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p66 / SHC

SHC (Src homology 2 domain containing) transforming protein 1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Name: SHC (Src homology 2 domain containing) transforming protein 1
Synonyms: SHC1, p46 shc, p52 shc, SH2 domain protein C1, p66, SHCA, SHC, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A
Target Sequences: NM_003029 NP_003020.2 P29353

Publications (2)

1
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L. Scientific reports. 2016 6:29302. (WB; Human) [Full Text Article] [PubMed:27377870] [PMC:PMC4932503] Related Antibodies: LS-C10119.
2
The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss. A R Fetoni, S L M Eramo, F Paciello, R Rolesi, D Samengo, G Paludetti, D Troiani, G Pani. Scientific reports. 2016 May;6:25450. [Full Text Article] [PubMed:27157635] [PMC:PMC4860599] Related Antibodies: LS-C10119.

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Antibodies (85)
Primary (85)
p66 / SHC (85)
Human (74)
Mouse (51)
Rat (41)
Bat (5)
Bovine (11)
Chimpanzee (4)
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Gibbon (3)
Guinea pig (4)
Hamster (4)
Horse (10)
Monkey (10)
Orangutan (3)
Pig (10)
Rabbit (4)
Sheep (1)
Xenopus (6)
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IHC (47)
IHC-Fr (2)
IHC-P (18)
WB (78)
Flo (6)
ELISA (31)
ICC (1)
IF (18)
IP (6)
Peptide-ELISA (4)
PLA (1)
rabbit (71)
mouse (14)
Product Group
IHCPlus (2)
IgG (46)
IgG,k (1)
IgG1 (13)
monoclonal mc (15)
polyclonal pc (70)
2F7C7 (1)
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6E10 (1)
EP332Y (1)
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OTI1H8 (2)
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AP Conjugated (1)
APC (1)
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Azide-free (1)
Biotin Conjugated (4)
Carrier-free (4)
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FITC Conjugated (4)
HRP Conjugated (4)
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Unconjugated (66)
pTyr427 (10)
pTyr349 (9)
aa272-559 (8)
aa378-405 (8)
aa371-420 (4)
290-370 aa (2)
370-450 aa (2)
pTyr239/Tyr240 (2)
pTyr317 (2)
10-90 aa (1)
Glu343 (1)
Leu421 (1)
N-Terminus (1)
SH2 Domain (1)
aa300-350 (1)
aa315-364 (1)
aa393-442 (1)
aa424-440 (1)
aa536-564 (1)
p349 (1)
p427 (1)
pSer36 (1)
No (84)
Yes (1)
p66 / SHC Antibody - Anti-SHC1 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 1 ug/ml.
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p66 / SHC Mouse anti-Human Monoclonal (3F4) Antibody
Human
ELISA, IF, IHC, IHC-P, PLA, WB
Unconjugated
50 µg/$460
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p66 / SHC Mouse anti-Human Monoclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$568; 100 µg/$847
p66 / SHC Antibody - Anti-p66 / SHC antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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p66 / SHC Rabbit anti-Human Monoclonal (SH2 Domain) (EP332Y) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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p66 / SHC Mouse anti-Human Monoclonal (pSer36) (6E10) Antibody
Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$568; 100 µg/$847
p66 / SHC Antibody - IHC of paraffin-embedded breast tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
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p66 / SHC Mouse anti-Human Monoclonal (OTI3A1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
p66 / SHC Antibody - IHC of paraffin-embedded breast tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
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p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3A1) Antibody
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$473
p66 / SHC Antibody - Fetal lung cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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p66 / SHC Rabbit anti-Human Polyclonal (aa371-420) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
WB
Unconjugated
100 µl/$414
p66 / SHC Antibody - p66 / SHC antibody. IHC(P): Rat Brain Tissue.
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p66 / SHC Rabbit anti-Human Polyclonal (aa424-440) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$421
p66 / SHC Antibody - SHC1 antibody IHC-paraffin: Mouse Brain Tissue.
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p66 / SHC Rabbit anti-Human Polyclonal (aa536-564) Antibody
Mouse, Sheep, Rat, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$421
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p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody
Human
IHC, WB
Unconjugated
100 µg/$536
p66 / SHC Antibody - IHC of paraffin-embedded colon tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
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p66 / SHC Mouse anti-Human Monoclonal (OTI1H8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
p66 / SHC Antibody - IHC of paraffin-embedded colon tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
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p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1H8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$473
p66 / SHC Antibody - 1:100 staining human lymphoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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p66 / SHC Rabbit anti-Human Polyclonal (pTyr349) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
p66 / SHC Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
p66 / SHC Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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p66 / SHC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µl/$369; 200 µl/$411
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p66 / SHC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
Select
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
p66 / SHC Antibody
Select
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$531
p66 / SHC Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Shc (Ab-349) antibody.
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p66 / SHC Rabbit anti-Human Polyclonal (p349) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$347
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
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p66 / SHC Mouse anti-Human Monoclonal (OTI1D3) Antibody
Flo, IF, WB
Unconjugated
100 µl/$409
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
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p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1D3) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$473
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
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p66 / SHC Mouse anti-Human Monoclonal (OTI3H1) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$409
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
Select
p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3H1) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$473
p66 / SHC Antibody - Immunohistochemistry of paraffin-embedded human prostate cancer using SHC1 Antibody at dilution of 1:100
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p66 / SHC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$284; 100 µg/$348
p66 / SHC Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
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p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody
IF, IHC, WB
Unconjugated
50 µl/$306; 100 µl/$381; 200 µl/$489
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).