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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 396,169 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-APLNR/ Apelin Receptor / APJ Antibody (C-Terminus) IHC-plus™ LS-A65

LS-A65 is a rabbit anti-APLNR/ Apelin Receptor / APJ polyclonal antibody approved for use in Immunocytochemistry and Immunohistochemistry - Paraffin.

About APLNR/ Apelin Receptor / APJ: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. (more)

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Anti-FFAR2 / GPR43 Antibody (Extracellular Domain) IHC-plus™ LS-A6600

LS-A6600 is a rabbit anti-FFAR2 / GPR43 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About FFAR2 / GPR43: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). (more)

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Anti-Dipeptidylpeptidase 8 / DPP8 Antibody (N-Terminus) IHC-plus™ LS-A8035

LS-A8035 is a rabbit anti-Dipeptidylpeptidase 8 / DPP8 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About Dipeptidylpeptidase 8 / DPP8: Dipeptidylpeptidase 8 / DPP8 is a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2199

LS-B2199 is a sheep anti-EGFR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-CFH / Complement Factor H Antibody (clone OX-24) IHC-plus™ LS-B2889

LS-B2889 is a mouse anti-CFH / Complement Factor H monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About CFH / Complement Factor H: CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (more)

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Anti-SUV39H2 Antibody (C-Terminus) LS-C116360

LS-C116360 is a rabbit anti-SUV39H2 polyclonal antibody approved for use in Western blot.

About SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. (more)

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Anti-CAMK2 / CAMKII Antibody (aa509-558) LS-C119025

LS-C119025 is a rabbit anti-CAMK2 / CAMKII polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot. (more)

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Anti-DNASE1 / DNase I Antibody IHC-plus™ LS-B4846

LS-B4846 is a rabbit anti-DNASE1 / DNase I polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Paraffin and Western blot.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Anti-IL-10 Antibody (clone JES5-2A5) IHC-plus™ LS-B4913

LS-B4913 is a rat anti-IL-10 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About IL-10: IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. (more)

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Anti-RARA / RAR Alpha Antibody (clone 2C9-1F8) IHC-plus™ LS-B5524

LS-B5524 is a mouse anti-RARA / RAR Alpha monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About RARA / RAR Alpha: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. (more)

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Anti-FABP7 / BLBP / MRG Antibody (aa1-132, clone AT1D1) IHC-plus™ LS-B6684

LS-B6684 is a mouse anti-FABP7 / BLBP / MRG monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About FABP7 / BLBP / MRG: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. (more)

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Anti-IL17A Antibody IHC-plus™ LS-B7397

LS-B7397 is a rabbit anti-IL17A polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Neutralization and Western blot.

About IL17A: IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (more)

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Anti-HEXB Antibody (aa481-530) IHC-plus™ LS-B8401

LS-B8401 is a rabbit anti-HEXB polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About HEXB: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-FAP Alpha Antibody (Extracellular Domain) IHC-plus™ LS-A8027

LS-A8027 is a rabbit anti-FAP Alpha polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About FAP Alpha: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). (more)

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Anti-MSLN / Mesothelin Antibody (clone B35) LS-C179484

LS-C179484 is a rat anti-MSLN / Mesothelin monoclonal antibody approved for use in Flow Cytometry.

About MSLN / Mesothelin: This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. (more)

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Anti-SLC35D3 / FRCL1 Antibody (C-Terminus) IHC-plus™ LS-B9577

LS-B9577 is a rabbit anti-SLC35D3 / FRCL1 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About SLC35D3 / FRCL1: May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules. (more)

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Anti-DDX39 Antibody IHC-plus™ LS-B10959

LS-B10959 is a rabbit anti-DDX39 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About DDX39: DDX39 is a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. (more)

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Anti-Fgf15 Antibody (aa25-218) LS-C293897

LS-C293897 is a rabbit anti-Fgf15 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About Fgf15: Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19. (more)

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Anti-IFN Gamma / Interferon Gamma Antibody (aa24-166) LS-C294753

LS-C294753 is a rabbit anti-IFN Gamma / Interferon Gamma polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About IFN Gamma / Interferon Gamma: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (more)

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Anti-ANGPTL4 Antibody (Fibrinogen-like domain) LS-C345010

LS-C345010 is a rabbit anti-ANGPTL4 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. (more)

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Most Popular ELISA Kits
Human SDF1 / CXCL12 ELISA Kit (Sandwich ELISA) - LS-F695

LS-F695 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SDF1 / CXCL12 in samples of Cell Lysates, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SDF1 / CXCL12 as low as 32 picograms per milliliter.

About SDF1 / CXCL12: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. (more)

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Human Phospho-NFKB1 / NF-Kappa-B (Ser337) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F891

LS-F891 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NFKB1 / NF-Kappa-B in samples of Cell Lysates and Nuclear Lysates. It is based upon a DNA Binding Phosphorylation assay principle.

About NFKB1 / NF-Kappa-B: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (more)

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Human GH / Growth Hormone ELISA Kit (Sandwich ELISA) - LS-F2589

LS-F2589 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GH / Growth Hormone in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GH / Growth Hormone as low as 15.6 picograms per milliliter.

About GH / Growth Hormone: GH / Growth Hormone is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. (more)

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Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 156 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Canine CST3 / Cystatin C ELISA Kit (Sandwich ELISA) - LS-F3490

LS-F3490 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Canine CST3 / Cystatin C in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CST3 / Cystatin C as low as 10.24 picograms per milliliter.

About CST3 / Cystatin C: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. (more)

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Mouse Angiotensin II ELISA Kit (Competitive EIA) - LS-F3954

LS-F3954 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Angiotensin II in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 24.69 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Mouse HP / Haptoglobin ELISA Kit (Sandwich ELISA) - LS-F4253

LS-F4253 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse HP / Haptoglobin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HP / Haptoglobin as low as 31.2 nanograms per millilter.

About HP / Haptoglobin: HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. (more)

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Rat THBS1 / Thrombospondin-1 ELISA Kit (Sandwich ELISA) - LS-F4335

LS-F4335 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat THBS1 / Thrombospondin-1 in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of THBS1 / Thrombospondin-1 as low as 7.81 picograms per milliliter.

About THBS1 / Thrombospondin-1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. (more)

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Human LRP1 / CD91 ELISA Kit (Sandwich ELISA) - LS-F4389

LS-F4389 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LRP1 / CD91 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of LRP1 / CD91 as low as 62.5 picograms per milliliter.

About LRP1 / CD91: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A. (more)

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Human SFTPB / Surfactant Protein B ELISA Kit (Sandwich ELISA) - LS-F4439

LS-F4439 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SFTPB / Surfactant Protein B in samples of Cell Culture Supernatants, Cell Lysates, Lung Lavage Fluid, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SFTPB / Surfactant Protein B as low as 1.56 nanograms per millilter.

About SFTPB / Surfactant Protein B: SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. (more)

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Human ITLN1 / Omentin ELISA Kit (Sandwich ELISA) - LS-F4709

LS-F4709 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human ITLN1 / Omentin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ITLN1 / Omentin as low as 15.63 picograms per milliliter.

About ITLN1 / Omentin: Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism. (more)

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Mouse APOE / Apolipoprotein E ELISA Kit (Sandwich ELISA) - LS-F4714

LS-F4714 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse APOE / Apolipoprotein E in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of APOE / Apolipoprotein E as low as 15.63 nanograms per millilter.

About APOE / Apolipoprotein E: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. (more)

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Mouse IL18 ELISA Kit (Sandwich ELISA) - LS-F5094

LS-F5094 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse IL18 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL18 as low as 15.63 picograms per milliliter.

About IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (more)

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Pig MMP9 / Gelatinase B ELISA Kit (Sandwich ELISA) - LS-F5334

LS-F5334 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig MMP9 / Gelatinase B in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP9 / Gelatinase B as low as 3.12 nanograms per millilter.

About MMP9 / Gelatinase B: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (more)

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Mouse Osteocalcin ELISA Kit (Sandwich ELISA) - LS-F5375

LS-F5375 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Osteocalcin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Osteocalcin as low as 0.156 nanograms per millilter.

About Osteocalcin: Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone. (more)

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Pig SELP / P-Selectin / CD62P ELISA Kit (Sandwich ELISA) - LS-F5647

LS-F5647 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig SELP / P-Selectin / CD62P in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SELP / P-Selectin / CD62P as low as 6.25 nanograms per millilter.

About SELP / P-Selectin / CD62P: SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (more)

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Chicken LYZ / Lysozyme ELISA Kit (Sandwich ELISA) - LS-F5726

LS-F5726 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Chicken LYZ / Lysozyme in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LYZ / Lysozyme as low as 0.625 nanograms per millilter.

About LYZ / Lysozyme: LYZ / Lysozyme is human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. (more)

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Human EREG / Epiregulin ELISA Kit (Sandwich ELISA) - LS-F5753

LS-F5753 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human EREG / Epiregulin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of EREG / Epiregulin as low as 15.6 picograms per milliliter.

About EREG / Epiregulin: Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. (more)

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Human TOP1 / Topoisomerase I ELISA Kit (Sandwich ELISA) - LS-F6459

LS-F6459 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TOP1 / Topoisomerase I in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TOP1 / Topoisomerase I as low as 0.156 nanograms per millilter.

About TOP1 / Topoisomerase I: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). (more)

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Human GDF5 / GDF-5 ELISA Kit (Sandwich ELISA) - LS-F6582

LS-F6582 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GDF5 / GDF-5 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GDF5 / GDF-5 as low as 78 picograms per milliliter.

About GDF5 / GDF-5: GDF5 / GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (more)

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Human SFRP4 ELISA Kit (Sandwich ELISA) - LS-F6799

LS-F6799 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SFRP4 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SFRP4 as low as 62.5 picograms per milliliter.

About SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Human LAMA5 / Laminin Alpha 5 ELISA Kit (Sandwich ELISA) - LS-F6934

LS-F6934 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LAMA5 / Laminin Alpha 5 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LAMA5 / Laminin Alpha 5 as low as 250 picograms per milliliter.

About LAMA5 / Laminin Alpha 5: Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. (more)

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Human PIK3CD / PI3K Delta ELISA Kit (Sandwich ELISA) - LS-F7042

LS-F7042 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PIK3CD / PI3K Delta in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PIK3CD / PI3K Delta as low as 0.313 nanograms per millilter.

About PIK3CD / PI3K Delta: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. (more)

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Human Eosinophil Peroxidase / EPX ELISA Kit (Sandwich ELISA) - LS-F7094

LS-F7094 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Eosinophil Peroxidase / EPX in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Eosinophil Peroxidase / EPX as low as 1.25 nanograms per millilter.

About Eosinophil Peroxidase / EPX: Eosinophil Peroxidase / EPX is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. (more)

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Rat TNNT2 / CTNT ELISA Kit (Sandwich ELISA) - LS-F7134

LS-F7134 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat TNNT2 / CTNT in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNNT2 / CTNT as low as 15.63 picograms per milliliter.

About TNNT2 / CTNT: TNNT2 / CTNT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. (more)

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Mouse CHIT1 / Chitotriosidase ELISA Kit (Sandwich ELISA) - LS-F7277

LS-F7277 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CHIT1 / Chitotriosidase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CHIT1 / Chitotriosidase as low as 0.156 nanograms per millilter.

About CHIT1 / Chitotriosidase: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. (more)

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Pig MMP2 ELISA Kit (Sandwich ELISA) - LS-F7320

LS-F7320 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig MMP2 in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MMP2 as low as 31.2 picograms per milliliter.

About MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. (more)

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Mouse TPH2 ELISA Kit (Sandwich ELISA) - LS-F7454

LS-F7454 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse TPH2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPH2 as low as 0.156 nanograms per millilter.

About TPH2: TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. (more)

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Mouse LOXL2 ELISA Kit (Sandwich ELISA) - LS-F7478

LS-F7478 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LOXL2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LOXL2 as low as 0.156 nanograms per millilter.

About LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. (more)

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Mouse FTH1 / Ferritin Heavy Chain ELISA Kit (Sandwich ELISA) - LS-F7520

LS-F7520 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse FTH1 / Ferritin Heavy Chain in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FTH1 / Ferritin Heavy Chain as low as 0.156 nanograms per millilter.

About FTH1 / Ferritin Heavy Chain: FTH1 / Ferritin Heavy Chain is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. (more)

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Human COL15A1 / Collagen XV Alpha 1 ELISA Kit (Sandwich ELISA) - LS-F7575

LS-F7575 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human COL15A1 / Collagen XV Alpha 1 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of COL15A1 / Collagen XV Alpha 1 as low as 3.13 nanograms per millilter.

About COL15A1 / Collagen XV Alpha 1: COL15A1 / Collagen XV Alpha 1 is the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (more)

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Human OSTN / Musclin / Osteocrin ELISA Kit (Sandwich ELISA) - LS-F7799

LS-F7799 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human OSTN / Musclin / Osteocrin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of OSTN / Musclin / Osteocrin as low as 15.6 picograms per milliliter.

About OSTN / Musclin / Osteocrin: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. (more)

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Human FCGR3A / CD16A ELISA Kit (Sandwich ELISA) - LS-F7838

LS-F7838 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FCGR3A / CD16A in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FCGR3A / CD16A as low as 125 picograms per milliliter.

About FCGR3A / CD16A: FCGR3A / CD16A is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. (more)

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Rat APOC3 / Apolipoprotein C III ELISA Kit (Sandwich ELISA) - LS-F7840

LS-F7840 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat APOC3 / Apolipoprotein C III in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of APOC3 / Apolipoprotein C III as low as 1.56 nanograms per millilter.

About APOC3 / Apolipoprotein C III: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. (more)

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Human SIRT6 / Sirtuin 6 ELISA Kit (Sandwich ELISA) - LS-F7874

LS-F7874 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SIRT6 / Sirtuin 6 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SIRT6 / Sirtuin 6 as low as 0.313 nanograms per millilter.

About SIRT6 / Sirtuin 6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. (more)

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Human UPK3A / UPK3 / Uroplakin III ELISA Kit (Sandwich ELISA) - LS-F8031

LS-F8031 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human UPK3A / UPK3 / Uroplakin III in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of UPK3A / UPK3 / Uroplakin III as low as 0.313 nanograms per millilter.

About UPK3A / UPK3 / Uroplakin III: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. (more)

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Rat CYP1A1 ELISA Kit (Sandwich ELISA) - LS-F8460

LS-F8460 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat CYP1A1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYP1A1 as low as 0.129 nanograms per millilter.

About CYP1A1: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. (more)

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Rat UGT1A / UGT1A1 ELISA Kit (Sandwich ELISA) - LS-F8467

LS-F8467 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat UGT1A / UGT1A1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of UGT1A / UGT1A1 as low as 0.61 nanograms per millilter.

About UGT1A / UGT1A1: UGT1A / UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. (more)

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Rat POSTN / Periostin ELISA Kit (Sandwich ELISA) - LS-F8662

LS-F8662 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat POSTN / Periostin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of POSTN / Periostin as low as 31.2 picograms per milliliter.

About POSTN / Periostin: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX By similarity. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. (more)

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Mouse QSOX1 / QSCN6 ELISA Kit (Sandwich ELISA) - LS-F8712

LS-F8712 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse QSOX1 / QSCN6 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of QSOX1 / QSCN6 as low as 78.13 picograms per milliliter.

About QSOX1 / QSCN6: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation. (more)

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Human IL11RA ELISA Kit (Sandwich ELISA) - LS-F8919

LS-F8919 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IL11RA in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL11RA as low as 0.156 nanograms per millilter.

About IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. (more)

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Mouse TPH1 / Tryptophan Hydroxylase ELISA Kit (Sandwich ELISA) - LS-F8942

LS-F8942 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse TPH1 / Tryptophan Hydroxylase in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPH1 / Tryptophan Hydroxylase as low as 0.156 nanograms per millilter.

About TPH1 / Tryptophan Hydroxylase: TPH1 / TPH encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. (more)

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Ovalbumin ELISA Kit (Sandwich ELISA) - LS-F9540

LS-F9540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Ovalbumin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Ovalbumin as low as 78 picograms per milliliter.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Human Prekallikrein ELISA Kit (Sandwich ELISA) - LS-F10424

LS-F10424 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Prekallikrein in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of Prekallikrein as low as 0.018 micrograms per millilter. (more)

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Estrone ELISA Kit (Competitive EIA) - LS-F10566

LS-F10566 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Estrone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Estrone as low as 15.6 picograms per milliliter. (more)

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Rat ACTH ELISA Kit (Sandwich ELISA) - LS-F10570

LS-F10570 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ACTH in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTH as low as 15.6 picograms per milliliter. (more)

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IP3 / Inositol Trisphosphate ELISA Kit (Competitive EIA) - LS-F10644

LS-F10644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of IP3 / Inositol Trisphosphate in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IP3 / Inositol Trisphosphate as low as 0.625 nanograms per millilter. (more)

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Human ADM / Adrenomedullin ELISA Kit (Sandwich ELISA) - LS-F10754

LS-F10754 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ADM / Adrenomedullin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ADM / Adrenomedullin as low as 15.6 picograms per milliliter.

About ADM / Adrenomedullin: Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. (more)

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Rat CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11016

LS-F11016 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CASP3 / Caspase 3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CASP3 / Caspase 3 as low as 0.312 nanograms per millilter.

About CASP3 / Caspase 3: CASP3 / Caspase 3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. (more)

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Human CAV1 / Caveolin 1 ELISA Kit (Sandwich ELISA) - LS-F11036

LS-F11036 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CAV1 / Caveolin 1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CAV1 / Caveolin 1 as low as 0.156 nanograms per millilter.

About CAV1 / Caveolin 1: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. (more)

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Rat CYP1A2 ELISA Kit (Sandwich ELISA) - LS-F11188

LS-F11188 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat CYP1A2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYP1A2 as low as 0.312 nanograms per millilter.

About CYP1A2: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. (more)

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Mouse HAMP / Hepcidin ELISA Kit (Sandwich ELISA) - LS-F11620

LS-F11620 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse HAMP / Hepcidin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HAMP / Hepcidin as low as 6.25 picograms per milliliter.

About HAMP / Hepcidin: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). (more)

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Mouse HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F11642

LS-F11642 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse HMG1 / HMGB1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 0.156 nanograms per millilter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Human IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F11685

LS-F11685 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IDO1 / IDO in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 1.56 nanograms per millilter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Mouse EBI3 / IL-27B ELISA Kit (Sandwich ELISA) - LS-F11771

LS-F11771 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse EBI3 / IL-27B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of EBI3 / IL-27B as low as 15.6 picograms per milliliter.

About EBI3 / IL-27B: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. (more)

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Human ITGA4 / VLA-4 / CD49d ELISA Kit (Sandwich ELISA) - LS-F11845

LS-F11845 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ITGA4 / VLA-4 / CD49d in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ITGA4 / VLA-4 / CD49d as low as 0.156 nanograms per millilter.

About ITGA4 / VLA-4 / CD49d: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). (more)

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Human MFGE8 /Lactadherin ELISA Kit (Sandwich ELISA) - LS-F12031

LS-F12031 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MFGE8 /Lactadherin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MFGE8 /Lactadherin as low as 31.2 picograms per milliliter.

About MFGE8 /Lactadherin: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. (more)

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Rat PLP1 / Myelin PLP ELISA Kit (Sandwich ELISA) - LS-F13344

LS-F13344 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat PLP1 / Myelin PLP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PLP1 / Myelin PLP as low as 78 picograms per milliliter.

About PLP1 / Myelin PLP: PLP1 / Myelin PLP is a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. (more)

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Mouse FGF23 ELISA Kit (Sandwich ELISA) - LS-F15141

LS-F15141 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse FGF23 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FGF23 as low as 31.2 picograms per milliliter.

About FGF23: FGF23 is a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). (more)

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Mouse MYC / c-Myc ELISA Kit (Sandwich ELISA) - LS-F16761

LS-F16761 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MYC / c-Myc in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MYC / c-Myc as low as 15.6 picograms per milliliter.

About MYC / c-Myc: MYC / c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human BMP1 ELISA Kit (Sandwich ELISA) - LS-F20954

LS-F20954 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human BMP1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of BMP1 as low as 0.16 nanograms per millilter.

About BMP1: BMP1 encodes a Metallopeptidase M12A type protease that is comprised of an amino terminal signal peptide, prodomain and an astacin-like protease domain followed by CUB and EGF-like motifs. BMP1 protein has been shown to cleave chordin, the C-terminal propeptides of procollagen I, II, III and VII, pro-lysyl oxidase, probiglycan, and laminin-5, and its expression has been shown to induce cartilage and bone formation in vivo. At least six spliced variants have been reported. These share the N-terminal protease domain but differ in the C-terminus, and thus contain varying numbers of CUB and EGF-like domains. (more)

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Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F21017

LS-F21017 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLIT2 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SLIT2 as low as 0.16 nanograms per millilter.

About SLIT2: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. (more)

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Human NPHS1 / Nephrin ELISA Kit (Sandwich ELISA) - LS-F21185

LS-F21185 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human NPHS1 / Nephrin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NPHS1 / Nephrin as low as 0.156 nanograms per millilter.

About NPHS1 / Nephrin: NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. (more)

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Mouse HSP90 / Heat Shock Protein 90 ELISA Kit (Sandwich ELISA) - LS-F21385

LS-F21385 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse HSP90 / Heat Shock Protein 90 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HSP90 / Heat Shock Protein 90 as low as 0.16 nanograms per millilter.

About HSP90 / Heat Shock Protein 90: Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs. Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. As their name implies, heat shock proteins protect cells when stressed by elevated temperatures. They account for 1–2% of total protein in unstressed cells. However, when cells are heated, the fraction of heat shock proteins increases to 4–6% of cellular proteins. Heat shock protein 90 (Hsp90) is one of the most common of the heat-related proteins. (more)

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Rat ALPL / Alkaline Phosphatase ELISA Kit (Sandwich ELISA) - LS-F21496

LS-F21496 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ALPL / Alkaline Phosphatase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of ALPL / Alkaline Phosphatase as low as 0.16 nanograms per millilter.

About ALPL / Alkaline Phosphatase: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. (more)

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Human TNC / Tenascin C ELISA Kit (Sandwich ELISA) - LS-F22079

LS-F22079 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TNC / Tenascin C in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TNC / Tenascin C as low as 0.31 nanograms per millilter.

About TNC / Tenascin C: Tenascin C (TNC) is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. TNC has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One mechanism to explain this may come from its ability to bind to the extracellular matrix glycoprotein fibronectin and block fibronectin's interactions with specific syndecans. The expression of tenascin-C in the stroma of certain tumors is associated with a poor prognosis. (more)

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Human Complement C4 ELISA Kit (Sandwich ELISA) - LS-F22483

LS-F22483 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Complement C4 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C4 as low as 4.688 nanograms per millilter.

About Complement C4: Complement component 4 is a protein involved in the complement system. It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d. C4a is an anaphylatoxin. C4b forms part of C3-convertase, in conjunction with 2a, and can bind CR1. C4d has been identified as a biomarker for systemic lupus erythematosus. (more)

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Rat Trypsinogen Activation Peptide ELISA Kit (Competitive EIA) - LS-F22914

LS-F22914 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Trypsinogen Activation Peptide in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Trypsinogen Activation Peptide as low as 0.156 nanograms per millilter. (more)

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Human Complement C1q ELISA Kit (Sandwich ELISA) - LS-F23976

LS-F23976 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Complement C1q in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C1q as low as 78.13 picograms per milliliter.

About Complement C1q: C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits (C1QA, C1QB, and C1QC). Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. (more)

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Rat GUSB / Beta Glucuronidase ELISA Kit (Sandwich ELISA) - LS-F24073

LS-F24073 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat GUSB / Beta Glucuronidase in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GUSB / Beta Glucuronidase as low as 78.13 picograms per milliliter.

About GUSB / Beta Glucuronidase: GUSB / Beta Glucuronidase is a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. (more)

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Rabbit IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F25157

LS-F25157 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rabbit IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 15.63 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Human KRT15 / CK15 / Cytokeratin 15 ELISA Kit (Sandwich ELISA) - LS-F25187

LS-F25187 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human KRT15 / CK15 / Cytokeratin 15 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KRT15 / CK15 / Cytokeratin 15 as low as 31.25 picograms per milliliter.

About KRT15 / CK15 / Cytokeratin 15: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. (more)

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Human BMP4 ELISA Kit (CLIA) - LS-F25876

LS-F25876 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human BMP4 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich CLIA assay principle and can be used to detect levels of BMP4 as low as 75 picograms per milliliter.

About BMP4: BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. (more)

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Human Procalcitonin ELISA Kit (CLIA) - LS-F26027

LS-F26027 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Procalcitonin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich CLIA assay principle and can be used to detect levels of Procalcitonin as low as 6.86 picograms per milliliter. (more)

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Human Acetyl-CoA Carboxylase / ACC ELISA Kit (Sandwich ELISA) - LS-F26696

LS-F26696 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Acetyl-CoA Carboxylase / ACC in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Acetyl-CoA Carboxylase / ACC as low as 50 picograms per milliliter.

About Acetyl-CoA Carboxylase / ACC: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. (more)

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Rat Acetylcholine ELISA Kit (Competitive EIA) - LS-F27870

LS-F27870 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Acetylcholine in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Acetylcholine as low as 50 picograms per milliliter. (more)

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Mouse Angiotensin 1-7 ELISA Kit (Competitive EIA) - LS-F28147

LS-F28147 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Angiotensin 1-7 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin 1-7 as low as 50 picograms per milliliter. (more)

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