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Catalog Number Size Price
LS-B1388-50 50 µg (1 mg/ml) $545 
PDCD4 Antibody - Anti-PDCD4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PDCD4 Antibody - Western blot of PDCD4 in A-20 cell lysate with PDCD4 antibody at (A) 0.5 and (B) 1ug/ml.
PDCD4 Antibody - Anti-PDCD4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PDCD4 Antibody - Western blot of PDCD4 in A-20 cell lysate with PDCD4 antibody at (A) 0.5 and (B) 1ug/ml.
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PathPlus™ Polyclonal Rabbit anti‑Human PDCD4 Antibody (IHC, WB) LS‑B1388

PathPlus™ Polyclonal Rabbit anti‑Human PDCD4 Antibody (IHC, WB) LS‑B1388

Note: This antibody replaces LS-C19651, LS-C56837
Antibody:
PDCD4 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$545
LS-B1388-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
PDCD4 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
PDCD4 is a protein that localizes to the nucleus in proliferating cells. PDCD4 expression is modulated by cytokines in natural killer and T cells, and it is thought to play a role in apoptosis. PDCD4 inhibits the translation initiation factor E1F4A, and phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis. In immunohistochemistry, PDCD4 has nuclear and cytoplasmic positivity in a majority of tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804;
Target
Human PDCD4
Synonyms
PDCD4 | H731 | Nuclear antigen H731-like | Nuclear antigen H731 | Protein 197/15a
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Immunogen
A 19 amino acid synthetic peptide near the C-Terminus of human PDCD4. The immunogen is located within the last 50 amino acids of PDCD4.
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
PDCD4 antibody can be used for detection of PDCD4 by Western blot at 0.5 - 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Western Blot:
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PDCD4
Q53EL6 NM_014456 NP_055271.2

Validation

PDCD4 Antibody - Anti-PDCD4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-PDCD4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-PDCD4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

LSBio Ratings

PathPlus™ PDCD4 Antibody for IHC, WB/Western, ELISA LS-B1388 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)

Publications (2)

Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Carcinogenesis. 2012 Sep;33:1736-44.

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency. Fong LY, Taccioli C, Jing R, Smalley KJ, Alder H, Jiang Y, Fadda P, Farber JL, Croce CM. Oncotarget. 2016 7:10723-38. (WB; Human)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021