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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TOPBP1 Antibody (phospho‑Ser1159, APC) LS‑C271959
TOPBP1 antibody LS-C271959 is an APC-conjugated rabbit polyclonal antibody to human TOPBP1. Validated for DB and ELISA.
Antibody
Catalog
Size
Price
LS-C271959-200
200 µl
$680

Popular TOPBP1 Products

Immunohistochemistry - Paraffin Image
Species: Human
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded human gastric cancer tissue.
Species: Human, Mouse
Applications: IHC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded rat lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Species: Human, Mouse, Rat
Applications: IHC, Western blot
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.
Species: Human
Applications: IHC, IHC - Paraffin, ELISA
Antibody
Species: Human
Applications: ICC, Western blot

Product Description

TOPBP1 antibody LS-C271959 is an APC-conjugated rabbit polyclonal antibody to human TOPBP1. Validated for DB and ELISA.
About TOPBP1
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. Q92547 NM_007027 NP_008958.2

TOPBP1 Antibody, KIAA0259 Antibody, TOP2BP1 Antibody


Specifications

Target
Human TOPBP1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Allophycocyanin. Also available Unconjugated or conjugated with AP, Biotin, HRP, FITC, PE.
Purification
Affinity purified
Modifications
Unmodified
Applications
  • ELISA
  • Dot Blot
  • (applications tested for the base form of this product only)
Epitope
pSer1159
Specificity
This TOPBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1159 of human TOPBP1.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
PBS, No preservatives added
Storage
Short term: store at 4°C. Long term: aliquot and store -20°C for up to 6 months. Avoid freeze-thaw cycles. Protect from light.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/26/2018

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