Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Chicken Polyclonal (IgY) to Human CCL4 / MIP-1 Beta
Western blot, ELISA
Human CCL4 / MIP-1 Beta
Human (tested or 100% immunogen sequence identity)
Monkey, Horse (at least 90% immunogen sequence identity)
ELISA (0.1 - 0.5 µg/ml)
Specificity and Use
CCL4 / MIP-1 Beta antibody was raised against synthetic peptide: GSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN, corresponding to amino acids 27-92 of Human Macrophage Inflammatory Protein 1 beta. Percent identity by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey, Horse (97%); Panda (90%); Bovine, Dog, Pig (87%); Rat, Hamster, Rabbit (84%); Mouse (81%).
Species cross-reactivity: Cross-reacts with Human. Not yet tested in other species.
Suitable for use in ELISA and Western Blot. ELISA: 0.1-0.5 ug/ml.
PBS, pH 7.2. No preservative added.
+4°C or -20°C, Avoid repeated freezing and thawing.
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells.