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IL2RA / CD25

interleukin 2 receptor, alpha

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

Gene Name: interleukin 2 receptor, alpha
Family/Subfamily: Interleukin
Synonyms: IL2RA, CD25 antigen, CD25, IDDM10, IL-2 receptor subunit alpha, IL2R, Interleukin 2 receptor, alpha, IL-2-RA, IL2-RA, TCGFR, IL-2R subunit alpha, p55, TAC antigen
Target Sequences: NM_000417 NP_000408.1 P01589

Publications (3)

1
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C40810.
2
A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils. Li J, D'Annibale-Tolhurst MA, Adler KB, Fang S, Yin Q, Birkenheuer AJ, Levy MG, Jones SL, Sung EJ, Hawkins EC, Yoder JA, Nordone SK. American journal of respiratory cell and molecular biology. 2013 48:314-21. [PubMed:23221047] Related Antibodies: LS-C40810.
3
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. PloS one. 2015 10:e0134276. (WB, Flo; Human, Rat) [Full Text Article] [PubMed:26248280] [PMC:PMC4527837]

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IL2RA / CD25 (279)
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200-280 aa (2)
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IL2RA / CD25 Antibody - Anti-CD25 antibody IHC of human plasma cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IL2RA / CD25 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$460
IL2RA / CD25 Antibody - IHC of paraffin-embedded rectum cancer tissues using IL2RA mouse monoclonal antibody with DAB staining.
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IL2RA / CD25 Mouse anti-Human Monoclonal (aa34-139) (1B5D12) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
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IL2RA / CD25 Mouse anti-Rat Monoclonal (OX-39) Antibody
Rat
ELISA, Flo, IHC, IHC-Fr, IHC-P, IP
Unconjugated
0.1 mg/$395
IL2RA / CD25 Antibody - Flow cytometry of IL2RA / CD25 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
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IL2RA / CD25 Mouse anti-Human Monoclonal (Azide-free) (7G7B6) Antibody
Human
Flo, IHC
Unconjugated, Azide-free
100 µg/$411
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IL2RA / CD25 Mouse anti-Human Monoclonal (Concentrated) (4C9) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,098
IL2RA / CD25 Antibody - Immunofluorescence analysis of HeLa cells, using IL-2R alpha/CD25 Antibody. The picture on the right is blocked with the synthesized peptide.
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IL2RA / CD25 Rabbit anti-Human Polyclonal (aa223-272) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL2RA / CD25 Antibody - Immunofluorescence analysis of HeLa cells, using IL-2R alpha/CD25 (Phospho-Ser268) Antibody. The picture on the right is blocked with the phospho peptide.
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IL2RA / CD25 Rabbit anti-Human Polyclonal (pSer268) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL2RA / CD25 Antibody - IHC of CD25 on FFPE Tonsil tissue.
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IL2RA / CD25 Mouse anti-Human Monoclonal (4C9) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$365
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IL2RA / CD25 Rat anti-Mouse Monoclonal (PE, Cy7) (7D4) Antibody
Mouse
Flo
PE, Cy7 Conjugated
0.1 mg/$404
IL2RA / CD25 Antibody - Western blot analysis of CD25 expression in THP1 (A); H9C2 (B); Raw264.7 (C) whole cell lysates.
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IL2RA / CD25 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µl/$299
IL2RA / CD25 Antibody - PHA-stimulated human peripheral blood lymphocytes (3 days) stained with purified BC96 and anti-mouse IgGs FITC
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IL2RA / CD25 Mouse anti-Human Monoclonal (BC96) Antibody
Human
Flo
Unconjugated
100 µg/$239
IL2RA / CD25 Antibody - Flow cytometry of IL2RA / CD25 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL2RA / CD25 Mouse anti-Human Monoclonal (Biotin) (7G7B6) Antibody
Human
Flo, IHC
Biotin Conjugated
100 µg/$446
IL2RA / CD25 Antibody - Flow cytometry of IL2RA / CD25 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL2RA / CD25 Mouse anti-Human Monoclonal (FITC) (7G7B6) Antibody
Human
Flo, IHC
FITC Conjugated
120 Tests/$446
IL2RA / CD25 Antibody - IHC on rat spleens.
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IL2RA / CD25 Human anti-Human Recombinant Monoclonal (IL-2R alpha (CD25)) (Basiliximab) Antibody
Human, Monkey-Cynomolgus, Monkey-Rhesus
Block, Flo, IF, IHC, WB
Unconjugated
0.2 mg/$540
IL2RA / CD25 Antibody - IHC on rat spleens.
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IL2RA / CD25 Rabbit anti-Human Recombinant Monoclonal (IL-2R alpha (CD25)) (Basiliximab) Antibody
Human, Monkey-Cynomolgus, Monkey-Rhesus
Block, Flo, IF, IHC, WB
Unconjugated
0.2 mg/$540
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IL2RA / CD25 Rat anti-Mouse Monoclonal Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 250 µg/$755
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IL2RA / CD25 Mouse anti-Human Monoclonal (B489) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
0.5 ml/$328
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IL2RA / CD25 Rat anti-Mouse Monoclonal (G1/G1-4) Antibody
Mouse
Flo, IHC
Unconjugated
500 µg/$587
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IL2RA / CD25 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL2RA / CD25 Antibody - Staining LOVO cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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IL2RA / CD25 Rabbit anti-Human Polyclonal (aa250-272) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL2RA / CD25 Antibody - anti-CD25/IL-2sR Alpha antibody, IHC(P): Human Tonsil Tissue
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IL2RA / CD25 Rabbit anti-Human Polyclonal (aa39-57) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IL2RA / CD25 Antibody - Staining of rat splenocytes with FITC anti-rat CD4 and 0.06 ug of APC Mouse IgG1, K Isotype Control (left) or 0.06 ug of APC anti-rat CD25 (right). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL2RA / CD25 Mouse anti-Rat Monoclonal (APC) (OX-39) Antibody
Rat
Flo, IHC, IHC-Fr
APC Conjugated
100 µg/$398
IL2RA / CD25 Antibody - Western blot of recombinant IL2RA / CD25.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL2RA / CD25 Rabbit anti-Mouse Polyclonal (aa22-235) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
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IL2RA / CD25 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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IL2RA / CD25 Mouse anti-Sheep Monoclonal (FITC) (9.14) Antibody
Sheep
Flo
FITC Conjugated
0.1 mg/$540
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).