Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Gene Name: transient receptor potential cation channel, subfamily V, member 4
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPV4, CMT2C, HMSN2C, OTRPC4, SSQTL1, VR-OAC, VRL-2, Osm-9-like TRP channel 4, SPSMA, TRP12, VRL2, VROAC, SMAL
Target Sequences: NM_021625 NP_067638.3 Q9HBA0

Publications (8)

1
The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentera RC, Liedtke W, Krizaj D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:7089-101. (WB, IHC-Fr; Mouse, Human) [Full Text Article] [PubMed:21562271] [PMC:PMC3109951] Related Antibodies: LS-A8583, LS-C94498.
2
Neurite outgrowth and synaptophysin expression of postnatal CNS neurons on GaP nanowire arrays in long-term retinal cell culture. Piret G, Perez MT, Prinz CN. Biomaterials. 2013 34:875-87. (ICC, IHC-Fr; Mouse) [PubMed:23131535] Related Antibodies: LS-C94498.
3
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. Arredondo Zamarripa D, Noguez Imm R, Bautista Cortés AM, Vázquez Ruíz O, Bernardini M, Fiorio Pla A, Gkika D, Prevarskaya N, López-Casillas F, Liedtke W, Clapp C, Thébault S. Scientific reports. 2017 7:13094. (IHC; Rat) [Full Text Article] [PubMed:29026201] [PMC:PMC5638810] Related Antibodies: LS-C94498.
4
Polarity of varicosity initiation in central neuron mechanosensation. Gu Y, Jukkola P, Wang Q, Esparza T, Zhao Y, Brody D, Gu C,. The Journal of cell biology. 2017 216:2179-2199. (IHC; Mouse) [Full Text Article] [PubMed:28606925] Related Antibodies: LS-C94498.
5
TRPV4 Does Not Regulate the Distal Retinal Light Response. Yarishkin O, Phuong TTT, Lakk M, Križaj D. Advances in experimental medicine and biology. 2018 1074:553-560. [Full Text Article] [PubMed:29721987] [PMC:PMC6414060] Related Antibodies: LS-C94498.
6
The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Gao F, Yang Z, Jacoby RA, Wu SM, Pang JJ. Cell death & disease. 2019 May;10:364. [Full Text Article] [PubMed:31064977] [PMC:PMC6504919] Related Antibodies: LS-C94498.
7
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. American journal of physiology. Heart and circulatory physiology. 2012 Feb;302:H634-42. [Full Text Article] [PubMed:22140047] [PMC:PMC3353785] Related Antibodies: LS-A8583.
8
Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions. Senadheera S, Bertrand PP, Grayson TH, Leader L, Murphy TV, Sandow SL. Journal of anatomy. 2013 Dec;223:677-86. [Full Text Article] [PubMed:24128141] Related Antibodies: LS-A8583.
more


TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg   50µl   1mg/ml   $425.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
PE Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
AP Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
APC Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
HRP Conjugated, Azide-free
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TRPV4
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
Unconjugated
50µg   0.91mg/ml   $425.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
TRPV4 Antibody - Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
TRPV4 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human TRPV4
Chicken, Bovine, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
Select
Rabbit Polyclonal to Mouse TRPV4
Mouse, Rat
IF, IHC, IHC-Fr, WB
Unconjugated
100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg   $325.00
Select
Sheep Polyclonal (IgG) to Mouse TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg   $325.00
TRPV4 Antibody - Western blot analysis of TRPV4 using HeLa whole cells lysates
Select
Rabbit Polyclonal (IgG) to Human TRPV4
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   1mg/ml   $385.00
TRPV4 Antibody - TRPV4 Antibody western blot of HeLa cell line lysates (35 ug/lane). The TRPV4 antibody detected the TRPV4 protein (arrow).
Select
Rabbit Polyclonal to Human TRPV4
Human
WB
Unconjugated
400µl   $325.00
TRPV4 Antibody - TRPV4 antibody Western blot of HT1080 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human TRPV4
Rabbit, Mouse, Dog, Rat, Human
WB
Unconjugated
100µl   0.5mg/ml   $385.00
TRPV4 Antibody - TRPV4 antibody Western blot of HT1080 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human TRPV4
Rabbit, Mouse, Dog, Rat, Gibbon, Human
WB
Biotin Conjugated
100µl   1mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human TRPV4
Human
ELISA, IHC, WB
Unconjugated
100µg   $435.00
Viewing 1-25 of 52 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).