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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TRPV4

transient receptor potential cation channel, subfamily V, member 4

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Gene Name: transient receptor potential cation channel, subfamily V, member 4
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPV4, CMT2C, HMSN2C, OTRPC4, SSQTL1, VR-OAC, VRL-2, Osm-9-like TRP channel 4, SPSMA, TRP12, VRL2, VROAC, SMAL
Target Sequences: NM_021625 NP_067638.3 Q9HBA0

Publications (8)

1
The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentera RC, Liedtke W, Krizaj D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:7089-101. (WB, IHC-Fr; Mouse, Human) [Full Text Article] [PubMed:21562271] [PMC:PMC3109951] Related Antibodies: LS-A8583, LS-C94498.
2
Neurite outgrowth and synaptophysin expression of postnatal CNS neurons on GaP nanowire arrays in long-term retinal cell culture. Piret G, Perez MT, Prinz CN. Biomaterials. 2013 34:875-87. (ICC, IHC-Fr; Mouse) [PubMed:23131535] Related Antibodies: LS-C94498.
3
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. Arredondo Zamarripa D, Noguez Imm R, Bautista Cortés AM, Vázquez Ruíz O, Bernardini M, Fiorio Pla A, Gkika D, Prevarskaya N, López-Casillas F, Liedtke W, Clapp C, Thébault S. Scientific reports. 2017 7:13094. (IHC; Rat) [Full Text Article] [PubMed:29026201] [PMC:PMC5638810] Related Antibodies: LS-C94498.
4
Polarity of varicosity initiation in central neuron mechanosensation. Gu Y, Jukkola P, Wang Q, Esparza T, Zhao Y, Brody D, Gu C,. The Journal of cell biology. 2017 216:2179-2199. (IHC; Mouse) [Full Text Article] [PubMed:28606925] Related Antibodies: LS-C94498.
5
TRPV4 Does Not Regulate the Distal Retinal Light Response. Yarishkin O, Phuong TTT, Lakk M, Križaj D. Advances in experimental medicine and biology. 2018 1074:553-560. [Full Text Article] [PubMed:29721987] [PMC:PMC6414060] Related Antibodies: LS-C94498.
6
The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Gao F, Yang Z, Jacoby RA, Wu SM, Pang JJ. Cell death & disease. 2019 May;10:364. [Full Text Article] [PubMed:31064977] [PMC:PMC6504919] Related Antibodies: LS-C94498.
7
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. American journal of physiology. Heart and circulatory physiology. 2012 Feb;302:H634-42. [Full Text Article] [PubMed:22140047] [PMC:PMC3353785] Related Antibodies: LS-A8583.
8
Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions. Senadheera S, Bertrand PP, Grayson TH, Leader L, Murphy TV, Sandow SL. Journal of anatomy. 2013 Dec;223:677-86. [Full Text Article] [PubMed:24128141] Related Antibodies: LS-A8583.
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Filtered by: None
Target
TRPV4 (52)
Reactivity
Human (51)
Mouse (29)
Rat (28)
Bovine (9)
Chicken (1)
Chimpanzee (3)
Dog (15)
Gibbon (9)
Hamster (7)
Horse (7)
Monkey (11)
Pig (9)
Rabbit (8)
Application
IHC (24)
IHC-Fr (8)
IHC-P (17)
WB (42)
ELISA (16)
IF (10)
Peptide-ELISA (1)
Host
rabbit (51)
sheep (1)
Isotype
IgG (21)
Clonality
polyclonal pc (52)
Format
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (25)
Epitope
N-Terminus (11)
Internal (9)
aa160-189 (8)
aa719-768 (8)
1st Cytoplasmic Domain (1)
aa1-230 (1)
aa100-150 (1)
aa113-133 (1)
aa125-487 (1)
aa300-400 (1)
aa417-466 (1)
Publications
No (50)
Yes (2)
Showing 1-25 of 52 results

IHC-plus™ TRPV4 Antibody (Internal) LS-A8583
Publications (3)
Publications (3)
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, Biotin) LS-A108085
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, FITC) LS-A108086
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, AP) LS-A108083
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
AP Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, APC) LS-A108084
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
APC Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, PE) LS-A108088
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
PE Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (Internal, Azide-free, HRP) LS-A108087
Rabbit Polyclonal to Human TRPV4
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
HRP Conjugated, Azide-free
100µl  $650.00
Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody LS-B10184
Rabbit Polyclonal (IgG) to Human TRPV4
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-TRPV4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-TRPV4 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TRPV4 Antibody (aa100-150) LS-C94498
Publications (6)
Publications (6)
Rabbit Polyclonal to Mouse TRPV4
Mouse, Rat
IF, IHC, IHC-Fr, WB
Unconjugated
100µl 1mg/ml  $325.00

TRPV4 Antibody (aa300-400) LS-C95181
Rabbit Polyclonal (IgG) to Mouse TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg  $325.00

TRPV4 Antibody (1st Cytoplasmic Domain) LS-C95200
Sheep Polyclonal (IgG) to Mouse TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
500µg  $325.00

TRPV4 Antibody (aa113-133) LS-C313110
Rabbit Polyclonal to Human TRPV4
Mouse, Rat, Human
WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
WB of TRPV4 antibody. Lane 1: Rat Kidney Tissue Lysate. Lane 2: HEPA Cell Lysate.
Western blot analysis of TRPV4 using anti-TRPV4 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: Rat Kidney tissue lysates, Lane 2: HEPA whole cell lysates, After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TRPV4 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for TRPV4 at approximately 98KD. The expected band size for TRPV4 is at 98KD.

IHC-plus™ TRPV4 Antibody (N-Terminus) LS-A8581
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
Unconjugated
50µg 0.91mg/ml  $425.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (N-Terminus, Biotin) LS-A108079
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (N-Terminus, FITC) LS-A108080
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (N-Terminus, AP) LS-A108077
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (N-Terminus, APC) LS-A108078
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TRPV4 Antibody (N-Terminus, Azide-free, HRP) LS-A108081
Rabbit Polyclonal to Human TRPV4
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-TRPV4 antibody IHC of human trachea. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TRPV4 Antibody LS-C341813
Rabbit Polyclonal to Human TRPV4
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl 1mg/ml  $385.00

TRPV4 Antibody (aa719-768) LS-C110035
Rabbit Polyclonal to Human TRPV4
Rabbit, Mouse, Dog, Rat, Human
WB
Unconjugated
100µl 0.5mg/ml  $385.00
TRPV4 antibody Western blot of HT1080 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TRPV4 Antibody (aa719-768, Biotin) LS-C432648
Rabbit Polyclonal to Human TRPV4
Rabbit, Mouse, Dog, Rat, Gibbon, Human
WB
Biotin Conjugated
100µl 1mg/ml  $405.00
TRPV4 antibody Western blot of HT1080 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TRPV4 Antibody (aa160-189) LS-C157286
Rabbit Polyclonal to Human TRPV4
Human
WB
Unconjugated
400µl  $325.00
TRPV4 Antibody western blot of HeLa cell line lysates (35 ug/lane). The TRPV4 antibody detected the TRPV4 protein (arrow).

IHC-plus™ TRPV4 Antibody (Internal) LS-B14080
Rabbit Polyclonal to Human TRPV4
Chicken, Bovine, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $425.00
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

TRPV4 Antibody LS-C661293
Rabbit Polyclonal (IgG) to Human TRPV4
Human
ELISA, IHC, WB
Unconjugated
100µg  $435.00

TRPV4 Antibody LS-C809861
Rabbit Polyclonal (IgG) to Human TRPV4
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Western blot Image
Western blot Image
Showing 1-25 of 52 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).