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ACTA2 / Smooth Muscle Actin

actin, alpha 2, smooth muscle, aorta

ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: actin, alpha 2, smooth muscle, aorta
Synonyms: ACTA2, ACTVS, Alpha-actin-2, Alpha-cardiac actin, AAT6, Actin, aortic smooth muscle, ACTSA, Smooth Muscle Actin, MYMY5, SMA
Target Sequences: NM_001613 NP_001604.1 P62736

Publications (10)

1
Infection of Human Retinal Pigment Epithelium with Chlamydia trachomatis. Boiko E, Maltsev D, Savicheva A, Shalepo K, Khusnutdinova T, Pozniak A, Kvetnoi I, Polyakova V, Suetov A. PloS one. 2015 10:e0141754. (IHC-P; Human) [Full Text Article] [PubMed:26536616] [PMC:PMC4633144]
2
Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response. Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR,. Cellular and molecular gastroenterology and hepatology. 2017 5:67-82. (WB; Human) [Full Text Article] [PubMed:29276753] Related Antibodies: LS-B3933.
3
Towards an in vitro fibrogenesis model of human vocal fold scarring. Graupp M, Rinner B, Frisch MT, Weiss G, Fuchs J, Sundl M, El-Heliebi A, Moser G, Kamolz LP, Karbiener M, Gugatschka M. European Archives of Oto-Rhino-Laryngology and Head & Neck. 2018 May;275:1211-1218. (Human) [Full Text Article] [PubMed:29520499] [PMC:PMC5893733] Related Antibodies: LS-B3933.
4
Excessive Production of Transforming Growth Factor ß1 Causes Mural Cell Depletion From Cerebral Small Vessels. Taisuke Kato, Yumi Sekine, Hiroaki Nozaki, Masahiro Uemura, Shoichiro Ando, Sachiko Hirokawa, Osamu Onodera. Frontiers in aging neuroscience. 2020 June;12:151. [Full Text Article] [PubMed:32581764] [PMC:PMC7283554]
5
Complete dependence on CD4+ cells in late asthmatic response, but limited contribution of the cells to airway remodeling in sensitized mice. Takeshi Nabe, Toyoko Morishita, Kouki Matsuya, Ayumu Ikedo, Masanori Fujii, Nobuaki Mizutani, Shin Yoshino. Journal of pharmacological sciences. 2011 July;116:373-83. [Full Text Article] [PubMed:21778663]
6
Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Mark A Chapman, Kavitha Mukund, Shankar Subramaniam, David Brenner, Richard L Lieber. American journal of physiology. Cell physiology. 2017 February;312:C131-C143. [Full Text Article] [PubMed:27881411] [PMC:PMC5336596] Related Antibodies: LS-C124868.
7
Characterization of a mouse model of hypereosinophilia-associated heart disease. Daniel R Prows, Andrea Klingler, William J Gibbons Jr, Shelli M Homan, Nives Zimmermann. American journal of physiology. Heart and circulatory physiology. 2019 August;317:H405-H414. [Full Text Article] [PubMed:31199184] [PMC:PMC6732473]
8
Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma. Joseph Ojo, Max Eisenbaum, Ben Shackleton, Cillian Lynch, Utsav Joshi, Nicole Saltiel, Andrew Pearson, Charis Ringland, Daniel Paris, Benoit Mouzon, Michael Mullan, Fiona Crawford, Corbin Bachmeier. Neurobiology of disease. 2021 Mar;;150:105237. [Full Text Article] [PubMed:33383188] [PMC:PMC8170787]
9
Impairment of cerebrovascular reactivity in response to hypercapnic challenge in a mouse model of repetitive mild traumatic brain injury. Cillian E Lynch, Maxwell Eisenbaum, Moustafa Algamal, Matilde Balbi, Scott Ferguson, Benoit Mouzon, Nicole Saltiel, Joseph Ojo, Ramon Diaz-Arrastia, Mike Mullan, Fiona Crawford, Corbin Bachmeier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 June;41:1362-1378. [Full Text Article] [PubMed:33050825] [PMC:PMC8142124]
10
Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel. Elle Koivunotko, Jasmi Snirvi, Arto Merivaara, Riina Harjumäki, Swarna Rautiainen, Minna Kelloniemi, Kirsi Kuismanen, Susanna Miettinen, Marjo Yliperttula, Raili Koivuniemi. Biomedicines. 2022 October;10: [Full Text Article] [PubMed:36289846] [PMC:PMC9599553] Related Antibodies: LS-B16663.
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ACTA2 / Smooth Muscle Actin (132)
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ACTA2 / Smooth Muscle Actin Antibody - Anti-ACTA2 antibody IHC of human colon, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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Cancer Pathology
Cancer
ACTA2 / Smooth Muscle Actin Goat anti-Human Polyclonal (aa1-50) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ACTA2 / Smooth Muscle Actin Antibody - Anti-Smooth Muscle Actin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:10.
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (1A4) Antibody
Chicken, Bovine, Rabbit, Mouse, Rat, Baboon, Human
IF, IHC, IHC-P
Unconjugated
250 µl/$460
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (PE) (1A4) Antibody
Rabbit, Mouse, Rat, Human
Flo
PE Conjugated
100 Tests/$896
ACTA2 / Smooth Muscle Actin Antibody - Anti-ACTA2 antibody IHC of human colon, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rabbit, Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$515
ACTA2 / Smooth Muscle Actin Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
120 µl/$460
ACTA2 / Smooth Muscle Actin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (N-Terminus) (1A4) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$395
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse, Human, Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$768
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ACTA2 / Smooth Muscle Actin Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
ACTA2 / Smooth Muscle Actin Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (1H8) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACTA2 / Smooth Muscle Actin Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (AT132D3) Antibody
Human
ELISA, ICC, IF, IHC-P, WB
Unconjugated
100 µl/$460
ACTA2 / Smooth Muscle Actin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
25 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
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ACTA2 / Smooth Muscle Actin Mouse anti-Baboon Monoclonal (N-Terminus) (Biotin) (1A4) Antibody
IF, IHC, IHC-Fr, IHC-P
Biotin Conjugated
500 µl/$1,281
ACTA2 / Smooth Muscle Actin Antibody - Immunohistochemical analysis of Smooth Muscle Actin staining in human skeletal muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rabbit, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
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ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
IHC, WB
FITC Conjugated
50 µg/$592
ACTA2 / Smooth Muscle Actin Antibody - Anti-ACTA2 antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (1D11-2B9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ACTA2 / Smooth Muscle Actin Antibody - Smooth Muscle Actin Antibody in Immunofluorescence (IF)
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (1H8) Antibody
Mouse, Rat, Non-Human Primate, Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$541
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (APC) (1A4) Antibody
Human
Flo
APC Conjugated
100 Tests/$947
ACTA2 / Smooth Muscle Actin Antibody - The expression of a-SMA and a-Ac-Tub in lung tissue measured by IHC
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ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Human
IF, IHC, IP, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ACTA2 / Smooth Muscle Actin Antibody - Formalin-fixed, paraffin-embedded Leiomyosarcoma stained with Smooth Muscle Actin antibody (SPM332).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (SPM332) Antibody
Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
ACTA2 / Smooth Muscle Actin Antibody - Frozen section of human small intestine immunostained with SM1 (1:1000)
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ACTA2 / Smooth Muscle Actin Mouse anti-Human Monoclonal (IA4) Antibody
Chicken, Sheep, Mouse, Goat, Rat, Pig, Human
ELISA, EM, IHC, IHC-Fr, WB
Unconjugated
50 µg/$470
ACTA2 / Smooth Muscle Actin Antibody - Anti-ACTA2 antibody IHC of human lung, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ACTA2 / Smooth Muscle Actin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rabbit, Mouse, Rat, Baboon, Human
IHC, IHC-P
Unconjugated
250 µl/$460
Viewing 1-25 of 132 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).