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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CASP7 / Caspase 7

caspase 7, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

Gene Name: caspase 7, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP7, Apoptotic protease Mch-3, Caspase 7, Caspase-7, ICE-LAP3, LICE2, MCH3, ICE-like apoptotic protease 3, CASP-7, CMH-1
Target Sequences: NM_001227 NP_001218.1 P55210

Publications (1)

1
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Blanc-Brude OP, Mesri M, Wall NR, Plescia J, Dohi T, Altieri DC. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:2683-92. [PubMed:12855648]

Filtered By: None
Target
CASP7 / Caspase 7 (121)
Reactivity
Human (97)
Mouse (63)
Rat (56)
Chimpanzee (3)
Dog (5)
Gerbil (2)
Gibbon (3)
Guinea pig (1)
Hamster (2)
Horse (4)
Monkey (7)
Pig (12)
Rabbit (1)
Sheep (1)
Zebrafish (4)
Application
IHC (83)
IHC-Fr (1)
IHC-P (18)
WB (118)
Flo (1)
ELISA (18)
ICC (6)
IF (3)
IP (10)
Peptide-ELISA (4)
Host
rabbit (110)
mouse (10)
rat (1)
Isotype
IgG (83)
IgG1 (3)
IgG1,k (1)
IgG2a (1)
IgG2b (1)
Clonality
monoclonal mc (10)
polyclonal pc (111)
Clone
10-1-62 (1)
25B881.1 (1)
4D10B2 (1)
4G2 (1)
7-1-11 (1)
G1/G1-4 (1)
Format
AP Conjugated (4)
APC (5)
APC Conjugated (7)
Biotin Conjugated (11)
Cy3 Conjugated (5)
Cy7 Conjugated (5)
FITC Conjugated (11)
HRP Conjugated (11)
PE Conjugated (9)
Unconjugated (58)
Epitope
aa207-303 (16)
aa24-198 (16)
aa107-156 (4)
120-200 aa, Internal (2)
C-Terminus (2)
Internal (2)
N-Terminal (2)
N-Terminus (2)
aa149-198 (2)
150-230 aa, Internal (1)
160-240 aa, Internal (1)
Asp198 (1)
Cleavage Site (1)
Met45 (1)
aa117-198 (1)
aa180-229 (1)
aa217-262 (1)
aa237-255 (1)
aa45-94 (1)
Publications
No (121)
Showing 1-25 of 121 results

CASP7 / Caspase 7 Antibody IHC-plus™ LS-B3795
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Rat, Human
ELISA IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Caspase 7 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP7 / Caspase 7 Antibody (clone 7-1-11) IHC-plus™ LS-B3670
Mouse Monoclonal [clone 7-1-11] (IgG) to Human CASP7 / Caspase 7
Rabbit, Mouse, Dog, Sheep, Rat, Hamster, Pig, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-Caspase 7 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

CASP7 / Caspase 7 Antibody IHC-plus™ LS-B239
Mouse Monoclonal (IgG1,k) to Human CASP7 / Caspase 7
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl  $425.00
Anti-Caspase 7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.

CASP7 / Caspase 7 Antibody (clone 10-1-62) IHC-plus™ LS-B3671
Mouse Monoclonal [clone 10-1-62] (IgG) to Human CASP7 / Caspase 7
Mouse, Rat, Hamster, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $425.00
Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-Caspase 7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

CASP7 / Caspase 7 Antibody (clone 25B881.1) IHC-plus™ LS-B2020
Mouse Monoclonal [clone 25B881.1] (IgG1) to Human CASP7 / Caspase 7
Human
IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-Caspase 7 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot analysis of Caspase-7 in Jurkat cells using Caspase-7 antibody at 1 ug/ml. Cells were treated with 2 uM staurosporine for different time periods. Caspase-7 activation is detected in western blots by the presence of Caspase-7 cleavage fragments. The antibody detected both pro (full-length) and active (cleaved) Caspase-7, depending on the treatment time points. A basal level of endogenous intermediate Caspase-7 can be see in untreated Jurkat cells.

CASP7 / Caspase 7 Antibody LS-C331515
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Rat, Human
ICC IF IHC IP WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat heart.
Immunohistochemistry of paraffin-embedded rat heart using CASP7 antibodyat dilution of 1:100 (40x lens).

CASP7 / Caspase 7 Antibody (clone 4D10B2) LS-C682361
Mouse Monoclonal [clone 4D10B2] (IgG1) to Human CASP7 / Caspase 7
Human
ELISA Flo IHC WB
Unconjugated
100µl  $365.00
Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CASP-7 mouse mAb with DAB staining.
Western blot analysis using CASP-7 mAb against HEK293 (1) and CASP-7 (AA: 29-198)-hIgGFc transfected HEK293 (2) cell lysate.

CASP7 / Caspase 7 Antibody (N-Terminus) LS-C351917
Rabbit Polyclonal to Human CASP7 / Caspase 7
Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Caspase 7 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Caspase 7 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

CASP7 / Caspase 7 Antibody (aa107-156) LS-C135480
Rabbit Polyclonal to Human CASP7 / Caspase 7
Zebrafish, Pig, Horse, Rat, Mouse, Dog, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
CASP7 / Caspase 7 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASP7 / Caspase 7 Antibody (N-Terminal) LS-C382454
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Human
ELISA ICC IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Caspase-7 antibody

CASP7 / Caspase 7 Antibody IHC-plus™ LS-B3794
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Rat, Human
ELISA IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Caspase 7 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Caspase 7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CASP7 / Caspase 7 Antibody (N-Terminus) LS-C12507
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Rat, Human
ELISA ICC IP WB
Unconjugated
100µl  $575.00

CASP7 / Caspase 7 Antibody LS-C148244
Rabbit Polyclonal to Human CASP7 / Caspase 7
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
Western blot of Caspase-7. Recombinant catalytically active Caspase-7was western blotted with anti-Active/Cleaved Caspase-7 (Polyclonal Antibody to Active/Cleaved Caspase-7). The antisera detected both the large and small subunits of active/cleaved Caspase-7.

CASP7 / Caspase 7 Antibody LS-C400470
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using CASP7 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human lung cancer using CASP7 Polyclonal Antibody at dilution of 1:20.

CASP7 / Caspase 7 Antibody (aa149-198) LS-C121032
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 7 (Cleaved-Asp198) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from Jurkat cells, treated with Etoposide 25 uM 24h, using Caspase 7 (Cleaved-Asp198) Antibody. The lane on the right is treated with the synthesized peptide.

CASP7 / Caspase 7 Antibody (aa180-229) LS-C121033
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 7 (Cleaved-Asp198) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from 293 cells, treated with Etoposide 25 uM 60', using Caspase 7 (Cleaved-Asp198) Antibody. The lane on the right is treated with the synthesized peptide.

CASP7 / Caspase 7 Antibody (Internal) LS-C351918
Rabbit Polyclonal to Human CASP7 / Caspase 7
Mouse, Rat, Pig, Human
ICC IF WB
Unconjugated
100µl 1mg/ml  $245.00
Immunofluorescent analysis of Caspase 7 p11 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of Caspase 7 p11 expression in HEK293T (A); mouse spleen (B); rat spleen (C) whole cell lysates.

CASP7 / Caspase 7 Antibody (120-200 aa, Internal) LS-C380451
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cleaved-Caspase-7 p20 (D198) antibody

CASP7 / Caspase 7 Antibody (150-230 aa, Internal) LS-C380450
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cleaved-Caspase-7 (S199) antibody

CASP7 / Caspase 7 Antibody (aa24-198) LS-C293217
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $235.00; 200µl 0.5mg/ml  $275.00; 1ml 0.5mg/ml  $445.00; 10ml 0.5mg/ml  $1,680.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

CASP7 / Caspase 7 Antibody (C-Terminus) LS-C202789
Rabbit Polyclonal to Human CASP7 / Caspase 7
Human
IHC IHC-P WB
Unconjugated
0.1mg  $680.00

CASP7 / Caspase 7 Antibody LS-C358673
Rabbit Polyclonal to Human CASP7 / Caspase 7
Mouse, Rat, Gerbil, Human
IHC IP WB
Unconjugated
50µl  $315.00

CASP7 / Caspase 7 Antibody (aa207-303) LS-C293215
Rabbit Polyclonal (IgG) to Human CASP7 / Caspase 7
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $235.00; 200µl 0.5mg/ml  $275.00; 1ml 0.5mg/ml  $445.00; 10ml 0.5mg/ml  $1,680.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CASP7 / Caspase 7.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CASP7 / Caspase 7 Antibody LS-C48212
Rabbit Polyclonal to Human CASP7 / Caspase 7
Mouse, Rat, Human
IHC IP WB
Unconjugated
30µg  $245.00; 100µg 500µl 0.2mg/ml  $605.00
Western blot of Caspase 7 antibody.

CASP7 / Caspase 7 Antibody (aa237-255) LS-C312604
Rabbit Polyclonal to Human CASP7 / Caspase 7
Mouse, Guinea pig, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
WB of CASP7 / Caspase 7 antibody. Lane 1: HELA Cell Lysate. Lane 2: MCF-7 Cell Lysate. Lane 3: SMMC Cell Lysate.
Showing 1-25 of 121 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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