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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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LSBio
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Phone:
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CXCR4

chemokine (C-X-C motif) receptor 4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Name: chemokine (C-X-C motif) receptor 4
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR4, CD184, CD184 antigen, Cmkar4, Cxc chemokine receptor 4, CXCR-4, CXC-R4, D2S201E, FB22, Fusin, HM89, LCR1, NPY3R, NPYRL, NPYY3R, Npyy3, HSY3RR, SDF-1 receptor, WHIM, C-x-c chemokine receptor 4, LESTR, Neuropeptide Y receptor Y3, NPYR
Target Sequences: NM_003467 NP_003458.1 P61073

Publications (5)

1
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55. [PubMed:17289675] [PMC:PMC2366813] Related Antibodies: LS-B1986.
2
VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. Andrew Wragg, Jason A Mellad, Leilani E Beltran, Mikhail Konoplyannikov, Hong San, Sherry Boozer, Robert J. Deans, Anthony Mathur, Robert J Lederman, Jason C Kovacic, and Manfred Boehm. Journal of molecular medicine (Berlin, Germany). 2008 86:1221-32. (WB, Flo; Mouse, Rat) [Full Text Article] [PubMed:18690419] [PMC:PMC2575081]
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36. [PubMed:20231422] [PMC:PMC3373152] Related Antibodies: LS-B1986.
4
Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance. Reaux-Le Goazigo A, Rivat C, Kitabgi P, Pohl M, Melik Parsadaniantz S. The European journal of neuroscience. 2012 Sep;36:2619-31. [Full Text Article] [PubMed:22694179] Related Antibodies: LS-A1380.
5
CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2. Ghosh MC, Makena PS, Gorantla V, Sinclair SE, Waters CM. American journal of physiology. Lung cellular and molecular physiology. 2012 May;302:L846-56. [Full Text Article] [PubMed:22345572] [PMC:PMC3362158] Related Antibodies: LS-C250.
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Viewing 1-25 of 156 items
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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(1) Publication(s)
Rabbit Polyclonal to Human CXCR4
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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(2) Publication(s)
Mouse Monoclonal [clone 12G5] (IgG2a) to Human CXCR4
Human, Monkey, Baboon
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50µg   0.5mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
Rabbit Polyclonal to Human CXCR4
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal (IgG) to Mouse CXCR4
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR4
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   0.7mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, astrocytes microglia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human CXCR4
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Mouse CXCR4
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human CXCR4
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
CXCR4 Antibody - Western blot of 15 ug of whole cell lysate from HeLa cells with anti-CXCR4 at 1 ug/ml.
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Rabbit Polyclonal (IgG) to Human CXCR4
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µg   100µl   1mg/ml   $335.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human CXCR4
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Human CXCR4
Human
ELISA, WB
Unconjugated
100µg   $755.00
CXCR4 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rat Monoclonal [clone A145] (IgG1) to Human CXCR4
Human
Flo
FITC Conjugated
100µl   0.5mg/ml   $355.00
CXCR4 Antibody - Immunohistochemistry of CXCR4 in human spleen tissue with CXCR4 antibody at 5 µg/mL.
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(1) Publication(s)
Rabbit Polyclonal (IgG) to Human CXCR4
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
Unconjugated
0.1mg   1mg/ml   $365.00
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Rat Monoclonal [clone 247506] (IgG2b) to Mouse CXCR4
Mouse
Flo
PE Conjugated
100tst   $605.00
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR4
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
CXCR4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Monoclonal (IgG) to Human CXCR4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   0.89mg/ml   $425.00
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Rabbit Polyclonal to Human CXCR4
Dog, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100µg   $590.00
CXCR4 Antibody - Western blot of CXCR4 expression in K562 cells
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Rabbit Polyclonal to Human CXCR4
Mouse, Rat, Human
IHC, WB
Unconjugated
100µg   1mg/ml   $305.00
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Goat Polyclonal to Zebrafish CXCR4
Zebrafish
Peptide-ELISA
Unconjugated
100µg   0.5mg/ml   $335.00
CXCR4 Antibody - Immunohistochemistry: CXCR4 Antibody - Figure 1 illustrates immunostaining of CXCR4 in human cervical carcinoma tissue sections.
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Rabbit Polyclonal to Human CXCR4
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µl   $335.00
Select
Goat Polyclonal (IgG) to Mouse CXCR4
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
0.1mg   $425.00
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Mouse Monoclonal [clone 12G5] (IgG2a) to Human CXCR4
Human, Non-Human Primates
Flo, Func, ICC, IHC-P
Unconjugated
0.1mg   1mg/ml   $255.00
CXCR4 Antibody - IHC of CXCR4 antibody. Formalin-fixed, paraffin-embedded human spleen.
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Goat Polyclonal to Human CXCR4
Human
ELISA, IHC, IHC-P, WB
Unconjugated
200µg   $475.00
CXCR4 Antibody - Immunohistochemistry of paraffin-embeddedi human spleen stained with Goat anti-Human CD184 (N-terminal)
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Goat Polyclonal (IgG) to Human CXCR4
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1mg   $425.00
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Rabbit Polyclonal (IgG) to Human CXCR4
Human
IHC, IHC-Fr, IP, WB
Unconjugated
100µg   $575.00

Viewing 1-25 of 156 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).