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SUMO2

small ubiquitin-like modifier 2

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Gene Name: small ubiquitin-like modifier 2
Synonyms: SUMO2, HSMT3, SMT3 homolog 2, SMT3A, Sentrin 2, Smt3B, SMT3H2, SUMO-2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Ubiquitin-like protein SMT3B
Target Sequences: NM_006937 NP_008868.3 P61956

Publications (2)

1
SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. The Journal of biological chemistry. 2005 280:24330-8. [PubMed:15857832]
2
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A. Human molecular genetics. 2010 19:181-95. [PubMed:19843541] Related Antibodies: LS-C98825.

☰ Filters
Products
Antibodies (52)
Primary (52)
SUMO2 (52)
Human (46)
Mouse (13)
Rat (22)
Bovine (1)
Pig (9)
Xenopus (1)
Zebrafish (1)
IHC (21)
IHC-P (16)
WB (39)
Flo (8)
ELISA (17)
ICC (2)
IF (17)
IP (1)
Peptide-ELISA (2)
rabbit (37)
mouse (15)
Product Group
IHCPlus (1)
IgG (16)
IgG1,k (13)
IgG2b (1)
monoclonal mc (15)
polyclonal pc (37)
973CT8.1.1 (1)
S23MT-1 (3)
S2MT-1 (3)
SPM572 (2)
SPM621 (2)
SUMO2/1199 (3)
APC (1)
APC Conjugated (2)
Azide-free (6)
Biotin Conjugated (4)
BSA-free (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Preservative Free (2)
Ready-to-Use (3)
Unconjugated (36)
N-Terminus (9)
aa1-95 (8)
Gly93 (1)
Internal (1)
aa2-95 (1)
aa44-93 (1)
aa63-93 (1)
No (51)
Yes (1)
SUMO2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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SUMO2 Rabbit anti-Human Polyclonal (aa63-93) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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SUMO2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Unconjugated
50 µl/$303; 100 µl/$365
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody (SUMO2/1199).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (SUMO2/1199) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody (SUMO2/1199).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Ready-to-Use) (SUMO2/1199) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody (SUMO2/1199).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SUMO2/1199) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO2 Antibody - Anti-SUMO2 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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SUMO2 Rabbit anti-Human Polyclonal (aa44-93) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-2/3 antibody (SPM572).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (SPM572) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-2/3 antibody (SPM572).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM572) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO2 antibody (SPM621).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (SPM621) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO2 antibody (SPM621).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM621) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO2 Antibody - Immunohistochemistry of paraffin-embedded human esophagus using SUMO2 antibody at dilution of 1:100 (200x lens).
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SUMO2 Antibody - IHC analysis of human tonsil with SUMO2/3 antibody (clone S23MT-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (S23MT-1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
SUMO2 Antibody - IHC analysis of human tonsil with SUMO2/3 antibody (clone S23MT-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (S23MT-1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO2 Antibody - IHC analysis of human tonsil with SUMO2/3 antibody (clone S23MT-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Ready-to-Use) (S23MT-1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IP, WB
Unconjugated
100 µl/$412
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (S2MT-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Ready-to-Use) (S2MT-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SUMO2 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with SUMO-2 antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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SUMO2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (S2MT-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SUMO2 Antibody - Immunohistochemistry of paraffin-embedded rat lung using SUMO2 antibody at dilution of 1:100 (40x lens).
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SUMO2 Antibody - Immunohistochemistry of paraffin-embedded human melanoma cancer at dilution of 1:100
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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SUMO2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$379
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SUMO2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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SUMO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
Viewing 1-25 of 52 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).