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MAPK3 / ERK1

mitogen-activated protein kinase 3

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Gene Name: mitogen-activated protein kinase 3
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK3, ERK-1, ERT2, HUMKER1A, HS44KDAP, MAP kinase 1, MAP kinase isoform p44, MAPK 1, MAPK 3, p44, p44MAPK, p44-MAPK, p44ERK1, MAP kinase 3, p44-ERK1, ERK1, PRKM3
Target Sequences: X60188 CAA42744.1 P27361

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Antibodies (212)
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MAPK3 / ERK1 (212)
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No (212)
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
MAPK3 / ERK1 Antibody - Immunoperoxidase of monoclonal antibody to MAPK3 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (3C9) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$423
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (pThr202/Tyr204) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, Flo, ICC, IF, IP, WB
Unconjugated
200 µl/$771
MAPK3 / ERK1 Antibody - ERK1 Antibody in Immunohistochemistry (IHC)
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (100000) Antibody
Mouse, Rat, Non-Human Primate, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$528
MAPK3 / ERK1 Antibody - IHC of paraffin-embedded breast cancer tissues using MAPK3 mouse monoclonal antibody with DAB staining.
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (1E5) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$447
MAPK3 / ERK1 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded breast cancer tissues with DAB staining using ERK 1 Monoclonal Antibody.
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MAPK3 / ERK1 Mouse anti-Human Monoclonal Antibody
Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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MAPK3 / ERK1 Rabbit anti-Rat Polyclonal (aa336-367) Antibody
Rabbit, Mouse, Rat, Hamster
IHC, IP, WB
Unconjugated
50 µg/$652; 200 µg/$1,105
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MAPK3 / ERK1 Mouse anti-Rat Monoclonal (aa324-345) Antibody
Mouse, Dog, Rat, Human
ELISA, IP, WB
Unconjugated
200 µg/$838
MAPK3 / ERK1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MAPK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (OTI4D7) Antibody
Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAPK3 / ERK1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MAPK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4D7) Antibody
Dog, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (pThr202/Tyr204) Antibody
Mouse, Rat, Hamster, Human
ELISA, Flo, ICC, IF, IP, WB
Unconjugated
200 µl/$771
MAPK3 / ERK1 Antibody - 1:50 staining human colon carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal Antibody
Fish, Zebrafish, Pig, Horse, Mouse, Dog, Sheep, Bovine, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPK3 / ERK1 Antibody - Phospho-ERK1/2 (Thr202/Tyr204) antibody for IHC in human testis
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (pTyr204,pThr202) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPK3 / ERK1 Antibody - Immunohistochemistry of paraffin-embedded human prostate using MAPK3 / ERK1 antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
MAPK3 / ERK1 Antibody - Immunohistochemistry of paraffin-embedded human prostate using MAPK3 / ERK1 antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
MAPK3 / ERK1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Rat, Primate, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MAPK3 / ERK1 Antibody - MAPK3/1 Antibody (Center) staining MAPK3/1 in human breast carcinoma sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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MAPK3 / ERK1 Mouse anti-Human Monoclonal (Internal) (1129CT3.4.3) Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
200 µl/$393
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
MAPK3 / ERK1 Rabbit anti-Human Polyclonal (aa350-400) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
MAPK3 / ERK1 Antibody - Immunohistochemistry of paraffin-embedded mouse brain using MAPK3 Antibodyat dilution of 1:100 (40x lens).
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
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MAPK3 / ERK1 Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$361; 100 µl/$421; 200 µl/$481
MAPK3 / ERK1 Antibody - Anti-MAPK3 rabbit polyclonal antibody at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate. Lane B: K562 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 43 kDa. Observed band size: 43 kDa. (We are unsure as to the identity of these extra bands.)
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IP, WB
Unconjugated, Preservative Free
50 µl/$317; 100 µl/$375; 200 µl/$473
MAPK3 / ERK1 Antibody - IHC-P: ERK1 antibody testing of human breast cancer tissue
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (aa287-301) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Bat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$567
MAPK3 / ERK1 Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
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MAPK3 / ERK1 Rabbit anti-Human Polyclonal (pThr202) Antibody
IF, IHC, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).