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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SPP1 / Osteopontin

secreted phosphoprotein 1

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Name: secreted phosphoprotein 1
Synonyms: SPP1, BSPI, BNSP, Bone sialoprotein 1, ETA-1, Nephropontin, OPN, Secreted phosphoprotein 1, SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, Uropontin, Osteopontin, Bone sialoprotein I
Target Sequences: NM_000582 NP_000573.1 P10451

Publications (5)

1
Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, Rashid MM, Morimoto J, Inobe M, Shijubo N, Chambers AF, Uede T. Journal of cellular biochemistry. 2002 84:420-32. [PubMed:11787071]
2
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Robertson BW, Chellaiah MA. Experimental cell research. 2010 316:11-Jan. [PubMed:19850036] [PMC:PMC2787770] Related Antibodies: LS-B425.
3
Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Rui YF, Lui PP, Rolf CG, Wong YM, Lee YW, Chan KM. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2012 20:1409-17. (IHC; Human) [PubMed:21946950]
4
Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR-induced -catenin degradation. Xu L, Song C, Ni M, Meng F, Xie H, Li G. The international journal of biochemistry & cell biology. 2012 44:612-9. [PubMed:22230368]
5
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B425.
more

Viewing 1-25 of 182 items
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
Select
Cancer
(2) Publication(s)
Rabbit Polyclonal to Human SPP1 / Osteopontin
Mouse, Dog, Rat, Pig, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µl   82mg/ml   $447.00
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer
Rabbit Polyclonal to Human SPP1 / Osteopontin
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $250.00
SPP1 / Osteopontin Antibody - Anti-Hemopexin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone 1B20] (IgG1) to Human SPP1 / Osteopontin
Rabbit, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $425.00
SPP1 / Osteopontin Antibody - Anti-Hemopexin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 1B20] (IgG1) to Human SPP1 / Osteopontin
Rabbit, Rat, Human
ICC, IHC, IHC-P, IP, WB
Biotin Conjugated
100µl   0.8mg/ml   $365.00
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human SPP1 / Osteopontin
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone X1] (IgG2b,k) to Human SPP1 / Osteopontin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
Select
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Human
IHC, IHC-P, WB
Unconjugated
250µl   $425.00
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human SPP1 / Osteopontin
Rabbit, Guinea pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
SPP1 / Osteopontin Antibody - SPP1 / Osteopontin antibody ARP36677_T100-NP_000573-SPP1 Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $335.00
SPP1 / Osteopontin Antibody - Western blot of SPP1 / Osteopontin antibody LS-X223133.
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Mouse Monoclonal [clone 2C5] (IgG1,k) to Human SPP1 / Osteopontin
Human
ELISA, WB
Unconjugated
100µg   $395.00
SPP1 / Osteopontin Antibody - Western blot of SPP1 / Osteopontin antibody LS-X223134.
Select
Mouse Monoclonal [clone 2F10] (IgG1,k) to Human SPP1 / Osteopontin
Human
ELISA, WB
Unconjugated
100µg   1mg/ml   $415.00
Select
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Human
ELISA, IF, IHC, WB
Unconjugated
200µl   $590.00
SPP1 / Osteopontin Antibody - Western blot of SPP1 / Osteopontin antibody LS-X223137.
Select
Mouse Monoclonal [clone 1F11] (IgG1,k) to Human SPP1 / Osteopontin
Human
ELISA, WB
Unconjugated
100µg   $395.00
SPP1 / Osteopontin Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma with SPP1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human SPP1 / Osteopontin
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Goat Polyclonal (IgG) to Mouse SPP1 / Osteopontin
Mouse
Flo
PE Conjugated
100tst   $650.00
Select
Rabbit Polyclonal to Mouse SPP1 / Osteopontin
Mouse
IHC, IHC-Fr, IHC-P
Unconjugated
0.5ml   $465.00
Select
Mouse Monoclonal [clone 2E11] (IgG1) to Human SPP1 / Osteopontin
Mouse, Human
ELISA, WB
Unconjugated
1mg   $710.00
SPP1 / Osteopontin Antibody
Select
Mouse Monoclonal (IgG1) to Human SPP1 / Osteopontin
Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $385.00
SPP1 / Osteopontin Antibody - IHC of paraffin-embedded prostate cancer tissues using SPP1 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 7C5H12] (IgG1) to Human SPP1 / Osteopontin
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   1mg/ml   $365.00
Select
Rabbit Polyclonal to Human SPP1 / Osteopontin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µl   $485.00
Select
Rabbit Polyclonal to Human SPP1 / Osteopontin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
20µl   $425.00; 100µl   $890.00
Select
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Human
ELISA, IHC, IHC-P
Unconjugated
100µl   $785.00
SPP1 / Osteopontin Antibody
Select
Rabbit Polyclonal (IgG) to Human SPP1 / Osteopontin
Human
ELISA, WB
Unconjugated
100µl   $275.00

Viewing 1-25 of 182 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).