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Catalog Number Size Price
LS-C56352-1 1 ml $405 
Antibody

Leptin Antibody (aa57‑70) LS‑C56352

Leptin Antibody (aa57‑70) LS‑C56352

Antibody:
Sheep Polyclonal to Leptin
Application:
ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$405 
LS-C56352-1
1 ml
Toll Free North America
866-819-4732

Overview

Antibody:
Sheep Polyclonal to Leptin
Application:
ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
Leptin antibody LS-C56352 is an unconjugated sheep polyclonal antibody to Leptin from human, mouse and rat. Validated for ELISA.
Host
Sheep
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • ELISA (1:10000 - 1:50000)
Immunogen
HMW conjugated leptin amino acids 57-70.
Epitope
aa57-70
Specificity
Recognizes leptin, a 16kD secreted protein hormone encoded by the OB gene, which plays a key role in the regulation of metabolism, body weight and reproduction and is expressed primarily by white adipocytes, and to a lesser extent by stomach endothelium and the placenta. Regulation of food intake and energy expenditure by leptin is thought to predominantly occur in the hypothalamus of the brain, where leptin binds with high affinity to neuronal leptin receptors (OB-R), inhibiting the action of the feeding stimulants neuropeptide Y (NPY) and agouti-related peptide (AgRP), or promoting the effects of the appetite regulator a-melanocyte-stimulating hormone (a-MSH). Leptin also acts as a direct stimulator of fatty acid oxidation in the mitochondria of liver and skeletal muscle cells, and influences glucose and fat metabolism. The expression of leptin in relation to metabolic status is influenced by hormonal and metabolite control: stimulators of leptin include insulin and cortisol, whilst cAMP, thiazolidinediones and beta-adrenergic receptor agonists, reduce leptin expression.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About Leptin
P41159 NM_000230 NP_000221.1

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Requested From: United States
Date Requested: 10/15/2019