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TNF Alpha

tumor necrosis factor

TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Gene Name: tumor necrosis factor
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNF, APC1 protein, Cachectin, DIF, TNF Alpha, Tumor necrosis factor-alpha, TNF-alpha, TNF-a, TNFA, Tumor necrosis factor, TNF, macrophage-derived, TNF, monocyte-derived, TNFSF2
Target Sequences: NM_000594 NP_000585.2 P01375

Publications (20)

1
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells. Ivanov VN, Ronai Z. The Journal of biological chemistry. 1999 274:14079-89. [PubMed:10318823] Related Antibodies: LS-C41024.
2
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41025.
3
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3885-90. [PubMed:22355106] [PMC:PMC3309713] Related Antibodies: LS-C41024.
4
Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide. Qu X, Pröll M, Neuhoff C, Zhang R, Cinar MU, Hossain MM, Tesfaye D, Große-Brinkhaus C, Salilew-Wondim D, Tholen E, Looft C, Hölker M, Schellander K, Uddin MJ. PloS one. 2015 10:e0121574. (WB; Bovine) [Full Text Article] [PubMed:25793534] [PMC:PMC4368608] Related Antibodies: LS-C43037.
5
Supervised Clustering of Adipokines and Hormonal Receptors Predict Prognosis in a Population of Obese Women with Type 1 Endometrial Cancer. Uzan J, Laas E, Alsamad IA, Skalli D, Mansouri D, Haddad B, Touboul C. International journal of molecular sciences. 2017 18: (WB; Human) [Full Text Article] [PubMed:28505082] [PMC:PMC5454967]
6
The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats. Andrzej Wróbel, Lukasz Zapala, Tomasz Kluz, Artur Rogowski, Marcin Misiek, Kajetan Juszczak, Jacek Sienko, Daniela Gold, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Piotr Radziszewski. International journal of molecular sciences. 2021 May;22: [Full Text Article] [PubMed:34072606] [PMC:PMC8198845]
7
CD4 T-cell immune stimulation of HER2?+?breast cancer cells alters response to trastuzumab in vitro. Patrick N Song, Ameer Mansur, Kari J Dugger, Tessa R Davis, Grant Howard, Thomas E Yankeelov, Anna G Sorace. Cancer cell international. 2020 November;20:544. [Full Text Article] [PubMed:33292267] [PMC:PMC7654187]
8
O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment. Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Daniela Ulrich, Ewa Poleszak, Tomasz Rechberger. Frontiers in pharmacology. 2020 August;11:1002. [Full Text Article] [PubMed:32733244] [PMC:PMC7360849]
9
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]
10
Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Yan-Fang Xian, Chang Qu, Yue Liu, Siu-Po Ip, Qiu-Ju Yuan, Wen Yang, Zhi-Xiu Lin. Oxidative medicine and cellular longevity. 2020 July;2020:5920476. [PubMed:32714487] [PMC:PMC7354664]
11
Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]
12
Inhibition of lncRNA H19/miR-370-3p pathway mitigates neuronal apoptosis in an in vitro model of spinal cord injury (SCI). Xin Li, Yan Qian, Kaihua Tang, Yang Li, Rui Tao, Chunyan Gong, Li Huang, Kaiwen Zou, Lindong Liu. Translational neuroscience. 2021 Mar;12:103-113. [Full Text Article] [PubMed:33708438] [PMC:PMC7925972] Related Antibodies: LS-B6067.
13
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C18838.
14
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
15
Carbocisteine as a Modulator of Nrf2/HO-1 and NF?B Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis. Amir Mohamed Abdelhamid, Mahmoud E Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, Sara T Elazab, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A Amin, Ahmed Shata, Osama A Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Ahmed Alhowail, Gaber El-Saber Batiha, Engy A El-Mahmoudy, Maram Attia, Alaa Allam, Mona Y Zaater, Mona M Osman, Manar Nader, Aya Taha, Nada Abul Makarem, Sameh Saber. Frontiers in pharmacology. 2022 June;13:887233. [Full Text Article] [PubMed:35754464] [PMC:PMC9214041]
16
Immunohistochemical Inflammation in Histologically Normal Appendices in Patients with Right Iliac Fossa Pain. Emmanouil Psaltis, Abed M Zaitoun, Keith R Neal, Dileep N Lobo. World journal of surgery. 2021 December;45:3592-3602. [Full Text Article] [PubMed:34392384] [PMC:PMC8572837] Related Antibodies: LS-B7268.
17
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
18
Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Nancy S Younis, Maged E Mohamed, Nermin A El Semary. Marine drugs. 2022 January;20:56. [Full Text Article] [PubMed:35049911] [PMC:PMC8781738]
19
Cellular and mitochondrial adaptation mechanisms in the colon of lactating dairy cows during hyperthermia. Mehdi Eslamizad, Dirk Albrecht, Björn Kuhla, Franziska Koch. Journal of dairy science. 2023 December; [Full Text Article] [PubMed:38056565]
20
Proteome of the early embryo-maternal dialogue in the cattle uterus. Mu[Character f1]oz M, Corrales FJ, Caama[Character f1]o JN, D[Character ed]ez C, Trigal B, Mora MI, Mart[Character ed]n D, Carrocera S, G[Character f3]mez E. Journal of proteome research. 2012 Feb;11:751-66. [Full Text Article] [PubMed:22148898] Related Antibodies: LS-C43037.
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
10 µg/$268; 50 µg/$349
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E. coli
DDK (Flag)
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~17kDa (SDS-PAGE)
50 µg/$337; 10 µg/$267
TNF Alpha Protein - Recombinant Tumor Necrosis Factor Alpha By SDS-PAGE
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E. coli
His-GST
38.1 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
TNF Alpha Protein - 12.5% SDS-PAGE of human TNF stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
51.37 kDa
10 µg/$479; 25 µg/$670
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CHO Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
50 µg/$790
TNF Alpha Protein - Biological Activity TNF-alpha, Human stimulates cytotoxicity of L-929 mouse fibrosarcoma cells. The ED 50 for this effect is typically 11-50 pg/mL.
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E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$304; 10 µg/$262; 1 mg/$990
TNF Alpha Protein - Eukaryotic Tumor Necrosis Factor Alpha (TNFa) by SDS-PAGE
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293F Cells
His, N-Terminal
24kDa
10 µg/$315; 50 µg/$652; 200 µg/$1,228; 1 mg/$2,469; 5 mg/$4,551; 2 mg/$2,661
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
TNF Alpha Protein
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Yeast
His
19.2 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
TNF Alpha Protein - Recombinant Tumor Necrosis Factor Alpha (TNFa) by SDS-PAGE
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E. coli
His, N-Terminal
20kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 1 mg/$1,876; 5 mg/$2,838; 2 mg/$2,060
TNF Alpha Protein
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E. coli
6His, C-terminus
17 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
TNF Alpha Protein - Human TNF-α cytotoxicity on L929 cells.
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E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 157 amino acid recombinant protein has a predicted molecular mass of 17,352 Da. The DTT-reduced protein and non-reduced protein migrate at approximately 16kDa by SDS-PAGE. The N-terminal amino acid is Val.
10 µg/$306; 50 µg/$363; 100 µg/$485; 500 µg/$1,000
TNF Alpha Protein - Rat TNF-a cytotoxicity on L929 cells
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E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 157 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of approximately 17,361 Da. The DTT-reduced protein migrates at approximately 17kDa and the non-reduced protein migrates at approximately 16kDa by SDS-PAGE.
10 µg/$325; 25 µg/$436; 100 µg/$938
TNF Alpha Protein - Cytotoxic effect on L929 mouse fibroblast cells induced by mouse TNF-α in the presence of actinomycin D.
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E. coli
None
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 156 amino acid recombinant protein has a predicted molecular mass of 17,257 Da. The DTT-reduced and non-reduced protein migrate at approximately 16 kD by SDS-PAGE. The N-terminal amino acid is Leu.
10 µg/$306; 25 µg/$367; 100 µg/$689; 500 µg/$1,577
TNF Alpha Protein - Recombinant Pig TNF alpha detected using Rabbit anti Pig TNF alpha as the capture reagent and Rabbit anti Pig TNF alpha:Biotin as the detection reagent followed by Streptavidin:HRP.
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Yeast
None
16.9 kDa
5 µg/$390
TNF Alpha Protein - Recombinant Dog TNF alpha detected using Goat anti Dog TNF alpha as the capture reagent and Goat anti Dog TNF alpha:Biotin as the detection reagent followed by Streptavidin:HRP.
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Yeast
None
16.9 kDa
5 µg/$390
TNF Alpha Protein - Recombinant bovine TNF alpha detected using Rabbit anti Bovine TNF alpha as the capture reagent and Rabbit anti Bovine TNF alpha:Biotin as the detection reagent followed by Streptavidin:HRP.
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Yeast
None
17.4 kDa
5 µg/$390
Select
E. coli
None
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
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E. coli
GST
44.6 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
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E. coli
None
17 kDa
100 µg/$728; 20 µg/$360
Select
E. coli
None
17.4 kDa
20 µg/$379
TNF Alpha Protein
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
17.5 kDa
100 µg/$677
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
17.4 kDa
20 µg/$364
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.2 kDa
1 mg/$1,063; 10 µg/$253; 50 µg/$300
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).