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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAPK3 / ERK1

mitogen-activated protein kinase 3

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Gene Name: mitogen-activated protein kinase 3
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK3, ERK-1, ERT2, HUMKER1A, HS44KDAP, MAP kinase 1, MAP kinase isoform p44, MAPK 1, MAPK 3, p44, p44MAPK, p44-MAPK, p44ERK1, MAP kinase 3, p44-ERK1, ERK1, PRKM3
Target Sequences: X60188 CAA42744.1 P27361

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Viewing 1-25 of 252 items
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human MAPK3 / ERK1
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Neuroscience
Rabbit Polyclonal (IgG) to Human MAPK3 / ERK1
Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
MAPK3 / ERK1 Antibody - Anti-MAPK3 / ERK1 antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal [clone 3C9] (IgG2a,k) to Human MAPK3 / ERK1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
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Rabbit Polyclonal (IgG) to Human MAPK3 / ERK1
Chicken, Rat, Hamster, Mouse, Human
ELISA, Flo, ICC, IF, IP, WB
Unconjugated
200µl   $575.00
MAPK3 / ERK1 Antibody - Immunofluorescence analysis of NIH-3T3 cells using MAPK1/MAPK3 antibody.
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Rabbit Monoclonal to Human MAPK3 / ERK1
Mouse, Rat, Human
Flo, IF, IP, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00

Viewing 1-25 of 252 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).