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Leptin

Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Gene Name: Leptin
Synonyms: LEP, Leptin, LEPD, Obese protein, Obese, mouse, homolog of, Obesity factor, OBS, OB
Target Sequences: NM_000230 NP_000221.1 P41159

Publications (6)

1
Leptin as a potential target for estrogen receptor-positive breast cancer. Yom CK, Lee KM, Han W, Kim SW, Kim HS, Moon BI, Jeong KY, Im SA, Noh DY. Journal of breast cancer. 2013 16:138-45. (WB; Human) [Full Text Article] [PubMed:23843844] [PMC:PMC3706857] Related Antibodies: LS-C25172.
2
Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, Owens KJ, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Placenta. 2015 36:1078-86. (WB; Mouse) [Full Text Article] [PubMed:26278057] Related Antibodies: LS-B1459.
3
Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse. Bello AR, Puertas-Avendaño RA, González-Gómez MJ, González-Gómez M, Laborda J, Damas C, Ruiz-Hidalgo M, Diaz C. Journal of neuroendocrinology. 2017 August;29: [Full Text Article] [PubMed:28718206] [PMC:PMC6084355]
4
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
5
Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and resumption of ovarian cyclicity in dairy cows. A Melgar, M T Harper, J Oh, F Giallongo, M E Young, T L Ott, S Duval, A N Hristov. Journal of dairy science. 2020 Jan;103:410-432. [Full Text Article] [PubMed:31733848]
6
Repeated photodynamic therapy using a chlorin e6-embedded device to prolong the therapeutic effects on obesity. Jung-Hoon Park, Ji Won Kim, Dae Sung Ryu, Hyeonseung Lee, Hee Kyong Na, Jin Hee Noh, Do Hoon Kim, Sanghee Lee, Kun Na, Hwoon-Yong Jung. Obesity (Silver Spring, Md.). 2024 May;32:911-922. [Full Text Article] [PubMed:38558513]
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Leptin Antibody - Anti-LEP / Leptin antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Leptin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$480
Leptin Antibody - Human, Kidney:Formalin-Fixed Paraffin-Embedded (FFPE)
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Leptin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
500 µg/$460
Leptin Antibody - Anti-LEP / Leptin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Leptin Antibody - Anti-LEP / Leptin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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Leptin Rabbit anti-Human Polyclonal (aa8-37) (PE) Antibody
Human
ELISA, ICC, IF, IHC-P, WB
PE Conjugated
200 µl/$952
Leptin Antibody - Detection limit for recombinant GST tagged LEP is approximately 0.1 ng/ml as a capture antibody.
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Leptin Mouse anti-Human Monoclonal (3G1-1C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Goat anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Goat anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
Leptin ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
Leptin ELISA Kit
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Sandwich
96-Well Microplate
Human
1.638 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Leptin ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
Leptin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$779
Leptin ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Leptin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Leptin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Leptin ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
Leptin ELISA Kit
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Sandwich
96-Well Strip Plate
Horse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$795
Leptin ELISA Kit
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Sandwich
96-Well Microplate
Rat
10.97 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Leptin ELISA Kit
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Sandwich
96-Well Strip Plate
Hamster
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody
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Leptin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western blot of recombinant Leptin.
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Leptin Rabbit anti-Cow Polyclonal (aa29-160) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
Leptin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
4.096 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$426
Leptin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.0 kDa
200 µg/$268; 1 mg/$349
Viewing 1-25 of 265 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).