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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASP4 / Caspase 4

caspase 4, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease. The rodent homolog is known as Caspase 4 and Caspase 11.

Gene Name: caspase 4, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP4, CASP-4, Casp11, Caspase 4, Caspase-4, Cysteine protease icerel-ii, ICE(rel)-II, ICE(rel)II, ICH-2, Ich-3, ICH2, Protease ICH-2, TX, Tx protease, Caspase 11, ICEREL-II, Mih1/TX, Protease TX
Target Sequences: NM_001225 NP_001216.1 P49662

Filtered by: None
Target
CASP4 / Caspase 4 (138)
Reactivity
Human (77)
Mouse (58)
Rat (14)
Bovine (24)
Chimpanzee (6)
Cow (24)
Gibbon (6)
Monkey (2)
Application
IHC (73)
IHC-P (12)
WB (135)
Flo (3)
ELISA (17)
ICC (2)
IF (3)
IP (2)
Peptide-ELISA (5)
Host
rabbit (121)
mouse (11)
goat (1)
chicken (1)
rat (4)
Isotype
IgG (32)
IgG1 (2)
IgG1,k (3)
IgG2a (1)
IgG2a,k (1)
IgY (1)
Clonality
monoclonal mc (15)
polyclonal pc (123)
Clone
4B9 (1)
4E11 (1)
7G7 (1)
8A5 (1)
9F6 (1)
G1/G1-4 (1)
Format
AP Conjugated (1)
APC (9)
APC Conjugated (9)
Biotin Conjugated (15)
Cy3 Conjugated (9)
Cy7 Conjugated (9)
FITC Conjugated (16)
HRP Conjugated (13)
PE Conjugated (10)
Unconjugated (56)
Epitope
aa81-270 (17)
aa290-377 (16)
aa944-1148 (10)
aa286-373 (9)
aa78-265 (8)
aa81-266 (8)
Internal (4)
aa161-210 (4)
aa211-260 (4)
N-Terminus (3)
aa969-1165 (2)
40-120 aa, Internal (1)
C-Terminus (1)
Gln81 (1)
Glu124 (1)
aa1-89 (1)
aa104-124 (1)
aa118-132 (1)
aa163-197 (1)
aa202-217 (1)
aa337-372 (1)
aa62-111 (1)
aa75-124 (1)
aa85-101 (1)
Publications
No (138)
Showing 1-25 of 138 results

CASP4 / Caspase 4 Antibody IHC-plus™ LS-B710
Rabbit Polyclonal to Human CASP4 / Caspase 4
Mouse, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $505.00
Anti-CASP4 / Caspase 4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-CASP4 / Caspase 4 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP4 / Caspase 4 Antibody (40-120 aa, Internal) LS-C380473
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cleaved-Caspase-4 p20 (Q81) antibody
Western blot of Cleaved-Caspase-4 p20 (Q81) antibody

CASP4 / Caspase 4 Antibody IHC-plus™ LS-B3789
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-CASP4 / Caspase 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of Caspase-4 in Mouse Spleen 100 cells with Caspase-4 antibody.

CASP4 / Caspase 4 Antibody LS-C48139
Rabbit Polyclonal to Human CASP4 / Caspase 4
Mouse, Rat, Human
WB
Unconjugated
30µg  $245.00; 100µg 500µl  $405.00
Western blot of Caspase 4 antibody.

CASP4 / Caspase 4 Antibody (aa1-89) IHC-plus™ LS-B728
Chicken Polyclonal (IgY) to Human CASP4 / Caspase 4
Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $485.00
Anti-CASP4 / Caspase 4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

CASP4 / Caspase 4 Antibody IHC-plus™ LS-B3793
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-CASP4 / Caspase 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-CASP4 / Caspase 4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP4 / Caspase 4 Antibody (aa290-377) LS-C293210
Rabbit Polyclonal to Human CASP4 / Caspase 4
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $495.00; 10ml 0.5mg/ml  $1,980.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

CASP4 / Caspase 4 Antibody (N-Terminus) LS-C121481
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Human
IHC IHC-P WB
Unconjugated
100µg  $950.00

CASP4 / Caspase 4 Antibody (N-Terminus) LS-C121482
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Human
IHC IHC-P WB
Unconjugated
100µg  $575.00

CASP4 / Caspase 4 Antibody (C-Terminus) LS-C35307
Rabbit Polyclonal (IgG) to Mouse CASP4 / Caspase 4
Mouse
ELISA WB
Unconjugated
100µg  $755.00

CASP4 / Caspase 4 Antibody (aa202-217) LS-C35304
Rabbit Polyclonal to Mouse CASP4 / Caspase 4
Mouse, Rat
WB
Unconjugated
100µg  $545.00

CASP4 / Caspase 4 Antibody LS-C498510
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Human
ELISA IF IHC WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CASP4 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CASP4 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CASP4 / Caspase 4 Antibody (clone 4E11) LS-C344797
Rat Monoclonal [clone 4E11] (IgG1,k) to Mouse CASP4 / Caspase 4
Mouse, Rat
ELISA Flo IP WB
Unconjugated
100µg  $385.00
Western blot using anti-Caspase-11 (mouse), mAb (4E11) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
Immunoprecipitation of caspase-11 using anti-caspase-11 mAbs (4E11 and 8A5) .

CASP4 / Caspase 4 Antibody (clone 8A5) LS-C344952
Rat Monoclonal [clone 8A5] (IgG1,k) to Mouse CASP4 / Caspase 4
Mouse, Rat
ELISA Flo IP WB
Unconjugated
100µg  $385.00
Western blot using anti-Caspase-11 (mouse), mAb (8A5) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
Immunoprecipitation of caspase-11 using anti-caspase-11 mAbs (4E11 and 8A5) .

CASP4 / Caspase 4 Antibody LS-C662763
Rabbit Polyclonal to Human CASP4 / Caspase 4
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $355.00
Immunohistochemistry - Anti-Caspase 4 Picoband antibody
Immunohistochemistry - Anti-Caspase 4 Picoband antibody

CASP4 / Caspase 4 Antibody LS-C659550
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Human
ELISA IHC WB
Unconjugated
100µg  $405.00

CASP4 / Caspase 4 Antibody LS-C664179
Rabbit Polyclonal to Mouse CASP4 / Caspase 4
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $285.00; 1ml 0.5mg/ml  $485.00; 10ml 0.5mg/ml  $1,935.00
Immunohistochemistry - Paraffin Image
Western blot Image

CASP4 / Caspase 4 Antibody (Internal) LS-C382451
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CASP4 / Caspase 4 Antibody (aa944-1148) LS-C373894
Rabbit Polyclonal to Human CASP4 / Caspase 4
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $245.00; 200µl 0.5mg/ml  $285.00; 1ml 0.5mg/ml  $475.00; 10ml 0.5mg/ml  $1,875.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

CASP4 / Caspase 4 Antibody (N-Terminus) LS-C202788
Rabbit Polyclonal to Human CASP4 / Caspase 4
Human
IHC IHC-P WB
Unconjugated
0.1mg  $680.00

CASP4 / Caspase 4 Antibody LS-C35306
Rat Monoclonal (IgG1) to Mouse CASP4 / Caspase 4
Mouse, Rat
Flo WB
Unconjugated
100µg  $680.00

CASP4 / Caspase 4 Antibody (clone 7G7) LS-C196818
Mouse Monoclonal [clone 7G7] (IgG2a,k) to Human CASP4 / Caspase 4
Human
ELISA WB
Unconjugated
100µg  $355.00
CASP4 monoclonal antibody (M02), clone 7G7. Western Blot analysis of CASP4 expression in HeLa.
Western Blot analysis of CASP4 expression in transfected 293T cell line by CASP4 monoclonal antibody (M02), clone 7G7.Lane 1: CASP4 transfected lysate (Predicted MW: 43.3 KDa).Lane 2: Non-transfected lysate.

CASP4 / Caspase 4 Antibody (Glu124) LS-C177726
Rabbit Polyclonal to Human CASP4 / Caspase 4
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of Caspase-4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of Caspase-4 (E124) pAb in extracts from K562 cells.

CASP4 / Caspase 4 Antibody (aa75-124) LS-C291682
Rabbit Polyclonal (IgG) to Human CASP4 / Caspase 4
Mouse, Rat, Human
IHC Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of Caspase-4 antibody in paraffin-embedded human lung carcinoma tissue.
Western blot analysis of lysate from K562 cells, using Caspase-4 antibody.

CASP4 / Caspase 4 Antibody (aa104-124) LS-C312648
Rabbit Polyclonal to Human CASP4 / Caspase 4
Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
CASP4 / Caspase 4 antibody. IHC(P): Human Breast Cancer Tissue.
WB of CASP4 / Caspase 4 antibody. Lane 1: MCF-7 Cell Lysate. Lane 2: HELA Cell Lysate. Lane 3: JURKAT Cell Lysate . Lane 4: CEM Cell Lysate . Lane 5: SW620 Cell Lysate.
Showing 1-25 of 138 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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