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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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NR4A1 / NUR77

nuclear receptor subfamily 4, group A, member 1

Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.

Gene Name: nuclear receptor subfamily 4, group A, member 1
Family/Subfamily: NHR , NR4 Nerve growth factor-like
Synonyms: NR4A1, GFRP1, Early response protein NAK1, HMR, NGFIB, Orphan nuclear receptor TR3, Orphan receptor tr3, Steroid receptor TR3, TR3, NAK1, NGFI-B, NP10, Receptor NGFIB, Testicular receptor 3, TR3 orphan receptor, N10, NAK-1, NUR77, Orphan nuclear receptor HMR
Target Sequences: NM_002135 NP_002126.2 P22736

Publications (5)

1
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Circulation. 2009 119:577-86. (WB, IHC-P; Mouse) [Full Text Article] [PubMed:19153266] [PMC:PMC2748681]
2
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng Z, Vlkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. European heart journal. 2011 32:2179-88. (ICC, IHC-P; Mouse, Rat) [Full Text Article] [PubMed:21228009] [PMC:PMC3164102]
3
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin gene: analysis of TRH knockout mice. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M. PloS one. 2012 7:e40437. (ICC, WB, IHC-P, ChrIP; Mouse, Human, Rat) [Full Text Article] [PubMed:22792320] [PMC:PMC3392219]
4
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Wu H #, Bi J #, Peng Y #, Huo L #, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J,. Oncotarget. 2017 8:54364-54377. (ICC; Human) [Full Text Article] [PubMed:28903348] Related Antibodies: LS-B114.
5
Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease. Tabuchi Y, Kitamura T, Fukuhara A, Mukai K, Onodera T, Miyata Y, Hamasaki T, Oshino S, Saitoh Y, Morii E, Otsuki M, Shimomura I. Endocrine Journal. 2016 June;63:545-554. [Full Text Article] [PubMed:27025408] Related Antibodies: LS-B114.
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NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse, Rat, Human
ChrIP, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µg   100µl   1mg/ml   $425.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human primary follicles. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
50µg   0.3mg/ml   $425.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Mouse, Rat, Hamster, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human NR4A1 / NUR77
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
Unconjugated
50µg   0.4mg/ml   $425.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human NR4A1 / NUR77
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
NR4A1 / NUR77 Antibody - Anti-NUR77 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human NR4A1 / NUR77
Rabbit, Dog, Guinea pig, Bovine, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
NR4A1 / NUR77 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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Rabbit Polyclonal (IgG) to Human NR4A1 / NUR77
Mouse
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).