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BAX

BCL2-associated X protein

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

Gene Name: BCL2-associated X protein
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BAX, BCL2-associated X protein, Bcl2-L-4, Apoptosis regulator BAX, Bcl-2-like protein 4, BCL2L4
Target Sequences: NM_004324 NP_004315.1 Q07812

Publications (6)

1
Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Arduini A, Serviddio G, Escobar J, Tormos AM, Bellanti F, Via J, Monsalve M, Sastre J. American journal of physiology. Gastrointestinal and liver physiology. 2011 301:G119-27. [PubMed:21415417]
2
Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart. Ayesheh Enayati #, Aref Salehi #, Mostafa Alilou, Hermann Stuppner, Mirali Polshekan, Maryam Rajaei, Mona Pourabouk, Ali Jabbari , Zohreh Mazaheri, Narguess Yassa, Hamid Reza Moheimani, Vahid Khori #. BMC complementary medicine and therapies. 2021 Nov;21:288. [Full Text Article] [PubMed:34823510] [PMC:PMC8620719] Related Antibodies: LS-C353915.
3
GANT61/BI-847325 combination: a new hope in lung cancer treatment. Abdel Halim M El-Kishky, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:144. [Full Text Article] [PubMed:35834029] [PMC:PMC9283175]
4
Myricetin (3,3',4',5,5',7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity. Azher Arafah, Muneeb U Rehman, Ajaz Ahmad, Khalid M AlKharfy, Saeed Alqahtani, Basit L Jan, Nada M Almatroudi. ACS Omega. 2022 February;7:4514-4524. [Full Text Article] [PubMed:35155943] [PMC:PMC8829927]
5
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617]
6
Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training. Mohammad Amin Rajizadeh , Kayvan Khoramipour , Siyavash Joukar, Fatemeh Darvishzadeh-Mahani, Maryam Iranpour, Mohammad Abbas Bejeshk, Maryam Doustaki Zaboli. BMC pulmonary medicine. 2024 January;24:37. [Full Text Article] [PubMed:38233819] [PMC:PMC10792831]
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0.312 - 20 ng/ml
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0.156 - 10 ng/ml
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0.156 - 10 ng/ml
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0.156 - 10 ng/ml
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31.25 - 2000 pg/ml
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1.563 - 100 ng/ml
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0.156 - 10 ng/ml
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0.156 - 10 ng/ml
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0.312 - 20 ng/ml
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0.781 - 50 ng/ml
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1.25 - 80 ng/ml
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1.56 - 100 ng/ml
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0.781 - 50 ng/ml
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0.625 - 40 ng/ml
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78.125 - 5000 pg/ml
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50 - 1000 pg/ml
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50 - 1000 pg/ml
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50 - 1000 pg/ml
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).