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PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation.

Gene Name: p21 protein (Cdc42/Rac)-activated kinase 1
Family/Subfamily: Protein Kinase , PAK (STE20)
Synonyms: PAK1, Alpha-PAK, p21-activated kinase 1, p65-PAK, Rac/p21-activated kinase, STE20 homolog, yeast, PAKalpha, PAK-1
Target Sequences: NM_002576 NP_002567.3 Q13153

☰ Filters
Antibodies (95)
Proteins (9)
ELISA Kits (7)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (2)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Primary (95)
Recombinant (5)
Sandwich (2)
PAK1 (111)
Human (95)
Mouse (45)
Rat (52)
Bat (2)
Bovine (6)
Chicken (1)
Dog (4)
Guinea pig (3)
Hamster (1)
Horse (2)
Monkey (4)
Non-Human Primate (1)
Pig (2)
Rabbit (4)
Sheep (2)
Zebra Fish (1)
IHC (49)
IHC-P (19)
WB (84)
DB (9)
ELISA (45)
ICC (7)
IF (18)
IP (14)
Peptide-ELISA (10)
rabbit (92)
mouse (2)
goat (1)
Product Group
IHCPlus (4)
IgG (64)
IgG1,k (2)
monoclonal mc (2)
polyclonal pc (93)
1E11 (1)
4D1 (1)
96-Well Microplate (3)
96-Well Strip Plate (4)
AP Conjugated (4)
APC (1)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Preservative Free (1)
Unconjugated (64)
pThr212 (14)
Thr423 (8)
aa252-501 (8)
pThr423 (8)
Internal (3)
pSer204 (3)
140-220 aa (2)
150-230 aa (2)
N-Terminus (2)
pSer199 (2)
pThr84 (2)
Glu195 (1)
Ile206 (1)
Lys198 (1)
aa1-14 (1)
aa1-240 (1)
aa1-50 (1)
aa149-198 (1)
aa165-214 (1)
aa170-219 (1)
aa178-227 (1)
aa238-251 (1)
aa333-545 (1)
aa40-90 (1)
p204 (1)
p212 (1)
No (111)
Adherent Cell Cultures (3)
Plasma (2)
Serum (2)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
PAK1 Antibody - Immunofluorescence of monoclonal antibody to PAK1 on HeLa cell. [antibody concentration 35 ug/ml]
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PAK1 Mouse anti-Human Monoclonal (4D1) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
PAK1 Antibody - Antibody (1 ug/ml) staining of Rat Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PAK1 Goat anti-Human Polyclonal (aa238-251) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
PAK1 Antibody - Anti-PAK1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PAK1 Mouse anti-Human Monoclonal (1E11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PAK1 Antibody - Anti-PAK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PAK1 Rabbit anti-Human Polyclonal (aa178-227) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
PAK1 Antibody - Immunohistochemical analysis of PAK1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PAK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
PAK1 Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PAK1 Antibody (T423) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PAK1 Rabbit anti-Human Polyclonal (Thr423) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PAK1 Protein
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E. coli
His-SUMO
76.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PAK1 Antibody - Anti-PAK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PAK1 Rabbit anti-Human Polyclonal (aa165-214) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PAK1 Antibody - Anti-PAK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PAK1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PAK1 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using PAK1 (Phospho-Ser204) antibody.
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PAK1 Rabbit anti-Human Polyclonal (pSer204) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$391
PAK1 Antibody - Immunohistochemical analysis of PAK1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PAK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
PAK1 Antibody - Immunohistochemical analysis of PAK1 (pT212) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PAK1 Rabbit anti-Human Polyclonal (pThr212) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
PAK1 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PAK1 Rabbit anti-Human Polyclonal (pThr212) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PAK1 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PAK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PAK1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PAK1 (Ab-212) antibody.
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PAK1 Rabbit anti-Human Polyclonal (p212) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PAK1 Antibody - Western blot of PAK1 expression in Etoposide treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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PAK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
Select
PAK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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PAK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
PAK1 Antibody - Western blot of PAK alpha antibody
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PAK1 Rabbit anti-Human Polyclonal (150-230 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PAK1 Antibody - IHC of PAK1 (I206) pAb in paraffin-embedded human colon carcinoma tissue.
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PAK1 Rabbit anti-Human Polyclonal (Ile206) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PAK1 Antibody - IHC of PAK (E195) pAb in paraffin-embedded human breast carcinoma tissue.
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PAK1 Rabbit anti-Human Polyclonal (Glu195) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PAK1 Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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PAK1 Rabbit anti-Human Polyclonal Antibody
Mouse
ICC, IHC, IP, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PAK1 Antibody - Immunofluorescence staining of PAK1 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-rat PAK1 polyclonal antibody (dilution ratio: 1:5000) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm.
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PAK1 Rabbit anti-Rat Polyclonal (Preservative Free) Antibody
Rat
ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
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PAK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Guinea pig, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$688
PAK1 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
Viewing 1-25 of 111 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).