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CASP8 / Caspase 8

caspase 8, apoptosis-related cysteine peptidase

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Gene Name: caspase 8, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP8, ALPS2B, Apoptotic protease Mch-5, Apoptotic cysteine protease, Casp-8, Caspase-8, CAP4, Caspase 8, MACH, MCH5, MORT1-associated ced-3 homolog, ICE-like apoptotic protease 5, Pro Caspase 8, FADD-like ICE, FLICE, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein
Target Sequences: nm_001228 AAC50645.1 Q14790

Publications (2)

1
ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3a/ß signaling in pancreatic cancer. Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Toshiji Saibara. International journal of oncology. 2018 Nov;53:2224-2240. [Full Text Article] [PubMed:30226582] Related Antibodies: LS-C344789.
2
BaxDelta2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. Zhang H, Lin Y, Ma[Character f1]as A, Zhao Y, Denning MF, Ma L, Xiang J. Molecular cancer research : MCR. 2014 Sep;12:1225-32. [Full Text Article] [PubMed:24842234] Related Antibodies: LS-C99287.

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Antibodies (162)
ELISA Kits (29)
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CASP8 / Caspase 8 Antibody - Anti-Caspase 8 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP8 / Caspase 8 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CASP8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa432-461) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CASP8 / Caspase 8 Antibody - Immunofluorescence analysis of U2OS cells using CASP8 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
CASP8 / Caspase 8 Antibody - Western blot analysis of extracts of various cell lines, using Casp8 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CASP8 / Caspase 8 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CASP8 / Caspase 8 Antibody
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal (5F7) Antibody
Human
WB
Unconjugated
100 µg/$425
CASP8 / Caspase 8 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CASP8 / Caspase 8 Antibody - Western blot analysis of Caspase 8 (pY380) expression in HEK293T PMA-treated (A); Jurkat etoposide-treated (B); HeLa PMA-treated (C); H9C2 PMA-treated (D) whole cell lysates.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pTyr380) Antibody
Rat, Human, Monkey
WB
Unconjugated
100 µl/$315
CASP8 / Caspase 8 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (Internal) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal (aa181-478) (C15) Antibody
Human
ICC, IP, WB
Unconjugated
50 µg/$358; 100 µg/$449
CASP8 / Caspase 8 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CASP8 / Caspase 8 Antibody - Anti-Caspase 8 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal (FLICE 4-1-20) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CASP8 / Caspase 8 Antibody
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa7-216) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$289; 200 µl/$323; 500 µl/$435; 1 ml/$491; 2 ml/$605; 5 ml/$1,045
CASP8 / Caspase 8 Antibody - Immunohistochemical analysis of Caspase 8 staining in mouse spleen formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
CASP8 / Caspase 8 Antibody - Western blot using anti-Caspase-8 (mouse), mAb (3B10) detecting endogenous caspase-8 in various mouse cell line, but not in human cell lines.
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CASP8 / Caspase 8 Rat anti-Mouse Monoclonal (3B10) Antibody
Mouse
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$414
CASP8 / Caspase 8 Antibody - Western blot analysis of lysates from LOVO cells treated with UV 15', using Caspase 8 (Phospho-Tyr380) Antibody. The lane on the right is blocked with the phospho peptide.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pTyr380) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP8 / Caspase 8 Antibody - Western blot using anti-Caspase-8 (mouse), mAb (1G12) detecting endogenous caspase-8 in various mouse cell line, but not in human cell lines.
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CASP8 / Caspase 8 Rat anti-Mouse Monoclonal (1G12) Antibody
Mouse
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$414
CASP8 / Caspase 8 Antibody - IHC of paraffin-embedded colon cancer tissues using CASP8 mouse monoclonal antibody with DAB staining.
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal (1H11) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CASP8 / Caspase 8 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded colon cancer tissues with DAB staining using Caspase-8 Monoclonal Antibody.
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
CASP8 / Caspase 8 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa313-362) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CASP8 / Caspase 8 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
CASP8 / Caspase 8 Antibody - Western Blot ;Sample: Recombinant CASP8, Bovine.
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CASP8 / Caspase 8 Mouse anti-Cow Monoclonal (aa25-175) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,393
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CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$351
CASP8 / Caspase 8 Antibody - 1:100 staining rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP8 / Caspase 8 Antibody - 1:100 staining human appendix tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
Viewing 1-25 of 207 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).