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Anti-TRPV4 Antibody (1st Cytoplasmic Domain) LS-C95200

Ordering

Wt. Vol. Conc. Price
500 µg 500 µl 1 mg/ml $325

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Sheep Polyclonal (IgG) to Mouse TRPV4
Mouse, Human, Rat
Western blot
Unconjugated

Details

Mouse TRPV4
Sheep
Mouse, Human, Rat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Purified

Applications

Western blot (10 - 50 µg/ml)

Specificity and Use

TRPV4 antibody was raised against a synthetic peptide from the 1st cytoplasmic loop of mouse TRPV4 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and human.
1st Cytoplasmic Domain
Appears to be specific for TRPV4.
IHC: Antigen retrieval is essential for use on paraffin sections.

Packaging

Lyophilized. Centrifuge to remove any insoluble material
500 µl Reconstitute with sterile water.
Maintain the lyophilized/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
For research use only.

About TRPV4

Q9HBA0 NM_021625 NP_067638.3

TRPV4 Antibody, CMT2C Antibody, HMSN2C Antibody, OTRPC4 Antibody, SSQTL1 Antibody, VR-OAC Antibody, VRL-2 Antibody, Osm-9-like TRP channel 4 Antibody, SPSMA Antibody, TRP12 Antibody, VRL2 Antibody, VROAC Antibody, SMAL Antibody

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.

Requested From: United States
Date Requested: 8/29/2015

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