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| Catalog Number | Size | Price |
|---|---|---|
| LS-B15645-50 | 50 µl (2.08 mg/ml) | $460 |
1 of 2
2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human Proenkephalin / PENK Antibody (aa 25‑267, IHC, WB) LS‑B15645
PathPlus™ Polyclonal Rabbit anti‑Human Proenkephalin / PENK Antibody (aa 25‑267, IHC, WB) LS‑B15645
Note: This antibody replaces LS-C334627
Antibody:
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa 25-267) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
Proenkephalin / PENK Rabbit anti-Human Polyclonal (aa 25-267) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Specifications
Description
PENK (proenkephalin) is an endogenous opioid polypeptide hormone that produces multiple enkephalin peptides. Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human Proenkephalin / PENK
Synonyms
PENK | Enkephalin A | Met enkephalin | Preproenkephalin | Proenkephalin | Proenkephalin-A
Host
Rabbit
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-267 of human PENK (NP_001129162.1). ECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF
Epitope
aa 25-267
Specificity
Human Proenkephalin / PENK
Applications
- IHC
- IHC - Paraffin (1:100)
- Western blot (1:500 - 1:2000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
The predicted MW is 30kDa, while the observed MW by Western blot was 31kDa.
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About Proenkephalin / PENK
Validation
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
See More About...
LSBio Ratings
PathPlus™ Proenkephalin / PENK Antibody (aa 25-267) for IHC, WB/Western LS-B15645 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Anna Piotrowska, Joanna Starnowska-Sokól, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewlocka. Pain. 2021 February;162:432-445.
Customer Reviews (0)
Featured Products
Species:
Mouse, Rat
Applications:
IHC - Frozen, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
Western blot, ELISA
Species:
Human
Applications:
IHC, Radioimmunoassay
Species:
Cat, Rat, Pig
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Immunofluorescence
Species:
Rat, Guinea pig, Hamster, Rabbit
Applications:
IHC, IHC - Frozen, ICC
Reactivity:
Mouse
Range:
78-5000 pg/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/24/2024
Date Requested: 4/24/2024
