Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
Gene Name: | topoisomerase (DNA) II binding protein 1 |
Family/Subfamily: | DNA repair |
Synonyms: | TOPBP1, KIAA0259, TOP2BP1 |
Target Sequences: | NM_007027 NP_008958.2 Q92547 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.