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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAP1LC3B / LC3B

microtubule-associated protein 1 light chain 3 beta

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Name: microtubule-associated protein 1 light chain 3 beta
Synonyms: MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B-a
Target Sequences: NM_022818 NP_073729.1 Q9GZQ8

Publications (52)

1
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK. Autophagy. 2008 4:315-21. [PubMed:18196969]
2
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Autophagy. 2008 4:467-75. (ICC, WB, IHC-Fr; Mouse) [PubMed:18259115]
3
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Overmeyer JH, Kaul A, Johnson EE, Maltese WA. Molecular cancer research : MCR. 2008 6:965-77. [PubMed:18567800] [PMC:PMC2994605] Related Antibodies: LS-C165711.
4
Induction of autophagic cell death by a novel molecule is increased by hypoxia. Tafani M, Schito L, Anwar T, Indelicato M, Sale P, Di Vito M, Morgante E, Beraldi R, Makovec F, Letari O, Caselli G, Spadafora C, Pucci B, Russo MA. Autophagy. 2008 4:1042-53. (ICC, WB; Human) [PubMed:18927491]
5
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE. Human molecular genetics. 2009 18:1937-50. (ICC, WB; Mouse) [PubMed:19279159] [PMC:PMC2678926]
6
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M. The American journal of pathology. 2009 174:1891-909. (ICC, WB; Human) [PubMed:19349362] [PMC:PMC2671277]
7
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. The American journal of pathology. 2009 175:736-47. [PubMed:19628769] [PMC:PMC2716969]
8
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. Liu MT, Kuan YH, Wang J, Hen R, Gershon MD. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:9683-99. (ICC; Mouse) [PubMed:19657021] [PMC:PMC2749879]
9
Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. Wartosch L, Fuhrmann JC, Schweizer M, Stauber T, Jentsch TJ. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 23:4056-68. [PubMed:19661288] Related Antibodies: LS-C165711.
10
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Human molecular genetics. 2010 19:2445-55. [PubMed:20354076] [PMC:PMC2876889]
11
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR. Human molecular genetics. 2011 20:40-50. [PubMed:20940149] [PMC:PMC3000675]
12
Enhanced activation of autophagy in -thalassemia/Hb E erythroblasts during erythropoiesis. Lithanatudom P, Wannatung T, Leecharoenkiat A, Svasti S, Fucharoen S, Smith DR. Annals of hematology. 2011 90:747-58. (ICC, WB; Human) [PubMed:21221583]
13
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL. Human molecular genetics. 2011 20:1820-33. [PubMed:21320871]
14
JNK regulates FoxO-dependent autophagy in neurons. Xu P, Das M, Reilly J, Davis RJ. Genes & development. 2011 25:310-22. [PubMed:21325132] [PMC:PMC3042155]
15
Pancreatic cancers require autophagy for tumor growth. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Genes & development. 2011 25:717-29. [PubMed:21406549] [PMC:PMC3070934]
16
Inflammasome-independent modulation of cytokine response by autophagy in human cells. Crian TO, Plantinga TS, van de Veerdonk FL, Farca MF, Stoffels M, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG. PloS one. 2011 6:e18666. [PubMed:21490934] [PMC:PMC3072416]
17
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 17:5353-66. [PubMed:21690574]
18
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Castino R, Fiorentino I, Cagnin M, Giovia A, Isidoro C. Toxicological sciences : an official journal of the Society of Toxicology. 2011 123:523-41. [PubMed:21742779] [PMC:PMC3218672]
19
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Journal of virology. 2011 85:10561-71. [PubMed:21835792] [PMC:PMC3187495] Related Antibodies: LS-C165711.
20
Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells. Sobolewska A, Motyl T, Gajewska M. European journal of cell biology. 2011 90:854-64. [PubMed:21868124]
21
Impaired cardiac autophagy in patients developing postoperative atrial fibrillation. Garcia L, Verdejo HE, Kuzmicic J, Zalaquett R, Gonzalez S, Lavandero S, Corbalan R. The Journal of thoracic and cardiovascular surgery. 2012 143:451-9. [PubMed:21885071]
22
Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses. Morris S, Swanson MS, Lieberman A, Reed M, Yue Z, Lindell DM, Lukacs NW. Journal of immunology (Baltimore, Md. : 1950). 2011 187:3953-61. [PubMed:21911604] [PMC:PMC3186849]
23
Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. PLoS genetics. 2011 7:e1002321. [PubMed:22022281] [PMC:PMC3192827]
24
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, Pags G, Pouyssgur J, McGargill MA, Green DR, Kanneganti TD. The Journal of biological chemistry. 2011 286:42981-91. [PubMed:22033934] [PMC:PMC3234870]
25
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Autophagy. 2012 8:609-22. [PubMed:22361619] [PMC:PMC3405840]
26
Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages. Kawano A, Tsukimoto M, Mori D, Noguchi T, Harada H, Takenouchi T, Kitani H, Kojima S. Biochemical and biophysical research communications. 2012 420:102-7. (WB; Mouse) [PubMed:22405772]
27
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, Wu MC, Wei LX. Cancer letters. 2012 320:171-9. (WB; Human) [PubMed:22406827]
28
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. Human molecular genetics. 2012 21:2651-62. (WB; Human) [PubMed:22437840] [PMC:PMC3363339]
29
Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells. Delk NA, Farach-Carson MC. Autophagy. 2012 8:650-63. [PubMed:22441019] [PMC:PMC3405839]
30
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. The Journal of experimental medicine. 2012 209:855-69. (WB; Human) [PubMed:22473955] [PMC:PMC3328359]
31
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A. Gastroenterology. 2012 143:177-87.e8. (WB; Human) [PubMed:22504094]
32
BNip3 regulates mitochondrial function and lipid metabolism in the liver. Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW, Brady MJ, Macleod KF. Molecular and cellular biology. 2012 32:2570-84. (WB; Mouse) [PubMed:22547685] [PMC:PMC3434502]
33
Amyloid- secretion, generation, and lysosomal sequestration in response to proteasome inhibition: involvement of autophagy. Agholme L, Hallbeck M, Benedikz E, Marcusson J, Kgedal K. Journal of Alzheimer's disease : JAD. 2012 31:343-58. [PubMed:22555375]
34
MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:3030-41. (WB; Human) [PubMed:22619307]
35
A quantitative TR-FRET plate reader immunoassay for measuring autophagy. Hancock MK, Hermanson SB, Dolman NJ. Autophagy. 2012 8:1227-44. [PubMed:22622129]
36
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:7454-65. [PubMed:22649225] [PMC:PMC3454486] Related Antibodies: LS-C165711.
37
Caspase activation regulates the extracellular export of autophagic vacuoles. Sirois I, Groleau J, Pallet N, Brassard N, Hamelin K, Londono I, Pshezhetsky AV, Bendayan M, Hbert MJ. Autophagy. 2012 8:927-37. [PubMed:22692030] [PMC:PMC3427258]
38
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:11008-13. (ICC, IHC; Mouse) [PubMed:22715292] [PMC:PMC3390880]
39
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Cancer research. 2012 72:3938-47. [PubMed:22719070] Related Antibodies: LS-C165711.
40
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Lai AY, McLaurin J. Biochimica et biophysica acta. 2012 1822:1629-37. (WB; Mouse) [PubMed:22800931]
41
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. Gal J, Bang Y, Choi HJ. Neurochemistry international. 2012 61:992-1000. (WB; Human) [PubMed:22819792]
42
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. PloS one. 2012 7:e41831. (ICC, WB; Human) [PubMed:22848625] [PMC:PMC3406086]
43
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Elrick MJ, Yu T, Chung C, Lieberman AP. Human molecular genetics. 2012 21:4876-87. (ICC, IHC; Mouse) [PubMed:22872701] [PMC:PMC3607480]
44
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung AL, Bradner JE, Weinstock DM. Blood. 2012 120:2843-52. [PubMed:22904298] [PMC:PMC3466965]
45
Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines. Gwak HS, Kim TH, Jo GH, Kim YJ, Kwak HJ, Kim JH, Yin J, Yoo H, Lee SH, Park JB. PloS one. 2012 7:e47449. (WB; Human) [PubMed:23077620] [PMC:PMC3471817]
46
Proliferative and survival effects of PUMA promote angiogenesis. Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X. Cell reports. 2012 2:1272-85. (ICC, WB; Mouse) [PubMed:23122957]
47
UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Bess AS, Ryde IT, Hinton DE, Meyer JN. Journal of biochemical and molecular toxicology. 2013 27:28-41. (WB; Human) [PubMed:23132756]
48
An autophagy-independent role for LC3 in equine arteritis virus replication. Monastyrska I, Ulasli M, Rottier PJ, Guan JL, Reggiori F, de Haan CA. Autophagy. 2013 9:164-74. [PubMed:23182945] [PMC:PMC3552881]
49
Immunohistochemical analysis of macroautophagy: recommendations and limitations. Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR. Autophagy. 2013 9:386-402. (ICC; Human) [Full Text Article] [PubMed:23242143] [PMC:PMC3590258]
50
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Nature. 2013 493:679-83. (WB; Mouse) [PubMed:23263183]
51
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. Humbert M, Medov M, Aebersold DM, Blaukat A, Bladt F, Fey MF, Zimmer Y, Tschan MP. Biochemical and biophysical research communications. 2013 431:264-9. (WB; Human) [PubMed:23313490]
52
Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein. Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. American journal of hematology. 2013 [PubMed:23440701] Related Antibodies: LS-C165711.
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Target
MAP1LC3B / LC3B (117)
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Human (116)
Mouse (53)
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Primate (2)
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IHC (49)
IHC-Fr (5)
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ELISA (74)
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IP (6)
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rabbit (103)
mouse (14)
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monoclonal mc (14)
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AP Conjugated (8)
APC Conjugated (8)
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aa9-33 (12)
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Publications
No (116)
Yes (1)
Showing 1-25 of 117 results

IHC-plus™ MAP1LC3B / LC3B Antibody (N-Terminus) LS-B9650
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Zebrafish, Rat, Pig, Mouse, Dog, Bovine, Human, Primate
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
100µl 1mg/ml  $425.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of treated U373-MG (human glioblastoma) cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (N-Terminus, Biotin) LS-C83854
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Zebrafish, Rat, Pig, Mouse, Dog, Bovine, Human, Primate
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100µl  $365.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of treated U373-MG (human glioblastoma) cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (N-Terminus, DY550) LS-C142309
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
100µl  $365.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of treated U373-MG (human glioblastoma) cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (N-Terminus, DY488) LS-C142308
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
100µl  $365.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of treated U373-MG (human glioblastoma) cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (N-Terminus, DY650) LS-C142307
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
100µl  $365.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of treated U373-MG (human glioblastoma) cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (aa25-121, Biotin) LS-C83721
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Fish, Zebrafish, Mouse, Dog, Rat, Human
IHC, IHC-P, IP, WB
Biotin Conjugated
100µl 1mg/ml  $365.00
MAP1LC3A antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of autophagic LC3 in mouse ES cell lysate using LC3 (human) Antibody. The atg5-/- lane (ES cells, cultured to form embryonic bodies, that are deficient in conversion of LC3-1 to LC3-11) demonstrates the specificity of LC3 (human) Antibody, as there is no detection of LC3-11. Photo courtesy of Dr. Beth Levine, UT Southwestern Medical Center.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3B / LC3B Antibody (aa1-30) LS-C165711
Publications (6)
Publications (6)
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
200µl  $325.00
Immunofluorescence of U251 cells, using LC3 Antibody (APG8B). U251 cells(right) were treated with Chloroquine (50 mu M,16h). Antibody was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).
Immunofluorescence of U251 cells, using LC3 Antibody (APG8B). U251 cells(right) were treated with Chloroquine (50 mu M,16h). Antibody was diluted at 1:100 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).

IHC-plus™ MAP1LC3B / LC3B Antibody (Thr6) LS-B9807
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot of APG8b (MAP1LC3B) Antibody (T6) in Y79 cell line lysates and mouse brain tissue lysates (35 ug/lane). MAP1LC3B (arrow) was detected using the purified antibody.

MAP1LC3B / LC3B Antibody (aa1-100, Biotin) LS-C83716
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Zebrafish, Rat, Human
IHC, IHC-P, IP, WB
Biotin Conjugated
100µl 0.9mg/ml  $365.00
MAP1LC3A antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of LC3 in human brain lysate using LC3 (human) Antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ MAP1LC3B / LC3B Antibody (aa100-125) LS-B9581
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Fluorescent image of U251 cells stained with APG8a/b (MAP1LC3A/B) antibody. U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated APG8a/b (MAP1LC3A/B) primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). APG8a/b (MAP1LC3A/B) immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.

MAP1LC3B / LC3B Antibody (aa89-122) LS-C168823
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
ICC, IF, IHC
Unconjugated
400µl  $325.00
Fluorescent image of U251 cells stained with cleaved LC3B antibody. U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated cleaved LC3B primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LC3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.
Time course study of mouse leukemic monocyte macrophage cells treated with U18666A, a drug that causes cholesterol and lipid storage in cells, thereby blocking fusion between late endosomes and lysosomes. Cleaved-LC3 (APG8b) antibody detected punctuate staining indicative of autophagic vacuole or phagosome structures. Data courtesy of Dr. Barry Boland, Department of Pharmacology, Oxford University.

IHC-plus™ MAP1LC3B / LC3B Antibody LS-B10153
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-MAP1LC3B / LC3B antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence of MAP1LC3B in human brain tissue with MAP1LC3B antibody at 20 µg/mL.

MAP1LC3B / LC3B Antibody (aa1-72) LS-C308873
Mouse Monoclonal (IgG2b,k) to Human MAP1LC3B / LC3B
Human
ELISA
Unconjugated
100µg  $560.00

MAP1LC3B / LC3B Antibody (N-Terminus) LS-C71557
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
100µl  $590.00

MAP1LC3B / LC3B Antibody LS-C747176
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
50µl  $265.00; 100µl  $345.00

MAP1LC3B / LC3B Antibody (aa74-106) LS-C156410
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
APG8b (MAP1LC3B)-T93/Y99 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the APG8b (MAP1LC3B)-T93/Y99 Antibody for immunohistochemistry.
Western blot of APG8b (MAP1LC3B) Antibody (T93/Y99) in MCF-7 cell line lysates (35 ug/lane). MAP1LC3B (arrow) was detected using the purified antibody.

MAP1LC3B / LC3B Antibody LS-C801480
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

MAP1LC3B / LC3B Antibody LS-C754833
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg  $335.00

MAP1LC3B / LC3B Antibody LS-C755321
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Human
ELISA, IF, IHC, WB
Unconjugated
100µg  $355.00

MAP1LC3B / LC3B Antibody LS-C754836
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg  $355.00

MAP1LC3B / LC3B Antibody (aa9-33) LS-C319532
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

MAP1LC3B / LC3B Antibody LS-C746931
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Pig, Human
IF, IHC, WB
Unconjugated
50µl  $275.00; 100µl  $355.00; 200µl  $455.00
Immunohistochemistry of paraffin-embedded rat lung using MAP1LC3B antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using MAP1LC3B antibody at dilution of 1:100 (40x lens).

MAP1LC3B / LC3B Antibody LS-C750554
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded rat brain using MAP1LC3B antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human breast cancer using MAP1LC3B antibody at dilution of 1:100 (40x lens).

MAP1LC3B / LC3B Antibody LS-C746932
Rabbit Polyclonal (IgG) to Human MAP1LC3B / LC3B
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded rat brain using MAP1LC3B antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using MAP1LC3B antibody at dilution of 1:100 (40x lens).

MAP1LC3B / LC3B Antibody (aa9-33) LS-C156411
Rabbit Polyclonal to Human MAP1LC3B / LC3B
Mouse, Human
Flo, IHC, WB
Unconjugated
400µl  $325.00
APG8b(MAP1LC3B) Antibody (N-term T29) immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.This data demonstrates the use of APG8b(MAP1LC3B) Antibody (N-term T29) for immunohistochemistry.
APG8b(MAP1LC3B) Antibody (T29) western blot of HepG2 cell line lysates (35 ug/lane). The APG8b(MAP1LC3B) antibody detected the APG8b(MAP1LC3B) protein (arrow).
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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).