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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASP1 / Caspase 1

caspase 1, apoptosis-related cysteine peptidase

CASP1 / Caspase 1 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Gene Name: caspase 1, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP1, Caspase-1, CASP-1, CASP1 nirs variant 1, Caspase 1, ICE, ICE-like protease, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BCE, p45, IL1B-convertase, Interleukin-1 beta convertase
Target Sequences: NM_001223 NP_001214.1 P29466

Filtered By: None
Target
CASP1 / Caspase 1 (131)
Reactivity
Human (117)
Mouse (41)
Rat (28)
Horse (4)
Monkey (1)
Pig (9)
Application
IHC (79)
IHC-P (17)
WB (117)
Flo (2)
ELISA (30)
ICC (3)
IF (3)
IP (3)
Peptide-ELISA (5)
Host
rabbit (123)
mouse (4)
goat (1)
rat (3)
Isotype
IgG (96)
IgG1 (1)
IgG1,k (3)
IgG2a (2)
IgG2a,k (1)
Clonality
monoclonal mc (7)
polyclonal pc (124)
Clone
11J26 (1)
14F468 (2)
1H11 (1)
3D2 (1)
ABM1B93 (1)
SB122a (1)
Format
AP Conjugated (4)
APC (5)
APC Conjugated (8)
Azide-free (1)
Biotin Conjugated (12)
Cy3 Conjugated (5)
Cy7 Conjugated (5)
FITC Conjugated (15)
HRP Conjugated (12)
PE Conjugated (9)
Unconjugated (61)
Epitope
aa119-296 (18)
aa120-297 (18)
aa317-404 (8)
aa30-79 (4)
C-Terminus (3)
Internal (3)
320-400 aa (2)
N-Terminus (2)
aa371-390 (2)
pSer376 (2)
130-210 aa, Internal (1)
170-250 aa, Internal (1)
270-350 aa, C-terminal (1)
70-150 aa, Internal (1)
Asn120 (1)
Asp210 (1)
Lys372 (1)
aa101-150 (1)
aa135-152 (1)
aa137-157 (1)
aa161-210 (1)
aa192-241 (1)
aa203-400 (1)
aa206-220 (1)
aa225-242 (1)
aa249-262 (1)
aa31-45 (1)
aa327-372 (1)
aa342-391 (1)
Publications
No (131)
Showing 1-25 of 131 results

CASP1 / Caspase 1 Antibody (aa371-390, clone 14F468) IHC-plus™ LS-B112
Mouse Monoclonal [clone 14F468] (IgG1,k) to Human CASP1 / Caspase 1
Mouse, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

CASP1 / Caspase 1 Antibody IHC-plus™ LS-B3394
Rabbit Polyclonal to Human CASP1 / Caspase 1
Human
IHC IHC-P
Unconjugated
250µl  $425.00
Anti-Caspase 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

CASP1 / Caspase 1 Antibody (aa206-220, clone 1H11) LS-C21290
Rat Monoclonal [clone 1H11] (IgG1) to Mouse CASP1 / Caspase 1
Mouse
ELISA Flo WB
Unconjugated
100µg 1mg/ml  $665.00

CASP1 / Caspase 1 Antibody (N-Terminus) LS-C51684
Rabbit Polyclonal to Human CASP1 / Caspase 1
Human
IHC IP WB
Unconjugated
200µg 1000µl 0.2mg/ml  $295.00

CASP1 / Caspase 1 Antibody IHC-plus™ LS-B3199
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Caspase 1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP1 / Caspase 1 Antibody (aa225-242) LS-C21288
Rabbit Polyclonal to Human CASP1 / Caspase 1
Mouse, Rat, Human
ICC IP WB
Unconjugated
100µg 0.2mg/ml  $620.00

CASP1 / Caspase 1 Antibody (aa249-262) LS-C312683
Rabbit Polyclonal to Human CASP1 / Caspase 1
Human
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
CASP1 / Caspase 1 antibody. IHC(P): Human Breast Cancer Tissue.
WB of CASP1 / Caspase 1 antibody. Lane 1: NIH Cell Lysate. Lane 2: MCF-7 Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: SMMC Cell Lysate. Lane 5: HT1080 Cell Lysate. Lane 6: SW620 Cell Lysate. Lane 7: JURKAT Cell Lysate. Lane 8: RAJI Cell Lysate. Lane 9: CEM Cell Lysate. Lane 10: PC-12 Cell Lysate.

CASP1 / Caspase 1 Antibody (clone 3D2) LS-C133008
Mouse Monoclonal [clone 3D2] (IgG2a,k) to Human CASP1 / Caspase 1
Human
ELISA WB
Unconjugated
100µg 0.5mg/ml  $355.00
Western blot of CASP1 expression in transfected 293T cell line by CASP1 monoclonal antibody (M01), clone 3D2.
Detection limit for recombinant GST tagged CASP1 is approximately 0.1 ng/ml as a capture antibody.

CASP1 / Caspase 1 Antibody IHC-plus™ LS-B3200
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Caspase 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP1 / Caspase 1 Antibody (aa31-45) LS-C642
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Formalin-fixed, paraffin-embedded section of human reactive lymph node stained for Caspase-1 expression (antibody) using a DAB chromogen and Hematoxylin counterstain. B is a higher magnification of A. Staining in macrophages is observed.
Western blot of Caspase-1 in HeLa cell lysate using antibody at 0.5 ug/ml.

CASP1 / Caspase 1 Antibody (aa135-152) LS-C312601
Rabbit Polyclonal to Human CASP1 / Caspase 1
Human
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
CASP1 / Caspase 1 antibody. IHC(P): Human Breast Cancer Tissue.
WB of CASP1 / Caspase 1 antibody. Lane 1: JURKAT Cell Lysate. Lane 2: RAJI Cell Lysate. Lane 3: CEM Cell Lysate . Lane 4: PC-12 Cell Lysate.

CASP1 / Caspase 1 Antibody LS-C95899
Rabbit Polyclonal to Human CASP1 / Caspase 1
Mouse, Rat, Human
IHC WB
Unconjugated
0.5ml  $425.00; 1ml  $665.00

CASP1 / Caspase 1 Antibody (N-Terminus) LS-C47034
Rabbit Polyclonal to Insect CASP1 / Caspase 1
ELISA WB
Unconjugated
100µg 0.5mg/ml  $325.00

CASP1 / Caspase 1 Antibody (aa30-79) LS-C116984
Rabbit Polyclonal to Human CASP1 / Caspase 1
Horse, Human
WB
Unconjugated
100µl 0.5mg/ml  $365.00
CASP1 / Caspase 1 antibody Western blot of 721_B cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASP1 / Caspase 1 Antibody LS-C393307
Rabbit Polyclonal to Human CASP1 / Caspase 1
Mouse, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
100µl  $305.00

CASP1 / Caspase 1 Antibody LS-C211765
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IHC WB
Unconjugated
50µg  $285.00; 100µg  $385.00

CASP1 / Caspase 1 Antibody (FITC) IHC-plus™ LS-B11160
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IHC IHC-P WB
FITC Conjugated
50µg 0.25mg/ml  $425.00
Anti-CASP1 / Caspase 1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

CASP1 / Caspase 1 Antibody (aa342-391) LS-C117942
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Caspase 1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from 293, MCF-7, and HeLa cells, using Caspase 1 Antibody. The lane on the right is blocked with the synthesized peptide.

CASP1 / Caspase 1 Antibody (phospho-Ser376) LS-C198724
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using Caspase 1 (Phospho-Ser376) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from 293 cells, using Caspase 1 (Phospho-Ser376) Antibody. The lane on the right is blocked with the phospho peptide.

CASP1 / Caspase 1 Antibody (C-Terminus) LS-C353917
Rabbit Polyclonal to Human CASP1 / Caspase 1
Human
IHC IHC-P IP WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Caspase 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of Caspase 1 expression in A549 (A); Caco2 (B); THP1 (C) whole cell lysates.

CASP1 / Caspase 1 Antibody (C-Terminus) LS-C351905
Rabbit Polyclonal to Human CASP1 / Caspase 1
Mouse, Rat, Human
ICC IF WB
Unconjugated
100µl 1mg/ml  $245.00
Immunofluorescent analysis of Caspase 1 p10 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of Caspase 1 p10 expression in HeLa (A); mouse spleen (B); rat spleen (C) whole cell lysates.

CASP1 / Caspase 1 Antibody (320-400 aa) LS-C381347
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CASP1 / Caspase 1 Antibody LS-C659464
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IHC WB
Unconjugated
100µg  $435.00

CASP1 / Caspase 1 Antibody LS-C658386
Rabbit Polyclonal (IgG) to Human CASP1 / Caspase 1
Human
ELISA IHC WB
Unconjugated
50µl  $425.00

CASP1 / Caspase 1 Antibody (aa119-296) LS-C293196
Rabbit Polyclonal (IgG) to Mouse CASP1 / Caspase 1
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00; 10ml 0.5mg/ml  $2,040.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CASP1 / Caspase 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 131 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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