PDCD4

programmed cell death 4 (neoplastic transformation inhibitor)

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. PDCD4 inhibits the translation initiation factor E1F4A. Phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis.

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Products

Proteins (5)

Type

Recombinant (5)

Target

PDCD4 (5)

Publications

No (5)

Tag

6His, C-terminus (2)

GST (1)

His, N-terminus + His, C-terminus (1)

Species

Human (5)

Source

E. coli (4)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human PDCD4 Protein (Recombinant His, N-terminus + His, C-terminus) - LS-G146205

Source:

E. coli

Tag:

His, N-terminus + His, C-terminus

Molecular Weight:

36.9kDa

Price:

20 µg/$270; 100 µg/$390

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Human PDCD4 Protein (Recombinant GST) (Full Length) - LS-G33309

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.33 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PDCD4 Protein (Recombinant) - LS-G3512

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PDCD4 Protein (Recombinant 6His, C-terminus) (Lys212-Pro357) - LS-G139662

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.0 kDa

Price:

10 µg/$288; 50 µg/$436

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Human PDCD4 Protein (Recombinant 6His, C-terminus) (Lys212-Pro357) - LS-G39676

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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