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Proenkephalin / PENK

proenkephalin

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

Gene Name: proenkephalin
Family/Subfamily: Endogenous opioids , not assigned-Endogenous opioids
Synonyms: PENK, Enkephalin A, Met enkephalin, Preproenkephalin, Proenkephalin, Proenkephalin-A
Target Sequences: NM_006211 NP_006202.1 P01210

Publications (6)

1
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics. Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J. PLoS biology. 2018 June;16:e2006387. (Rat) [Full Text Article] [PubMed:29912866] [PMC:PMC6029811]
2
Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. Krajeski RN, Macey-Dare A, van Heusden F, Ebrahimjee F, Ellender TJ. The Journal of physiology. 2019 November;597:5265-5293. [Full Text Article] [PubMed:31531863] [PMC:PMC6900874]
3
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Anna Piotrowska, Joanna Starnowska-Sokól, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewlocka. Pain. 2021 February;162:432-445. [Full Text Article] [PubMed:32826750] [PMC:PMC7808367] Related Antibodies: LS-B15645.
4
A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition. Asier Aristieta, Massimo Barresi, Shiva Azizpour Lindi, Grégory Barrière, Gilles Courtand, Brice de la Crompe, Lise Guilhemsang, Sophie Gauthier, Stéphanie Fioramonti, Jérôme Baufreton, Nicolas P Mallet. Current biology : CB. 2020 December; [Full Text Article] [PubMed:33306949]
5
Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Farid N Garas, Rahul S Shah, Eszter Kormann, Natalie M Doig, Federica Vinciati, Kouichi C Nakamura, Matthijs C Dorst, Yoland Smith, Peter J Magill, Andrew Sharott. eLife. 2016 Sep;5:e16088. [Full Text Article] [PubMed:27669410] [PMC:PMC5036963]
6
Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon. Fran van Heusden, Anežka Macey-Dare, Jack Gordon, Rohan Krajeski, Andrew Sharott, Tommas Ellender. Cell reports. 2021 Apr;35:109041. [Full Text Article] [PubMed:33910016] [PMC:PMC8097690]
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Antibodies (36)
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Proenkephalin / PENK (54)
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aa145-174 (6)
aa143-192 (4)
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aa25-267 (2)
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Proenkephalin / PENK Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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Neuroscience
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa 25-267) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Proenkephalin / PENK Antibody - Western Blot analysis of PENK expression in transfected 293T cell line by PENK monoclonal antibody (M04), clone 9E7.Lane 1: PENK transfected lysate (Predicted MW: 29.48 KDa).Lane 2: Non-transfected lysate.
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Proenkephalin / PENK Mouse anti-Human Monoclonal (9E7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Proenkephalin / PENK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
Proenkephalin / PENK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
Proenkephalin / PENK Antibody - Goat Anti-Proenkephalin (mouse) Antibody (0.02µg/ml) staining of PFA-perfused cryosection of Mouse Stria terminalis. HRP-staining with Ni-DAB after Biotin-SP-anti-goat amplification. Data obtained by Prof. Erik Hrabovszky, Inst, Exp, Med., Budapest, Hungary.
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Proenkephalin / PENK Goat anti-Mouse Polyclonal (aa84-94) Antibody
Mouse, Rat
IHC-Fr, Peptide-ELISA
Unconjugated
100 µg/$503
Proenkephalin / PENK Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Proenkephalin / PENK Antibody - PENK antibody immunohistochemistry of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
400 µl/$393
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Proenkephalin / PENK Rabbit anti-Cat Polyclonal Antibody
Rat, Pig, Cat
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$952
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Proenkephalin / PENK Mouse anti-Rat Monoclonal (C-Terminus) Antibody
Rabbit, Guinea pig, Rat, Hamster
ICC, IHC, IHC-Fr
Unconjugated
100 µl/$748
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Proenkephalin / PENK Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
IHC, RIA
Unconjugated
500 µl/$1,167
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Proenkephalin / PENK Rabbit anti-Rat Polyclonal Antibody
Rat
IF
Unconjugated
50 µl/$786
Proenkephalin / PENK Antibody - Western blot using a recombinant protein encoding Proenkephalin / PENK antibody.
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
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Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
ELISA, ICC, IHC, RIA
Unconjugated
100 µl/$487
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
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Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa145-174) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2kD
50 µg/$534
Proenkephalin / PENK Protein - 12.5% SDS-PAGE of human PENK stained with Coomassie Blue
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Wheat Germ Extract
GST
55.11 kDa
2 µg/$439
Proenkephalin / PENK Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Proenkephalin / PENK Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Proenkephalin / PENK Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Viewing 1-25 of 54 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).