27 / Collectrin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TMEM27 / Collectrin as low as 0.156 nanograms per millilter.

About TMEM27 / Collectrin: TMEM27 / Collectrin is a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. (more)

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Mouse CD33 ELISA Kit (Sandwich ELISA) - LS-F9886

LS-F9886 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD33 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD33 as low as 0.156 nanograms per millilter.

About CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). (more)

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Biotin ELISA Kit (Competitive EIA) - LS-F10160

LS-F10160 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Biotin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Biotin as low as 4.986 picograms per milliliter.

About Biotin: Biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. Biotin's small size means the biological activity of the protein will most likely be unaffected. This process is called biotinylation. Because both streptavidin and avidin bind biotin with high affinity (Kd of 10-14 mol/l to 10-15 mol/l) and specificity, biotinylated proteins of interest can be isolated from a sample by exploiting this highly stable interaction. The sample is incubated with streptavidin/avidin beads, allowing capture of the biotinylated protein of interest. Any other proteins binding to the biotinylated molecule will also stay with the bead and all other unbound proteins can be washed away. (more)

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Mouse Anti-Hepatitis B virus surface antibody ELISA Kit (Competitive EIA) - LS-F10243

LS-F10243 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Anti-Hepatitis B virus surface antibody in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle. (more)

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Rat ACTH ELISA Kit (Sandwich ELISA) - LS-F10570

LS-F10570 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ACTH in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTH as low as 15.6 picograms per milliliter. (more)

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Vitamin D3 ELISA Kit (Competitive EIA) - LS-F10658

LS-F10658 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Vitamin D3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Vitamin D3 as low as 1.56 nanograms per millilter. (more)

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Human ADA / Adenosine Deaminase ELISA Kit (Sandwich ELISA) - LS-F10747

LS-F10747 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ADA / Adenosine Deaminase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ADA / Adenosine Deaminase as low as 0.312 nanograms per millilter.

About ADA / Adenosine Deaminase: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. (more)

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Human BSN / Bassoon ELISA Kit (Sandwich ELISA) - LS-F10959

LS-F10959 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human BSN / Bassoon in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BSN / Bassoon as low as 78 picograms per milliliter.

About BSN / Bassoon: Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. (more)

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Human CTSK / Cathepsin K ELISA Kit (Sandwich ELISA) - LS-F11032

LS-F11032 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CTSK / Cathepsin K in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTSK / Cathepsin K as low as 4.69 picomoles per liter.

About CTSK / Cathepsin K: CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. (more)

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Rat CFD / Factor D / Adipsin ELISA Kit (Sandwich ELISA) - LS-F11119

LS-F11119 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CFD / Factor D / Adipsin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CFD / Factor D / Adipsin as low as 12.5 nanograms per millilter.

About CFD / Factor D / Adipsin: Complement factor D is a member of the trypsin family of peptidases. DF is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Adipsin is a serine protease that is secreted by adipocytes into the bloodstream. Adipsin is equivalent to complement factor D and has a high level of expression in fat. This suggests a role for adipose tissue in immune system biology. (more)

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Human HMMR / CD168 / RHAMM ELISA Kit (Sandwich ELISA) - LS-F11646

LS-F11646 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMMR / CD168 / RHAMM in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMMR / CD168 / RHAMM as low as 15.6 picograms per milliliter.

About HMMR / CD168 / RHAMM: The receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts. In human, it is expressed as an intracellular protein in breast cancer cells. No correlation between the level of HMMR mRNA and protein expression with known metastatic/malignant potential of the tumor cell lines was observed. (more)

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Human IL36A ELISA Kit (Sandwich ELISA) - LS-F11791

LS-F11791 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL36A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36A as low as 0.156 nanograms per millilter. (more)

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Human IL36B ELISA Kit (Sandwich ELISA) - LS-F11792

LS-F11792 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL36B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL36B as low as 31.2 picograms per milliliter.

About IL36B: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. (more)

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Mouse AMH / Anti-Mullerian Hormone ELISA Kit (Sandwich ELISA) - LS-F12041

LS-F12041 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse AMH / Anti-Mullerian Hormone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AMH / Anti-Mullerian Hormone as low as 0.156 nanograms per millilter.

About AMH / Anti-Mullerian Hormone: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. (more)

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Human S100A7 / Psoriasin ELISA Kit (Sandwich ELISA) - LS-F12536

LS-F12536 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human S100A7 / Psoriasin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of S100A7 / Psoriasin as low as 0.156 nanograms per millilter.

About S100A7 / Psoriasin: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. (more)

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Human TNFAIP6 / TSG-6 ELISA Kit (Sandwich ELISA) - LS-F12868

LS-F12868 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNFAIP6 / TSG-6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNFAIP6 / TSG-6 as low as 0.156 nanograms per millilter.

About TNFAIP6 / TSG-6: TNFAIP6 / TSG-6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. (more)

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Human WNT7A ELISA Kit (Sandwich ELISA) - LS-F12978

LS-F12978 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human WNT7A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of WNT7A as low as 31.2 picograms per milliliter.

About WNT7A: WNT7A is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. (more)

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Mouse/Human/Rat GNRH ELISA Kit (Competitive EIA) - LS-F13002

LS-F13002 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GNRH in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GNRH as low as 12.35 picograms per milliliter.

About GNRH: GNRH is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. (more)

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Human ACTA2 / Smooth Muscle Actin ELISA Kit (Sandwich ELISA) - LS-F13051

LS-F13051 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ACTA2 / Smooth Muscle Actin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTA2 / Smooth Muscle Actin as low as 3.12 nanograms per millilter.

About ACTA2 / Smooth Muscle Actin: ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Rat AQP2 / Aquaporin 2 ELISA Kit (Sandwich ELISA) - LS-F14835

LS-F14835 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat AQP2 / Aquaporin 2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AQP2 / Aquaporin 2 as low as 0.312 nanograms per millilter.

About AQP2 / Aquaporin 2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human ABCA1 ELISA Kit (Sandwich ELISA) - LS-F20946

LS-F20946 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ABCA1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ABCA1 as low as 0.16 nanograms per millilter.

About ABCA1: ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters. It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway. ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters. (more)

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Human CALR / Calreticulin ELISA Kit (Sandwich ELISA) - LS-F20965

LS-F20965 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CALR / Calreticulin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CALR / Calreticulin as low as 0.16 nanograms per millilter.

About CALR / Calreticulin: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. (more)

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Human CRYAB / Alpha B Crystallin ELISA Kit (Sandwich ELISA) - LS-F21122

LS-F21122 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CRYAB / Alpha B Crystallin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CRYAB / Alpha B Crystallin as low as 0.16 nanograms per millilter.

About CRYAB / Alpha B Crystallin: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (more)

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Human MBTPS1 / S1P ELISA Kit (Sandwich ELISA) - LS-F21833

LS-F21833 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MBTPS1 / S1P in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MBTPS1 / S1P as low as 3.13 nanograms per millilter.

About MBTPS1 / S1P: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. (more)

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Human GRIN2B / NMDAR2B / NR2B ELISA Kit (Sandwich ELISA) - LS-F22095

LS-F22095 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GRIN2B / NMDAR2B / NR2B in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GRIN2B / NMDAR2B / NR2B as low as 0.31 nanograms per millilter.

About GRIN2B / NMDAR2B / NR2B: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged; memory impaired animals have deficiencies in NR2B expression. (more)

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Human FNDC5 / Irisin ELISA Kit (Sandwich ELISA) - LS-F22775

LS-F22775 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human FNDC5 / Irisin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FNDC5 / Irisin as low as 0.469 nanograms per millilter.

About FNDC5 / Irisin: FNDC5 / Irisin is a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. (more)

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Human FGF21 ELISA Kit (Sandwich ELISA) - LS-F23399

LS-F23399 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human FGF21 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FGF21 as low as 18.75 picograms per milliliter.

About FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. (more)

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Human OxLDL / Oxidized LDL ELISA Kit (Sandwich ELISA) - LS-F23411

LS-F23411 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human OxLDL / Oxidized LDL in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of OxLDL / Oxidized LDL as low as 18.75 picograms per milliliter. (more)

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Human ADAM17 / TACE ELISA Kit (Sandwich ELISA) - LS-F23826

LS-F23826 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ADAM17 / TACE in samples of Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ADAM17 / TACE as low as 62.5 picograms per milliliter.

About ADAM17 / TACE: Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. (more)

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Most Popular Proteins
Human CST9 Recombinant (His) Protein - LS-G1476

LS-G1476 is a Human CST9 recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About CST9: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted protein that may play a role in hematopoietic differentiation or inflammation. (more)

Human YWHAG / 14-3-3 Gamma Recombinant Protein - LS-G3601

LS-G3601 is a Human YWHAG / 14-3-3 Gamma recombinant protein generated in E. coli. This protein contains low levels of endotoxin.

About YWHAG / 14-3-3 Gamma: YWHAG / 14-3-3 Gamma belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. (more)

Human YWHAH / 14-3-3 Eta Recombinant (His) Protein - LS-G3603

LS-G3603 is a Human YWHAH / 14-3-3 Eta recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About YWHAH / 14-3-3 Eta: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. (more)


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