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TNF Alpha
tumor necrosis factor
TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
| Gene Name: | tumor necrosis factor |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNF, APC1 protein, Cachectin, DIF, TNF Alpha, Tumor necrosis factor-alpha, TNF-alpha, TNF-a, TNFA, Tumor necrosis factor, TNF, macrophage-derived, TNF, monocyte-derived, TNFSF2 |
| Target Sequences: | NM_000594 NP_000585.2 P01375 |
Publications (19)
1
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells. Ivanov VN, Ronai Z. The Journal of biological chemistry. 1999 274:14079-89.
[PubMed:10318823]
Related Antibodies: LS-C41024.
2
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57.
[PubMed:17641010]
Related Antibodies: LS-C41025.
3
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3885-90.
[PubMed:22355106]
[PMC:PMC3309713]
Related Antibodies: LS-C41024.
☰ Filters
Products
Proteins
(99)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(94)
Target
TNF Alpha
(99)
Application
SDS-PAGE
(3)
Product Group
Coronavirus Antibodies Proteins cDNAs
(99)
Cytokine Release Syndrome
(99)
Cytokine Release Syndrome Proteins
(99)
Format
Animal-free
(2)
Publications
No
(99)
Tag
10His, N-terminus
(1)
6His, C-terminus
(4)
6His, N-terminus
(6)
6His-B2M, N-terminus
(1)
6His-SUMO, N-terminus
(1)
DDK (Flag)
(1)
DDK (Flag)-Human ACRP30headless aa 16-108
(1)
DDK,N-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
(6)
His, N-Terminal
(7)
His,C-terminus
(1)
His-DDK (Flag), N-terminus
(1)
His-GST
(1)
His-T7
(7)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(3)
Chicken
(1)
Dog
(3)
Horse
(2)
Human
(40)
Mouse
(21)
Pig
(6)
Rabbit
(4)
Rat
(10)
Rhesus monkey
(1)
Sheep
(3)
Woodchuck
(2)
Source
293F Cells
(2)
293T Cells
(1)
Baculovirus
(1)
CHO Cells
(1)
E. coli
(70)
HEK 293 Cells
(8)
Wheat Germ Extract
(2)
Yeast
(7)
Purification
Purified
(37)
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(47)
Biologically Active
Biologically active
(39)
Animal-free
Animal-free
(2)
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
10 µg/$268; 50 µg/$349
E. coli
DDK (Flag)
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~17kDa (SDS-PAGE)
50 µg/$337; 10 µg/$267
E. coli
His-GST
38.1 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
Wheat Germ Extract
GST, N-terminus
51.37 kDa
10 µg/$479; 25 µg/$670
CHO Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
50 µg/$790
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$304; 10 µg/$262; 1 mg/$990
293F Cells
His, N-Terminal
24kDa
10 µg/$315; 50 µg/$652; 200 µg/$1,228; 1 mg/$2,469; 5 mg/$4,551; 2 mg/$2,661
Yeast
His
19.2 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
E. coli
6His, C-terminus
17 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
His, N-Terminal
20kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 1 mg/$1,876; 5 mg/$2,838; 2 mg/$2,060
HEK 293 Cells
Myc-DDK (Flag)
25.5 kDa
100 µg/$494
E. coli
None
Less than 0.1 ng/µg protein.
17.5 kDa
10 µg/$330; 50 µg/$412; 1000 µg/$2,005
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 157 amino acid recombinant protein has a predicted molecular mass of 17,352 Da. The DTT-reduced protein and non-reduced protein migrate at approximately 16kDa by SDS-PAGE. The N-terminal amino acid is Val.
10 µg/$306; 50 µg/$363; 100 µg/$485; 500 µg/$1,000
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 157 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of approximately 17,361 Da. The DTT-reduced protein migrates at approximately 17kDa and the non-reduced protein migrates at approximately 16kDa by SDS-PAGE.
10 µg/$325; 25 µg/$436; 100 µg/$938
E. coli
None
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 156 amino acid recombinant protein has a predicted molecular mass of 17,257 Da. The DTT-reduced and non-reduced protein migrate at approximately 16 kD by SDS-PAGE. The N-terminal amino acid is Leu.
10 µg/$306; 25 µg/$367; 100 µg/$689; 500 µg/$1,577
E. coli
None
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
E. coli
None
17 kDa
100 µg/$728; 20 µg/$360
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
None
SDS-PAGE
Biologically active
The recombinant human TNF-a consists of 158 amino acids and has a predicted molecular mass of 17.4 kDa which is also estimated by SDS-PAGE.
10 µg/$255; 100 µg/$364; 1 mg/$1,452
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