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  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Antibodies
Antibodies

We have a collection of over 250,000 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry.

ELISA Kits
ELISA Kits

ELISA Kits are a fast, cost effective way to measure the presence of specific protein or molecular analytes in a variety of sample types, such as urine, cell lysates, and in vitro. We offer multiple types of immunoassays, covering 1000's of analytes, in order to meet your specific needs.

Proteins
Proteins

Proteins can be used in a wide variety of applications, such as for the development of functional assays, small-molecule screening, receptor activation in-situ, or simply as controls for a Western Blot. We offer extracted native proteins and recombinant proteins in the form of cell lysates, or purified from bacterial or mammalian expression systems. Many proteins are bio-active and certified low-endotoxin.

Immunohistochemistry
Immunohistochemistry

Over the past 20 years we've conducted 1000's of custom IHC studies. Our staff of pathologists are experienced in designing effective IHC studies and interpreting the results in relation to normal and disease processes. These services are supported by our massive tissue bank that contains virtually every tissue type and disease.

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Most Popular Antibodies
Anti-GPR39 Antibody (Extracellular Domain) IHC-plus™ LS-A139

LS-A139 is a rabbit anti-GPR39 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About GPR39: Zn2+ acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. (more)

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Anti-GPR65 / TDAG8 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1625

LS-A1625 is a rabbit anti-GPR65 / TDAG8 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About GPR65 / TDAG8: GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1 (Wang et al. 2004.) (more)

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Anti-PTGER4 / EP4 Antibody (N-Terminus) IHC-plus™ LS-A3898

LS-A3898 is a rabbit anti-PTGER4 / EP4 polyclonal antibody approved for use in Immunocytochemistry and Immunohistochemistry - Paraffin.

About PTGER4 / EP4: PTGER4 / EP4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. (more)

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Anti-OXTR / Oxytocin Receptor Antibody (N-Terminus) IHC-plus™ LS-A3878

LS-A3878 is a rabbit anti-OXTR / Oxytocin Receptor polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About OXTR / Oxytocin Receptor: The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect. (more)

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Anti-IGF1R / IGF1 Receptor Antibody (C-Terminus) LS-C24709

LS-C24709 is a rabbit anti-IGF1R / IGF1 Receptor polyclonal antibody approved for use in Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About IGF1R / IGF1 Receptor: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. (more)

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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

LS-B1347 is a rabbit anti-CDKN2A / p16INK4a polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About CDKN2A / p16INK4a: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. (more)

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Anti-PKM / Pyruvate Kinase, Muscle Antibody IHC-plus™ LS-B1450

LS-B1450 is a goat anti-PKM / Pyruvate Kinase, Muscle polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Immunoprecipitation and Western blot.

About PKM / Pyruvate Kinase, Muscle: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. (more)

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Anti-RORC / ROR Gamma Antibody (aa1-50) IHC-plus™ LS-B1797

LS-B1797 is a rabbit anti-RORC / ROR Gamma polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About RORC / ROR Gamma: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (more)

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Anti-CXCR4 Antibody (clone 12G5) IHC-plus™ LS-B1986

LS-B1986 is a mouse anti-CXCR4 monoclonal antibody approved for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. (more)

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Anti-V5 Tag Antibody (clone SV5-Pk1) LS-C57305

LS-C57305 is a mouse anti-V5 Tag monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Frozen, Immunoprecipitation, Radioimmunoassay and Western blot.

About V5 Tag: V5 Tag, GKPIPNPLLGLDST, is from the C-terminal sequence of the P and V proteins of Simian Virus 5. (more)

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Anti-LAG3 Antibody (aa70-99, clone 17B4, FITC) IHC-plus™ LS-B2237

LS-B2237 is a Fluorescein mouse anti-LAG3 monoclonal antibody approved for use in Flow Cytometry and Immunohistochemistry - Paraffin.

About LAG3: Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. (more)

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Anti-TNFSF15 / TL1A / VEGI Antibody (N-Terminus) IHC-plus™ LS-B2406

LS-B2406 is a rabbit anti-TNFSF15 / TL1A / VEGI polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About TNFSF15 / TL1A / VEGI: TNFSF15 / TL1A / VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Anti-AMACR / P504S Antibody (clone 13H4) LS-C88844

LS-C88844 is a rabbit anti-AMACR / P504S monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About AMACR / P504S: AMACR / P504S is a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. (more)

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Anti-STEAP1 / STEAP Antibody (aa1-70, clone J2D2) IHC-plus™ LS-B3003

LS-B3003 is a mouse anti-STEAP1 / STEAP monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About STEAP1 / STEAP: Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. (more)

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Anti-CD9 Antibody (clone SN4/C3-3A2, Biotin) LS-C105919

LS-C105919 is a Biotin mouse anti-CD9 monoclonal antibody approved for use in Flow Cytometry.

About CD9: CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. (more)

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Anti-SLC18A2 / VMAT2 Antibody (clone 9E11) LS-C114605

LS-C114605 is a mouse anti-SLC18A2 / VMAT2 monoclonal antibody approved for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About SLC18A2 / VMAT2: Slc18a2 (Solute carrier family 18 (Vesicular monoamine), Member 2), is also known as VMAT2 (Vesicular monoamine transporter 2) or SVMT (Synaptic vesicular monoamine transporter, brain) or SVAT (Synaptic vesicular amine transporter, brain). This transporter supports the accumulation of cytosolic monoamines by synaptic vesicles. Its function is essential for the correct activity of the monoaminergic brain system. Reduced expression of the Slc18a2 is associated with several neuropsychiatric disorders, such as dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease. Slc18a2 transporter is a site of action of important drugs, including reserpine and tetrabenazine. (more)

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Anti-TOM20 Antibody (clone 4F3) IHC-plus™ LS-B4488

LS-B4488 is a mouse anti-TOM20 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry - Paraffin and Western blot.

About TOM20: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. (more)

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Anti-PECAM-1 / CD31 Antibody IHC-plus™ LS-B4737

LS-B4737 is a rabbit anti-PECAM-1 / CD31 polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About PECAM-1 / CD31: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. (more)

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Anti-PLIN2 / ADFP / Adipophilin Antibody IHC-plus™ LS-B4850

LS-B4850 is a rabbit anti-PLIN2 / ADFP / Adipophilin polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PLIN2 / ADFP / Adipophilin: PLIN2 / ADFP / Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. (more)

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Anti-BTLA / CD272 Antibody (clone ANC6E9, Azide-free) LS-C134635

LS-C134635 is a mouse anti-BTLA / CD272 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Flow Cytometry.

About BTLA / CD272: BTLA / CD272 is a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. (more)

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Anti-TNFSF4 / OX40L Antibody (clone ANC10G1, Biotin) LS-C134809

LS-C134809 is a Biotin mouse anti-TNFSF4 / OX40L monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Flow Cytometry and Functional Assay.

About TNFSF4 / OX40L: TNFSF4 / OX40L is a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. (more)

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Anti-FAP Alpha Antibody (Extracellular Domain) IHC-plus™ LS-A8023

LS-A8023 is a rabbit anti-FAP Alpha polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About FAP Alpha: Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). (more)

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Anti-IL36B Antibody (clone 1E4) LS-C139455

LS-C139455 is a mouse anti-IL36B monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Western blot.

About IL36B: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. (more)

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Anti-CEACAM8 / CD66b Antibody (clone 80H3) IHC-plus™ LS-B7134

LS-B7134 is a mouse anti-CEACAM8 / CD66b monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin.

About CEACAM8 / CD66b: Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a human gene. Its main function is cell adhesion, cell migration, and pathogen binding. (more)

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Anti-CTSS / Cathepsin S Antibody IHC-plus™ LS-B7312

LS-B7312 is a mouse anti-CTSS / Cathepsin S monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay and Immunohistochemistry - Paraffin.

About CTSS / Cathepsin S: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. (more)

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Anti-IL17A Antibody IHC-plus™ LS-B7397

LS-B7397 is a rabbit anti-IL17A polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin, Neutralization and Western blot.

About IL17A: IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (more)

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Anti-HSPA5 / GRP78 / BiP Antibody (aa541-568) LS-C165063

LS-C165063 is a rabbit anti-HSPA5 / GRP78 / BiP polyclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About HSPA5 / GRP78 / BiP: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. (more)

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Anti-HLA-A24 Antibody (clone 22E1, PE) LS-C179737

LS-C179737 is a Phycoerythrin mouse anti-HLA-A24 monoclonal antibody approved for use in Flow Cytometry.

About HLA-A24: HLA (human leukocyte antigen)-A24 is a class I MHC antigen. It is the most frequent HLA class I molecule in Asian populations, present in 70% of Japanese. It is also found in 35% of Indians and 19% of Caucasians. (more)

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Anti-SATB2 Antibody (clone SATBA4B10) LS-C184274

LS-C184274 is a mouse anti-SATB2 monoclonal antibody approved for use in Dot Blot, Immunocytochemistry, Immunoprecipitation and Western blot.

About SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. (more)

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Anti-CD300A Antibody (clone P192, FITC) LS-C187547

LS-C187547 is a Fluorescein mouse anti-CD300A monoclonal antibody approved for use in Flow Cytometry.

About CD300A: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. (more)

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Anti-ZFP91 Antibody (aa216-245) IHC-plus™ LS-B10151

LS-B10151 is a rabbit anti-ZFP91 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About ZFP91: ZFP91 is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. (more)

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Anti-MCAM / CD146 Antibody (aa84-189, clone 6C3F1) LS-C285856

LS-C285856 is a mouse anti-MCAM / CD146 monoclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About MCAM / CD146: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. (more)

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Anti-Spectrin Antibody (clone RBC2/3D5) LS-C312169

LS-C312169 is a mouse anti-Spectrin monoclonal antibody approved for use in Immunohistochemistry - Frozen and Immunohistochemistry - Paraffin. (more)

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Anti-COMMD1 Antibody (clone 1F2) LS-C337778

LS-C337778 is a mouse anti-COMMD1 monoclonal antibody approved for use in Flow Cytometry, Immunohistochemistry - Paraffin and Western blot.

About COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. (more)

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Anti-CD20 Antibody IHC-plus™ LS-B12186

LS-B12186 is a rabbit anti-CD20 polyclonal antibody approved for use in Enzyme-Linked Immunosorbent Assay, Immunohistochemistry - Paraffin and Western blot.

About CD20: CD20 is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. (more)

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Anti-PVR / CD155 Antibody IHC-plus™ LS-B12331

LS-B12331 is a rabbit anti-PVR / CD155 polyclonal antibody approved for use in Immunohistochemistry - Paraffin and Western blot.

About PVR / CD155: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. (more)

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Anti-CDH1 / E Cadherin Antibody IHC-plus™ LS-B12414

LS-B12414 is a goat anti-CDH1 / E Cadherin polyclonal antibody approved for use in Immunohistochemistry - Paraffin.

About CDH1 / E Cadherin: CDH1 / E Cadherin is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. (more)

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Anti-EMA / MUC1 Antibody (clone GP1.4, Azide-free) IHC-plus™ LS-B12807

LS-B12807 is a mouse anti-EMA / MUC1 monoclonal antibody approved for use in Immunohistochemistry - Paraffin.

About EMA / MUC1: EMA / MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. (more)

Immunohistochemistry - Paraffin Image
Most Popular ELISA Kits
Mouse LPL / Lipoprotein Lipase ELISA Kit (Sandwich ELISA) - LS-F4201

LS-F4201 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse LPL / Lipoprotein Lipase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LPL / Lipoprotein Lipase as low as 15.6 picograms per milliliter.

About LPL / Lipoprotein Lipase: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. (more)

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Mouse/Human/Rat LGALS3 / Galectin 3 ELISA Kit (Cell-Based ELISA) - LS-F2009

LS-F2009 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LGALS3 / Galectin 3 in samples of Adherent Cell Cultures. It is based upon a Cell-Based assay principle.

About LGALS3 / Galectin 3: LGALS3 / Galectin 3 is a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. (more)

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Human HMG1 / HMGB1 ELISA Kit (Sandwich ELISA) - LS-F4038

LS-F4038 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human HMG1 / HMGB1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of HMG1 / HMGB1 as low as 62.5 picograms per milliliter.

About HMG1 / HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. (more)

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Mouse Complement C3a ELISA Kit (Sandwich ELISA) - LS-F4210

LS-F4210 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse Complement C3a in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Complement C3a as low as 15.6 picograms per milliliter.

About Complement C3a: C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue peptide that binds to the C3a receptor (C3aR) a class A G protein-coupled receptor. It stimulates mast cell degranulation, thus triggering an immune response. C3a plays an important role in chemotaxis, though not as important a role as C5a. It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B. Because C3a is rapidly degraded in serum, stable small molecule agonists and antagonists may be used as tools to probe the physiological effects of C3a in vivo. (more)

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Human DNASE1 / DNase I ELISA Kit (Sandwich ELISA) - LS-F4463

LS-F4463 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human DNASE1 / DNase I in samples of Plasma, Saliva, Seminal Plasma, Serum and Urine. It is based upon a Sandwich assay principle and can be used to detect levels of DNASE1 / DNase I as low as 78 picograms per milliliter.

About DNASE1 / DNase I: DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (more)

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Human PTHLH / PTHRP ELISA Kit (Competitive EIA) - LS-F4270

LS-F4270 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PTHLH / PTHRP in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of PTHLH / PTHRP as low as 12.35 picograms per milliliter.

About PTHLH / PTHRP: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. (more)

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Human BPI ELISA Kit (Sandwich ELISA) - LS-F4494

LS-F4494 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human BPI in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BPI as low as 12.5 picograms per milliliter.

About BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. (more)

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Human SOD2 / Mn SOD ELISA Kit (Sandwich ELISA) - LS-F4420

LS-F4420 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SOD2 / Mn SOD in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SOD2 / Mn SOD as low as 0.781 nanograms per millilter.

About SOD2 / Mn SOD: MNSOD / SOD2 is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (more)

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Rat PLG / Plasmin / Plasminogen ELISA Kit (Sandwich ELISA) - LS-F4994

LS-F4994 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat PLG / Plasmin / Plasminogen in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PLG / Plasmin / Plasminogen as low as 15.6 nanograms per millilter.

About PLG / Plasmin / Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. (more)

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Mouse MMP7 / Matrilysin ELISA Kit (Sandwich ELISA) - LS-F5515

LS-F5515 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse MMP7 / Matrilysin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of MMP7 / Matrilysin as low as 15.6 picograms per milliliter.

About MMP7 / Matrilysin: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (more)

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Human CTSK / Cathepsin K ELISA Kit (Sandwich ELISA) - LS-F4596

LS-F4596 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CTSK / Cathepsin K in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTSK / Cathepsin K as low as 15.63 picograms per milliliter.

About CTSK / Cathepsin K: CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. (more)

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Human Collagen I ELISA Kit (Sandwich ELISA) - LS-F5275

LS-F5275 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Collagen I in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Collagen I as low as 62.5 picograms per milliliter.

About Collagen I: Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is encoded by the COL1A1 gene. Collagen alpha-2(I) chain is encoded by the COL1A2 gene. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. (more)

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Human CRH / CRF ELISA Kit (Competitive EIA) - LS-F5352

LS-F5352 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CRH / CRF in samples of Plasma and Serum. It is based upon a Competitive EIA assay principle and can be used to detect levels of CRH / CRF as low as 12.35 picograms per milliliter.

About CRH / CRF: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. (more)

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Human GLP1 / Glucagon-Like Peptide 1 ELISA Kit (Competitive EIA) - LS-F5658

LS-F5658 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GLP1 / Glucagon-Like Peptide 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of GLP1 / Glucagon-Like Peptide 1 as low as 12.35 picograms per milliliter.

About GLP1 / Glucagon-Like Peptide 1: Glucagon-like peptide-1 (GLP-1) is an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. Those peptides result from selective cleavage of the proglucagon molecule. (more)

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Human GSN / Gelsolin ELISA Kit (Sandwich ELISA) - LS-F5675

LS-F5675 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human GSN / Gelsolin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of GSN / Gelsolin as low as 62.5 picograms per milliliter.

About GSN / Gelsolin: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. (more)

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Human CYP19 / Aromatase ELISA Kit (Sandwich ELISA) - LS-F6192

LS-F6192 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CYP19 / Aromatase in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CYP19 / Aromatase as low as 0.066 nanograms per millilter.

About CYP19 / Aromatase: CYP19 / Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. (more)

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Mouse ARG1 / Arginase 1 ELISA Kit (Sandwich ELISA) - LS-F6864

LS-F6864 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse ARG1 / Arginase 1 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ARG1 / Arginase 1 as low as 0.156 nanograms per millilter.

About ARG1 / Arginase 1: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. (more)

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Pig Trypsin ELISA Kit (Sandwich ELISA) - LS-F6198

LS-F6198 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig Trypsin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Trypsin as low as 1.56 nanograms per millilter.

About Trypsin: Trypsin is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is produced in the pancreas as the inactive protease trypsinogen, which is encoded by several genes (PRSS1, PRSS2, PRSS3). Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. (more)

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Human LTA4H / LTA4 ELISA Kit (Sandwich ELISA) - LS-F6921

LS-F6921 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human LTA4H / LTA4 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of LTA4H / LTA4 as low as 0.312 nanograms per millilter.

About LTA4H / LTA4: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. (more)

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Mouse CTGF ELISA Kit (Sandwich ELISA) - LS-F5553

LS-F5553 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CTGF in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CTGF as low as 31.2 picograms per milliliter.

About CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. (more)

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Mouse C5b-9 Terminal Complement Complex / TCC ELISA Kit (Sandwich ELISA) - LS-F6103

LS-F6103 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse C5b-9 Terminal Complement Complex / TCC in samples of Plasma and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of C5b-9 Terminal Complement Complex / TCC as low as 78 picograms per milliliter.

About C5b-9 Terminal Complement Complex / TCC: The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. (more)

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Human SCG2 / Secretogranin II ELISA Kit (Sandwich ELISA) - LS-F7028

LS-F7028 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SCG2 / Secretogranin II in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SCG2 / Secretogranin II as low as 0.57 nanograms per millilter.

About SCG2 / Secretogranin II: SCG2 / Secretogranin II is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (more)

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Human Properdin / CFP ELISA Kit (Sandwich ELISA) - LS-F6408

LS-F6408 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human Properdin / CFP in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Properdin / CFP as low as 15.6 nanograms per millilter.

About Properdin / CFP: Properdin / CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Mouse IDO1 / IDO ELISA Kit (Sandwich ELISA) - LS-F7495

LS-F7495 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse IDO1 / IDO in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of IDO1 / IDO as low as 15.63 picograms per milliliter.

About IDO1 / IDO: IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. (more)

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Human FGF11 / FGF-11 ELISA Kit (Sandwich ELISA) - LS-F6976

LS-F6976 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FGF11 / FGF-11 in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of FGF11 / FGF-11 as low as 5.9 picograms per milliliter.

About FGF11 / FGF-11: FGF11 / FGF-11 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. (more)

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Human FGF12 ELISA Kit (Sandwich ELISA) - LS-F6977

LS-F6977 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human FGF12 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FGF12 as low as 8.1 picograms per milliliter.

About FGF12: FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (more)

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Human TSG101 ELISA Kit (Sandwich ELISA) - LS-F8581

LS-F8581 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TSG101 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TSG101 as low as 0.31 nanograms per millilter.

About TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. (more)

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Mouse KRT18 / CK18 / Cytokeratin 18 ELISA Kit (Sandwich ELISA) - LS-F8614

LS-F8614 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse KRT18 / CK18 / Cytokeratin 18 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of KRT18 / CK18 / Cytokeratin 18 as low as 78.5 picograms per milliliter.

About KRT18 / CK18 / Cytokeratin 18: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. (more)

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Human CDX2 ELISA Kit (Sandwich ELISA) - LS-F8623

LS-F8623 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human CDX2 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CDX2 as low as 0.156 nanograms per millilter.

About CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. (more)

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Mouse NQO1 ELISA Kit (Sandwich ELISA) - LS-F7100

LS-F7100 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse NQO1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NQO1 as low as 0.312 nanograms per millilter.

About NQO1: NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (more)

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Human SLC40A1 / Ferroportin-1 ELISA Kit (Sandwich ELISA) - LS-F7703

LS-F7703 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human SLC40A1 / Ferroportin-1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SLC40A1 / Ferroportin-1 as low as 0.312 nanograms per millilter.

About SLC40A1 / Ferroportin-1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). (more)

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Human PADI4 / PAD4 ELISA Kit (Sandwich ELISA) - LS-F7962

LS-F7962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PADI4 / PAD4 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PADI4 / PAD4 as low as 0.312 nanograms per millilter.

About PADI4 / PAD4: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. (more)

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Human TICAM1 / TRIF ELISA Kit (Sandwich ELISA) - LS-F8865

LS-F8865 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human TICAM1 / TRIF in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TICAM1 / TRIF as low as 78.13 picograms per milliliter.

About TICAM1 / TRIF: TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3. TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kB. (more)

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Human PTHR / PTHR1 ELISA Kit (Sandwich ELISA) - LS-F8828

LS-F8828 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human PTHR / PTHR1 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PTHR / PTHR1 as low as 0.313 nanograms per millilter.

About PTHR / PTHR1: PTHR / PTHR1 is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. (more)

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Ovalbumin ELISA Kit (Sandwich ELISA) - LS-F9540

LS-F9540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Ovalbumin in samples of Cell Culture Supernatants, Cell Lysates, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Ovalbumin as low as 78.5 picograms per milliliter.

About Ovalbumin: Non-inhibitory serpin. Storage protein of egg white. (more)

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Human NKX2-1 / Thyroid-Specific TF ELISA Kit (Sandwich ELISA) - LS-F9011

LS-F9011 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Human NKX2-1 / Thyroid-Specific TF in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NKX2-1 / Thyroid-Specific TF as low as 0.156 nanograms per millilter.

About NKX2-1 / Thyroid-Specific TF: TTF-1 / Thyroid-Specific TF is a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. (more)

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Mouse CS / Citrate Synthase ELISA Kit (Sandwich ELISA) - LS-F9531

LS-F9531 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CS / Citrate Synthase in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CS / Citrate Synthase as low as 1.56 nanograms per millilter.

About CS / Citrate Synthase: The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. (more)

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Human HMMR / CD168 / RHAMM ELISA Kit (Sandwich ELISA) - LS-F11646

LS-F11646 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMMR / CD168 / RHAMM in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMMR / CD168 / RHAMM as low as 15.6 picograms per milliliter.

About HMMR / CD168 / RHAMM: The receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts. In human, it is expressed as an intracellular protein in breast cancer cells. No correlation between the level of HMMR mRNA and protein expression with known metastatic/malignant potential of the tumor cell lines was observed. (more)

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Bovine BMP2 ELISA Kit (Sandwich ELISA) - LS-F9310

LS-F9310 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Bovine BMP2 in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of BMP2 as low as 15.63 picograms per milliliter.

About BMP2: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. (more)

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Human NOG / Noggin ELISA Kit (Sandwich ELISA) - LS-F12164

LS-F12164 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human NOG / Noggin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NOG / Noggin as low as 0.156 nanograms per millilter.

About NOG / Noggin: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. (more)

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Human AMH / Anti-Mullerian Hormone ELISA Kit (Sandwich ELISA) - LS-F12040

LS-F12040 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human AMH / Anti-Mullerian Hormone in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of AMH / Anti-Mullerian Hormone as low as 0.78 nanograms per millilter.

About AMH / Anti-Mullerian Hormone: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. (more)

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Mouse Cortisol ELISA Kit (Competitive EIA) - LS-F10026

LS-F10026 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse Cortisol in samples of Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of Cortisol as low as 0.049 nanograms per millilter. (more)

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Human ACTA2 / Smooth Muscle Actin ELISA Kit (Sandwich ELISA) - LS-F13051

LS-F13051 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human ACTA2 / Smooth Muscle Actin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of ACTA2 / Smooth Muscle Actin as low as 3.12 nanograms per millilter.

About ACTA2 / Smooth Muscle Actin: ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. (more)

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Mouse CD33 ELISA Kit (Sandwich ELISA) - LS-F9886

LS-F9886 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Mouse CD33 in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of CD33 as low as 0.156 nanograms per millilter.

About CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). (more)

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Mouse SST / Somatostatin ELISA Kit (Sandwich ELISA) - LS-F12622

LS-F12622 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse SST / Somatostatin in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SST / Somatostatin as low as 7.8 picograms per milliliter.

About SST / Somatostatin: The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. (more)

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Rat NT-proBNP ELISA Kit (Competitive EIA) - LS-F13010

LS-F13010 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat NT-proBNP in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of NT-proBNP as low as 15.6 picograms per milliliter. (more)

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Lipopolysaccharide / LPS ELISA Kit (Sandwich ELISA) - LS-F17912

LS-F17912 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Lipopolysaccharide / LPS in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of Lipopolysaccharide / LPS as low as 0.78 nanograms per millilter.

About Lipopolysaccharide / LPS: Lipopolysaccharides (LPS), also known as lipoglycans and endotoxin, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals. (more)

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Human PDCD1 / CD279 / PD-1 ELISA Kit (Sandwich ELISA) - LS-F12279

LS-F12279 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human PDCD1 / CD279 / PD-1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of PDCD1 / CD279 / PD-1 as low as 0.156 nanograms per millilter.

About PDCD1 / CD279 / PD-1: PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (more)

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Pig S100A12 ELISA Kit (Sandwich ELISA) - LS-F17699

LS-F17699 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Pig S100A12 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of S100A12 as low as 0.156 nanograms per millilter.

About S100A12: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. (more)

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Human SLC11A2 / DMT1 ELISA Kit (Sandwich ELISA) - LS-F12192

LS-F12192 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SLC11A2 / DMT1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of SLC11A2 / DMT1 as low as 15.6 picograms per milliliter.

About SLC11A2 / DMT1: Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate. SLC11A2 has been demonstrated on the apical membrane of duodenal enterocytes, transferrin cycle endosomes in erythroid precursors, hepatocytes where it has been postulated to be involved in non-transferrin-bound iron uptake, and placenta where it has been implicated in transfer of iron from mother to fetus. (more)

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Rat FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F21607

LS-F21607 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat FLT1 / VEGFR1 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of FLT1 / VEGFR1 as low as 0.16 nanograms per millilter.

About FLT1 / VEGFR1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). (more)

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Rat TIMP2 ELISA Kit (Sandwich ELISA) - LS-F2962

LS-F2962 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat TIMP2 in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of TIMP2 as low as 10 picograms per milliliter.

About TIMP2: TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. (more)

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Human HMG2 / HMGB2 ELISA Kit (Sandwich ELISA) - LS-F11643

LS-F11643 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human HMG2 / HMGB2 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of HMG2 / HMGB2 as low as 0.31 nanograms per millilter.

About HMG2 / HMGB2: HMG2 / HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. (more)

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Human CD38 ELISA Kit (Sandwich ELISA) - LS-F22857

LS-F22857 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human CD38 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of CD38 as low as 0.938 nanograms per millilter.

About CD38: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. (more)

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Mouse NTx-I ELISA Kit (Sandwich ELISA) - LS-F21840

LS-F21840 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse NTx-I in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of NTx-I as low as 3.13 nanograms per millilter. (more)

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Human TPSAB1 / Mast Cell Tryptase ELISA Kit (Sandwich ELISA) - LS-F13484

LS-F13484 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human TPSAB1 / Mast Cell Tryptase in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of TPSAB1 / Mast Cell Tryptase as low as 1.56 nanograms per millilter.

About TPSAB1 / Mast Cell Tryptase: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. (more)

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IP3 / Inositol Trisphosphate ELISA Kit (Competitive EIA) - LS-F10644

LS-F10644 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of IP3 / Inositol Trisphosphate in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Competitive EIA assay principle and can be used to detect levels of IP3 / Inositol Trisphosphate as low as 0.625 nanograms per millilter. (more)

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Rat COL1A1 / Collagen I Alpha 1 ELISA Kit (Sandwich ELISA) - LS-F11152

LS-F11152 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat COL1A1 / Collagen I Alpha 1 in samples of Cell Culture Supernatants, Plasma, Serum and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of COL1A1 / Collagen I Alpha 1 as low as 1.56 nanograms per millilter.

About COL1A1 / Collagen I Alpha 1: COL1A1 / Collagen I Alpha 1 is the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. (more)

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Rat Calprotectin ELISA Kit (Sandwich ELISA) - LS-F22540

LS-F22540 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat Calprotectin in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of Calprotectin as low as 6.25 nanograms per millilter. (more)

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Human SELP / P-Selectin / CD62P ELISA Kit (Sandwich ELISA) - LS-F24453

LS-F24453 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human SELP / P-Selectin / CD62P in samples of Cell Culture Supernatants, Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of SELP / P-Selectin / CD62P as low as 62.5 picograms per milliliter.

About SELP / P-Selectin / CD62P: SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (more)

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Human AKR1B10 ELISA Kit (Sandwich ELISA) - LS-F24019

LS-F24019 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human AKR1B10 in samples of Plasma and Serum. It is based upon a Sandwich assay principle and can be used to detect levels of AKR1B10 as low as 78.1 picograms per milliliter.

About AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. (more)

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Most Popular Proteins
Human HK2 / Hexokinase 2 Recombinant (His) Protein - LS-G3459

LS-G3459 is a Human HK2 / Hexokinase 2 recombinant protein generated in E. coli. This protein has been engineered to contain a His tag and is biologically active.

About HK2 / Hexokinase 2: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. (more)


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