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CASP4 / Caspase 4

caspase 4, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease. The rodent homolog is known as Caspase 4 and Caspase 11.

Gene Name: caspase 4, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP4, CASP-4, Casp11, Caspase 4, Caspase-4, Cysteine protease icerel-ii, ICE(rel)-II, ICE(rel)II, ICH-2, Ich-3, ICH2, Protease ICH-2, TX, Tx protease, Caspase 11, ICEREL-II, Mih1/TX, Protease TX
Target Sequences: NM_001225 NP_001216.1 P49662

☰ Filters
Antibodies (128)
ELISA Kits (22)
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CASP4 / Caspase 4 (164)
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CASP4 / Caspase 4 Antibody - Anti-CASP4 / Caspase 4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$545
CASP4 / Caspase 4 Antibody - Western blot of Cleaved-Caspase-4 p20 (Q81) antibody
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (40-120 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP4 / Caspase 4 Antibody - Anti-CASP4 / Caspase 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP4 / Caspase 4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$798
CASP4 / Caspase 4 Antibody - Anti-CASP4 / Caspase 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$1,049
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$729
CASP4 / Caspase 4 Antibody - Immunofluorescence staining of CASP4 in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human CASP4 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
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CASP4 / Caspase 4 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
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CASP4 / Caspase 4 Rabbit anti-Mouse Polyclonal (aa202-217) Antibody
Mouse, Rat
WB
Unconjugated
100 µg/$811
CASP4 / Caspase 4 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic cancer using CASP4 Antibody at dilution of 1:100
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
CASP4 / Caspase 4 Antibody - Western blot of recombinant CASP4 / Caspase 4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (aa290-377) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
CASP4 / Caspase 4 Antibody - Immunohistochemistry - Anti-Caspase 4 Picoband antibody
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP4 / Caspase 4 Antibody - Western blot using anti-Caspase-11 (mouse), mAb (4E11) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
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CASP4 / Caspase 4 Rat anti-Mouse Monoclonal (4E11) Antibody
Mouse, Rat
ELISA, Flo, IP, WB
Unconjugated
100 µg/$435
CASP4 / Caspase 4 Antibody - Western blot using anti-Caspase-11 (mouse), mAb (8A5) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
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CASP4 / Caspase 4 Rat anti-Mouse Monoclonal (8A5) Antibody
Mouse, Rat
ELISA, Flo, IP, WB
Unconjugated
100 µg/$435
CASP4 / Caspase 4 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
36.3 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484
CASP4 / Caspase 4 Antibody - IHC analysis of Caspase 4 using anti-Caspase 4 antibody. Caspase 4 was detected in paraffin-embedded section of human placenta tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Caspase 4 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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CASP4 / Caspase 4 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP4 / Caspase 4 Antibody - CASP4 / Caspase 4 antibody. IHC(P): Human Breast Cancer Tissue.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (aa104-124) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
CASP4 / Caspase 4 Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CASP4 / Caspase 4 Rat anti-Mouse Monoclonal Antibody
Mouse, Rat
Flo, WB
Unconjugated
100 µg/$720
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (N-Terminus) (Concentrated) Antibody
Human
IHC, IHC-P, WB
Unconjugated, Concentrated
0.1 mg/$734
CASP4 / Caspase 4 Antibody - CASP4 monoclonal antibody (M02), clone 7G7. Western Blot analysis of CASP4 expression in HeLa.
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CASP4 / Caspase 4 Mouse anti-Human Monoclonal (7G7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
CASP4 / Caspase 4 Antibody - IHC of Caspase-4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.
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CASP4 / Caspase 4 Rabbit anti-Human Polyclonal (Glu124) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Viewing 1-25 of 164 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).