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Vimentin

Vimentin is a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

Gene Name: Vimentin
Synonyms: VIM, Vimentin, vimenin
Target Sequences: NM_003380 NP_003371.2 P08670

Publications (11)

1
Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Rankin EB, Tomaszewski JE, Haase VH. Cancer research. 2006 66:2576-83. [PubMed:16510575] [PMC:PMC3514875]
2
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. Genes & development. 2007 21:2788-803. [PubMed:17974918] [PMC:PMC2045132]
3
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, Rustgi AK. Molecular and cellular biology. 2008 28:687-704. [PubMed:17998334] [PMC:PMC2223422]
4
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Ponzo MG, Lesurf R, Petkiewicz S, O'Malley FP, Pinnaduwage D, Andrulis IL, Bull SB, Chughtai N, Zuo D, Souleimanova M, Germain D, Omeroglu A, Cardiff RD, Hallett M, Park M. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:12903-8. [PubMed:19617568] [PMC:PMC2722321]
5
Genomic analysis of reactive astrogliosis. Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:6391-410. (ICC, IHC; Mouse) [PubMed:22553043] [PMC:PMC3480225]
6
Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro. Muir AB, Lim DM, Benitez AJ, Modayur Chandramouleeswaran P, Lee AJ, Ruchelli ED, Spergel JM, Wang ML. Experimental cell research. 2013 319:850-9. (ICC, IHC; Human) [PubMed:23237990] [PMC:PMC3593809]
7
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C92412.
8
Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri NO, Almutairi M, Parry L, Wakeman JA, McFarlane RJ. Molecular cancer. 2017 16:84. (ICC, IHC-P; Human) [Full Text Article] [PubMed:28446200] [PMC:PMC5406905] Related Antibodies: LS-B7191.
9
Ductal tree ablation by local delivery of ethanol prevents tumor formation in an aggressive mouse model of breast cancer. Elizabeth Kenyon, Jennifer J Westerhuis, Maximilian Volk, Jeremy Hix, Shatadru Chakravarty, Ethan Claucherty, Erin Zaluzec, Lisa Ramsey, Zach Madaj, Galen Hostetter, Bryn Eagleson, Erik Shapiro, Anna Moore, Lorenzo F Sempere. Breast cancer research : BCR. 2019 November;21:129. [Full Text Article] [PubMed:31779648] [PMC:PMC6883550] Related Antibodies: LS-B291.
10
Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation. Quan He, Fangfei Wang, Takashi Honda, Kenneth D Greis, Andrew N Redington. Scientific reports. 2020 Apr;10:6127. [Full Text Article] [PubMed:32273567] [PMC:PMC7145828]
11
Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis. Yamana D, Shimizu T, Fan Y, Miura T, Nanashima N, Yamada T, Hakamada K, Tsuchida S. Cancer science. 2011 Apr;102:735-41. [Full Text Article] [PubMed:21214675] Related Antibodies: LS-C40195.
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Vimentin Antibody - Anti-Vimentin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Vimentin Mouse anti-Human Monoclonal (RV203) Antibody
Goat, Dog, Rat, Hamster, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$485
Vimentin Antibody - Anti-Vimentin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Vimentin Chicken anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
Vimentin Antibody - Anti-Vimentin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Vimentin Mouse anti-Pig Monoclonal (V9) Antibody
Chicken, Sheep, Rat, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
Vimentin Antibody - Anti-Vimentin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Vimentin Mouse anti-Human Monoclonal (VI-10) Antibody
Chicken, Porcine, Rat, Mouse, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$440
Vimentin Antibody - Anti-Vimentin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
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Cancer Pathology
Cancer
Vimentin Mouse anti-Human Monoclonal (23H2) Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
Vimentin Antibody - Anti-Vimentin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cancer Pathology
Cancer
Vimentin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Vimentin Antibody - Frozen section of swine colon immunostained with RV202-FITC (1:200)
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Vimentin Mouse-Balb/c anti-Dog Monoclonal (FITC) (RV202) Antibody
Chicken, Zebrafish, Pig, Rat, Mouse, Goat, Dog, Human, Monkey
Flo, ICC, IHC, IHC-Fr
FITC Conjugated
1 ml/$510
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Vimentin Mouse anti-Pig Monoclonal (V9) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Cat, Horse, Gerbil, Rabbit, Mouse, Dog, Human, Monkey
Unconjugated
100 µl/$339; 500 µl/$545; 1 ml/$623
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Vimentin Rabbit anti-Human Polyclonal (APC) Antibody
Human
Flo, IHC, WB
APC Conjugated
200 µl/$854
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Vimentin Rabbit anti-Human Polyclonal (aa300-350) Antibody
Human
ELISA, IHC, WB
Unconjugated
40 µg/$458
Vimentin Antibody - Anti-Vimentin antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.
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Vimentin Mouse anti-Pig Monoclonal (Azide-free) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Cat, Horse, Gerbil, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated, Azide-free
50 µg/$585
Vimentin Antibody - Anti-Vimentin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
Vimentin Mouse anti-Bovine Monoclonal (RV202) Antibody
Chicken, Bovine, Mouse, Goat, Dog, Rat, Hamster, Pig, Human, Monkey
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
Vimentin Antibody - Anti-Vimentin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
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Vimentin Mouse anti-Human Monoclonal (33C7) Antibody
Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
Vimentin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
Vimentin Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
Vimentin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Vimentin Mouse anti-Human Monoclonal (2A52) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
Vimentin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
Vimentin Mouse anti-Human Monoclonal (AT5H8) Antibody
Human
ELISA, ICC, IF, IHC-P, WB
Unconjugated
100 µl/$460
Select
Vimentin Mouse anti-Human Monoclonal Antibody
Chicken, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$612
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Vimentin Chicken anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, WB
Unconjugated
100 µl/$448
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Vimentin Mouse anti-Pig Monoclonal Antibody
Chicken, Bovine, Rat, Hamster, Pig, Cat, Horse, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
500 µl/$631
Vimentin Antibody - Immunohistochemical analysis of Vimentin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Vimentin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
Vimentin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Vimentin Goat anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
Vimentin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Vimentin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IF, IHC-P, WB
Unconjugated
200 µl/$460
Select
Vimentin Goat anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µl/$732
Vimentin Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Vimentin Mouse anti-Pig Monoclonal (Magnetic beads) (VMT-24) Antibody
Rat, Pig, Human
IP
Magnetic beads Conjugated
100 µg/$373
Vimentin Antibody
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Vimentin Mouse anti-Human Monoclonal (pSer6) (MO6) Antibody
Human
ICC, IHC, WB
Unconjugated
100 µg/$413
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).