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NR4A1 / NUR77

nuclear receptor subfamily 4, group A, member 1

Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.

Gene Name: nuclear receptor subfamily 4, group A, member 1
Family/Subfamily: NHR , NR4 Nerve growth factor-like
Synonyms: NR4A1, GFRP1, Early response protein NAK1, HMR, NGFIB, Orphan nuclear receptor TR3, Orphan receptor tr3, Steroid receptor TR3, TR3, NAK1, NGFI-B, NP10, Receptor NGFIB, Testicular receptor 3, TR3 orphan receptor, N10, NAK-1, NUR77, Orphan nuclear receptor HMR
Target Sequences: NM_002135 NP_002126.2 P22736

Publications (6)

1
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Circulation. 2009 119:577-86. (WB, IHC-P; Mouse) [Full Text Article] [PubMed:19153266] [PMC:PMC2748681]
2
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng Z, Vlkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. European heart journal. 2011 32:2179-88. (ICC, IHC-P; Mouse, Rat) [Full Text Article] [PubMed:21228009] [PMC:PMC3164102]
3
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin gene: analysis of TRH knockout mice. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M. PloS one. 2012 7:e40437. (ICC, WB, IHC-P, ChrIP; Mouse, Human, Rat) [Full Text Article] [PubMed:22792320] [PMC:PMC3392219]
4
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Wu H #, Bi J #, Peng Y #, Huo L #, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J,. Oncotarget. 2017 8:54364-54377. (ICC; Human) [Full Text Article] [PubMed:28903348] Related Antibodies: LS-B114.
5
Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease. Tabuchi Y, Kitamura T, Fukuhara A, Mukai K, Onodera T, Miyata Y, Hamasaki T, Oshino S, Saitoh Y, Morii E, Otsuki M, Shimomura I. Endocrine Journal. 2016 June;63:545-554. [Full Text Article] [PubMed:27025408] Related Antibodies: LS-B114.
6
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe. Molecular carcinogenesis. 2022 Janurary;61:73-84. [Full Text Article] [PubMed:34699643] [PMC:PMC8665050] Related Antibodies: LS-C118011.
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Antibodies (60)
Primary (60)
NR4A1 / NUR77 (60)
Human (59)
Mouse (23)
Rat (17)
Bat (10)
Bovine (11)
Chimpanzee (6)
Dog (15)
Gibbon (9)
Guinea pig (7)
Hamster (5)
Horse (16)
Monkey (12)
Orangutan (12)
Pig (3)
Rabbit (8)
Sheep (1)
Zebrafish (3)
IHC (20)
IHC-P (14)
WB (50)
ChrIP (1)
DB (8)
ELISA (20)
ICC (2)
IF (5)
IP (1)
Peptide-ELISA (4)
rabbit (56)
mouse (2)
goat (2)
Product Group
IHCPlus (7)
IgG (36)
IgG1 (2)
monoclonal mc (3)
polyclonal pc (57)
11C1052 (1)
NR4AB9G12 (1)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (2)
Unconjugated (38)
pSer351 (11)
Ser351 (8)
N-Terminus (6)
aa324-373 (4)
aa346-395 (4)
aa484-533 (4)
Internal (3)
290-370 aa (1)
Gly347 (1)
aa1-170 (1)
aa251-266 (1)
aa317-366 (1)
aa372-408 (1)
aa401-414 (1)
aa99-112 (1)
p351 (1)
No (58)
Yes (2)
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa251-266) Antibody
Mouse, Rat, Human
ChrIP, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
50 µg/$440
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Internal) Antibody
Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
NR4A1 / NUR77 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Nuclear Receptor NR4A1 Antibody. The picture on the right is blocked with the synthesized peptide.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa317-366) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NR4A1 / NUR77 Goat anti-Human Polyclonal (aa401-414) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
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NR4A1 / NUR77 Rabbit anti-Human Monoclonal (pSer351) (11C1052) Antibody
Human
WB
Unconjugated
100 µl/$763
NR4A1 / NUR77 Antibody - Western blot of Phospho-Nur77 (S351) antibody
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (pSer351) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR4A1 / NUR77 Antibody - IHC of Nur77/NR4A1 (G347) pAb in paraffin-embedded human colon carcinoma tissue.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Gly347) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
NR4A1 / NUR77 Antibody - WB of NR4A1 / NUR77 antibody. All lanes: Anti-NR4A1 at 0.5ug/ml. Lane 1: A431 Whole Cell Lysate at 40ug. Lane 2: HELA Whole Cell Lysate at 40ug. Lane 3: JURKAT Whole Cell Lysate at 40ug. Predicted bind size: 64KD. Observed bind size: 64KD.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa99-112) Antibody
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
NR4A1 / NUR77 Antibody
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
NR4A1 / NUR77 Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NR4A1 mAb.
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NR4A1 / NUR77 Mouse anti-Human Monoclonal (NR4AB9G12) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) (HRP) Antibody
Rabbit, Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody
Rabbit, Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR4A1 / NUR77 Antibody - Western blot of Nur77 antibody
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (290-370 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (pSer351) (APC) Antibody
Human
DB, ELISA
APC Conjugated
200 µl/$952
NR4A1 / NUR77 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR4A1 / NUR77 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR4A1 / NUR77 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Nuclear Receptor NR4A1 (Ab-351) antibody.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (p351) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
NR4A1 / NUR77 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa1-170) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NR4A1 / NUR77 Antibody - Immunohistochemical analysis of NUR77 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
NR4A1 / NUR77 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using Nuclear Receptor NR4A1 (Phospho-Ser351) Antibody. The picture on the right is blocked with the phospho peptide.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (pSer351) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
NR4A1 / NUR77 Antibody - Immunofluorescence analysis of U2OS cells using NR4A1 antibody. Blue: DAPI for nuclear staining.
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).