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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NR4A1 / NUR77

nuclear receptor subfamily 4, group A, member 1

Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.

Gene Name: nuclear receptor subfamily 4, group A, member 1
Family/Subfamily: NHR , NR4 Nerve growth factor-like
Synonyms: NR4A1, GFRP1, Early response protein NAK1, HMR, NGFIB, Orphan nuclear receptor TR3, Orphan receptor tr3, Steroid receptor TR3, TR3, NAK1, NGFI-B, NP10, Receptor NGFIB, Testicular receptor 3, TR3 orphan receptor, N10, NAK-1, NUR77, Orphan nuclear receptor HMR
Target Sequences: NM_002135 NP_002126.2 P22736

Publications (4)

1
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Circulation. 2009 119:577-86. (WB, IHC-P; Mouse) [Full Text Article] [PubMed:19153266] [PMC:PMC2748681]
2
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng Z, Vlkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. European heart journal. 2011 32:2179-88. (ICC, IHC-P; Mouse, Rat) [Full Text Article] [PubMed:21228009] [PMC:PMC3164102]
3
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin gene: analysis of TRH knockout mice. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M. PloS one. 2012 7:e40437. (ICC, WB, IHC-P, ChrIP; Mouse, Human, Rat) [Full Text Article] [PubMed:22792320] [PMC:PMC3392219]
4
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Wu H #, Bi J #, Peng Y #, Huo L #, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J,. Oncotarget. 2017 8:54364-54377. (ICC; Human) [Full Text Article] [PubMed:28903348] Related Antibodies: LS-B114.
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Target
NR4A1 / NUR77 (83)
Reactivity
Human (79)
Mouse (34)
Rat (24)
Bat (13)
Bovine (14)
Chimpanzee (6)
Dog (19)
Gibbon (9)
Guinea pig (9)
Hamster (12)
Horse (26)
Monkey (21)
Orangutan (12)
Pig (4)
Rabbit (10)
Sheep (1)
Zebrafish (4)
Application
IHC (36)
IHC-P (33)
WB (56)
Flo (1)
ChrIP (1)
DB (10)
ELISA (23)
ICC (3)
IF (4)
IP (1)
Peptide-ELISA (3)
Host
rabbit (75)
mouse (6)
goat (2)
Isotype
IgG (37)
IgG1 (5)
IgG2b,k (1)
Clonality
monoclonal mc (7)
polyclonal pc (76)
Clone
11C1052 (1)
12.14 (2)
357 (1)
NR4AB9G12 (2)
Format
AP Conjugated (5)
APC Conjugated (5)
Azide-free (5)
Biotin Conjugated (9)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (6)
Unconjugated (40)
Epitope
N-Terminus (18)
pSer351 (10)
Internal (9)
Ser351 (8)
aa324-373 (4)
aa346-395 (4)
aa484-533 (4)
290-370 aa (1)
Gly347 (1)
Phospho-Nur77 (1)
aa1-170 (1)
aa251-266 (1)
aa317-366 (1)
aa372-408 (1)
aa401-414 (1)
aa99-112 (1)
Publications
No (82)
Yes (1)
Showing 1-25 of 83 results

IHC-plus™ NR4A1 / NUR77 Antibody (Internal) LS-A2830
Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (aa251-266) LS-B114
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
ChrIP, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µg 100µl 1mg/ml  $425.00
Anti-NUR77 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Western blot of Nak-1 in 15 ugs of NIH3T3 cell lysate using antibody at 1:500 dilution.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus) LS-A3386
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
50µg 0.3mg/ml  $425.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, Biotin) LS-A103903
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, Azide-free, HRP) LS-A103905
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (aa401-414) LS-B2456
Goat Polyclonal to Human NR4A1 / NUR77
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-NUR77 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Antibody (2 ug/ml) staining of Human Thyroid lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

NR4A1 / NUR77 Antibody (phospho-Ser351, clone 11C1052) LS-C183978
Rabbit Monoclonal [clone 11C1052] (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
WB
Unconjugated
100µl  $575.00

NR4A1 / NUR77 Antibody (Phospho-Nur77) LS-C381613
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-Nur77 (S351) antibody

NR4A1 / NUR77 Antibody (aa317-366) LS-C118011
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Nuclear Receptor NR4A1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COS7 cells, using Nuclear Receptor NR4A1 Antibody. The lane on the right is blocked with the synthesized peptide.

NR4A1 / NUR77 Antibody (Internal) LS-C137086
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl  $275.00
Western blot Image

NR4A1 / NUR77 Antibody (Gly347) LS-C177440
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of Nur77/NR4A1 (G347) pAb in paraffin-embedded human colon carcinoma tissue.
Western blot of Nur77/NR4A1 (G347) pAb in extracts from Jurkat cells.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus) LS-A1812
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
Unconjugated
50µg 0.4mg/ml  $425.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, Biotin) LS-A101941
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, AP) LS-A101939
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, APC) LS-A101940
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (N-Terminus, Azide-free, HRP) LS-A101943
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ NR4A1 / NUR77 Antibody (aa324-373) LS-B6837
Rabbit Polyclonal to Human NR4A1 / NUR77
Rabbit, Dog, Guinea pig, Bovine, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
NR4A1 / NUR77 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR4A1 / NUR77 Antibody (290-370 aa) LS-C385004
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Nur77 antibody
Western blot of Nur77 antibody

NR4A1 / NUR77 Antibody (clone 12.14) LS-C107127
Mouse Monoclonal [clone 12.14] (IgG1) to Mouse NR4A1 / NUR77
Mouse
WB
Unconjugated
100µg 0.5mg/ml  $335.00
Western Blot of PMA and ionomycin-stimulated (lane 1) and unstimulated mouse thymocytes (lane 2) with 5 ug/mL anti-mouse Nur77 antibody. The band was visualized using HRP-conjugated rat anti-mouse IgG.

NR4A1 / NUR77 Antibody (clone 12.14, PE) LS-C105819
Mouse Monoclonal [clone 12.14] (IgG1) to Mouse NR4A1 / NUR77
Mouse
Flo
PE Conjugated
25µg 0.2mg/ml  $245.00; 100µg  $355.00
Surface staining of unstimulated thymocytes (left) and 2-hr PMA/Iono-stimulated C57Bl/6 thymocytes (right) with APC anti-mouse CD4 (GK1.5) (LS-C107336) followed by intracellular staining with 0.5 ug of PE anti-mouse Nur77 (12.14) using Foxp3 buffers. Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR4A1 / NUR77 Antibody (phospho-Ser351, APC) LS-C225957
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Human
DB, ELISA
APC Conjugated
200µl  $740.00

IHC-plus™ NR4A1 / NUR77 Antibody LS-B15527
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
Immunohistochemistry of paraffin-embedded mouse kidney tissue, at a dilution of 1:200.

NR4A1 / NUR77 Antibody (clone NR4AB9G12) LS-C342359
Mouse Monoclonal [clone NR4AB9G12] (IgG1) to Human NR4A1 / NUR77
Human
DB, ICC, IF, WB
Unconjugated
100µg 100µg/ml  $415.00
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NR4A1 mAb.
Left : Western blot analysis of immunized recombinant protein, using anti-NR4A1 monoclonal antibody. Right : CBB staining of immunized recombinant protein.

NR4A1 / NUR77 Antibody LS-C806887
Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

NR4A1 / NUR77 Antibody (clone NR4AB9G12) LS-C184299
Mouse Monoclonal [clone NR4AB9G12] (IgG1) to Human NR4A1 / NUR77
Human
DB, ICC, WB
Unconjugated
100µg  $560.00
Western blot of immunized recombinant protein using NR4A1 antibody. Left: NR4A1staining. Right: Coomassie Blue staining of immunized recombinant protein.
Showing 1-25 of 83 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).