LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Immunohistochemistry Reagents
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Research Areas
  • Cancer Research:
  • Breast Cancer IHC
  • Colorectal Cancer IHC
  • Lung Cancer IHC
  • Prostate Cancer IHC
  • Cell Cycle:
  • Apoptosis
  • Protein Family and Group:
  • Caspases
  • Chemokines
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Reviews
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

CASP6 / Caspase 6

caspase 6, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.

Gene Name: caspase 6, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP6, Apoptotic protease Mch-2, Caspase 6, CASP-6, Caspase-6, Mch-2, MCH2
Target Sequences: NM_001226 NP_001217.2 P55212

Publications (1)

1
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Cell death and differentiation. 2014 21:696-706. (ICC; Human) [Full Text Article] [PubMed:24413155] [PMC:PMC3978300] Related Antibodies: LS-B477.

Filtered By: None
Target
casp6-caspase-6 (130)
Reactivity
Human (100)
Mouse (42)
Rat (29)
Bovine (28)
Chimpanzee (3)
Cow (24)
Dog (3)
Gerbil (3)
Horse (1)
Monkey (3)
Pig (5)
Rabbit (2)
Application
IHC (78)
IHC-Fr (3)
IHC-P (21)
WB (127)
ELISA (39)
ICC (7)
IF (8)
IP (11)
Peptide-ELISA (6)
Host
rabbit (108)
mouse (20)
goat (2)
Isotype
IgG (96)
IgG1 (1)
IgG1,k (8)
Clonality
monoclonal mc (20)
polyclonal pc (110)
Clone
3E8 (1)
6CSP03 (2)
Format
AP Conjugated (6)
APC (4)
APC Conjugated (10)
Azide-free (4)
Biotin Conjugated (13)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
FITC Conjugated (14)
HRP Conjugated (12)
PE Conjugated (10)
Unconjugated (57)
Epitope
aa81-179 (19)
aa194-293 (16)
pSer257 (10)
aa17-45 (8)
aa235-263 (8)
C-Terminus (4)
aa161-210 (4)
Internal (3)
N-Terminus (2)
aa24-293 (2)
Asp162 (1)
Asp179 (1)
Cleavage Site (1)
Cleaved Asp162 (1)
Cleaved Asp179 (1)
Leu251 (1)
aa130-179 (1)
aa144-193 (1)
aa181-193 (1)
aa20-100 (1)
aa200-280 (1)
aa223-272 (1)
aa24-44 (1)
aa253-267 (1)
aa7-27 (1)
Publications
No (129)
Yes (1)
Showing 1-25 out of 130 results
CASP6 / Caspase 6 Antibody (Internal) IHC-plus™ LS-B477
Anti-Caspase 6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B477 concentration 5 ug/ml.
Immunocytochemistry of caspase-6 in MCF7 with caspase-6 antibody at 1 µg/mL.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Human
ICC IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (Cleavage Site) IHC-plus™ LS-B2679
Anti-Caspase 6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2679 concentration 5 ug/ml.

Rabbit Polyclonal (IgG) to Mouse CASP6 / Caspase 6
Rabbit, Mouse, Human
ELISA IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (N-Terminus) IHC-plus™ LS-B1345
Anti-Caspase 6 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1345 concentration 5 ug/ml.
Anti-Caspase 6 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1345 concentration 5 ug/ml.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Human
ICC IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (Cleaved Asp162) LS-C380448
Western blot of Cleaved-Caspase-6 p18 (D162) antibody
Western blot of Cleaved-Caspase-6 p18 (D162) antibody

Rabbit Polyclonal (IgG) to Mouse CASP6 / Caspase 6
Mouse, Rat
ELISA IHC WB
Unconjugated
CASP6 / Caspase 6 Antibody (C-Terminus) IHC-plus™ LS-B8731
Anti-CASP6 / Caspase 6 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot of Caspase 6 antibody LS-B8731.

Rabbit Polyclonal (IgG) to Rat CASP6 / Caspase 6
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (phospho-Ser257) LS-C97423
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-Phospho-Caspase-pS257 in liver cell line lysates (35 ug/lane). Casp6-pS257(arrow) was detected using the purified antibody.

Rabbit Polyclonal to Human CASP6 / Caspase 6
Human
IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa253-267) LS-C204983
CASP6 antibody (0.5 ug/ml) staining of Human Colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Polyclonal to Human CASP6 / Caspase 6
Rabbit, Mouse, Rat, Pig, Horse, Human, Monkey
Peptide-ELISA WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa130-179) IHC-plus™ LS-B7726
Anti-Caspase 6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7726 dilution 10 ug/ml.
Western blot of extracts from 293 cells, treated with Etoposide 25 uM 60', using Caspase 6 (Cleaved-Asp162) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
CASP6 / Caspase 6 Antibody (C-Terminus) LS-C358441
Immunohistochemical analysis of Caspase 6 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Caspase 6 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human CASP6 / Caspase 6
Mouse, Bovine, Rat, Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (Internal) LS-C351920
Immunohistochemical analysis of Caspase 6 p18 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Caspase 6 p18 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human CASP6 / Caspase 6
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (phospho-Ser257) LS-C198728
IHC of paraffin-embedded human colon carcinoma, using Caspase 6 (Phospho-Ser257) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells, using Caspase 6 (Phospho-Ser257) Antibody. The sample on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
CASP6 / Caspase 6 Antibody LS-C658394

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
CASP6 / Caspase 6 Antibody (phospho-Ser257) LS-C380647
Western blot of Phospho-Caspase-6 (S257) antibody

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa200-280) LS-C382456
Western blot of Caspase-6 antibody

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa24-293) LS-C375409
Immunohistochemistry of paraffin-embedded human small intestine tissue using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human tonsil tissue using antibody at 1:100 dilution.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Human
ELISA IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa24-293) LS-C375410
Immunohistochemistry of paraffin-embedded human small intestine tissue using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human tonsil tissue tissue using antibody at 1:100 dilution.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Human
ELISA IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (Leu251) LS-C176265
IHC of Caspase-6 (L251) pAb pAb in paraffin-embedded human lung carcinoma.
Western blot of Caspase-6 (L251) pAb in extracts from HepG2.

Rabbit Polyclonal to Human CASP6 / Caspase 6
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa223-272) LS-C117553
Immunofluorescence of HUVEC cells, using Caspase 6 (Ab-257) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from HepG2/RAW264.7 cells, using Caspase 6 (Ab-257) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Rat, Human
IF IHC Peptide-ELISA WB
Unconjugated
CASP6 / Caspase 6 Antibody (clone 6CSP03, Azide-free) LS-C87557

Mouse Monoclonal [clone 6CSP03] (IgG1,k) to Human CASP6 / Caspase 6
Human
IHC IHC-P IP WB
Unconjugated, Azide-free
CASP6 / Caspase 6 Antibody (aa144-193) LS-C121031
IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from HeLa cells, treated with Etoposide 25 uM 60', using Caspase 6 (Cleaved-Asp162) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Mouse CASP6 / Caspase 6
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa7-27) LS-C343887
Caspase-6(P18) antibody IHC-paraffin: Rat Spleen Tissue.
Caspase-6(P18) antibody IHC-paraffin: Rat Intestine Tissue.

Rabbit Polyclonal to Rat CASP6 / Caspase 6
Mouse, Rat
IHC IHC-Fr IHC-P WB
Unconjugated
CASP6 / Caspase 6 Antibody LS-C77897

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Dog, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
CASP6 / Caspase 6 Antibody LS-C148243
Formalin-fixed paraffin-embedded tissue section of dog cerebellum stained for Active/Cleaved Caspase-6 expression using Caspase-6 antibody at 1:2000. Hematoxylin-Eosin counterstain.
Formalin-fixed paraffin-embedded tissue sections of human gliomas stained for Active/Cleaved Caspase-6 expression using Caspase-6 antibody at 1:2000. Gemistocytoma (low grade tumor) at low (A) and high (B) magnification. Two examples of anaplastic, high grade (III) infiltrating gliomas (C and D). Increased active/cleaved Caspase-6 may be seen in high grade, compared to low grade tumors. Hematoxylin-Eos in counterstain.

Rabbit Polyclonal to Human CASP6 / Caspase 6
Mouse, Dog, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
CASP6 / Caspase 6 Antibody (aa235-263) LS-C327024

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Mouse, Human
ELISA IHC WB
Unconjugated
CASP6 / Caspase 6 Antibody (phospho-Ser257) LS-C327032

Rabbit Polyclonal (IgG) to Human CASP6 / Caspase 6
Human
ELISA IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number