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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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p66 / SHC

SHC (Src homology 2 domain containing) transforming protein 1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Name: SHC (Src homology 2 domain containing) transforming protein 1
Synonyms: SHC1, p46 shc, p52 shc, SH2 domain protein C1, p66, SHCA, SHC, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A
Target Sequences: NM_003029 NP_003020.2 P29353

Publications (1)

1
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L. Scientific reports. 2016 6:29302. (WB; Human) [Full Text Article] [PubMed:27377870] [PMC:PMC4932503] Related Antibodies: LS-C10119.

Viewing 1-25 of 88 items
p66 / SHC Antibody - Anti-SHC1 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 1 ug/ml.
Select
Mouse Monoclonal [clone 3F4] (IgG,k) to Human p66 / SHC
Human
ELISA, IF, IHC, IHC-P, PLA, WB
Unconjugated
50µg   0.42mg/ml   $495.00
p66 / SHC Antibody - Anti-p66 / SHC antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Rabbit Monoclonal [clone EP332Y] (IgG) to Human p66 / SHC
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
Select
Mouse Monoclonal (IgG1) to Human p66 / SHC
Human
ELISA, WB
Unconjugated
50µg   0.1mg/ml   $545.00; 100µg   $890.00
p66 / SHC Antibody
Select
Mouse Monoclonal (IgG1,k) to Human p66 / SHC
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100µl   1mg/ml   $305.00
Select
Mouse Monoclonal [clone 6E10] (IgG1) to Human p66 / SHC
Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
ELISA, WB
Unconjugated
50µg   $545.00; 100µg   $890.00
p66 / SHC Antibody - IHC of paraffin-embedded breast tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI3A1] (IgG1) to Human p66 / SHC
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
p66 / SHC Antibody - IHC of paraffin-embedded breast tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI3A1] (IgG1) to Human p66 / SHC
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
p66 / SHC Antibody - Fetal lung cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
p66 / SHC Antibody - p66 / SHC antibody. IHC(P): Rat Brain Tissue.
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Rabbit Polyclonal to Human p66 / SHC
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $325.00
p66 / SHC Antibody - WB: no primary antibody (lane 1); and A431 cell lysate probed with anti-SHC (lane 2)
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Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Pig, Human
IHC, IP, WB
Unconjugated
250µg   1mg/ml   $475.00
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human
IHC, WB
Unconjugated
100µg   $495.00
p66 / SHC Antibody - IHC of paraffin-embedded colon tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI1H8] (IgG1) to Human p66 / SHC
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   0.92mg/ml   $345.00
p66 / SHC Antibody - IHC of paraffin-embedded colon tissue using anti-SHC1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI1H8] (IgG1) to Human p66 / SHC
Human
IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
p66 / SHC Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
p66 / SHC Antibody - 1:100 staining human lymphoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
p66 / SHC Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00
p66 / SHC Antibody
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $435.00
p66 / SHC Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Shc (Ab-349) antibody.
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
Select
Mouse Monoclonal [clone OTI1D3] (IgG1) to Human p66 / SHC
Flo, IF, WB
Unconjugated
100µl   0.93mg/ml   $345.00
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
Select
Mouse Monoclonal [clone OTI1D3] (IgG1) to Human p66 / SHC
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg   $395.00
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
Select
Mouse Monoclonal [clone OTI3H1] (IgG1) to Human p66 / SHC
Human
Flo, IF, WB
Unconjugated
100µl   0.86mg/ml   $345.00
p66 / SHC Antibody - Anti-SHC1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1.
Select
Mouse Monoclonal [clone OTI3H1] (IgG1) to Human p66 / SHC
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg   $395.00
p66 / SHC Antibody - Immunohistochemistry of paraffin-embedded human prostate cancer using SHC1 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human p66 / SHC
Human
ELISA, IF, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00

Viewing 1-25 of 88 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).