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CASP7 / Caspase 7

caspase 7, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

Gene Name: caspase 7, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP7, Apoptotic protease Mch-3, Caspase 7, Caspase-7, ICE-LAP3, LICE2, MCH3, ICE-like apoptotic protease 3, CASP-7, CMH-1
Target Sequences: NM_001227 NP_001218.1 P55210

Publications (1)

1
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Blanc-Brude OP, Mesri M, Wall NR, Plescia J, Dohi T, Altieri DC. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:2683-92. [PubMed:12855648]

☰ Filters
Antibodies (104)
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CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal (7-1-11) Antibody
Rabbit, Mouse, Dog, Sheep, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$440
CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP7 / Caspase 7 Protein - Recombinant Caspase 7 By SDS-PAGE
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E. coli
His-T7
15.1 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
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E. coli
His, N-Terminal
19.5 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
CASP7 / Caspase 7 Antibody - Immunohistochemistry of paraffin-embedded rat heart.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
CASP7 / Caspase 7 Antibody - Immunohistochemical analysis of Caspase 7 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal (10-1-62) Antibody
Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal (25B881.1) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP7 / Caspase 7 Antibody
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal (4G2) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µg/$403
CASP7 / Caspase 7 Antibody - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CASP-7 mouse mAb with DAB staining.
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CASP7 / Caspase 7 Mouse anti-Human Monoclonal (4D10B2) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CASP7 / Caspase 7 Antibody - CASP7 / Caspase 7 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (aa107-156) Antibody
Human
WB
Unconjugated
100 µl/$424
CASP7 / Caspase 7 Antibody - 1:100 staining rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP7 / Caspase 7 Antibody - Western blot of Caspase-7 antibody
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Human
ELISA, ICC, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP7 / Caspase 7 Antibody - Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, ICC, IP, WB
Unconjugated
100 µl/$689
CASP7 / Caspase 7 Protein
Select
E. coli
His
23.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CASP7 / Caspase 7 Antibody - IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 7 (Cleaved-Asp198) Antibody. The picture on the right is treated with the synthesized peptide.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (aa149-198) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP7 / Caspase 7 Antibody - IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 7 (Cleaved-Asp198) Antibody. The picture on the right is treated with the synthesized peptide.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (aa180-229) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP7 / Caspase 7 Antibody - Immunofluorescent analysis of Caspase 7 p11 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$299
CASP7 / Caspase 7 Antibody - Anti-Caspase-7(P11) antibody, IHC(P): Human Intestinal Cancer Tissue
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (aa237-255) Antibody
Mouse, Guinea pig, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP7 / Caspase 7 Antibody - Western blot of Cleaved-Caspase-7 (S199) antibody
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (150-230 aa, Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP7 / Caspase 7 Antibody - IHC image of CASP7 Antibody diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
CASP7 / Caspase 7 Antibody - Cl-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 7 (cleaved-Asp198) antibody.
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (Cleaved-Asp198) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
CASP7 / Caspase 7 Antibody - Cl-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 7 (Cleaved-Asp198) Antibody .
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CASP7 / Caspase 7 Rabbit anti-Human Polyclonal (Cleaved-Asp198) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 157 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).