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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of 554,363 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

Our traditional Sandwich, Competitive EIA, and Direct ELISA kits provide a means to quantitatively measure thousands of targets of interest, while our Cell-Based and DNA-Binding ELISA kits are ideal for in-vitro studies and transcription factor analysis. Chemiluminescent CLIA kits provide high-sensitivity detection of low-copy targets and our Development kits enable researchers to cost-effectively run large numbers of assays.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-ACAN / Aggrecan Antibody (C-Terminus) IHC-plus™ LS-A1561

LS-A1561 is a rabbit anti-ACAN / Aggrecan polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ACAN / Aggrecan: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. (more)

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Anti-ERBB2 / HER2 Antibody (clone SP3) LS-C88826

LS-C88826 is a rabbit anti-ERBB2 / HER2 monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ERBB2 / HER2: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. (more)

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Anti-LAG3 Antibody (clone 17B4) LS-C18692

LS-C18692 is a mouse anti-LAG3 monoclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry - Frozen, Immunoprecipitation and Western blot.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

Anti-EDN1 / Endothelin 1 Antibody (clone IC4) LS-C85079

LS-C85079 is a mouse anti-EDN1 / Endothelin 1 monoclonal antibody approved for use in Immunocytochemistry.

About EDN1 / Endothelin 1: EDN1 / Endothelin 1 is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. (more)

Anti-FGF19 Antibody LS-C129071

LS-C129071 is a sheep anti-FGF19 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About FGF19: FGF19 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. (more)

Anti-Diphtheria Toxin Antibody (clone 17.6B9G6C9) LS-C50792

LS-C50792 is a mouse anti-Diphtheria Toxin monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay.

About Diphtheria Toxin: Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A. (more)

Anti-VWF / Von Willebrand Factor Antibody (N-Terminus, clone VW92-3) LS-C83336

LS-C83336 is a mouse anti-VWF / Von Willebrand Factor monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Frozen, Immunohistochemistry - Paraffin and Western blot.

About VWF / Von Willebrand Factor: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. (more)

Anti-TNFRSF6B / DCR3 Antibody (clone 7G5) LS-C133572

LS-C133572 is a mouse anti-TNFRSF6B / DCR3 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TNFRSF6B / DCR3: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues. (more)

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Anti-MMP2 Antibody (clone SB13a) LS-C149696

LS-C149696 is a mouse anti-MMP2 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. (more)

Anti-TNFSF4 / OX40L Antibody (clone ANC10G1, Biotin) LS-C134809

LS-C134809 is a Biotin mouse anti-TNFSF4 / OX40L monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry and Functional Assay.

About TNFSF4 / OX40L: TNFSF4 / OX40L is a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. (more)

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Anti-AXL Antibody (clone 7E10) IHC-plus™ LS-B6124

LS-B6124 is a mouse anti-AXL monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About AXL: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. (more)

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Anti-BAFF Antibody (clone ANC2H3, Azide-free) LS-C134616

LS-C134616 is a mouse anti-BAFF monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Functional Assay.

About BAFF: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. (more)

Anti-CBT1 / SDHD Antibody (Internal) IHC-plus™ LS-B8827

LS-B8827 is a rabbit anti-CBT1 / SDHD polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CBT1 / SDHD: CBT1 / SDHD is a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. (more)

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Anti-KRT20 / CK20 / Cytokeratin 20 Antibody (clone 2G3-1C8) IHC-plus™ LS-B4527

LS-B4527 is a mouse anti-KRT20 / CK20 / Cytokeratin 20 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About KRT20 / CK20 / Cytokeratin 20: KRT20 / CK20 / Cytokeratin 20 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. (more)

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Anti-FOLH1 / PSMA Antibody (clone 107.1A4) LS-C150527

LS-C150527 is a mouse anti-FOLH1 / PSMA monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunocytochemistry, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About FOLH1 / PSMA: FOLH1 / PSMA is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. (more)

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Anti-ICOS / CD278 Antibody (C-Terminus, clone SP98) LS-C210350

LS-C210350 is a rabbit anti-ICOS / CD278 monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About ICOS / CD278: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. (more)

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Anti-PYCARD / ASC / TMS1 Antibody (DY488) LS-C180936

LS-C180936 is a DyLight 488 rabbit anti-PYCARD / ASC / TMS1 polyclonal antibody approved for use in Immunocytochemistry, Immunofluorescence and Immunohistochemistry - Paraffin.

About PYCARD / ASC / TMS1: Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. (more)

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Anti-CD32A Antibody (clone 13D7) IHC-plus™ LS-B11077

LS-B11077 is a mouse anti-CD32A monoclonal antibody approved for use in Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About CD32A: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. (more)

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Anti-HHV-8 / HHV8 / KSHV Antibody (clone 13B10) LS-C312211

LS-C312211 is a mouse anti-HHV-8 / HHV8 / KSHV monoclonal antibody approved for use in Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin. (more)

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Anti-BACH1 Antibody (clone 4E11) LS-C173634

LS-C173634 is a mouse anti-BACH1 monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About BACH1: BACH1 is a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. (more)

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Anti-MAPT / Tau Antibody (aa401-426) LS-C209741

LS-C209741 is a rabbit anti-MAPT / Tau polyclonal antibody approved for use in Dot Blot, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry and Western blot.

About MAPT / Tau: Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU. (more)

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Anti-ABCA7 Antibody (aa2096-2146) LS-C291064

LS-C291064 is a rabbit anti-ABCA7 polyclonal antibody approved for use in Western blot.

About ABCA7: ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. (more)

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Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2199

LS-B2199 is a sheep anti-EGFR polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. (more)

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Anti-ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) LS-C191759

LS-C191759 is a mouse anti-ALK3 / BMPR1A monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About ALK3 / BMPR1A: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. (more)

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Anti-SSPN / Sarcospan Antibody (aa144-193) LS-C111107

LS-C111107 is a rabbit anti-SSPN / Sarcospan polyclonal antibody approved for use in Western blot.

About SSPN / Sarcospan: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. (more)

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Anti-IL23A / IL-23 p19 Antibody (clone HLT2736) IHC-plus™ LS-B3708

LS-B3708 is a mouse anti-IL23A / IL-23 p19 monoclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About IL23A / IL-23 p19: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. (more)

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Anti-BRD4 Antibody LS-C408408

LS-C408408 is a rabbit anti-BRD4 polyclonal antibody approved for use in Immunocytochemistry, Immunohistochemistry and Western blot.

About BRD4: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. (more)

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Anti-CD20 Antibody IHC-plus™ LS-B12186

LS-B12186 is a rabbit anti-CD20 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About CD20: CD20 is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. (more)

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Anti-SLC12A2 / NKCC1 Antibody (N-Terminus) IHC-plus™ LS-A8899

LS-A8899 is a rabbit anti-SLC12A2 / NKCC1 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About SLC12A2 / NKCC1: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. (more)

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Anti-SLC2A1 / GLUT-1 Antibody (Extracellular Domain) LS-C129284

LS-C129284 is a mouse anti-SLC2A1 / GLUT-1 monoclonal antibody approved for use in Flow Cytometry and Western blot.

About SLC2A1 / GLUT-1: Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. (more)

Most Popular ELISA Kits
Mouse/Human/Rat Phospho-STAT6 (Tyr641) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1629

LS-F1629 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human STAT6 in samples of Adherent Cell Cultures. It is based upon a Cell-Based Phosphorylation assay principle.

About STAT6: STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. (more)

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Rat IFNA / Interferon Alpha ELISA Kit (Sandwich ELISA) - LS-F4130

LS-F4130 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat IFNA / Interferon Alpha in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFNA / Interferon Alpha as low as 15.63 picograms per milliliter. (more)

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Mouse AGT / Angiotensinogen ELISA Kit (Sandwich ELISA) - LS-F4241

LS-F4241 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse AGT / Angiotensinogen in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AGT / Angiotensinogen as low as 0.625 nanograms per millilter.

About AGT / Angiotensinogen: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. (more)

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Human F13 / Factor XIII ELISA Kit (Sandwich ELISA) - LS-F4432

LS-F4432 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human F13 / Factor XIII in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of F13 / Factor XIII as low as 25 picograms per milliliter. (more)

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Human TDP-43 / TARDBP ELISA Kit (Sandwich ELISA) - LS-F5278

LS-F5278 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TDP-43 / TARDBP in samples of Cerebrospinal Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TDP-43 / TARDBP as low as 62.5 picograms per milliliter.

About TDP-43 / TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. (more)

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Human GSTA1 ELISA Kit (Sandwich ELISA) - LS-F4372

LS-F4372 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GSTA1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GSTA1 as low as 62.5 picograms per milliliter.

About GSTA1: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. (more)

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Pig NPPB / BNP ELISA Kit (Sandwich ELISA) - LS-F5336

LS-F5336 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig NPPB / BNP in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NPPB / BNP as low as 31.25 picograms per milliliter.

About NPPB / BNP: NPPB / BNP is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. (more)

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Mouse SFTPA1 / Surfactant Protein A ELISA Kit (Sandwich ELISA) - LS-F4286

LS-F4286 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SFTPA1 / Surfactant Protein A in samples of Lung Lavage Fluid, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SFTPA1 / Surfactant Protein A as low as 31.25 picograms per milliliter.

About SFTPA1 / Surfactant Protein A: SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. (more)

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Mouse SAA1 / SAA / Serum Amyloid A ELISA Kit (Sandwich ELISA) - LS-F4256

LS-F4256 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SAA1 / SAA / Serum Amyloid A in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SAA1 / SAA / Serum Amyloid A as low as 1.56 nanograms per millilter.

About SAA1 / SAA / Serum Amyloid A: SAA1 / SAA / Serum Amyloid A is a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. (more)

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Human TNNI3 / Cardiac Troponin I ELISA Kit (Sandwich ELISA) - LS-F5307

LS-F5307 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TNNI3 / Cardiac Troponin I in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TNNI3 / Cardiac Troponin I as low as 31.25 picograms per milliliter.

About TNNI3 / Cardiac Troponin I: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). (more)

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Rhesus monkey IFN Beta / Interferon Beta ELISA Kit (Sandwich ELISA) - LS-F6091

LS-F6091 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rhesus monkey IFN Beta / Interferon Beta in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IFN Beta / Interferon Beta as low as 15.63 picograms per milliliter.

About IFN Beta / Interferon Beta: Interferon beta (IFNB1), acting via STAT1 and STAT2, upregulates and downregulates a wide variety of genes, most of which are involved in the antiviral immune response. Most IFN responses are induced by the presence of dsRNA, but both DNA and RNA viruses are sensitive to the effects of IFN-beta. (more)

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Dog MMP9 / Gelatinase B ELISA Kit (Sandwich ELISA) - LS-F7313

LS-F7313 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Dog MMP9 / Gelatinase B in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MMP9 / Gelatinase B as low as 3.12 nanograms per millilter.

About MMP9 / Gelatinase B: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (more)

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Mouse AGRP ELISA Kit (Sandwich ELISA) - LS-F7689

LS-F7689 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse AGRP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of AGRP as low as 7.8 picograms per milliliter.

About AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. (more)

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Mouse AMH / Anti-Mullerian Hormone ELISA Kit (Competitive EIA) - LS-F6145

LS-F6145 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse AMH / Anti-Mullerian Hormone in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of AMH / Anti-Mullerian Hormone as low as 123.5 picograms per milliliter.

About AMH / Anti-Mullerian Hormone: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. (more)

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Human OCLN / Occludin ELISA Kit (Sandwich ELISA) - LS-F6508

LS-F6508 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human OCLN / Occludin in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of OCLN / Occludin as low as 0.156 nanograms per millilter.

About OCLN / Occludin: OCLN / Occludin is an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. (more)

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Human IAPP / Amylin ELISA Kit (Competitive EIA) - LS-F9686

LS-F9686 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IAPP / Amylin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IAPP / Amylin as low as 6.17 picograms per milliliter.

About IAPP / Amylin: IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. (more)

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Mouse IgG ELISA Kit (Sandwich ELISA) - LS-F10451

LS-F10451 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Mouse IgG in samples of Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Mouse IgG as low as 0.1 nanograms per millilter.

About Mouse IgG: Representing approximately 75% of serum antibodies, IgG is the most common type of antibody found in the circulation. IgG molecules are created and released by plasma B cells. IgG antibodies are large molecules of about 150 kDa made of four peptide chains. It contains two identical class gamma heavy chains of about 50 kDa and two identical light chains of about 25 kDa. The two heavy chains are linked to each other and to a light chain each by disulfide bonds. The resulting tetramer has two identical halves, which together form the Y-like shape. Each end of the fork contains an identical antigen binding site. The Fc regions of IgGs bear a highly conserved N-glycosylation site. There are four IgG subclasses (IgG1, 2a, 2b, 3) in mice. (more)

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Mouse CRH / CRF ELISA Kit (Competitive EIA) - LS-F11216

LS-F11216 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse CRH / CRF in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 15.6 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Pig SELP / P-Selectin / CD62P ELISA Kit (Sandwich ELISA) - LS-F5647

LS-F5647 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig SELP / P-Selectin / CD62P in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SELP / P-Selectin / CD62P as low as 6.25 nanograms per millilter.

About SELP / P-Selectin / CD62P: SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (more)

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Mouse PTN / Pleiotrophin ELISA Kit (Sandwich ELISA) - LS-F8143

LS-F8143 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse PTN / Pleiotrophin in samples of Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PTN / Pleiotrophin as low as 7.81 picograms per milliliter.

About PTN / Pleiotrophin: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. (more)

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Human HLA-G ELISA Kit (Sandwich ELISA) - LS-F11636

LS-F11636 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HLA-G in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HLA-G as low as 0.312 nanograms per millilter.

About HLA-G: HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. (more)

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Rat HMG-CoA Reductase / HMGCR ELISA Kit (Sandwich ELISA) - LS-F15758

LS-F15758 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat HMG-CoA Reductase / HMGCR in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG-CoA Reductase / HMGCR as low as 0.625 nanograms per millilter.

About HMG-CoA Reductase / HMGCR: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F11641

LS-F11641 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG1 / HMGB1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 0.156 nanograms per millilter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Mouse THBS1 / Thrombospondin-1 ELISA Kit (Sandwich ELISA) - LS-F12876

LS-F12876 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse THBS1 / Thrombospondin-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of THBS1 / Thrombospondin-1 as low as 1.56 nanograms per millilter.

About THBS1 / Thrombospondin-1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. (more)

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Human LAPTM4B ELISA Kit (Sandwich ELISA) - LS-F11921

LS-F11921 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human LAPTM4B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LAPTM4B as low as 0.469 nanograms per millilter. (more)

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Pig Trypsin ELISA Kit (Sandwich ELISA) - LS-F20825

LS-F20825 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig Trypsin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Trypsin as low as 1.56 nanograms per millilter.

About Trypsin: Trypsin is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen, which is encoded by several genes (PRSS1, PRSS2, PRSS3). Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. (more)

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Rat KRT18 / CK18 / Cytokeratin 18 ELISA Kit (Sandwich ELISA) - LS-F21625

LS-F21625 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat KRT18 / CK18 / Cytokeratin 18 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of KRT18 / CK18 / Cytokeratin 18 as low as 0.16 nanograms per millilter.

About KRT18 / CK18 / Cytokeratin 18: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. (more)

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Rabbit Fibrin Degradation Product D-Dimer ELISA Kit (Sandwich ELISA) - LS-F21884

LS-F21884 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rabbit Fibrin Degradation Product D-Dimer in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Fibrin Degradation Product D-Dimer as low as 3.125 nanograms per millilter. (more)

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Human PAF / Platelet Activating Factor ELISA Kit (Sandwich ELISA) - LS-F22161

LS-F22161 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human PAF / Platelet Activating Factor in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of PAF / Platelet Activating Factor as low as 78.13 picograms per milliliter. (more)

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Human ANGPTL7 / CDT6 ELISA Kit (Sandwich ELISA) - LS-F10825

LS-F10825 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ANGPTL7 / CDT6 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ANGPTL7 / CDT6 as low as 78 picograms per milliliter. (more)

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Human F8 / FVIII / Factor VIII ELISA Kit (Sandwich ELISA) - LS-F10415

LS-F10415 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human F8 / FVIII / Factor VIII in samples of Plasma. It is based upon a Sandwich assay principle and can be used to detect levels of F8 / FVIII / Factor VIII as low as 0.0007 international units per milliliter.

About F8 / FVIII / Factor VIII: F8 / FVIII / Factor VIII is coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. (more)

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Ovalbumin ELISA Kit (Sandwich ELISA) - LS-F9540

LS-F9540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Ovalbumin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Ovalbumin as low as 78 picograms per milliliter.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Mouse Angiotensin I ELISA Kit (Competitive EIA) - LS-F25042

LS-F25042 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Angiotensin I in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin I as low as 12.35 picograms per milliliter.

About Angiotensin I: Angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu | Val-Ile-...) is formed by the action of renin on angiotensinogen. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide (des-Asp) angiotensin I. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure (<90mmHg systolic blood pressure) at the juxtaglomerular cells, or decreased delivery of Na+ and Cl- to the macula densa. If less Na+ is sensed by the macula densa, renin release by juxtaglomerular cells is increased. Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin II. (more)

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Human HAVCR2 / TIM-3 ELISA Kit (Sandwich ELISA) - LS-F8927

LS-F8927 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HAVCR2 / TIM-3 in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HAVCR2 / TIM-3 as low as 78.13 picograms per milliliter.

About HAVCR2 / TIM-3: HAVCR2 / TIM-3 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. (more)

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Mouse IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F7495

LS-F7495 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse IDO1 / IDO in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 15.6 picograms per milliliter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Mouse CTGF ELISA Kit (Sandwich ELISA) - LS-F5553

LS-F5553 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CTGF in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTGF as low as 31.2 picograms per milliliter.

About CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. (more)

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Human IL35 ELISA Kit (Sandwich ELISA) - LS-F27033

LS-F27033 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IL35 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IL35 as low as 50 picograms per milliliter. (more)

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Mouse TXA2 / Thromboxane A2 ELISA Kit (Competitive EIA) - LS-F28644

LS-F28644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse TXA2 / Thromboxane A2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of TXA2 / Thromboxane A2 as low as 50 picograms per milliliter. (more)

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Human CALR / Calreticulin ELISA Kit (Sandwich ELISA) - LS-F26799

LS-F26799 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CALR / Calreticulin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CALR / Calreticulin as low as 0.5 nanograms per millilter.

About CALR / Calreticulin: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. (more)

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Rat Complement C5a ELISA Kit (Sandwich ELISA) - LS-F4212

LS-F4212 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat Complement C5a in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C5a as low as 1.56 nanograms per millilter.

About Complement C5a: Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b. C5a plays an important role in chemotaxis. C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. (more)

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Canine/Human MMP8 ELISA Kit (Sandwich ELISA) - LS-F3500

LS-F3500 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Canine MMP8 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MMP8 as low as 0.069 nanograms per millilter.

About MMP8: MMP8 is a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. (more)

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Human VEGFB ELISA Kit (Sandwich ELISA) - LS-F5203

LS-F5203 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human VEGFB in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of VEGFB as low as 15.63 picograms per milliliter.

About VEGFB: VEGFB is a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. (more)

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Human IDE ELISA Kit (Sandwich ELISA) - LS-F6210

LS-F6210 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human IDE in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDE as low as 0.313 nanograms per millilter.

About IDE: IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. (more)

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Human GFAP ELISA Kit (Sandwich ELISA) - LS-F4258

LS-F4258 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GFAP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of GFAP as low as 0.156 nanograms per millilter.

About GFAP: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (more)

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Human DUSP4 / MKP2 ELISA Kit (Sandwich ELISA) - LS-F16494

LS-F16494 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human DUSP4 / MKP2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DUSP4 / MKP2 as low as 0.312 nanograms per millilter.

About DUSP4 / MKP2: TYP / DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. (more)

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Human MUC5AC ELISA Kit (Sandwich ELISA) - LS-F12104

LS-F12104 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MUC5AC in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MUC5AC as low as 0.78 nanograms per millilter.

About MUC5AC: MUC5AC has been isolated from airway secretions. It is found in the protective film of mucus coating the mucosal surfaces of the respiratory tract and the normal gastrointestinal tissues. Mucins are also expressed at low levels in human fetal gut. MUC5AC is involved in epithelial cell proliferation and differentiation in adult airway mucosa and can be used as a marker for hypersecretory disorders. MUC5AC has also been observed in various tumors. For instance it is expressed in primary mucinous ovarian tumors but not in colonic carcinoma metastatic to the ovary, which makes it a useful marker to distinguish the two types of cancer. (more)

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Human RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F16069

LS-F16069 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human RIPK3 / RIP3 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of RIPK3 / RIP3 as low as 0.156 nanograms per millilter.

About RIPK3 / RIP3: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. (more)

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Human MT2A / Metallothionein 2A ELISA Kit (Sandwich ELISA) - LS-F12092

LS-F12092 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human MT2A / Metallothionein 2A in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MT2A / Metallothionein 2A as low as 0.312 nanograms per millilter.

About MT2A / Metallothionein 2A: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (more)

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Human EBI3 / IL-27B ELISA Kit (Sandwich ELISA) - LS-F11772

LS-F11772 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human EBI3 / IL-27B in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of EBI3 / IL-27B as low as 15.6 picograms per milliliter.

About EBI3 / IL-27B: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. (more)

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Mouse GC / Vitamin D-Binding Protein ELISA Kit (Sandwich ELISA) - LS-F12959

LS-F12959 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse GC / Vitamin D-Binding Protein in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GC / Vitamin D-Binding Protein as low as 1.56 nanograms per millilter.

About GC / Vitamin D-Binding Protein: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. (more)

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Mouse Osteocalcin ELISA Kit (Sandwich ELISA) - LS-F12227

LS-F12227 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Osteocalcin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Osteocalcin as low as 15.6 picograms per milliliter.

About Osteocalcin: Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone. (more)

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Human IGF2 ELISA Kit (Sandwich ELISA) - LS-F11731

LS-F11731 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human IGF2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IGF2 as low as 0.156 nanograms per millilter.

About IGF2: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. (more)

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Mouse MYC / c-Myc ELISA Kit (Sandwich ELISA) - LS-F16761

LS-F16761 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MYC / c-Myc in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of MYC / c-Myc as low as 15.6 picograms per milliliter.

About MYC / c-Myc: MYC / c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (more)

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Human GBA / Glucosidase Beta Acid ELISA Kit (Sandwich ELISA) - LS-F11544

LS-F11544 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human GBA / Glucosidase Beta Acid in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GBA / Glucosidase Beta Acid as low as 0.312 nanograms per millilter.

About GBA / Glucosidase Beta Acid: GBA / Glucosidase Beta Acid encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. (more)

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IP3 / Inositol Trisphosphate ELISA Kit (Competitive EIA) - LS-F10644

LS-F10644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of IP3 / Inositol Trisphosphate in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IP3 / Inositol Trisphosphate as low as 0.625 nanograms per millilter. (more)

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Human DNASE1 / DNase I ELISA Kit (Sandwich ELISA) - LS-F11310

LS-F11310 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human DNASE1 / DNase I in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of DNASE1 / DNase I as low as 0.156 nanograms per millilter.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Human CDKN2A / p16INK4a ELISA Kit (Sandwich ELISA) - LS-F11076

LS-F11076 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CDKN2A / p16INK4a in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CDKN2A / p16INK4a as low as 1.56 nanograms per millilter.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Human CFL1 / Cofilin ELISA Kit (Sandwich ELISA) - LS-F17911

LS-F17911 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CFL1 / Cofilin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CFL1 / Cofilin as low as 0.156 nanograms per millilter.

About CFL1 / Cofilin: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. (more)

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Pig Angiotensin II ELISA Kit (Competitive EIA) - LS-F23294

LS-F23294 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Pig Angiotensin II in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of Angiotensin II as low as 15.63 picograms per milliliter.

About Angiotensin II: Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. (more)

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Human SCG2 / Secretogranin II ELISA Kit (Sandwich ELISA) - LS-F22872

LS-F22872 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SCG2 / Secretogranin II in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SCG2 / Secretogranin II as low as 1.25 nanograms per millilter.

About SCG2 / Secretogranin II: SCG2 / Secretogranin II is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (more)

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Mouse HDAC6 ELISA Kit (Sandwich ELISA) - LS-F9209

LS-F9209 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse HDAC6 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HDAC6 as low as 0.156 nanograms per millilter.

About HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. (more)

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Human Exendin 4 ELISA Kit (Sandwich ELISA) - LS-F26844

LS-F26844 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human Exendin 4 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Exendin 4 as low as 0.5 nanograms per millilter. (more)

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Mouse SSB / La ELISA Kit (Sandwich ELISA) - LS-F9593

LS-F9593 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse SSB / La in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SSB / La as low as 0.156 nanograms per millilter.

About SSB / La: SSB / La is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. (more)

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Mouse LYZ / Lysozyme ELISA Kit (Sandwich ELISA) - LS-F24252

LS-F24252 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse LYZ / Lysozyme in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of LYZ / Lysozyme as low as 125 picograms per milliliter.

About LYZ / Lysozyme: LYZ / Lysozyme is human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. (more)

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Rat ENPP2 / Autotaxin ELISA Kit (Sandwich ELISA) - LS-F25363

LS-F25363 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat ENPP2 / Autotaxin in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ENPP2 / Autotaxin as low as 0.156 nanograms per millilter.

About ENPP2 / Autotaxin: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. (more)

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Most Popular Proteins
Human CELA3B / ELA3B Recombinant (His, N-Terminal) Protein (aa29-270) - LS-G15434

LS-G15434 is a purified Human CELA3B / ELA3B recombinant protein generated in E. coli. This protein has been engineered to contain a His, N-Terminal tag.

About CELA3B / ELA3B: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. (more)

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Human TMEM173 / STING Recombinant (His, N-Terminal) Protein (Leu159-Pro373) - LS-G16258

LS-G16258 is a purified Human TMEM173 / STING recombinant protein generated in E. coli. This protein has been engineered to contain a His, N-Terminal tag.

About TMEM173 / STING: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. (more)

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Cynomolgus monkey TTR / Transthyretin Recombinant (His) Protein (aa21-147) - LS-G21296

LS-G21296 is a Cynomolgus monkey TTR / Transthyretin recombinant protein generated in E. coli. This protein has been engineered to contain a His tag.

About TTR / Transthyretin: TTR / Transthyretin is transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. (more)

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Human CELA1 / Pancreatic Elastase 1 Recombinant (His + GST, N-Terminal) Protein - LS-G24338

LS-G24338 is a purified Human CELA1 / Pancreatic Elastase 1 recombinant protein generated in E. coli. This protein has been engineered to contain a His + GST, N-Terminal tag.

About CELA1 / Pancreatic Elastase 1: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. (more)

Human CELA3A / ELA3 Recombinant (His + GST, N-Terminal) Protein - LS-G25435

LS-G25435 is a purified Human CELA3A / ELA3 recombinant protein generated in E. coli. This protein has been engineered to contain a His + GST, N-Terminal tag.

About CELA3A / ELA3: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. (more)


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