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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASP3 / Caspase 3

caspase 3, apoptosis-related cysteine peptidase

CASP3 / Caspase 3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene Name: caspase 3, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP3, Apopain, CASP-3, Caspase-3, CPP32B, CPP32, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Procaspase3, Caspase 3, CPP-32, PARP cleavage protease, Protein Yama
Target Sequences: NM_004346 NP_004337.2 P42574

Publications (13)

1
Caspase-9 and APAF-1 form an active holoenzyme. Rodriguez J, Lazebnik Y. Genes & development. 1999 13:3179-84. [PubMed:10617566] [PMC:PMC317200]
2
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:19488-93. [PubMed:18042711] [PMC:PMC2148316]
3
Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy. Tanaka K, Hashimoto H, Tachibana T, Ishikawa H, Ohki T. Pediatric surgery international. 2008 24:837-42. (IHC) [PubMed:18470518]
4
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:2417-25. [PubMed:19318489]
5
Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis. Gould Rothberg BE, Bracken MB, Rimm DL. Journal of the National Cancer Institute. 2009 101:452-74. [PubMed:19318635] [PMC:PMC2720709]
6
Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568. Hsu LC, Hsu YW, Liang YH, Kuo YH, Pan TM. Journal of agricultural and food chemistry. 2011 59:1124-30. (WB; Mouse) [PubMed:21261255]
7
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:8785-90. (WB, IP; Human) [PubMed:21555592] [PMC:PMC3102401]
8
Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. Hsu LC, Hsu YW, Liang YH, Liaw CC, Kuo YH, Pan TM. Molecules (Basel, Switzerland). 2012 17:664-73. [PubMed:22237681]
9
Regulation of TGF-1 expression by androgen deprivation therapy of prostate cancer. Fuzio P, Ditonno P, Rutigliano M, Battaglia M, Bettocchi C, Loverre A, Grandaliano G, Perlino E. Cancer letters. 2012 318:135-44. (IHC; Human) [PubMed:22269108]
10
Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep. Regan JK, Kannan PS, Kemp MW, Kramer BW, Newnham JP, Jobe AH, Kallapur SG. Reproductive sciences (Thousand Oaks, Calif.). 2016 January;23:69-80. (Human) [Full Text Article] [PubMed:26156854] [PMC:PMC5933192] Related Antibodies: LS-B2845.
11
IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human) [Full Text Article] [PubMed:29468159] [PMC:PMC5807897] Related Antibodies: LS-B2125.
12
Overexpression of facioscapulohumeral muscular dystrophy region gene 1 causes primary defects in myogenic stem cells. Xynos A, Neguembor MV, Caccia R, Licastro D, Nonis A, Di Serio C, Stupka E, Gabellini D. Journal of cell science. May;126:2236-45. [Full Text Article] [PubMed:23525014] Related Antibodies: LS-C12476.
13
Prevention of Anti-microbial Peptide LL-37-Induced Apoptosis and ATP Release in the Urinary Bladder by a Modified Glycosaminoglycan. Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD. PloS one. 2013 30-Oct; [Full Text Article] [PubMed:4204996] Related Antibodies: LS-C12499.
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Filtered By: None
Target
CASP3 / Caspase 3 (276)
Reactivity
Human (234)
Mouse (126)
Rat (110)
Bat (5)
Bovine (23)
Chicken (4)
Chimpanzee (3)
Dog (26)
Gerbil (4)
Gibbon (6)
Guinea pig (13)
Hamster (24)
Horse (1)
Monkey (25)
Pig (22)
Rabbit (25)
Sheep (19)
Xenopus (2)
Yeast (3)
Application
IHC (165)
IHC-Fr (4)
IHC-P (45)
WB (241)
Flo (18)
DB (23)
ELISA (63)
ICC (22)
IF (16)
IP (57)
Peptide-ELISA (7)
Host
rabbit (207)
mouse (65)
goat (2)
rat (2)
Isotype
IgG (153)
IgG1 (9)
IgG1,k (2)
IgG2a (32)
IgG2a,k (3)
IgG2b (2)
IgG2b,k (8)
Clonality
monoclonal mc (72)
polyclonal pc (204)
Clone
1262CT521.280.101 (1)
1F3 (1)
1F9 (1)
31A1067 (1)
31A893 (1)
3CSP01 (2)
3D4D10 (1)
3D4D7 (1)
4D3 (1)
5E1 (1)
7D12 (1)
ABM1C12 (1)
AMI-3-1-11 (1)
CAS3836 (1)
CPP32 4-1-18 (1)
SB71b (2)
Format
AF488 Conjugated (1)
AP Conjugated (11)
APC (7)
APC Conjugated (18)
Azide-free (6)
Biotin Conjugated (23)
Cy3 Conjugated (7)
Cy7 Conjugated (7)
DY488 Conjugated (1)
DY550 Conjugated (1)
FITC Conjugated (21)
HRP Conjugated (23)
Magnetic beads Conjugated (1)
PE Conjugated (18)
Sepharose Conjugated (1)
Unconjugated (143)
Epitope
aa29-175 (32)
aa183-277 (15)
N-Terminus (14)
aa149-179 (8)
pSer12 (8)
pSer26 (8)
Internal (7)
C-Terminus (6)
aa149-175 (6)
aa151-200 (4)
aa80-129 (4)
aa126-175 (3)
pSer150 (3)
100-180 aa, Internal (2)
90-170 aa (2)
110-190 aa, Internal (1)
130-210 aa, Internal (1)
171-220 aa, Internal (1)
20-100 aa, N-terminal (1)
Asp146 (1)
Asp175 (1)
aa 29-175 (1)
aa1-277 (1)
aa1-50 (1)
aa101-112 (1)
aa116-165 (1)
aa157-206 (1)
aa163-175 (1)
aa166-183 (1)
aa207-220 (1)
aa219-248 (1)
aa220-236 (1)
aa28-44 (1)
aa29-33 (1)
aa39-84 (1)
aa60-90 (1)
aa67-175 (1)
aa67-81 (1)
aa70-90 (1)
Publications
No (272)
Yes (4)
Showing 1-25 of 276 results

CASP3 / Caspase 3 Antibody (clone 31A1067) IHC-plus™ LS-B2125
Publications (1)
Publications (1)
Mouse Monoclonal [clone 31A1067] (IgG) to Human CASP3 / Caspase 3
Mouse, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 3 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of Caspase-3 in HeLa cells. The antibody detected both pro (full-length) and active (cleaved) Caspase-3, depending on the treatment time points.

CASP3 / Caspase 3 Antibody IHC-plus™ LS-B2845
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-Caspase 3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Caspase 3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP3 / Caspase 3 Antibody (N-Terminus) LS-C12476
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Mouse, Rat, Human
ELISA Flo ICC IF IHC IHC-Fr WB
Unconjugated
100µl  $575.00

CASP3 / Caspase 3 Antibody IHC-plus™ LS-B3404
Rabbit Polyclonal to Human CASP3 / Caspase 3
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey, Yeast
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

CASP3 / Caspase 3 Antibody LS-C148242
Rabbit Polyclonal to Human CASP3 / Caspase 3
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
Formalin-fixed, paraffin-embedded section of dog ischemic brain stained for Active/Cleaved Caspase-3 expression using Polyclonal Antibody to Active/Cleaved Caspase-3 at 1:2000. Staining is seen in the nuclei of dying neurons (black arrow) but not in the morphologically normal nuclei (open arrows). Caspase-3 expression in the nucleus is considered to be a marker of active/caspase-3 expression and apoptosis. Hematoxylin-Eosin counterstain.
Formalin-fixed, paraffin-embedded section of irradiated mouse spleen stained for Active/Cleaved Caspase-3 expression using Polyclonal Antibody to Active/Cleaved Caspase-3 at 1:2000. Staining is seen in the nuclei of a subset of the cell population. Caspase-3 expression in the nucleus is considered to be a marker of active/caspase-3 expression and apoptosis. Hematoxylin-Eos in counterstain.

CASP3 / Caspase 3 Antibody (Biotin) LS-C88630
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC IHC-P IP WB
Biotin Conjugated
100µl 1mg/ml  $345.00; 500µl  $845.00; 1000µl  $1,320.00

CASP3 / Caspase 3 Antibody LS-C12499
Publications (1)
Publications (1)
Rabbit Polyclonal to Human CASP3 / Caspase 3
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µg 0.2mg/ml  $770.00

CASP3 / Caspase 3 Antibody (aa126-175) LS-C121029
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 3 (Cleaved-Asp175) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from 293 cells, treated with Etoposide 25 uM 60', using Caspase 3 (Cleaved-Asp175) Antibody. The lane on the right is treated with the synthesized peptide.

CASP3 / Caspase 3 Antibody (N-Terminus) IHC-plus™ LS-B1666
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Human
IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Anti-Caspase 3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot of extracts from HeLa cells, using anti-caspase-3, Poly6341.

CASP3 / Caspase 3 Antibody LS-C95929
Rabbit Polyclonal to Human CASP3 / Caspase 3
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC IHC-P
Unconjugated
0.5ml  $415.00; 1ml  $620.00
Formalin-fixed, paraffin-embedded human tonsil stained with Caspase 3 antibody.

CASP3 / Caspase 3 Antibody (N-Terminus, AF488) LS-C12480
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Human
ELISA Flo ICC IF
AF488 Conjugated
100µl  $605.00

CASP3 / Caspase 3 Antibody (aa149-179, APC) LS-C253424
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Human
ELISA Flo IHC WB
APC Conjugated
200µl 0.35mg/ml  $680.00

CASP3 / Caspase 3 Antibody (aa149-179, PE) LS-C253430
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Human
ELISA Flo IHC WB
PE Conjugated
200µl 0.35mg/ml  $680.00

CASP3 / Caspase 3 Antibody (clone 3CSP01) LS-C87552
Mouse Monoclonal [clone 3CSP01] (IgG2a) to Human CASP3 / Caspase 3
Human
IHC IHC-P IP WB
Unconjugated
100µl  $285.00; 500µl  $590.00; 1000µl  $980.00
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic and nuclear staining of lymphoid cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.

CASP3 / Caspase 3 Antibody (clone 3CSP01, Azide-free) LS-C87553
Mouse Monoclonal [clone 3CSP01] (IgG2a) to Human CASP3 / Caspase 3
Human
IHC IHC-P IP WB
Unconjugated, Azide-free
0.1ml  $620.00; 0.2ml  $1,015.00
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic and nuclear staining of lymphoid cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.

CASP3 / Caspase 3 Antibody (clone CPP32 4-1-18) IHC-plus™ LS-B238
Mouse Monoclonal [clone CPP32 4-1-18] (IgG2a,k) to Human CASP3 / Caspase 3
Rat, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-Caspase 3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.

CASP3 / Caspase 3 Antibody LS-C497713
Rabbit Monoclonal to Human CASP3 / Caspase 3
Rat, Human
Flo IF IHC IP WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded human spleen using CASP3 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using CASP3 antibodyat dilution of 1:100 (40x lens).

CASP3 / Caspase 3 Antibody (N-Terminus) LS-C12477
Rabbit Monoclonal (IgG) to Human CASP3 / Caspase 3
Human
Flo IF IHC IHC-Fr IHC-P IP WB
Unconjugated
100µl  $605.00

CASP3 / Caspase 3 Antibody LS-C747159
Rabbit Monoclonal (IgG) to Human CASP3 / Caspase 3
Mouse, Rat, Human, Monkey
Flo IF IHC IP WB
Unconjugated
50µl  $295.00

CASP3 / Caspase 3 Antibody LS-C497711
Rabbit Monoclonal to Human CASP3 / Caspase 3
Human
IF IHC WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded human spleen using CASP3 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using CASP3 antibodyat dilution of 1:100 (40x lens).

CASP3 / Caspase 3 Antibody (aa166-183) IHC-plus™ LS-B1501
Rabbit Polyclonal (IgG) to Human CASP3 / Caspase 3
Human
IHC IHC-P WB
Unconjugated
1ea  $425.00
Anti-Caspase 3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of Caspase 3 antibody.

CASP3 / Caspase 3 Antibody (clone 5E1) IHC-plus™ LS-B14643
Mouse Monoclonal [clone 5E1] (IgG1) to Human CASP3 / Caspase 3
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of Active Caspase-3 antibody

CASP3 / Caspase 3 Antibody (clone ABM1C12) IHC-plus™ LS-B13310
Mouse Monoclonal [clone ABM1C12] (IgG1,k) to Human CASP3 / Caspase 3
Human
IHC IHC-P WB
Unconjugated
100µl 0.5mg/ml  $425.00
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

CASP3 / Caspase 3 Antibody (aa67-81) LS-C343908
Rabbit Polyclonal to Mouse CASP3 / Caspase 3
Mouse, Rat
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
Caspase-3(P17) antibody IHC-paraffin: Rat Intestine Tissue Lysate.
Caspase-3(P17) antibody Western blot. Lane 1: Rat Heart Tissue Lysate. Lane 2: Rat Liver Tissue Lysate. Lane 3: Rat Thymus Tissue Lysate. Lane 4: Rat Spleen Tissue Lysate.

CASP3 / Caspase 3 Antibody LS-C658481
Rabbit Monoclonal (IgG) to Human CASP3 / Caspase 3
Human
IHC WB
Unconjugated
50µl  $445.00
Showing 1-25 of 276 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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