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  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 554,804 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

Our traditional Sandwich, Competitive EIA, and Direct ELISA kits provide a means to quantitatively measure thousands of targets of interest, while our Cell-Based and DNA-Binding ELISA kits are ideal for in-vitro studies and transcription factor analysis. Chemiluminescent CLIA kits provide high-sensitivity detection of low-copy targets and our Development kits enable researchers to cost-effectively run large numbers of assays.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-CHUK / IKKA / IKK Alpha Antibody (clone 14A231) LS-C553

LS-C553 is a mouse anti-CHUK / IKKA / IKK Alpha monoclonal antibody approved for use in Immunoprecipitation and Western blot.

About CHUK / IKKA / IKK Alpha: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. (more)

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Anti-SERPING1 / C1 Inhibitor Antibody (HRP) LS-C12190

LS-C12190 is a Horseradish Peroxidase goat anti-SERPING1 / C1 Inhibitor polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunoelectrophoresis.

About SERPING1 / C1 Inhibitor: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. (more)

Anti-LAG3 Antibody (clone 17B4) LS-C18692

LS-C18692 is a mouse anti-LAG3 monoclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Frozen, Immunoprecipitation and Western blot.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

Anti-FAIM2 / LIFEGUARD Antibody (N-Terminus) IHC-plus™ LS-B567

LS-B567 is a rabbit anti-FAIM2 / LIFEGUARD polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About FAIM2 / LIFEGUARD: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. (more)

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Anti-MMP1 Antibody (N-Terminus) IHC-plus™ LS-B1229

LS-B1229 is a rabbit anti-MMP1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About MMP1: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. (more)

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Anti-Delta3 / DLL3 Antibody (aa27-488) LS-C36156

LS-C36156 is a mouse anti-Delta3 / DLL3 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Delta3 / DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. (more)

Anti-ACAN / Aggrecan Antibody (C-Terminus) IHC-plus™ LS-A1561

LS-A1561 is a rabbit anti-ACAN / Aggrecan polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ACAN / Aggrecan: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. (more)

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Anti-SLC40A1 / Ferroportin-1 Antibody (N-Terminus) IHC-plus™ LS-B1836

LS-B1836 is a rabbit anti-SLC40A1 / Ferroportin-1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Anti-CD3E Antibody (clone UCHT1, Biotin) LS-C78118

LS-C78118 is a Biotin mouse anti-CD3E monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry.

About CD3E: CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. (more)

Anti-TGM2 / Transglutaminase 2 Antibody (clone CUB 7402, Azide-free) LS-C87956

LS-C87956 is a mouse anti-TGM2 / Transglutaminase 2 monoclonal antibody approved for use in Blocking, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About TGM2 / Transglutaminase 2: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-SLC3A2 / CD98 Heavy Chain Antibody (clone 44D7) IHC-plus™ LS-B3177

LS-B3177 is a mouse anti-SLC3A2 / CD98 Heavy Chain monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Immunoprecipitation.

About SLC3A2 / CD98 Heavy Chain: Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. (more)

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Anti-KLB / Beta Klotho Antibody (Internal) IHC-plus™ LS-B3568

LS-B3568 is a rabbit anti-KLB / Beta Klotho polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About KLB / Beta Klotho: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. (more)

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Anti-PLIN2 / ADFP / Adipophilin Antibody IHC-plus™ LS-B4850

LS-B4850 is a rabbit anti-PLIN2 / ADFP / Adipophilin polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PLIN2 / ADFP / Adipophilin: PLIN2 / ADFP / Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. (more)

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Anti-CD27L / CD70 Antibody (clone BU69, RPE) LS-C134547

LS-C134547 is a R. Phycoerythrin mouse anti-CD27L / CD70 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Immunocytochemistry and Immunohistochemistry - Frozen.

About CD27L / CD70: CD27L / CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. (more)

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Anti-ICOS / CD278 Antibody (clone ANC6C6-A3, Azide-free) LS-C134612

LS-C134612 is a mouse anti-ICOS / CD278 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry and Functional Assay.

About ICOS / CD278: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. (more)

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Anti-CD9 Antibody IHC-plus™ LS-B5962

LS-B5962 is a mouse anti-CD9 monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About CD9: CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. (more)

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Anti-FBN1 / Fibrillin 1 Antibody (clone 3H6) IHC-plus™ LS-B6083

LS-B6083 is a mouse anti-FBN1 / Fibrillin 1 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FBN1 / Fibrillin 1: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. (more)

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Anti-c-Kit / CD117 Antibody (clone NU-c-kit, FITC) LS-C140410

LS-C140410 is a Fluorescein mouse anti-c-Kit / CD117 monoclonal antibody approved for use in Flow Cytometry.

About c-Kit / CD117: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. (more)

Anti-TNFRSF12A / TWEAK Receptor Antibody LS-C150061

LS-C150061 is a goat anti-TNFRSF12A / TWEAK Receptor polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Neutralization and Western blot.

About TNFRSF12A / TWEAK Receptor: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. (more)

Anti-SDC2 / Syndecan 2 Antibody (aa19-141) LS-C150258

LS-C150258 is a sheep anti-SDC2 / Syndecan 2 polyclonal antibody approved for use in Flow Cytometry, Immunohistochemistry and Western blot.

About SDC2 / Syndecan 2: SDC2 / Syndecan 2 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. (more)

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Anti-DAP12 Antibody IHC-plus™ LS-B9453

LS-B9453 is a rabbit anti-DAP12 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About DAP12: DAP12 is a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. (more)

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Anti-AAV5 Antibody (clone ADK5b) LS-C200914

LS-C200914 is a mouse anti-AAV5 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation. (more)

Anti-DLK1 / Pref-1 Antibody (FITC) LS-C256132

LS-C256132 is a Fluorescein rabbit anti-DLK1 / Pref-1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry and Western blot.

About DLK1 / Pref-1: DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. (more)

Anti-BMI1 / PCGF4 Antibody (aa276-326) LS-C288481

LS-C288481 is a rabbit anti-BMI1 / PCGF4 polyclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation, Proximity Ligation Assay and Western blot.

About BMI1 / PCGF4: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. (more)

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Anti-SMARCA4 / BRG1 Antibody (aa75-125, Agarose) LS-C291133

LS-C291133 is a Agarose rabbit anti-SMARCA4 / BRG1 polyclonal antibody approved for use in Immunoprecipitation.

About SMARCA4 / BRG1: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. (more)

Anti-PECAM-1 / CD31 Antibody (aa231-280) IHC-plus™ LS-B12093

LS-B12093 is a rabbit anti-PECAM-1 / CD31 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About PECAM-1 / CD31: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. (more)

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Anti-MUC13 Antibody (C-Terminus) LS-C345092

LS-C345092 is a rabbit anti-MUC13 polyclonal antibody approved for use in Western blot.

About MUC13: Mucin 13 (MUC13) is a member of the epithelial mucin family of secreted and cell-surface glycoproteins expressed by ductal and glandular epithelial tissues. These transmembrane mucins are involved in barrier functions in epithelial tissues. Biochemical studies have shown that Mucin 13 is cleaved into two subunits and that the subunit containing the cytoplasmic tail undergoes homodimerization. (more)

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Anti-FGF19 Antibody (clone FG369-1) IHC-plus™ LS-B12881

LS-B12881 is a mouse anti-FGF19 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FGF19: FGF19 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. (more)

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Anti-HP / Haptoglobin Antibody IHC-plus™ LS-B13232

LS-B13232 is a goat anti-HP / Haptoglobin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunodiffusion, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About HP / Haptoglobin: HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. (more)

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Anti-HPX / Hemopexin Antibody IHC-plus™ LS-B13234

LS-B13234 is a goat anti-HPX / Hemopexin polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunodiffusion, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About HPX / Hemopexin: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (more)

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Anti-G6PC / Glucose-6-Phosphatase Antibody LS-C395743

LS-C395743 is a rabbit anti-G6PC / Glucose-6-Phosphatase polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay.

About G6PC / Glucose-6-Phosphatase: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. (more)

Anti-BTNL8 Antibody (aa161-210, Biotin) LS-C453018

LS-C453018 is a Biotin rabbit anti-BTNL8 polyclonal antibody approved for use in Western blot.

About BTNL8: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production. (more)

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Anti-HPTPB / PTPRB Antibody LS-C497790

LS-C497790 is a mouse anti-HPTPB / PTPRB monoclonal antibody approved for use in Immunofluorescence and Immunohistochemistry.

About HPTPB / PTPRB: HPTPB / PTPRB is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. (more)

Most Popular ELISA Kits
Human VCAM1 / CD106 ELISA Kit (Sandwich ELISA) - LS-F209

LS-F209 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human VCAM1 / CD106 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of VCAM1 / CD106 as low as 0.3 nanograms per millilter.

About VCAM1 / CD106: Vascular cell adhesion molecule 1, VCAM-1, is a surface glycoprotein expressed by cytokine-activated endothelium that mediates the adhesion of monocytes and lymphocytes. VCAM-1 and integrin alpha-4-beta-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization. Studies of heart development have shown that deficiencies of VCAM and in alpha-4 integrin also result in epicardial dissolution and subsequent myocardial thinning. (more)

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Human MPO / Myeloperoxidase ELISA Kit (Sandwich ELISA) - LS-F713

LS-F713 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human MPO / Myeloperoxidase in samples of Cell Lysates, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MPO / Myeloperoxidase as low as 63 picograms per milliliter.

About MPO / Myeloperoxidase: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. (more)

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Mouse/Human/Rat Phospho-ADRB2 (Ser355, Ser356) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1286

LS-F1286 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ADRB2 in samples of Adherent Cell Cultures. It is based upon a Cell-Based Phosphorylation assay principle.

About ADRB2: ADRB2 is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. (more)

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Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 156 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F4038

LS-F4038 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 62.5 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human AQP3 / Aquaporin 3 ELISA Kit (Sandwich ELISA) - LS-F4074

LS-F4074 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human AQP3 / Aquaporin 3 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AQP3 / Aquaporin 3 as low as 0.156 nanograms per millilter.

About AQP3 / Aquaporin 3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. (more)

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Rat Complement C3a ELISA Kit (Sandwich ELISA) - LS-F4209

LS-F4209 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat Complement C3a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 6.25 picograms per milliliter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Mouse GFAP ELISA Kit (Sandwich ELISA) - LS-F4260

LS-F4260 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse GFAP in samples of Cell Culture Supernatants, Cell Lysates, Cerebrospinal Fluid, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GFAP as low as 7.8 picograms per milliliter.

About GFAP: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (more)

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Human VGF ELISA Kit (Sandwich ELISA) - LS-F4470

LS-F4470 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human VGF in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of VGF as low as 78 picograms per milliliter.

About VGF: VGF is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. (more)

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Human FCGR1A / CD64 ELISA Kit (Sandwich ELISA) - LS-F4795

LS-F4795 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FCGR1A / CD64 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FCGR1A / CD64 as low as 78.13 picograms per milliliter.

About FCGR1A / CD64: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. (more)

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Rat CCL17 / TARC ELISA Kit (Sandwich ELISA) - LS-F4911

LS-F4911 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CCL17 / TARC in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CCL17 / TARC as low as 15.63 picograms per milliliter.

About CCL17 / TARC: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. (more)

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Vitamin E / Alpha-Tocopherol ELISA Kit (Competitive EIA) - LS-F4970

LS-F4970 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Vitamin E / Alpha-Tocopherol in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Vitamin E / Alpha-Tocopherol as low as 1.23 micrograms per millilter. (more)

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Human Collagen III ELISA Kit (Sandwich ELISA) - LS-F5217

LS-F5217 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Collagen III in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Collagen III as low as 0.625 nanograms per millilter.

About Collagen III: Type-III Collagen is a fibrous scleroprotein in bone, cartilage, tendon, bone marrow stroma and other connective tissue. Mutations Collagen III are associated with type III and IV Ehlers-Danlos syndrome and with aortic and arterial aneurysms. (more)

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Guinea pig TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5322

LS-F5322 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Guinea pig TNF Alpha in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNF Alpha as low as 7.8 picograms per milliliter.

About TNF Alpha: TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. (more)

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Rat CCL7 / MCP3 ELISA Kit (Sandwich ELISA) - LS-F5529

LS-F5529 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CCL7 / MCP3 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CCL7 / MCP3 as low as 15.63 picograms per milliliter.

About CCL7 / MCP3: CCL7 / MCP3 is monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. (more)

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Human GSN / Gelsolin ELISA Kit (Sandwich ELISA) - LS-F5675

LS-F5675 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GSN / Gelsolin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GSN / Gelsolin as low as 62.5 picograms per milliliter.

About GSN / Gelsolin: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. (more)

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Rat FABP3 / H-FABP ELISA Kit (Sandwich ELISA) - LS-F5754

LS-F5754 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat FABP3 / H-FABP in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FABP3 / H-FABP as low as 0.781 nanograms per millilter.

About FABP3 / H-FABP: The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. (more)

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Rhesus monkey IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F6091

LS-F6091 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rhesus monkey IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 15.63 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Mouse C5b-9 Terminal Complement Complex / TCC ELISA Kit (Sandwich ELISA) - LS-F6103

LS-F6103 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse C5b-9 Terminal Complement Complex / TCC in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of C5b-9 Terminal Complement Complex / TCC as low as 1.56 nanograms per millilter.

About C5b-9 Terminal Complement Complex / TCC: The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. (more)

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Mouse Fibrin Degradation Product D-Dimer ELISA Kit (Competitive EIA) - LS-F6179

LS-F6179 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Fibrin Degradation Product D-Dimer in samples of Plasma. It is based upon a Competitive EIA assay principle and can be used to detect levels of Fibrin Degradation Product D-Dimer as low as 12.35 nanograms per millilter. (more)

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Human HSPA5 / GRP78 / BiP ELISA Kit (Sandwich ELISA) - LS-F6280

LS-F6280 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HSPA5 / GRP78 / BiP in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HSPA5 / GRP78 / BiP as low as 0.313 nanograms per millilter.

About HSPA5 / GRP78 / BiP: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. (more)

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Human TJP1 / ZO-1 ELISA Kit (Sandwich ELISA) - LS-F6434

LS-F6434 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TJP1 / ZO-1 in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TJP1 / ZO-1 as low as 0.156 nanograms per millilter.

About TJP1 / ZO-1: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. (more)

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Dog LF / LTF / Lactoferrin ELISA Kit (Competitive EIA) - LS-F6444

LS-F6444 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog LF / LTF / Lactoferrin in samples of Breast Milk, Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of LF / LTF / Lactoferrin as low as 493.8 picograms per milliliter.

About LF / LTF / Lactoferrin: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. (more)

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Human LAIR2 / CD306 ELISA Kit (Sandwich ELISA) - LS-F6502

LS-F6502 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LAIR2 / CD306 in samples of Plasma, Serum, Tissue Homogenates and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of LAIR2 / CD306 as low as 15.63 picograms per milliliter.

About LAIR2 / CD306: The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse GLS / Glutaminase ELISA Kit (Sandwich ELISA) - LS-F6990

LS-F6990 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse GLS / Glutaminase in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GLS / Glutaminase as low as 0.313 nanograms per millilter.

About GLS / Glutaminase: GLS / Glutaminase is the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. (more)

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Mouse Mannose Receptor / CD206 ELISA Kit (Sandwich ELISA) - LS-F7148

LS-F7148 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Mannose Receptor / CD206 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Mannose Receptor / CD206 as low as 15.6 picograms per milliliter.

About Mannose Receptor / CD206: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. (more)

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Human FLG / Filaggrin ELISA Kit (Sandwich ELISA) - LS-F7249

LS-F7249 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FLG / Filaggrin in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FLG / Filaggrin as low as 0.312 nanograms per millilter.

About FLG / Filaggrin: FLG / Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. (more)

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Human PIM1 / Pim-1 ELISA Kit (Sandwich ELISA) - LS-F7734

LS-F7734 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PIM1 / Pim-1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PIM1 / Pim-1 as low as 0.78 nanograms per millilter.

About PIM1 / Pim-1: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. (more)

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Human SPINK5 / LEKTI ELISA Kit (Sandwich ELISA) - LS-F7754

LS-F7754 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SPINK5 / LEKTI in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SPINK5 / LEKTI as low as 0.312 nanograms per millilter.

About SPINK5 / LEKTI: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. (more)

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Human CD200R1 / CD200R ELISA Kit (Sandwich ELISA) - LS-F7984

LS-F7984 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CD200R1 / CD200R in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD200R1 / CD200R as low as 15.6 picograms per milliliter.

About CD200R1 / CD200R: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. (more)

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Human CLDN5 / Claudin 5 ELISA Kit (Sandwich ELISA) - LS-F8302

LS-F8302 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CLDN5 / Claudin 5 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CLDN5 / Claudin 5 as low as 31.25 picograms per milliliter.

About CLDN5 / Claudin 5: CLDN5 / Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. (more)

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Human TSG101 ELISA Kit (Sandwich ELISA) - LS-F8581

LS-F8581 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TSG101 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TSG101 as low as 0.313 nanograms per millilter.

About TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. (more)

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Human PTHR / PTHR1 ELISA Kit (Sandwich ELISA) - LS-F8828

LS-F8828 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PTHR / PTHR1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PTHR / PTHR1 as low as 0.313 nanograms per millilter.

About PTHR / PTHR1: PTHR / PTHR1 is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. (more)

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Ovalbumin ELISA Kit (Sandwich ELISA) - LS-F9540

LS-F9540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Ovalbumin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Ovalbumin as low as 78 picograms per milliliter.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Human CSH1 / Placental Lactogen ELISA Kit (Sandwich ELISA) - LS-F9677

LS-F9677 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CSH1 / Placental Lactogen in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CSH1 / Placental Lactogen as low as 2.5 nanograms per millilter.

About CSH1 / Placental Lactogen: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. (more)

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Human APOA1 / Apolipoprotein A 1 ELISA Kit (Sandwich ELISA) - LS-F10071

LS-F10071 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human APOA1 / Apolipoprotein A 1 in samples of Cell Culture Supernatants, Plasma, Saliva, Serum and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of APOA1 / Apolipoprotein A 1 as low as 3.26 nanograms per millilter.

About APOA1 / Apolipoprotein A 1: APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. (more)

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Biotin ELISA Kit (Competitive EIA) - LS-F10160

LS-F10160 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Biotin in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Biotin as low as 4.986 picograms per milliliter.

About Biotin: Biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. Biotin's small size means the biological activity of the protein will most likely be unaffected. This process is called biotinylation. Because both streptavidin and avidin bind biotin with high affinity (Kd of 10-14 mol/l to 10-15 mol/l) and specificity, biotinylated proteins of interest can be isolated from a sample by exploiting this highly stable interaction. The sample is incubated with streptavidin/avidin beads, allowing capture of the biotinylated protein of interest. Any other proteins binding to the biotinylated molecule will also stay with the bead and all other unbound proteins can be washed away. (more)

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Human SERPINF2 / Alpha-2-Antiplasmin ELISA Kit (Sandwich ELISA) - LS-F10408

LS-F10408 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SERPINF2 / Alpha-2-Antiplasmin in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of SERPINF2 / Alpha-2-Antiplasmin as low as 0.1 nanograms per millilter.

About SERPINF2 / Alpha-2-Antiplasmin: SERPINF2 / Alpha-2-Antiplasmin is a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse IgG ELISA Kit (Sandwich ELISA) - LS-F10451

LS-F10451 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Mouse IgG in samples of Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Mouse IgG as low as 0.1 nanograms per millilter.

About Mouse IgG: Representing approximately 75% of serum antibodies, IgG is the most common type of antibody found in the circulation. IgG molecules are created and released by plasma B cells. IgG antibodies are large molecules of about 150 kDa made of four peptide chains. It contains two identical class gamma heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The two heavy chains are linked to each other and to a light chain each by disulfide bonds. The resulting tetramer has two identical halves, which together form the Y-like shape. Each end of the fork contains an identical antigen binding site. The Fc regions of IgGs bear a highly conserved N-glycosylation site. There are four IgG subclasses (IgG1, 2a, 2b, 3) in mice. (more)

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IP3 / Inositol Trisphosphate ELISA Kit (Competitive EIA) - LS-F10644

LS-F10644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of IP3 / Inositol Trisphosphate in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IP3 / Inositol Trisphosphate as low as 0.625 nanograms per millilter. (more)

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Rat CPB / Carboxypeptidase B ELISA Kit (Sandwich ELISA) - LS-F11040

LS-F11040 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CPB / Carboxypeptidase B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CPB / Carboxypeptidase B as low as 0.156 nanograms per millilter.

About CPB / Carboxypeptidase B: Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. (more)

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Rat CCL11 / Eotaxin ELISA Kit (Sandwich ELISA) - LS-F11046

LS-F11046 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CCL11 / Eotaxin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CCL11 / Eotaxin as low as 15.6 picograms per milliliter.

About CCL11 / Eotaxin: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. (more)

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Rat CTGF ELISA Kit (Sandwich ELISA) - LS-F11239

LS-F11239 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CTGF in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTGF as low as 15.6 picograms per milliliter.

About CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. (more)

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Human GLUL / Glutamine Synthetase ELISA Kit (Sandwich ELISA) - LS-F11546

LS-F11546 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GLUL / Glutamine Synthetase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GLUL / Glutamine Synthetase as low as 15.6 picograms per milliliter.

About GLUL / Glutamine Synthetase: GLUL / Glutamine Synthetase belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. (more)

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Human ITGAM / CD11b ELISA Kit (Sandwich ELISA) - LS-F11850

LS-F11850 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ITGAM / CD11b in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ITGAM / CD11b as low as 0.312 nanograms per millilter.

About ITGAM / CD11b: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. (more)

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Rat MYL3 ELISA Kit (Sandwich ELISA) - LS-F12113

LS-F12113 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat MYL3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MYL3 as low as 0.156 nanograms per millilter.

About MYL3: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. (more)

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Mouse THBS1 / Thrombospondin-1 ELISA Kit (Sandwich ELISA) - LS-F12876

LS-F12876 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse THBS1 / Thrombospondin-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of THBS1 / Thrombospondin-1 as low as 1.56 nanograms per millilter.

About THBS1 / Thrombospondin-1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. (more)

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Rat PLP1 / Myelin PLP ELISA Kit (Sandwich ELISA) - LS-F13344

LS-F13344 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat PLP1 / Myelin PLP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PLP1 / Myelin PLP as low as 78 picograms per milliliter.

About PLP1 / Myelin PLP: PLP1 / Myelin PLP is a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. (more)

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Human BECN1 / Beclin-1 ELISA Kit (Sandwich ELISA) - LS-F15658

LS-F15658 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human BECN1 / Beclin-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BECN1 / Beclin-1 as low as 0.156 nanograms per millilter.

About BECN1 / Beclin-1: Beclin 1 is a coiled coil protein that interacts with prototypic cellular antiapoptotic gene Bcl2. Beclin 1 is widely expressed with highest levels reported in skeletal muscle. Three alternativaly spliced isoforms have been identified. Allelic deletion of beclin 1 results in a wide variety of cancers including breast cancer. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human MMP24 ELISA Kit (Sandwich ELISA) - LS-F21108

LS-F21108 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MMP24 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MMP24 as low as 0.16 nanograms per millilter.

About MMP24: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. (more)

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Human CD33 ELISA Kit (Sandwich ELISA) - LS-F21205

LS-F21205 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CD33 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD33 as low as 0.16 nanograms per millilter.

About CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). (more)

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Human Glycocalicin ELISA Kit (Sandwich ELISA) - LS-F21930

LS-F21930 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Glycocalicin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Glycocalicin as low as 0.31 nanograms per millilter. (more)

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Human CD38 ELISA Kit (Sandwich ELISA) - LS-F22857

LS-F22857 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CD38 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD38 as low as 0.94 nanograms per millilter.

About CD38: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. (more)

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Human crp ELISA Kit (Sandwich ELISA) - LS-F23005

LS-F23005 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human crp in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of crp as low as 15.625 picograms per milliliter. (more)

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Rat TNNI / Troponin I Skeletal ELISA Kit (Sandwich ELISA) - LS-F23154

LS-F23154 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TNNI / Troponin I Skeletal in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNNI / Troponin I Skeletal as low as 15.63 picograms per milliliter. (more)

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Rat GUSB / Beta Glucuronidase ELISA Kit (Sandwich ELISA) - LS-F24073

LS-F24073 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat GUSB / Beta Glucuronidase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GUSB / Beta Glucuronidase as low as 78.13 picograms per milliliter.

About GUSB / Beta Glucuronidase: GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. (more)

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Human Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F26696

LS-F26696 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Acetyl-CoA Carboxylase / ACC in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Acetyl-CoA Carboxylase / ACC as low as 50 picograms per milliliter.

About Acetyl-CoA Carboxylase / ACC: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. (more)

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Human Citrulline ELISA Kit (Sandwich ELISA) - LS-F26729

LS-F26729 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Citrulline in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Citrulline as low as 10 picomoles per milliliter. (more)

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Human SDC4 / Syndecan 4 ELISA Kit (Sandwich ELISA) - LS-F27216

LS-F27216 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SDC4 / Syndecan 4 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SDC4 / Syndecan 4 as low as 250 picograms per milliliter.

About SDC4 / Syndecan 4: SDC4 / Syndecan 4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. (more)

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Rat Acetylcholine ELISA Kit (Competitive EIA) - LS-F27870

LS-F27870 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Acetylcholine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Acetylcholine as low as 50 picograms per milliliter. (more)

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Rat TAC1 / Substance P ELISA Kit (Competitive EIA) - LS-F28026

LS-F28026 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TAC1 / Substance P in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of TAC1 / Substance P as low as 25 picograms per milliliter.

About TAC1 / Substance P: TAC1 / Substance P is four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. (more)

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Mouse Cxcl15 ELISA Kit (Competitive EIA) - LS-F28431

LS-F28431 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Cxcl15 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Cxcl15 as low as 50 picograms per milliliter.

About Cxcl15: Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung, and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland. The gene for CXCL15 is found on mouse chromosome 5. (more)

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Mouse TXA2 / Thromboxane A2 ELISA Kit (Competitive EIA) - LS-F28644

LS-F28644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TXA2 / Thromboxane A2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of TXA2 / Thromboxane A2 as low as 50 picograms per milliliter. (more)

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Most Popular Proteins
Mouse MASP1 / MASP Recombinant (His + T7) Protein (aa25-453) - LS-G24542

LS-G24542 is a Mouse MASP1 / MASP recombinant protein generated in E. coli. This protein has been engineered to contain a His + T7 tag.

About MASP1 / MASP: MASP1 / MASP is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. (more)


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